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The purpose of this funding opportunity announcement (FOA) is twofold: 1. to accelerate translational and clinical Phase I and II a/b safety and efficacy studies for substantiating measurable functional benefits of probiotic/prebiotic components and/or their combinations; and; 2. to understand the underlying mechanisms of their action(s), and variability in responses to these interventions. This FOA calls for interdisciplinary collaborations across scientific disciplines engaged in microbiome and pro/prebiotic research including, but not limited to: nutritional science, microbiology, virology, microecology and microbiome, genomics, immunology, computational biology, chemistry, bioengineering, as well as integration of omics and computational approaches in DNA technologies.

The program is designed to bring together diverse interdisciplinary groups with expertise in genetics/genomics, immunology, microbiology, and proteomics along with the more traditional areas of parturition research such as maternal fetal medicine, obstetrics, and pediatrics to address scientific issues related to preterm birth. The fund has committed $3 million for the initiative and anticipates awarding five grants of up to $600,000 over a four-year period ($150,000 per year).

NineSigma, representing a major food manufacturer, seeks a technology of in vivo fluorescence labeling of any protein or mRNA using antibodies/probes. Specifically, the client anticipates proposals for technologies such as: Technology to design/produce fluorescence-labeled detection probes (antibodies, low molecular weight probes, etc.) Technology to easily introduce the fluorescence-labeled detection probe into living cells in a highly efficient manner