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This RFA invites applications for planning awards to develop and finalize protocols for well-powered cognitive training intervention trials to remediate or prevent age-related cognitive decline as well as possibly prevent or delay the onset of mild cognitive impairment and dementia. Planning activities may include the collection of pilot data and the refinement of cognitive training protocols consistent with Stage I of the NIH Stage Model. Trial designs must justify the means used to assess cognition and to explore the underlying mechanisms of change. Such methods as structural and functional neuroimaging with biomarkers justified by an underlying model of change, CSF fluids, and blood biomarkers are appropriate candidate tools.

JSMF is internationally recognized for supporting research on cognition and behavior; most recently, through the Understanding Human Cognition (UHC) Scholar Awards. JSMF suspended the Scholar Awards in 2019 and undertook an exploration of the new priorities for the foundation's support for the fields of cognitive science, cognitive psychology and developmental science with the intent of identifying a funding initiative that would be forward looking and responsive to contemporary questions, while building on JSMF's history. JSMF is announcing new grant guidelines for the Understanding Human Cognition program.

The purpose of this funding opportunity announcement (FOA) is to stimulate clinical research focused on biobehavioral or technological interventions to attenuate cognitive decline in individuals with dementia (such as Alzheimer's disease, Lewy body dementia, vascular dementia), mild cognitive impairment (MCI), or disease- or age-related cognitive decline. There is particular interest in interventions that can be implemented in community settings by the affected individual, informal caregivers, or others in the community. Research to inform the development of such interventions is also of interest, as well as research examining underlying mechanisms and biomarkers associated with response to interventions. It is anticipated that the results of this research will help affected individuals maintain independence and quality of life, improve their ability to perform activities of daily living (ADLs) and instrumental activities of daily living (IADLs), and additionally help to reduce stress, burden, and other poor outcomes in their caregivers.   

The purpose of this funding opportunity announcement (FOA) is to stimulate clinical research focused on biobehavioral or technological interventions to attenuate cognitive decline in individuals with dementia (such as Alzheimers disease, Lewy body dementia, vascular dementia), mild cognitive impairment (MCI), or disease- or age-related cognitive decline. There is particular interest in interventions that can be implemented in community settings by the affected individual, informal caregivers, or others in the community. Research to inform the development of such interventions is also of interest, as well as research examining underlying mechanisms and biomarkers associated with response to interventions. It is anticipated that the results of this research will help affected individuals maintain independence and quality of life, improve their ability to perform activities of daily living (ADLs) and instrumental activities of daily living (IADLs), and additionally help to reduce stress, burden, and other poor outcomes in their caregivers.

This Funding Opportunity Announcement (FOA) encourages transdisciplinary research that will leverage cognitive neuroscience to improve traditional measurement of cognitive impairment following cancer treatment, often referred to as chemobrain. A better understanding of the acute- and late-term cognitive changes following exposure to adjuvant chemotherapy and molecularly-targeted treatments, including hormonal therapy, for non-central nervous system tumors can inform clinical assessment protocols with downstream implications for survivorship care plans.

This funding opportunity supports projects that test whether modifying electrophysiological patterns during behavior can improve cognitive, affective, or social processing. Applications must use experimental designs that incorporate active manipulations to address at least one, and ideally more, of the following topics: (1) in animals or humans, determine which parameters of neural coordination, when manipulated in isolation, improve particular aspects of cognitive, affective, or social processing; (2) in animals or humans, determine how particular abnormalities at the genomic, molecular, or cellular levels affect the systems-level coordination of electrophysiological patterns during behavior; (3) determine whether in vivo, systems-level electrophysiological changes in behaving animals predict analogous electrophysiological and cognitive improvements in healthy persons or clinical populations; and (4) use biologically-realistic computational models that include systems-level aspects to understand the function and mechanisms by which oscillatory and other electrophysiological patterns unfold across the brain to impact cognitive, affective, or social processing.

The Practitioner-Researcher Partnership in Cognitive Behavioral Mentoring Program will support the development, implementation, and evaluation of innovative mentoring approaches for youth at high risk for delinquency/juvenile and criminal justice involvement or victimization and trauma. These mentoring approaches must incorporate practices that are informed by research on Cognitive behavioral interventions and techniques. The program will fund a partnership between a practitioner/service provider and an evaluator/researcher. Practitioner/service provider applicants should develop and implement Cognitive behavioral-informed practices within existing mentoring programs. These new or enhanced approaches should be piloted, manualized, and implemented with a diverse target population (defined as populations that differ demographically and/or in implementation setting). Researcher applicants should design a rigorous evaluation that examines the program design, implementation fidelity and process, and program impact. OJJDP expects the practitioner and researcher to work closely throughout the application and program development, implementation, and evaluation. OJJDP expects to make separate awards to support program development and service delivery (Category 1) and evaluation activities (Category 2). Authorizing Legislation: This program is authorized pursuant to the Department of Justice Appropriations Act, 2016 Pub. L. No. 114-113, 129 Stat. 2242, 2309.

A major goal of research on suicide is to improve our understanding of who is at most risk, why people transition from suicidal thoughts to action, and when to intervene (Prioritized Research Agenda for Suicide Prevention, Short-term Objective 1.C). Risk is a dynamic process and suicide attempts are often preceded by acute stressors. While many studies of suicide risk focus on emotion dysregulation, fewer studies have examined Arousal and Regulation and how these domains dynamically shape emotional and cognitive functions such as response to reward, frustrative non-reward, cognitive flexibility and control, or decision-making. Very few studies in the NIMH portfolio on suicide risk have focused on proximal risk. This FOA will fund research that will address these gaps, provide understanding of the mechanisms of how dysregulation interacts with Cognition, Negative and Positive Valence to determine time-varying risk, and identify modifiable targets for timely interventions during high risk periods.

A major goal of research on suicide is to improve our understanding of who is at most risk, why people transition from suicidal thoughts to action, and when to intervene (Prioritized Research Agenda for Suicide Prevention, Short-term Objective 1.C). Risk is a dynamic process and suicide attempts are often preceded by acute stressors. While many studies of suicide risk focus on emotion dysregulation, fewer studies have examined Arousal and Regulation and how these domains dynamically shape emotional and cognitive functions such as response to reward, frustrative non-reward, cognitive flexibility and control, or decision-making. Very few studies in the NIMH portfolio on suicide risk have focused on proximal risk. This FOA will fund research that will address these gaps, provide understanding of the mechanisms of how dysregulation interacts with Cognition, Negative and Positive Valence to determine time-varying risk, and identify modifiable targets for timely interventions during high risk periods.

A major goal of research on suicide is to improve our understanding of who is at most risk, why people transition from suicidal thoughts to action, and when to intervene (Prioritized Research Agenda for Suicide Prevention, Short-term Objective 1.C). Risk is a dynamic process and suicide attempts are often preceded by acute stressors. While many studies of suicide risk focus on emotion dysregulation, fewer studies have examined arousal and regulation and how these domains dynamically shape emotional and cognitive functions such as response to reward, frustrative non-reward, cognitive flexibility and control, or decision-making. Very few studies in the NIMH portfolio on suicide risk have focused on proximal risk. This Funding Opportunity Announcement (FOA) will fund research that will address these gaps by providing an understanding of the mechanisms of how dysregulation interacts with Cognition and Negative and Positive Valence in order to determine time-varying risk, and then to identify modifiable targets for timely interventions during highrisk periods. Also listed as R21.

We are interested in proposals that address memory or cognition under normal and pathological conditions. This includes proposals that address mechanisms of memory or cognition at the synaptic, cellular, or behavioral level in animals, including humans.We are particularly interested in proposals that incorporate fundamentally new approaches, as well as those that involve human experimentation. Collaborative and cross-disciplinary applications are encouraged.

The David Wechsler Early Career Grant for Innovative Work in Cognition supports early career psychologists pursuing innovative work in neuropsychology, intelligence and/or the assessment aspects of cognition. Those who work on positive applied neuropsychology are encouraged to apply.

With one in three people having a clinical stroke during their lifetime and dementia occurring in an estimated 30% of post-stroke patients, the public health impact is enormousþff. The purpose of this FOA is to determine the specific subsets of stroke events that cause (and do not cause) cognitive impairment and dementia in post-stroke populations in the United States, including in health disparities populations, and what additional clinical factors, as well as comorbidities including those along the AD/ADRD spectrum, may causally synergize with stroke to result in cognitive impairment and dementia outcomes. Applicants are encouraged to leverage existing resources for VCID, stroke and other dementia research.    

The Adolescent Brain Cognitive Development (ABCD) Study is collecting data on health and mental health, Cognitive function, substance use, cultural and environmental factors, and brain structure and function from youth starting when they are 9-10 years-old repeatedly for 10 years and makes that data available to the scientific community through the NIMH Data Archive. The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications proposing the analysis of this public use dataset to increase knowledge of adolescent health and development. More information about the ABCD Study may be found on the ABCD Study web page (www.abcdstudy.org).

The David Wechsler Early Career Grant for Innovative Work in Cognition supports early career psychologists pursuing innovative work in neuropsychology, intelligence and/or the assessment aspects of cognition. Those who work on positive applied neuropsychology are encouraged to apply. The grant is for up to $25,000.Applicants must: Be psychologists with an EdD, PsyD or PhD from an accredited university.Be no more than 10 years post doctoral.Have demonstrated competence and capacity to execute the proposed work.

We are interested in proposals that address memory or cognition under normal and pathological conditions. This includes proposals that address mechanisms of memory or cognition at the synaptic, cellular, or behavioral level in animals, including humans.We are particularly interested in proposals that incorporate fundamentally new approaches, as well as those that involve human experimentation. Collaborative and cross-disciplinary applications are encouraged. Projects restricted to the creation of conventional mouse knockouts in candidate disease genes identified by association studies, or to broadly overexpress those genes, are discouraged. In addition, projects to perform genetic interaction screens on disease genes in model organisms (yeast, worm, fly, fish) will not be considered, unless the project includes substantive specific aims that investigate the disease relevance of any new genes so discovered in human or mammalian model systems.

The FY18 PH/TBIRP CTRR-CRA is intended to support clinical research focused on understanding the clinical sequelae and mechanisms of recovery associated with TBI and TBI rehabilitation interventions. The overarching goals of this award are to address TBI-related impairments and deficits, including multimodal, and cognitive dysfunction to (1) develop and validate rehabilitation outcome measures; (2) systematically analyze standard of care cognitive interventions to identify optimal treatment ingredients; and (3) improve clinician-driven assessment strategies to guide return-to-duty decision making.

This Funding Opportunity Announcement (FOA) invites applications that focus on clarifying the relationship between delirium and Alzheimer's disease and related dementias (ADRD). Specifically sought is research focusing on understanding why persons with ADRD are at increased risk to develop delirium, often with a worse prognosis compared to those without antecedent ADRD, and why patients who experience delirium are at higher risk to develop subsequent short- and/or long-term mild cognitive impairment or ADRD, often with an accelerated rate of cognitive decline compared to those without preceding delirium. Relevant research projects may focus on, but are not limited to, those that A) provide insight into possible common, sequential, causative, contributory and/or synergistic pathways underlying both ADRD and delirium, B) elucidate mechanisms that lead to the development of delirium against the background of aging and/or neurodegeneration, with particular emphasis on use of appropriate animal models, C) identify risk factors for the onset and/or progression of delirium in those with ADRD and vice versa, D) diagnose and assess one condition in the setting of the other, E) identify putative phenotypes of patients with co-existing ADRD and delirium, or F) test pharmacologic and/or non-pharmacologic strategies to prevent, treat, or reduce the impact of delirium in patients with ADRD and vice versa. Research supported by this FOA is intended to provide mechanistic insight to improve risk assessment, diagnosis, phenotyping, prevention, and management approaches for both delirium and ADRD.

Understanding how behavior emerges from the dynamic patterns of electrical and chemical activity of brain circuits is universally recognized as one of the great, unsolved mysteries of science. Advances in recent decades have elucidated how individual elements of the nervous system and brain relate to specific behaviors and cognitive processes. However, there remains much to discover to attain a comprehensive understanding of how the healthy brain functions, specifically, the general principles underlying how cognition and behavior relate to the brain's structural organization and dynamic activities, how the brain interacts with its environment, and how brains maintain their functionality over time.

This FOA invites investigation of biological and clinical measures of TBI-related progressive neurodegeneration and neurocognitive decline associated with increased risk for dementia and /or traumatic encephalopathy syndrome (TES) (clinicopathologic diagnostic counterpart to the neuropathological diagnosis of Chronic Traumatic Encephalopathy (CTE)). Investigations should be based on existing, well-characterized populations of patients with a history of TBI that are enriched for increased risk of cognitive impairment or dementia and can continue to be followed longitudinally; additional subjects may be recruited as appropriate. The overall goal is to advance knowledge of the underlying pathophysiology and clinical characterization of the chronic effects of TBI that distinguish static-chronic TBI cognitive impairment from those that lead to progressive neurodegeneration associated with TES and dementia. A critical feature of this FOA includes the broad sharing of clinical, neuroimaging, physiological, and biospecimen data to further advance research in this area