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Nathan Goodyear

11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression o... - 0 views

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    inhibition of 11beta-HSD1 improves metabolic syndrome and atherosclerosis.  This suggests that metabolic syndrome is associated with increase 11beta-HSD1 expression/activity.  Animal study
Nathan Goodyear

11Beta hydroxysteroid dehydrogenase ty... [Clin Endocrinol (Oxf). 2006] - PubMed - NCBI - 0 views

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    11beta-HSD type I dominantly expressed in muscle.
Nathan Goodyear

Microglia express functional 11 beta-hydroxysteroid deh... [Glia. 2010] - PubMed - NCBI - 0 views

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    microglia in the brain express 11 beta-hydroxysteroid dehydrogenase type 1 only.  This consistent with the brain as a whole.
Nathan Goodyear

Inhibitory effects of some possible endocrine-di... [Environ Sci. 2005] - PubMed - NCBI - 0 views

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    11beta-HSD type I and type II are no equally expressed across all tissues.  Endocrine disrupting chemicals (EDC) inhibit both.
Nathan Goodyear

Immunohistochemical localization of ... [J Clin Endocrinol Metab. 1998] - PubMed - NCBI - 0 views

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    11beta-HSD type I is highly expressed in liver, adrenal glands, ovaries, and adipose tissue in human immunohistochemical analysis.
Nathan Goodyear

Liver X Receptors Downregulate 11β-Hydroxysteroid Dehydrogenase Type 1 Expres... - 0 views

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    11beta-HSD type 1 is predominantly expressed in liver and adipose tissue.
Nathan Goodyear

11β-HSD1 is the major regulator of ... [Proc Natl Acad Sci U S A. 2014] - Pub... - 0 views

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    Study proposes that 11beta-HSD type 1 is the key to linking glucocorticoids and metabolic dysfunction.  The key point of this study is that it is the adipose tissue expression of 11beta-HSD type 1 that is the key.
Nathan Goodyear

Hypertension and the cortisol-cortis... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI - 0 views

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    Abstract only available.  Cortisol-cortisone shuttle play a role in hypertension.  Those with 11betaHSD type II defects will have elevated blood pressure due to increase in mineralcorticoids.
Nathan Goodyear

Tissue-Specific Increases in 11β-Hydroxysteroid Dehydrogenase Type 1 in Norma... - 0 views

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    11 beta HSD type 1 increases in menopause in normal weight women.  This may explain some of the metabolism changes seen in women post-menopause.
Nathan Goodyear

JCI - Reduced activity of 11β-hydroxysteroid dehydrogenase in patients with c... - 0 views

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    good discussion of 11beta-HSD in cortisol metabolism
Nathan Goodyear

Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. - 0 views

  • These results suggest that cortisol acts as a potent mineralocorticoid in 11 beta-OHSD deficiency
  • major site for the oxidation of cortisol to cortisone is the kidney
  • congenital deficiency of 11 beta-OHSD results in high intrarenal cortisol levels which then act on renal type I mineralocorticoid receptors
  • ...1 more annotation...
  • deficiency of 11 beta-OHSD results in high intrarenal cortisol concentrations that then bind to the type I receptor.
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    mechanism of how cortisol acts as a mineralcorticoid in those with dysfunctional 11-beta HSD activity.
Nathan Goodyear

Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity - 0 views

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    dysregulated cortisol metabolism plays a role in obesity.  This study looked at obese men.  Decreased liver 11-betaHSD1 activity was found in the liver, with decreased cortisone to cortisol conversion.  Additionally, increase cortisol metabolites were found.  However, there was found to be an increase in 11-betaHSD1 activity in the adipose tissue increasing the cortisone to cortisol conversion indicating an increase in peripheral cortisol production.
Nathan Goodyear

Obesity - Abstract of article: 11[beta]-Hydroxysteroid Dehydrogenase 2 Activity Is Elev... - 0 views

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    11-betaHSD type II increased in adipose tissue.  This correlates with insulin sensitivity.
Nathan Goodyear

Body Fat Distribution and Cortisol Metabolism in Healthy Men: Enhanced 5β-Red... - 0 views

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    increased 11-betaHSD type 1 and increased 5-alpha reductase activity found to be associated with generalized obesity in men.  Both indicate increased cortisone to cortisol production.  
Nathan Goodyear

Increased 5α-Reductase Activity and Adrenocortical Drive in Women with Polycy... - 0 views

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    increased 5-alpha reductase activity found in women with PCOS. Weight showed no variance.  Additionally, no change in 11-betaHSD activity was found.
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