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Redefining dentistry through 'salivaomics' - 0 views

medicalxpress.com/...ing-dentistry-salivaomics.html

scibyte69

shared by Mars Base on 22 Oct 12 - No Cached
  • research findings show that saliva is made up of complex sets of molecules—including genes, proteins, DNA and RNA—that help paint a picture of an individual's biology
  • The study of the biological molecules in saliva is known as "salivaomics."
  • researchers have developed several informatics and statistical tools to help interpret biomarkers in saliva
  • ...4 more annotations...
  • can then be used for early detection of disease, treatment monitoring, recurrence prediction and other translational assessments.
  • Research
  • has shown that saliva, as a medium for health screening is just as useful as blood and other bodily fluids
  • it has been shown that 20 percent more Americans visit their dentists more regularly than their physicians, there will be substantial opportunities for dentists to engage in primary health care by taking saliva samples from their patients and, based on the medical findings of those samples
Mars Base

Very Important Invention: Hot Pizza And Coffee Will No Longer Burn Your Mouth | Popular... - 0 views

www.popsci.com/...e-against-hungry-and-impatient

scibyte69

shared by Mars Base on 22 Oct 12 - No Cached
  • University of Texas at Austin researchers have designed an oral strip that relieves burns from hot foods and liquids.
  • oral strip that immediately numbs the pain
  • Users can apply the strips directly to the burn for a dose of benzocaine and therapeutic polymers
  • ...3 more annotations...
  • essentially acts the same as a breath strip, sticking to your mouth and dissolving in your saliva
  • researchers, who are now based at the University of New Mexico
  • currently working on a strip to treat more severe burns that last two to three days
Mars Base

Lactation protein suppresses tumors and metastasis in breast cancer, scientists discover - 0 views

medicalxpress.com/...presses-tumors-metastasis.html

scibyte69

shared by Mars Base on 24 Oct 12 - No Cached
  • protein that is necessary for lactation in mammals inhibits the critical cellular transition that is an early indicator of breast cancer and metastasis
  • first confirmed report that this protein, called Elf5, is a tumor suppressor in breast cancer
  • findings provide new avenues to pursue in treating and diagnosing breast cancer and possibly cancers of other organs as well
  • ...17 more annotations...
  • includes findings from both animal and human breast cancer models.
  • Under normal circumstances, Elf5 is a transcription factor that controls the genes that allow for milk production
  • epithelial cells in the mammary glands also became more mesenchymal, that is, more like stem cells, an early harbinger of cancer
  • when Elf5 levels are low or absent, epithelial cells become more like stem cells, morphing into mesenchymal cells, changing their shape and appearance and migrating elsewhere in the body
  • how cancer spreads
  • Elf5 keeps normal breast cells in their current shape and restricts their movement
  • the protein
  • suppressing the epithelial-mesenchymal transition by directly repressing transcription of Snail2, a master regulator of mammary stem cells known to trigger the EMT
  • Elf5 loss is frequently detected early
  • experiments
  • conducted
  • also found that little or no Elf5 in human breast cancer samples correlated with increased morbidity.
  • loss of Elf5 is an initial event in the disease
  • could also be an important diagnostic tool
  • how early does the loss of Elf5 occur?
  • use loss of Elf5 as a reliable diagnostic tool?"
  • EMT-Snail 2 pathway is a valuable one to target for early breast cancer intervention
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