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This Funding Opportunity Announcement (FOA) invites applications for Early Psychosis Intervention Network (EPINET) regional scientific hubs to support practice-based research to improve early identification, diagnosis, clinical assessment, intervention effectiveness, service delivery, and health outcomes in clinics offering evidence-based specialty care to persons in the early stages of psychotic illness. For this FOA, early psychosis is defined as the period spanning the onset of an affective or non-affective psychotic disorder and up to 5 years following the first episode of psychosis (FEP).

To support projects that apply new or existing tools to monitor and/or manipulate the 4D nucleome in the context of human health and disease. Any human disease or biological process relevant to NIHs mission may be proposed including environmental exposures (e.g. addictive substances, toxins, psychosocial stress), or studies across development or lifespan. Other relevant timeframes may include but are not limited to: circadian rhythms, fasting and feeding cycles, reproductive cycles, and sleep/wake cycles.

NIMH seeks applications for innovative research projects to test strategies to increase the reach, efficiency, effectiveness, and quality of digital mental health interventions. This FOA is intended to support the development of digital health test beds that leverage well-established digital mental health platforms ,to rapidly refine and optimize existing evidence-based digital health interventions and conduct clinical trials testing digital mental health interventions that are statistically powered to provide a definitive answer regarding the intervention's effectiveness.

To support projects from NIH-defined New Investigators that apply new or existing tools to monitor and/or manipulate the 4D nucleome (4DN) in the context of human health and disease. Any human disease or biological process relevant to NIHs mission may be proposed including environmental exposures (e.g. addictive substances, toxins, psychosocial stress), or studies across development or lifespan. Other relevant time frames may include but are not limited to: circadian rhythms, fasting and feeding cycles, reproductive cycles, and sleep/wake cycles.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage practice-based research aimed at testing the effectiveness of developmentally-focused theory-based efficacious prevention interventions which may impact mental health outcomes, including suicide behaviors and serious mental illness. The research should test prevention approaches that are both scalable and sustainable for implementation in pediatric-serving primary care settings, with an emphasis on populations experiencing mental health disparities. This FOA seeks to supports clinical trials to establish the effectiveness of scalable prevention interventions when implemented using available resources within pediatric-serving primary care settings.

This Funding Opportunity Announcement (FOA) invites applications to enhance screening and treatment for mental and substance use disorders in HRSA Ryan White HIV/AIDS Program funded sites through implementation research, to advance the goals of the National "End the Epidemic" (EHE) initiative. This FOA is intended to support applications seeking to conduct definitive studies on implementation approaches to enhance screening and treatment of substance use or mental health disorders in the HRSA Ryan White HIV/AIDS Program. Applications seeking to conduct pilot or feasibility implementation studies should consider the companion R34 FOA at RFA-MH20-521

The purpose of this Funding Opportunity Announcement (FOA) is to encourage practice-based research aimed at refining and pilot testing developmentally-focused, theory-based efficacious prevention interventions that may impact mental health outcomes, including suicide behaviors and serious mental illness. The research should test prevention approaches that are both scalable and sustainable for implementation in pediatric-serving primary care settings, with an emphasis on populations experiencing mental health disparities.

The Dr. Christine Blasey-Ford Grant will provide up to $1,500 to support innovative work to support graduate students and early career researchers conducting work focusing on the understanding, prevention and/or treatment of the consequences of exposure to traumatic events such as sexual assault, sexual harassment and/or rape.

Modern mental health-related research can require expensive instruments that are often hard to obtain through traditional funding mechanisms. The goal of the NIMH Instrumentation Program is to make such instruments available to either individual laboratories or core facilities that conduct mental health-related research. These instruments can be commercial instruments or collections of components that others have already described how to assemble into a working instrument. Upgrades of existing instruments can also be requested. Investigators can propose instruments that will be used by their laboratory  or by a collection of investigators.  Investigators who are proposing to provide the instrument only to members of their laboratory must state why the instrument cannot be shared.  In either case, investigators are strongly encouraged to house the requested instrument in a core facility or other shared facility to ensure that the new instrument remains functional and available to the research community over its useful lifetime.

Substantial progress has been made in the development and testing of efficacious theory-based developmentally focused prevention interventions designed to address modifiable proximal risk and protective factors with the goal of having an impact on distal mental health outcomes, including suicide behaviors and the occurrence of serious mental illness. Pediatric-serving primary care (including obstetrics/gynecological for pregnancy and post-partum, pediatric care, family practice, adolescent medicine) is a health care setting that holds potential for the implementation of mental health prevention interventions because it offers broad access and is non-stigmatizing. In addition, there is the potential for prevention interventions found to be efficacious in the primary care setting to be endorsed by the United States Prevention Services Task Force (USPSTF) and covered under insurance. Because pediatric primary care offers broad access and is non-stigmatizing, it may be an appropriate setting for reaching populations who experience mental health disparities, including racial/ethnic minority groups, sexual and gender minorities, individuals living in rural areas, socioeconomically disadvantaged persons, or any other subgroup with documented disparities in prevalence of mental illnesses, mental illness trajectories, access to prevention services, and quality and outcomes of mental health care. Accordingly, this Funding Opportunity Announcement (FOA) encourages studies that involve diverse populations, including groups that might experience health disparities, and as appropriate, it encourages examination of whether prevention services in primary care can potentially reduce or eliminate disparities.

Substantial progress has been made in the development and testing of efficacious theory-based developmentally focused prevention interventions designed to address modifiable proximal risk and protective factors with the goal of having an impact on distal mental health outcomes, including suicide behaviors and the occurrence of serious mental illness. Pediatric-serving primary care (including obstetrics/gynecological for pregnancy and post-partum, pediatric care, family practice, adolescent medicine) is a health care setting that holds potential for the implementation of mental health prevention interventions because it offers broad access and is non-stigmatizing. In addition, there is the potential for prevention interventions found to be efficacious in the primary care setting to be endorsed by the United States Preventive Services Task Force (USPSTF) and covered under insurance. Because pediatric primary care offers broad access and is non-stigmatizing, it may be an appropriate setting for reaching populations who experience mental health disparities, including racial/ethnic minority groups, sexual and gender minorities, individuals living in rural areas, socioeconomically disadvantaged persons, or any other subgroup with documented disparities in prevalence of mental illnesses, mental illness trajectories, access to prevention services, and quality and outcomes of mental health care. Accordingly, this Funding Opportunity Announcement (FOA) encourages studies that involve diverse populations, including groups that might experience health disparities, and as appropriate, it encourages examination of whether prevention services in primary care can potentially reduce or eliminate disparities.

The goal of this FOA is to test the feasibility and safety of treatment protocols for rapid-acting interventions that have the potential to reduce severe suicide risk. Approaches considered should be feasibly integrated into existing appropriate healthcare settings, such as emergency departments (ED), psychiatric inpatient units, and/or settings that may need to meet Risk Evaluation and Mitigation Strategy (REMS) approaches. Of interest are promising, existing interventions that include pharmacological, psychosocial/behavioral, and device-based approaches, alone or in combination. Approaches should build upon extant intervention findings regarding efficacy, dosing, durability of effects, patient selection/matching, and safety. Principal outcomes of interest are the reduction of suicide events, including ideation, attempts, death, and the potential decrease in high resource utilization (e.g., ED visits, hospitalization). This FOA uses the R01 grant mechanism and invites clinical research applications that will build foundational work for larger trials that could expand the evidence base for rapid-acting treatments for youth and adults with severe suicide risk.

The Klingenstein Third Generation Foundation ("KTGF") funds programs in children's mental health, principally in the areas of childhood/adolescent depression and ADHD. It also funds medical student programs in child and adolescent psychiatry at select medical institutions. Through these programs, the KTGF seeks to further research in pediatric ADHD and pediatric depression, cultivate more child and adolescent psychiatrists and increase knowledge of mental health in physicians.

Purpose NIMH seeks applications for innovative research projects to test strategies to increase the reach, efficiency, effectiveness, and quality of digital mental health interventions which may impact mental health outcomes, including suicide behaviors and serious mental illness. This FOA is intended to support the development of digital health test beds that leverage well-established digital mental health platforms/infrastructure to rapidly refine and optimize existing evidence based digital health interventions and conduct clinical trials testing digital mental health interventions that are statistically powered to provide a definitive answer regarding the intervention's effectiveness. Background The healthcare landscape in the United States is constantly changing, creating new challenges to the delivery of high-quality treatments and services to children, youth, adults, and older adults with unmet or under-met mental health needs. Epidemiological findings suggest that approximately one half of the United States population meets lifetime criteria for a mental disorder, and approximately one quarter of the population meets criteria in any given year. However, only one half of people with any mental health disorder and only two thirds of people with a serious mental health disorder received mental health services in the previous year. Of those that find their way into mental health care, many fall out of care and/or do not receive guideline concordant treatment, including suicide risk assessment and evidence-based preventive interventions. Disparities in population status (e.g., members of racial, ethnic, sexual, and gender minority communities), a fragmented healthcare system, provider shortages, healthcare affordability, and other factors moderate these findings.

NIJ is seeking applications for research and evaluation related to the abuse, neglect, and exploitation of elderly individuals. As the elderly population grows, crimes against this population are expected to increase. NIJ is particularly interested in funding research to: (1) determine an estimate of the financial costs associated with elder abuse; (2) develop a taxonomy of case outcomes that can be used to define success from multiple perspectives; and (3) examine theoretical perspectives on elder abuse that move the field toward a better understanding of why perpetrators abuse, neglect, and/or exploit elderly individuals.