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This Funding Opportunity Announcement (FOA) is intended to stimulate model-driven research to understand the ways that people make decisions about engaging in behaviors that impact the risk of acquiring or transmitting HIV, or to adhere to treatments for HIV. Decision making processes may contribute to both substance use/abuse and other HIV acquisition or transmission risks. A better understanding of decision making processes in the context of brain neural networks and their associated functions would lead to the development of better strategies to reduce the frequency of HIV-risk behaviors. Therefore, this FOA encourages applications to study 1) cognitive, motivational or emotional mechanisms and/or 2) brain neuroendocrine and reinforcement systems that related to HIV-risk behaviors or treatment non-compliance. Interdisciplinary studies that incorporate approaches from psychology, economics, anthropology, sociology, decision sciences, neuroscience and computational modeling are encouraged. This FOA for R03 applications encourages small research projects that can be carried out in a short period of time with limited resources. The R03 activity code supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. In no cases, should research involving animals be proposed.

MOD invites all qualified scientists with faculty appointments or the equivalent, at universities, hospitals and research institutions (not for profit or profit), to submit applications for research grants relevant to our mission. This encompasses basic biological processes governing differentiation and development, genetics and genomics of these processes, clinical studies, reproductive health and environmental toxicology, and social and behavioral studies concerning cognitive and behavioral risks that affect outcomes of pregnancy, the perinatal period, and subsequent child development. Applications will be directed to one of three committees whose respective foci are:    * Cell Lineage and Differentiation  * Gene Discovery and Translational Medicine  * Social and Behavioral Sciences. This involves family units and includes genes, toxicants, social  determinants that adversely affect language or behavior, especially if involving premature  infants or children with birth defects.

This Funding Opportunity Announcement (FOA) encourages Research Project Grant (R01) applications from institutions/organizations that propose to study the developing brain or brain areas that play significant roles in mediating emotional and motivated behavior and in substance use and dependence. All stages of brain development are of interest, but a new emphasis of the current reissue of this initiative is to support basic neuroscience research on fundamental mechanisms of brain development during prepuberty and the adolescent period in relation to the problems of substance abuse and co-morbidity with psychiatric disorders. Topics of interest pertaining to brain development of this initiative include, but are not limited to, the euphoric properties of abused substances, actions of psychotherapeutic agents, and their consequences on memory, cognitive and emotional processes. An additional major goal of this initiative is to understand how exposure to substances of abuse affects the cellular and molecular mechanisms underlying nervous system development and neural circuit functions implicated in substance use and addiction.

This funding opportunity announcement (FOA) encourages grant applications from institutions or organizations that propose to investigate the underlying mechanisms that facilitate behavior change within our current empirically-supported behavioral treatments for alcohol use disorders. A further goal of this FOA is to enhance translational research efforts by identifying potential neurobiological or cognitive processes that may act as potential mechanisms of therapeutic change or mediate the direct link between specific active ingredients and alcohol use treatment outcomes.

This funding opportunity announcement (FOA) encourages grant applications from institutions or organizations that propose to investigate the underlying mechanisms that facilitate behavior change within our current empirically-supported behavioral treatments for alcohol use disorders. A further goal of this FOA is to enhance translational research efforts by identifying potential neurobiological or cognitive processes that may act as potential mechanisms of therapeutic change or mediate the direct link between specific active ingredients and alcohol use treatment outcomes.

This funding opportunity announcement (FOA) encourages grant applications from institutions or organizations that propose to investigate the underlying mechanisms that facilitate behavior change within our current empirically-supported behavioral treatments for alcohol use disorders. A further goal of this FOA is to enhance translational research efforts by identifying potential neurobiological or cognitive processes that may act as potential mechanisms of therapeutic change or mediate the direct link between specific active ingredients and alcohol use treatment outcomes.

Organizations -- private and public, established and entrepreneurial, designed and emergent, formal and informal, profit and nonprofit -- are critical to the well-being of nations and their citizens. They are of crucial importance for producing goods and services, creating value, providing jobs, and achieving social goals. The Science of Organizations (SoO) program funds basic research that yields a scientific evidence base for improving the design and emergence, development and deployment, and management and ultimate effectiveness of organizations of all kinds. SoO funds research that advances our fundamental understanding of how organizations develop, form and operate. Successful SoO research proposals use scientific methods to develop and refine theories, to empirically test theories and frameworks, and to develop new measures and methods. Funded research is aimed at yielding generalizable insights that are of value to the business practitioner, policy-maker and research communities. SoO welcomes any and all rigorous, scientific approaches that illuminate aspects of organizations as systems of coordination, management and governance. In considering whether a particular project might be a candidate for consideration by SoO, please note: Intellectual perspectives may involve (but are not limited to) organizational theory, behavior, sociology or economics, business policy and strategy, communication sciences, entrepreneurship, human resource management, information sciences, managerial and organizational cognition, operations management, public administration, social or industrial psychology, and technology and innovation management. Phenomena studied may include (but are not limited to) structures, routines, effectiveness, competitiveness, innovation, dynamics, change and evolution.Levels of analysis may include (but are not limited to) organizational, cross-organizational collaborations or relationships, and institutional and can address individuals, groups or tea

This cooperative agreement will establish and maintain an interdisciplinary, multicenter research forum for scientific collaboration and infrastructure building, which will provide national leadership in research designed to improve the behavioral, mental, social, and/or cognitive health and wellbeing of children and adolescents with Autism Spectrum Disorder (ASD) and other developmental disabilities. As authorized by Section 399BB of the Autism CARES Act, the research network will determine the evidence-based practices for interventions to improve the behavioral health of individuals with ASD and other developmental disabilities, develop guidelines for those interventions, and disseminate information related to such research and guidelines. The AIR-B Network will be one of two HRSA-supported research networks that will provide national leadership in research to advance the evidence base on effective interventions for children and adolescents with ASD and other developmental disabilities, with AIR-B having a focus on addressing behavioral health and wellbeing. As directed by the FY 2015 Congressional Appropriations for HRSA's Autism CARES Act programs, HRSA is broadening the scope of this funding opportunity to reflect an additional emphasis on addressing disparities in effective interventions and treatment and access to care experienced by underserved minority and rural communities. In particular, applicants should consider diverse ethnic/racial, cultural, linguistic, socioeconomic, and geographic (e.g., rural/urban, tribal) populations for whom there is little evidence regarding the effectiveness of interventions, or for whom access to effective treatments is limited. Applicants should include plans to conduct multi-site research protocols on innovative treatment models, including the use of telehealth networks, to improve behavioral health interventions and treatment for ASD in underserved minority and rural communities. It is expected that the AIR-B Netwo

The purpose of this FOA is to solicit an application for the next 5-year cycle of the Midlife in the United States (MIDUS) Study, a National Longitudinal Study of Health and Well-being. The goals of this next phase are to complete the third wave of longitudinal data collection and enhance content in the area of daily stress; complete the second wave of data collection of clinical biomarkers and affective neuroscience assessments; continue innovative sub-studies such as how psychosocial influences affect gene expression and novel methods to track and reinstate non-responders; connect these content areas through innovative analyses to data on health, functioning, personality, cognitive status, affective functioning, economic well-being, social relationships, and well-being; and maintain and enhance data distribution and user support. A central goal of the MIDUS study is to support data dissemination, user support of public use files, and encourage data use broadly by the scientific community.

his funding opportunity announcement (FOA) supports the development and testing of pragmatic strategies for assessing the quality of the delivery of psychosocial interventions (defined here as provider-delivered behavioral, cognitive, interpersonal or other psychosocial/psychotherapeutic approaches) for the treatment or prevention of mental health disorders.  Specifically, this FOA supports (1) the initial development of pragmatic tools and strategies to assess the quality of delivery of psychosocial interventions and (2) psychometric testing of the assessment strategy to examine the feasibility, reliability, validity, and utility of the approach for prospectively assessing the quality of psychosocial intervention delivery in a practice setting.  The goal is to support the development and testing of assessment tools and strategies that are both psychometrically rigorous (i.e., reliable, valid and strongly predictive of therapy outcomes and associated with other "gold standard" metrics of quality) and pragmatic (i.e., feasible for use in community practice settings and useful for advancing efforts at training, supervision, quality monitoring, and/or quality improvement).

The FY18 PH/TBIRP CTRR-CTA is intended to support clinical trials focused on TBI cognitive rehabilitation interventions. The award mechanism supports small, Phase I clinical trials to advance the development of knowledge and materiel products for rehabilitation and restoration of function following TBI in Service members, Veterans, and other individuals.

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is aimed at revolutionizing neuroscience through development and application of innovative technologies to map neural circuits, monitor and modulate their activity, and understand how they contribute to thoughts, sensations, emotions and behavior. NIH has issued a variety of Funding Opportunity Announcements (FOAs) that will support projects that apply technologies to understand neural circuit function in the context of specific circuits, resulting in a diverse portfolio of research into the fundamental biology of nervous system function. The purpose of this announcement is to notify the research community that NIH welcomes BRAIN Initiative applications targeting central nervous system nociceptive and pain circuits, as appropriate to the goals and requirements of specific BRAIN Initiative FOAs. Pain conditions represent an important public health problem and NIH continues to support research into pain pathologies through normal Institute and Center appropriations. However, pain and nociception are also components of normal nervous system function, and the BRAIN Initiative is committed to understanding pain circuits along with brain circuits underlying other sensory, motor, cognitive and emotional functions. It is expected that the unique opportunities of the BRAIN Initiative will enable production of detailed maps of pain circuits, and the adoption of powerful new tools for monitoring and modulating pain circuit activity, leading to significant advances in the understanding of pain and nociception. For a list of past and open BRAIN Initiative FOAs, see https://braininitiative.nih.gov/funding/.

This FOA invites applications that propose the comprehensive functional validation of newly identified therapeutic target candidates for Alzheimer's Disease-Related Dementias (ADRDs). This FOA seeks to promote critical target validation approaches to help de-risk subsequent translational research and accelerate the advancement of novel therapies for ADRD. Target(s) or molecular pathway(s) to be considered for validation must have been already identified using tissue expression or genetic data generated in human samples. In its initial phase, this FOA provided support for up to two years (UG3 stage) for the development of customized technologies, models, and protocols to modulate the expression or activity of target candidate(s) in cells or tissues and monitor their functional biological consequences in in vitro or in vivo disease models. Upon demonstration of technical feasibilities, a second phase (UH3 stage) will carefully and reproducibly measure and cross-validate the impact of the target modulation in different modalities across collaborating laboratories using the NIH rigor and reproducibility guidelines. Applicants responding to this FOA must address objectives for both the UG3 and UH3 phases and are expected to have a substantial collaborative effort between independents laboratories. This FOA is not specific for any one or group within the ADRD spectrum of disorders. Disorders covered in these applications are frontotemporal degeneration (FTD), Lewy body dementias (LBD) (including dementia with Lewy bodies (DLB)), Parkinson disease dementia (PDD), vascular contributions to cognitive impairment and dementia (VCID), mixed dementias including the associated diagnostic challenges of multiples etiology dementias (MED).

This Funding Opportunity Announcement (FOA) solicits applications for planning and initial development of a large scale multi-site research study to prospectively examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally through childhood (e.g., age 9-10), and the long-term impacts of pre/postnatal drug (expected oversampling for opioid prenatal exposures) and adverse environmental exposures on brain and behavioral health and risk for substance use and mental disorders. In addition to planning and testing the feasibility of study designs, awardees will be expected to participate in 2-3 grantee meetings to share lessons learned and to begin to form collaborations needed to establish the network of sites that will conduct this study.  

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) invites applications to evaluate the cumulative and progressive effects on brain structure and cognitive/behavioral function of combined HIV infection and alcohol abuse on older patients cohorts.

The IMEE program supports fundamental, multidisciplinary research on the impact of hazards and disasters upon civil infrastructure and society. The program is focused upon research on the mitigation of, preparedness for, response to, and recovery from multi-hazard disasters. Community and societal resilience and sustainability are important topics within the research portfolio of IMEE. The program is deeply multidisciplinary, integrating multiple perspectives, methods and results from diverse areas in engineering, social and natural sciences, and computing. Among these are civil, mechanical, transportation and system engineering; sociology, cognitive science and psychology, economics, geography, political science and urban planning; geology, biology and meteorology; and applied computing. Methodological innovations that span multiple, diverse disciplines are strongly encouraged.

This Funding Opportunity Announcement (FOA) invites applications that expand on foundational research demonstrating generally improved emotional function and emotion regulation with aging, to further clarify the trajectories of change in emotion processing and linked neurobiological factors in adults who are aging normally, as well as in individuals with mild cognitive impairment (MCI), Alzheimer's disease, and related dementias (ADRD). The goal is three-fold: to advance understanding of (1) normative maturational shifts in emotional processes, (2) how dysfunction in the integrative neural-behavioral mechanisms of emotional function might manifest in MCI and the early stages of ADRD, and/or (3) how such dysfunction might account for any of the neuropsychiatric symptoms observed in ADRD. Such studies may identify novel targets for interventions or prevention efforts, or provide clues to intervention strategies that might be applied to normalize emotion dysregulation or strengthen emotional resilience at different life stages in normal aging or disease stages in MCI and ADRD.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage projects to generate fundamental knowledge of affective processes. Basic affective science projects should have key consequences for single (e.g., cancer screening) and multiple (e.g., adherence to oral chemotherapy regimen) event decisions and behaviors across the cancer prevention and control continuum. The FOA is expected to encourage collaboration among cancer control researchers and those from scientific disciplines not traditionally connected to cancer control applications (e.g., affective and cognitive neuroscience, decision science, consumer science) to elucidate perplexing and understudied problems in affective and decision sciences with downstream implications for cancer prevention and control.

This program calls for innovative, convergent, boundary-crossing proposals that can best capture those opportunities and map out new research frontiers. NSF seeks proposals that are bold and risky, and transcend the perspectives and approaches typical of disciplinary research efforts. This cross-directorate program is one element of NSF’s broader effort directed at Understanding the Brain, a multi-year activity

This funding opportunity announcement (FOA) invites innovative research to characterize the consequences of psychosocial stress on affective/cognitive functioning and/or pain processing as it relates to opioid use disorder (OUD). This FOA encourages research that elucidates mechanisms of action and determinants of vulnerability and/or resilience by which psychosocial stress influence OUD trajectories. Research using basic or clinical approaches is appropriate.