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This case study was developed to teach the topic of human ABO blood type and genetic inheritance in biology courses at the lower undergraduate level or upper high school level. It is suitable for entry level biology, genetics, and physiology courses. The case narrative tells the story of Kevin, a teenager who is puzzled by the fact that neither of his parents can donate blood to him. He and his best friend ask their biology teacher for help, and she explains human ABO blood types at the molecular and genetic level to solve the mystery. The case consists of three sections, which can be used sequentially or separately. After completing the case study, students will understand the molecular basis of ABO blood types and how genes control the phenotype and genotype of an individual. They will also have a better understanding of how human ABO blood type is inherited from generation to generation.

Researchers have made dramatic inroads into the study of polygenic and other complex human diseases, due in large part to knowledge of the human genome sequence, the generation of widespread markers of genetic variation, and the development of new technologies that allow investigators to associate disease phenotypes with genetic loci. Although polygenic diseases are more common than single-gene disorders, studies of monogenic diseases provide an invaluable opportunity to learn about underlying molecular mechanisms, thereby contributing a great deal to our understanding of all forms of genetic disease.

DNA to Darwin allows 16-19 year-old school students to explore the molecular evidence for evolution through practical bioinformatics activities that use data analysis tools and molecular data. Each of the activities on this web site centres around an engaging story from recent research in molecular genetics encompassing microbiology, plant and animal biology and human evolution.

This case study examines the molecular methods that were used to reverse engineer the 1918 influenza virus strain in order to try and solve the mystery of why it was so deadly. The story starts in the 1950s with the unsuccessful attempts to culture the influenza virus and follows scientists through to the turn of the century when cutting edge molecular tools enabled scientists to finally resurrect the 1918 virus through reverse genetics. The history and methods involved in resurrecting this deadly virus are reviewed in class with a PowerPoint presentation containing clicker questions (answered with a personal response system) and discussion questions (answered in small groups). This "clicker case" is suitable for high school biology and lower division undergraduate biology classes for non-majors. It could also be used in any lower division non-major class focused on human disease and the history of human disease.

Book Chapter of gene therapy, nice figure on different approaches.

A new study shows that gene editing using CRISPR/Cas9 technology can work in rhesus monkey embryos. The results, published in the current issue of Human Molecular Genetics, open the door for pursuing gene editing in nonhuman primates as models for new therapies, including pharmacological, gene-, and stem cell-based therapies, says Keith Latham, animal science professor at Michigan State University and lead author of the study.

AMA statement on human cloning

cloning its an interesting topic it has its pros and cons