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Nathan Goodyear

Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. - 0 views

  • These results suggest that cortisol acts as a potent mineralocorticoid in 11 beta-OHSD deficiency
  • major site for the oxidation of cortisol to cortisone is the kidney
  • congenital deficiency of 11 beta-OHSD results in high intrarenal cortisol levels which then act on renal type I mineralocorticoid receptors
  • ...1 more annotation...
  • deficiency of 11 beta-OHSD results in high intrarenal cortisol concentrations that then bind to the type I receptor.
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    mechanism of how cortisol acts as a mineralcorticoid in those with dysfunctional 11-beta HSD activity.
Nathan Goodyear

Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity - 0 views

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    dysregulated cortisol metabolism plays a role in obesity.  This study looked at obese men.  Decreased liver 11-betaHSD1 activity was found in the liver, with decreased cortisone to cortisol conversion.  Additionally, increase cortisol metabolites were found.  However, there was found to be an increase in 11-betaHSD1 activity in the adipose tissue increasing the cortisone to cortisol conversion indicating an increase in peripheral cortisol production.
Nathan Goodyear

Obesity - Abstract of article: 11[beta]-Hydroxysteroid Dehydrogenase 2 Activity Is Elev... - 0 views

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    11-betaHSD type II increased in adipose tissue.  This correlates with insulin sensitivity.
Nathan Goodyear

Body Fat Distribution and Cortisol Metabolism in Healthy Men: Enhanced 5β-Red... - 0 views

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    increased 11-betaHSD type 1 and increased 5-alpha reductase activity found to be associated with generalized obesity in men.  Both indicate increased cortisone to cortisol production.  
Nathan Goodyear

Increased 5α-Reductase Activity and Adrenocortical Drive in Women with Polycy... - 0 views

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    increased 5-alpha reductase activity found in women with PCOS. Weight showed no variance.  Additionally, no change in 11-betaHSD activity was found.
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