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In 1674, Antonie van Leeuwenhoek looked at a drop of lake water through his homemade microscope and discovered an invisible world that no one knew existed. His work inspired countless microbiology researchers, including HHMI investigator Bonnie Bassler, one of the narrators of this animated feature. Leeuwenhoek was a haberdasher and city official in Delft, The Netherlands. He started making simple microscopes and using them to observe the world around him. He was the first to discover bacteria, protists, sperm cells, blood cells, rotifers, and much more. 

drag and drop review and comparison of plant and animal cells

From single-celled organisms to giant redwoods, Life Science explores all of Earth's life forms. Use interactive, animated activities to identify the living and nonliving components of an ecosystem, design a Venn diagram to compare the migrations of monarch butterflies and red knot shorebirds, and take a virtual field trip to a solar farm. Resources in Life Science gives you a wide range of topics, including the cell cycle, genetic disorders, and bioethics.

8:00 video cell structure labelled animation and narrated

8:00 video cell structure labelled animation to music

Collection of video animation/movies

6:45 video animation of types of cell division

University of Washington: lessons include - pasta genetics - Cells and scale -build an animal -Toothpick Fish -traits handout -sickle cell anemia -genetics of taste

Join us as we explore the fascinating transition from early cells to multi-celled animals. This transition, as well as several other major evolutionary transitions, dramatically increased the complexity of lifeforms on our planet.

A decade-old technique that allows researchers to control brain function in lab animals could partially restore sight to the blind. In a trial sponsored by RetroSense Therapeutics, a startup company in Ann Arbor, Michigan, doctors will inject a harmless virus loaded with DNA from photoreceptive algae into the eyes of 15 patients suffering from retinitis pigmentosa. The experimental procedure represents the first human test of optogenetics, which is a technique that genetically modifies neurons to make them responsive to light. Doctors from the Retina Foundation of the Southwest will perform the procedure, and attempt to transfer the job duties of photoreceptor cells to different cells in the eye to restore sight.

For the first time, biologists have succeeded in growing human stem cells in pig embryos, shifting from science fiction to the realm of the possible the idea of developing human organs in animals for later transplant.

videos and animations for cellular processes

animation with student friendly animator 5min

9 min video We have no ways to directly observe molecules and what they do -- Drew Berry wants to change that. At TEDxSydney he shows his scientifically accurate (and entertaining!) animations that help researchers see unseeable processes within our own cells.

1:20 Stages of Mitosis, a promotional piece, begins with a fly-through of cells preparing to undergo mitosis (cell division).

Single cell moving toward a micropipette containing the chemoattractant cAMP. Note that the cell changes direction in response to movement of the micropipette by extending a new pseudopod in the direction of the pipette tip.

In the study, published Monday (May 1) in Nature Biotechnology,  Luo and colleagues set their sights on two fusions genes they had previously found to be associated with prostate cancer and various forms of rapid and invasive cancer, including liver tumors. Using a modified CRISPR-Cas9 tool that creates a single- rather than double-stranded break in DNA, they targeted the chromosomal breakpoints that form these fusion genes and replaced fusion DNA with a gene encoding the enzyme HSV1-tk. This enzyme effectively kills tumor cells by converting the drug ganciclovir into its active form, which then blocks DNA synthesis and leads to cell death. (Ganciclovir is used to treat cytomegalovirus in humans.)

In their May 2015 Scientific American article "Cellular Small Talk," Dale W. Laird, Paul D. Lampe and Ross G. Johnson report on recent discoveries showing that the disruption of cellular structures called gap junctions can cause various diseases.

This PowerPoint-driven case study presents three different stories, each of which explores an aspect of membranes. The first (The Exploding Fish) covers diffusion, specifically addressing the question of why animal cells explode in freshwater but fish do not, and differences between saltwater and freshwater fish. The second case (The Pleasurable Poison) is designed to show that alcohol can slip across membranes and also highlights some of the problems of ingesting this toxin. The third case (The Dangerous Diet) explores a weight-loss drug, DNP, and how it operates in mitochondrial membranes. The first of these case studies also includes a number of "clicker" questions. These cases were originally designed for a semester-long, introductory biology course for non-majors, and instructors can choose to use one or all of the cases to suit their course.

Animated video walks students through a sickle cell anemia case study, guided by a genetic counselor, with breaks for questions and interactive responses.