Group items tagged

halofuginone (HF) triggers a stress-response pathway that blocks the development of a harmful class of immune cells

prevents the autoimmune response without dampening immunity altogether

This compound could inspire novel therapeutic approaches to a variety of autoimmune disorders."

exciting example of how solving the molecular mechanism of traditional herbal medicine can lead both to new insights into physiological regulation and to novel approaches to the treatment of disease

Prior research had shown that HF reduced scarring in tissue, scleroderma (a tightening of the skin), multiple sclerosis, scar formation and even cancer progression.

Recognized only since 2006, Th17 cells are "bad actors," implicated in many autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis and psoriasis

minute doses of HF reduced multiple sclerosis in a mouse model

Further analysis showed that HF was somehow turning on genes involved in a newly discovered pathway called the amino acid response pathway, or AAR

evidence that it extends lifespan and delays age-related inflammatory diseases in animal studies on caloric restriction

during a power outage we conserve what little juice we have left on our devices, foregoing chats in favor of emergency calls," said Whitman. "Cells use similar logic

Researchers do not yet fully understand the role that amino acid limitation plays in

researchers were able to home in on a single amino acid, called proline, and discovered that HF targeted and inhibited a particular enzyme (tRNA synthetase EPRS) responsible for incorporating proline into proteins that normally contain it.

proline also reversed other therapeutic effects of HF, inhibiting its effectiveness against the malaria parasite as well as certain cellular processes linked to tissue scarring