In 1676, Antonie van Leeuwenhoek applied his hobby of making microscopes from his own handmade lenses to observe some water running off a roof during a heavy rainstorm. He finds that it contains, in his words, “very little animalcules.” The life he has found in the runoff water is not present in pure rainwater. This was a fundamental discovery, for it showed that the bacteria and one-celled animals did not fall from the sky. When a ball of molten glass is inflated like a balloon, a small droplet of the hot fluid collects at the very bottom the bubble. Leeuwenhoek used these droplets as microscope lenses to view the animalcules. Despite their crude nature, those early lenses enabled Leeuwenhoek to describe an amazing world of microscopic life