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This interrupted case study examines basic concepts of chemical bonding by telling the story of "Madison," a young girl eager to learn how her hair can transition from natural curls to straight, smooth tresses. The case can be used to teach or review the major categories of bonds (ionic, covalent and hydrogen), major macromolecules of life, and hydrolytic and dehydration reactions. It also explores how chemical relaxers and heat through blow drying and flat-ironing can change the nature of straight, wavy and curly hair through the disruption of protein shape. Students will thus learn what it means when a protein has become denatured and how various variables such as pH, heat and salts can lead to the unraveling of the three-dimensional shape of proteins. This case is suitable for an AP high school course, or for an introductory biology or chemistry course for majors or non-majors. This activity can also be used as a review of basic biology and chemistry for students in an upper-level biochemistry course.

Students will use pineapple juice as an enzyme and Jell-O™ as a substrate to illustrate an enzyme/substrate complex. Students will discover that the processing of food will denature enzymes.

5:12 video animation describes the basics of enzyme structure and function. This includes enzyme substrates and active sites, enzyme denaturation, and competitive and non-competitive inhibition.