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This Funding Opportunity Announcement (FOA) seeks to support collaborative clinical studies, not involving treatment development, efficacy, or effectiveness trials. Primary areas of focus include mental health genetics, biomarker studies, and studies of mental illnesses (e.g., psychopathology, neurodevelopmental trajectories of psychopathology) also when associated with HIV/AIDS. Applicants should apply to this FOA when two or more sites are needed to complete the study. Accordingly, the collaborating studies share a specific protocol across the sites and are organized as such in order to increase sample size, accelerate recruitment, or increase sample diversity and representation. In studies with a large number of sites, it is expected that one site will be submitted as a coordinating R01 for data management and/or other centralized administration.

We are looking for ideas that can lead to new multi-grant research portfolios on human flourishing. We are particularly interested in ideas for interdisciplinary scientific research towards discoveries that can promote physical, mental, social, and spiritual well-being. We welcome ideas that bridge gaps between empirical science and the humanities. Such ideas may include (but are not limited to):  Experimental testing of philosophically grounded models of human flourishing; Research on biological complexity in humans, including genetics, epigenetics, and microbiome research; Investigation of key psychological, neuroscientific, or human developmental concepts, such as (but not limited to) altruism, creativity, imagination, narrative, and meta-cognition; Research on cognitive, affective, or social capacities of individuals or groups; Studies of human biological or cultural evolution.

The purpose of this FOA is to encourage mechanistic research to investigate the impact of sleep disturbances on pain. The mechanisms and processes underlying the contribution of sleep and sleep disturbances to pain perception and the development and maintenance of chronic pain may be very broad. This FOA encourages interdisciplinary research collaborations by experts from multiple fieldsneuroscientists, psychologists, endocrinologists, immunologists, geneticists, pharmacologists, chemists, physicists, behavioral scientists, clinicians, caregivers, and others in relevant fields of inquiry.