Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. - 0 views
These results suggest that cortisol acts as a potent mineralocorticoid in 11 beta-OHSD deficiency
major site for the oxidation of cortisol to cortisone is the kidney
congenital deficiency of 11 beta-OHSD results in high intrarenal cortisol levels which then act on renal type I mineralocorticoid receptors
- ...1 more annotation...
deficiency of 11 beta-OHSD results in high intrarenal cortisol concentrations that then bind to the type I receptor.