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The Dynamics of Coupled Natural and Human Systems (CNH) Program supports interdisciplinary research that examines human and natural system processes and the complex interactions among human and natural systems at diverse scales. Research projects to be supported by CNH must include analyses of four different components: (1) the dynamics of a natural system; (2) the dynamics of a human system; (3) the processes through which the natural system affects the human system; and (4) the processes through which the human system affects the natural system. CNH also supports research coordination networks (CNH-RCNs) designed to facilitate activities that promote future research by broad research communities that will include all four components necessary for CNH funding.

The purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and validation of novel therapeutic targets to facilitate the development of pain therapeutics. Specifically, the focus of this FOA is on the basic science discovery of targets in the peripheral nervous system, central nervous system, immune system or other tissues in the body that can be used to develop treatments that have minimal side effects and little to no abuse/addiction liability. Research supported by this FOA must include rigorous validation studies to demonstrate the robustness of the target as a pain treatment target. This will lower the risk of adopting the target in translational projects to develop small molecules, biologics, natural substances, or devices that interact with this target for new pain treatments. Translational research to develop new medical devices are not the focus of this FOA. Basic science studies of pain and related systems in the body are responsive to this FOA and are encouraged in the context of novel pain therapeutic target discovery. This FOA is not specific for any one or group of pain conditions. Projects to identify novel targets for acute pain, chronic pain, migraine, other headache disorders, osteoarthritis, diabetic neuropathy, chemotherapy-induced neuropathy, sickle-cell pain, post stroke pain, etc. will be considered. Projects to identify novel targets for a combination of chronic overlapping pain conditions or for specific pathological conditions will be considered. Projects that seek to identify novel targets in specific populations such as women, children, older adults or other underrepresented groups will also be responsive to this FOA.

The purpose of this FOA is to invite applications that investigate aspects of lymphatic vessel physiology, development and pathophysiology related to health and diseases of the digestive system. Studies to understand the factors that control local lymphatic vessel functional anatomy and physiology and development during health or disease in this system and its organs, and the mechanisms by which alterations of lymphatic vessel function affect organ function, are of interest. However, studies with the major focus on immune mechanisms, role of lymphatics in cancer metastasis and study of lymphatic vessels in organs other than those from the digestive system will not be considered responsive.

On behalf of the Governor's Office of Health Transformation (OHT), and the Ohio Departments of Medicaid (ODM), Health (ODH) and Higher Education (ODHE), the Ohio Colleges of Medicine Government Resource Center (GRC) is requesting applications from qualified investigators through the Infant Mortality (IM) Research Partnership to identify interventions and resources needed to improve health outcomes for underserved populations and address the complicated health issue of infant mortality from a systems perspective. The IM Research Partnership seeks to fund multiple research projects in areas including but not limited to: systems dynamics modeling of the impact of the following efforts on infant mortality: improved access to care, safe sleep, and impact of progesterone; predictive modeling for infant mortality; spatial GIS modeling for identifying high-risk communities; and evaluation of the impact of OIMRI home visiting programs.

his FOA will assist Liberia in intensifying its surveillance of EVD through training Epidemiologists at the local and National level, providing National Epidemiologist EVD subject matter experts to assist County field teams in their work; as well as provide logistical support, supplies and equipment for Epidemiology Field teams to be able to conduct EVD surveillance. Laboratory systems will be strengthened through the assistance of a Senior Laboratory Data specialist, upgrades to the Laboratory Data Integration systems, and provision of much needed laboratory supplies, reagents, and equipment. EVD Chain of Transmission activities will include assessment of facilities throughout the country; and epidemiological active surveillance country wide, at the county level. Health Care Workers and community health leaders will be trained on water, sanitation and hygiene (WASH) activities, and infection prevention and control (IPC) activities.

TRANSLATIONAL MEDICINE AND THERAPEUTICS: The goal of the PhRMA Foundation's Translational Medicine and Therapeutics Program is to promote the development and use of experimental and computational methods in an integrative approach towards clinical needs in diagnosis, treatment and prevention. This can involve enhanced understanding of human biological and disease processes but requires a strong translational component. This program will support the concepts of Translational Medicine and Therapeutics as defined by the Foundation: "Translational medicine and therapeutics is a discipline focused on bridging experimental and computational technologies and discoveries in the research laboratory to their application in clinical practice. Examples of research components include activities in molecular and cellular biology, pathophysiology, systems biology, bioinformatics, modeling and simulation, and other quantitative sciences to connect basic biological concepts and entities to directly address unmet medical needs. The goals are to use clinical observation as the basis for hypothesis generation to further basic research and to efficiently advance the product of basic research to patients." Translational Medicine and Therapeutics awards will advance training and support career development of scientists engaged in research that significantly integrates cutting-edge technologies with advanced biological, chemical, and pharmacological sciences and engineering methodologies in such areas as (but not restricted to): * Genetics (Molecular, Pharmaco-, Population, Medical) * Genomics (Functional, Structural, Toxico-, Pharmaco-, Comparative) * Systems (Biology and Pharmacology) * Pathways and networks * Integrative biology * Modeling and simulation * Target Identification and Validation * Biomarker Discovery and Validation * Vaccine Development * Molecular Epidimiology * Imaging * Disease Modeling

The intent of the PFCRA is to target the emerging need to provide extended trauma care prior to reaching a location that can provide definitive hemorrhage and contamination control. Trauma care during this period is often called "Prolonged Field Care" (PFC). Traditionally, improvements to the trauma care system have focused on shortening evacuation times from the point of injury to the first surgical site. However, in future conflicts or mass trauma events, it is anticipated that the initial evacuation time, and thus initial surgical hemorrhage and contamination control, may be delayed for hours or days.This challenge also requires research to develop new solutions to provide for prolonged Damage Control Resuscitation (pDCR) including: support for medical providers in the out-of-hospital setting (point of injury, austere environment, or en route care) with limited resources; understanding the physiologic impact of pDCR; and techniques to mitigate the negative effects of delayed surgical intervention. The research and solutions must be focused on patient-level interventions and outcomes, rather than the broader trauma system. However, proposed research and solutions should consider the entire continuum of trauma care.The JPC-6/CCCRP has identified three overarching Focus Areas for funding under this Program Announcement/Funding Opportunity.

PCORI seeks to fund pragmatic clinical trials, large simple trials, or large-scale observational studies that compare two or more alternatives for addressing prevention, diagnosis, treatment, or management of a disease or symptom; improving healthcare system-level approaches to managing care; communicating or disseminating research results to patients, caregivers, or clinicians; or eliminating health or healthcare disparities. Proposed studies must address critical clinical choices faced by patients, their caregivers, clinicians, or delivery systems. They must involve broadly representative patient populations and be large enough to provide precise estimates of hypothesized effectiveness differences and to support evaluation of potential differences in treatment effectiveness in patient subgroups.

All Applicants and Awardees Must be AHA Professional Members For programs with deadlines after June 1, 2018, all applicants -- including Predoctoral and Postdoctoral Fellowship applicants -- must be American Heart Association Professional Members (memberships start at $81). Do not wait until the application deadline to renew or join. There is a 3-5 day waiting period to process membership. Applicants may renew or join via the Grants@Heart application site or by phone at 301-223-2307 or 800-787-8984. Beginning with award start dates on July 1, 2018, awardees must maintain AHA Professional Membership for the entire term of funding. AHA awardees may use their funding to pay AHA membership dues. System Requirements Applications are submitted to AHA through the Grants@Heart online system. It is accessible from any location with Internet capabilities, 24 hours a day, 7 days a week (except during scheduled maintenance).

The U.S. Affiliated Pacific Islands (USAPI) are comprised of the three U.S. territories of American Samoa, the Commonwealth of the Northern Mariana Islands, and Guam, as well as the three sovereign nations of the Federated States of Micronesia, the Republic of the Marshall Islands, and the Republic of Palau.The public health care systems in these remote islands require assistance to improve the infrastructure, capacity, and local expertise to prevent HIV in high-risk populations and to effectively address the high burden of sexually transmitted diseases (STDs), tuberculosis (TB), and viral hepatitis (VH) in their jurisdictions. Additionally, laboratory capacity is limited, surveillance systems are fragmented, and provision of health care is challenging and costly due to the vast geographic distances and broadly dispersed population throughout islands across the Pacific Ocean. This integrated Funding Opportunity Announcement (FOA) is supported by the National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP) and aims to:Promote program collaboration and services integration to capitalize on the opportunity to diagnose, treat, and prevent HIV, STD, TB, and VH in persons with similar risk factors.Improve collection, sharing, reporting, analysis, interpretation, and use of surveillance data.

The Epilepsy Foundation has announced its seventh annual epilepsy "Shark Tank" competition for the most innovative ideas in epilepsy and seizure treatment and care. Some examples of novel ideas include a system to detect seizures with the capacity to provide early warning to the patient or family; a treatment that stops a seizure from progressing; a system that helps patients manage their daily treatment; a device that prevents physical injury that patients may experience when in seizure; or an entirely new product concept with the promise to dramatically improve the lives of people with epilepsy. Selected finalists will receive international recognition and compete for grants totaling $150,000 to support the development and commercialization of important new products, technologies, or therapeutic concepts. As many as six finalists will be selected to present at the 2018 Epilepsy Pipeline Conference (San Francisco, February 22-23, 2018). Each presenter will have five minutes to present the concept, followed by five minutes of questioning. The Shark Tank event will feature live voting among audience members and a panel of judges (Sharks) representative of industry, advocacy, investors, and the research and medical communities. The winning project, or projects, deemed to be the most innovative will be announced at the conclusion of the competition. To be eligible, applicants must demonstrate an ability to move the proposed plan to completion, showing how the prize can accelerate any step along the path to market. Inventors who submitted ideas for previous Shark Tank competitions are encouraged to re-submit their ideas if substantial progress has been made.

Through the PA-16-421 (R18) grant program, AHRQ addressed "patient safety and medication research by focusing on the safe usage of medications". This perspective centers on how medications move through the health care system and how this systemic process can be improved so that patients are not harmed, while health care delivery is improved. In addition, this program encouraged "the involvement of all members of the health care team, especially patients and families; nurses, pharmacists, technicians (pharmacy and medication administration technicians), health care administrators, risk managers, and physicians across all settings of care (including in the home)". Through this mechanism, AHRQ funded "investigative research demonstration projects that examine the effective implementation of processes, policies, and behaviors that support safe use of medication as well as its sustainment and dissemination."

In November 2018, the Moore Foundation announced its Diagnostic Excellence Initiative with a focus on diagnostic performance improvement. The initiative aims to reduce harm from erroneous or delayed diagnoses, reduce costs and redundancy in the diagnostic process, improve health outcomes and save lives. The initiative's first area of focus is to develop and validate new measures for diagnostic performance. Examples of our first cohort of grants for diagnostic clinical quality measures are now available for review. Starting with measure development is important - currently, U.S. health care systems are unable to systemically measure diagnostic performance in real time, which limits the ability to quantify performance and guide improvements. 

CMF works to improve health care outcomes through grant funding of: * Programs and initiatives that improve patient safety and quality of care through education and training of health care professionals or through systems changes and improvements; * Pilot programs that are designed to reduce medical errors; and * Development and implementation of checklists and other tools to improve disease management and transitions in care. The 2021 focus area is fragmentation across care settings. Breakdowns in care from a fragmented healthcare system can lead to readmissions, missed diagnoses, medication errors, delayed treatment, duplicative testing and procedures, and reduction in quality of care leading to general patient and provider dissatisfaction. Healthcare organizations must collaborate with each other and decide how to transfer information about patients they share. For example, health information technology can help providers share information about their patients. Organizations must devise strategies to "close the loop" and ensure that providers are aware of and address actionable patient information, such as test results.

NOTICE:  Applications are submitted to the American Heart Association via Grants@Heart, a Web-based application system.  Grants@Heart is scheduled to open on May 15, 2013.  In the meantime, please review the program listings, instructions and information in preparation for your application. 

The AONE Foundation for Nursing Leadership Research and Education offers Research Seed Grants of up to $10,000 to support research projects related to nursing administration practice in the following areas: workforce, work environment, leadership development, technology/informatics, health systems, patient safety and evidence-based management practices.

The AONE Foundation for Nursing Leadership Research and Education offers Research Seed Grants of up to $10,000 to support research projects related to nursing administration practice in the following areas: workforce, work environment, leadership development, technology/informatics, health systems, patient safety and evidence-based management practices. The AONE Foundation is now accepting proposals for the 2014 research seed grant program. Members and non-members are eligible to apply.  Proposals are due by October 1, 2013.

This award is in memory of Linda Arenth, an active ONS and ONCC member who served as the Johns Hopkins Cancer Center's first director of nursing.  She started what is now a nationally known system to assign nursing services for different categories of cancer patients.  This award recognizes and supports excellence in both cancer nursing management and administration.

The 711th Human Performance Wing intends to solicit White Papers under this announcement for Aerospace Medicine, Human Performance Research, and Expeditionary Medicine for innovative and state-of-the-art research to enhance the following fields of Force Health Protection, EN Route Care, Operational Medicine, Expeditionary Medicine, and Human Performance and Systems Integration.

This announcement solicits applications for the Life Course Research Network (LCRN).  The life course theory posits that multiple determinants, such as health care, nutrition, stress and supports, and environmental exposures, operating over the life course are critical drivers of MCH outcomes.  The LCRN is designed to accelerate the translation of the life course theory to MCH practice and policy and foster its rapid adoption into clinical and public health settings through systems integration and collaboration among entities interested in improving MCH outcomes. This cooperative agreement opportunity will establish and maintain an interdisciplinary, multi-site research network.  A network is a scientific forum for collaboration and infrastructure building that provides national leadership to improve and advance the field of life course research.