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Francesco Mureddu on 11 May 12Widespread use of a comprehensive CI framework has the potential to revolutionize every science and engineering discipline as well as education. Computing power, data volumes, software, and network capacities are all on exponential growth paths. Highly diverse, multidisciplinary collaborations and partnerships are growing dramatically, greatly enabled by new and emerging technologies, spanning multiple agencies and international domains to address complex grand challenge problems. Scientific discovery is being advanced by linking computational facilities and instruments to build highly-capable simulation models, sophisticated algorithms, software, and other tools and services. CIF21 will enable new approaches to research and education - supporting new modalities such as distributed collaborative networks, allowing researchers to more easily adapt to changes in the research and education process, and providing an integrated framework for people, instruments, and tools to address complex problems and conduct multidisciplinary research. CIF21 will consist of secure, geographically distributed, and connected CI: advanced computing facilities, scientific instruments, software environments, advanced networks, data storage capabilities, and the critically important human capital and expertise.