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This FOA encourages applications for multi-site exploratory and confirmatory clinical trials focused on promising interventions, as well as biomarker-or outcome measure validation studies that are immediately preparatory to trials in stroke prevention, treatment, and recovery.  Successful applicants will collaborate and conduct the trial within the NIH StrokeNet.  Following peer review, NINDS will prioritize trials among the highest scoring to be conducted in the NIH StrokeNet infrastructure. The NIH StrokeNet National Coordinating Center (NCC) will work with the successful applicant to implement the proposed study efficiently and the National Data Management Center (NDMC) will provide statistical and data management support.  The NIH StrokeNet Regional Coordinating Centers (RCCs) and their affiliated clinical sites will provide recruitment/retention support as well as on-site implementation of the clinical protocol.

The goal of this FOA is to support short courses geared to behavioral and social scientists who have existing expertise in aging research and can make research contributions in Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) with additional knowledge about the disease and related research resources. Fields of behavioral and social science research relevant for this FOA are health economics, labor economics, health services research, healthcare policy, public policy, demography, sociology, social epidemiology, psychology, and social neuroscience. Priority areas of focus include, but are not limited to, the following: dementia care; dementia caregiver research; cognitive and dementia epidemiology; behavioral and social pathways of AD/ADRD; role of social, contextual, environmental, and institutional factors in AD/ADRD; early psychological changes preceding AD/ADRD onset; prevention of AD/ADRD; disparities in AD/ADRD or dementia-related outcomes; and research resources and methods for studying the determinants and impact of AD/ADRD.

Each ACT Fellowship will provide up to $220,000 for up to thirty-three months in support of a systematic and sustained course of study in an empirical science such as physics, psychology, biology, genetics, cognitive science, neuroscience, or sociology. Acceptable courses of study might include a plan to audit undergraduate and graduate-level courses, a plan to spend time in residence at a research lab, or a plan to earn a degree in an empirical science. This iteration of the program also will permit applicants to request that up to one year of the ACT Fellowship be used to support a small-scale pilot scientific research project that improves or enhances the capacity, skill, and talent of the fellow to investigate the above-described Big Questions. Fellows may undertake their study at their home institution or another institution. All fellows must have a faculty mentor in their cross-training discipline.