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This Funding Opportunity Announcement (FOA) invites cooperative agreement applications that will contribute to a higher resolution understanding of the physical and functional organization of the human islet tissue environment by describing the composition (cellular and molecular) and function of important components of the pancreatic islet and peri-islet tissue architecture, the cell-cell relationships and means of communications used by cell types and cell subtypes within the pancreatic tissue ecosystem, and/or the contribution of adjacent (including acinar, ductal, lymphatic) and neighboring (intestinal, mesenteric and adipose) tissues to islet cell function and dysfunction. Successful projects will integrate the Human Pancreas Analysis Consortium (HPAC), that will consist of the research teams funded in response to this FOA with the Human Pancreas Analysis Program (HPAP), a resource-generation program that was funded in 2016 in response to RFA-DK-15-027. HPAC will become the fifth consortium of the Human Islet Research Network (HIRN, https://hirnetwork.org/ ). HIRN's overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This FOA will only support studies with a primary focus on increasing our understanding of human tissue structure and function, and human disease biology (as opposed to rodent or other animal models). This FOA will not accept applications proposing a clinical trial.

The Dynamics of Coupled Natural and Human Systems (CNH) Program supports interdisciplinary research that examineshuman and natural system processes and the complex interactions among human and natural systems at diverse scales. Research projects to be supported by CNH must include analyses of four different components: (1) the dynamics of a natural system; (2) the dynamics of a human system; (3) the processes through which the natural system affects the human system; and (4) the processes through which the human system affects the natural system. CNH also supports research coordination networks (CNH-RCNs) designed to facilitate activities that promote future research by broad research communities that will include all four components necessary for CNH funding.

The U.S. Environmental Protection Agency (U.S. EPA or EPA), through its Science to Achieve Results (STAR) program, seeks applications for collaborative, community-based research that will foster better understanding of how ecosystems support human health and well-being. Specifically, this research should examine how communities can integrate ecosystem services with human health and well-being to inform their decision making and management practices. It should also develop information that allows communities to integrate environmental, societal and economic information and to better manage multiple stressors and their cumulative impacts on humans and ecosystems. The ultimate goal is to help communities achieve their own objectives

The U.S. Environmental Protection Agency (U.S. EPA or EPA), through its Science to Achieve Results (STAR) program, seeks applications for collaborative, community-based research that will foster better understanding of how ecosystems support human health and well-being. Specifically, this research should examine how communities can integrate ecosystem services with human health and well-being to inform their decision making and management practices. It should also develop information that allows communities to integrate environmental, societal and economic information and to better manage multiple stressors and their cumulative impacts on humans and ecosystems. The ultimate goal is to help communities achieve their own objectives

Sustaining Cultural Heritage Collections (SCHC) helps cultural institutions meet the complex challenge of preserving large and diverse holdings of humanities materials for future generations by supporting sustainable conservation measures that mitigate deterioration and prolong the useful life of collections. Libraries, archives, museums, and historical organizations across the country face an enormous challenge: to preserve collections that facilitate research, strengthen teaching, and provide opportunities for life-long learning in the humanities. Ensuring the preservation of books and manuscripts, photographs, sound recordings and moving images, archaeological and ethnographic artifacts, art, and historical objects requires institutions to implement measures that slow deterioration and prevent catastrophic loss. This work is best accomplished through preventive conservation, which encompasses managing relative humidity, temperature, light, and pollutants in collection spaces; providing protective storage enclosures and systems for collections; and safeguarding collections from theft and from natural and man-made disasters. As museums, libraries, archives, and other collecting institutions strive to be effective stewards of humanities collections, they must find ways to implement preventive conservation measures that are sustainable. This program therefore helps cultural repositories plan and implement preservation strategies that pragmatically balance effectiveness, cost, and environmental impact. Sustainable approaches to preservation can contribute to an institution¿s financial health, reduce its use of fossil fuels, and benefit its green initiatives, while ensuring that collections are well cared for and available for use in humanities programming, education, and research.

This solicitation represents a significant update of the CNH program, which will be known henceforth as CNH2: Dynamics of Integrated Socio-Environmental Systems. The CNH2 program acknowledges a continuum of environments from those with very limited human impacts (e.g. the extreme poles) to those in which human systems and processes fully dominate (e.g. densely populated megacities). There are integrated systems operating in all these spaces, and many can be considered as domains for CNH2 study. For the purposes of this solicitation, we define the "socio" or human component of the system as one predominantly governed by human decisions, actions, and behaviors, and we define the "environmental" component of the system as one predominantly governed by biological, physical, and chemical processes. CNH2 projects can include research that investigates integrated socio-environmental systems in agricultural as well as in urban settings.

The Healthy Communities Grant Program is the U.S. Environmental Protection Agency, Region 1's (EPA New England) main competitive grant program to work directly with communities to support EPA's "Back-to- Basics" agenda to reduce environmental risks, protect and improve human health and improve the quality of life. The Healthy Communities Grant Program will achieve these goals through identifying and funding projects that: * Target resources to benefit communities at risk [areas needing to create community resilience, environmental justice areas of potential concern, sensitive populations (e.g., children, elderly, tribes, urban and rural residents, and others at increased risk)]. * Assess, understand, and reduce environmental and human health risks. * Increase collaboration through partnerships and community-based projects. * Build institutional and community capacity to understand and solve environmental and human health problems. * Advance emergency preparedness and ecosystem resilience. * Achieve measurable environmental and human health benefits.

The Biological Anthropology Program supports multifaceted research to advance scientific knowledge of human biology and ecology, including understanding of our evolutionary history and mechanisms that have shaped human and nonhuman primate biological diversity. Supported research focuses on living and fossil forms of both human and nonhuman primates, addressing time scales ranging from the short-term to evolutionary, encompassing multiple levels of analysis (e.g., molecular, organismal, population, ecosystem), conducted in field, laboratory, captive, and computational research environments, and often incorporating interactions between human biology and culture. 

The Dynamics of Coupled Natural and Human Systems (CNH) Program promotes interdisciplinary analyses of relevant human and natural system processes and complex interactions among human and natural systems at diverse scales.

The NIEHS is establishing an infrastructure, the Human Health Exposure Analysis Resource (HHEAR) as a continuation of the Children's Health Exposure Analysis Resource (CHEAR). The goal of this consortium is to provide the research community access to laboratory and statistical analyses to add or expand the inclusion of environmental exposures in their research and to make that data publicly available as a means to improve our knowledge of the comprehensive effects of environmental exposures on human health throughout the life course. This FOA solicits Laboratories (Lab Hubs) providing a comprehensive suite of analysis of environmental exposures in samples such as dust, soil, and drinking water related to the immediate environment of individuals and linked to health endpoints. Each Hub will incorporate a developmental core to develop novel measures for environmental samples, expanding the number of current, commonly measured analytes, and developing new methods for detecting analytes in other environmental samples and providing additional insight into the sources of exposures that influence human health. The Environmental Monitoring Lab will also serve as a 'clearinghouse for evaluation and provision of emerging tools and technologies for personal exposure assessment to the client community.

The Humans, Disasters and the Built Environment (HDBE) program supports fundamental, multidisciplinary research on the interactions between humans and the built environment within and among communities exposed to natural, technological and other types of hazards and disasters. The program's context is provided by ongoing and emerging changes in three interwoven elements of a community: its population, its built environment (critical infrastructures, physical and virtual spaces, and buildings and related structures) and the hazards and disasters to which it is exposed. The HDBE program seeks research that integrates these elements and that can contribute to theories that hold over a broad range of scales and conditions. Examples include but are not limited to unified frameworks and theoretical models that encompass non-hazard to extreme hazard and disaster conditions, theoretical and empirical studies that consider how interactions between a community's population and its built environment may suppress or amplify hazard exposure or its effects, and studies that seek to inform scholarship through the development of shared data and related resources. In these and other areas funded through the HDBE program, research that challenges conventional wisdom on the interactions among humans, the built environment and hazards and disasters is particularly encouraged. Given the richness of the phenomena under study, the HDBE program seeks research that advances theories, methods and data within and across diverse disciplines, whether in engineering, the social sciences, computing or other relevant fields. Ultimately, research funded through this program is expected to inform how communities can cultivate and engage a broad range of physical, social and other resources to ensure improved quality of life for their inhabitants.

The Environmental Sustainability program supports engineering research with the goal of promoting sustainable engineered systems that support human well-being and that are also compatible with sustaining natural (environmental) systems. These systems provide ecological services vital for human survival. The long-term viability of natural capital is critical for many areas of human endeavor. Research in Environmental Sustainability typically considers long time horizons and may incorporate contributions from the social sciences and ethics.This program supports engineering research that seeks to balance society's need to provide ecological protection and maintain stable economic conditions.

The Environmental Sustainability program supports engineering research with the goal of promoting sustainable engineered systems that support human well-being and that are also compatible with sustaining natural (environmental) systems.  These systems provide ecological services vital for human survival.  The long-term viability of natural capital is critical for many areas of human endeavor.  Research in Environmental Sustainability typically considers long time horizons and may incorporate contributions from the social sciences and ethics. This program supports engineering research that seeks to balance society's need to provide ecological protection and maintain stable economic conditions.  There are four principal general research areas which are supported, but others can be proposed by contacting the program director by email at:  bhamilto@nsf.gov Industrial Ecology Green Engineering Ecological Engineering Earth Systems Engineering

The goal of the Environmental Sustainability program is to promote sustainable engineered systems that support human well-being and that are also compatible with sustaining natural (environmental) systems.  These systems provide ecological services vital for human survival.  Research efforts supported by the program typically consider long time horizons and may incorporate contributions from the social sciences and ethics. The program supports engineering research that seeks to balance society's need to provide ecological protection and maintain stable economic conditions.

The goal of the Environmental Sustainability program is to promote sustainable engineered systems that support human well-being and that are also compatible with sustaining natural (environmental) systems.  These systems provide ecological services vital for human survival.  Research efforts supported by the program typically consider long time horizons and may incorporate contributions from the social sciences and ethics. The program supports engineering research that seeks to balance society's need to provide ecological protection and maintain stable economic conditions.

The Ecology and Evolution of Infectious Diseases program supports research on the ecological, evolutionary, and socio-ecological principles and processes that influence the transmission dynamics of infectious diseases. The central theme of submitted projects must be quantitative or computational understanding of pathogen transmission dynamics. The intent is discovery of principles of infectious disease transmission and testing mathematical or computational models that elucidate infectious disease systems. Projects should be broad, interdisciplinary efforts that go beyond the scope of typical studies. They should focus on the determinants and interactions of transmission among humans, non-human animals, and/or plants. This includes, for example, the spread of pathogens; the influence of environmental factors such as climate; the population dynamics and genetics of reservoir species or hosts; the cultural, social, behavioral, and economic dimensions of disease transmission. Research may be on zoonotic, environmentally-borne, vector-borne, or enteric diseases of either terrestrial or freshwater systems and organisms, including diseases of animals and plants, at any scale from specific pathogens to inclusive environmental systems. Proposals for research on disease systems of public health concern to developing countries are strongly encouraged, as are disease systems of concern in agricultural systems. Investigators are encouraged to develop the appropriate multidisciplinary team, including for example, modelers, bioinformaticians, genomics researchers, social scientists, economists, epidemiologists, entomologists, parasitologists, microbiologists, bacteriologists, virologists, pathologists or veterinarians, with the goal of integrating knowledge across disciplines to enhance our ability to predict and control infectious diseases.

The Ecology and Evolution of Infectious Diseases program supports research on the ecological, evolutionary, and socio-ecological principles and processes that influence the transmission dynamics of infectious diseases. The central theme of submitted projects must be quantitative or computational understanding of pathogen transmission dynamics. The intent is discovery of principles of infectious disease transmission and testing mathematical or computational models that elucidate infectious disease systems. Projects should be broad, interdisciplinary efforts that go beyond the scope of typical studies. They should focus on the determinants and interactions of transmission among humans, non-human animals, and/or plants. This includes, for example, the spread of pathogens; the influence of environmental factors such as climate; the population dynamics and genetics of reservoir species or hosts; the cultural, social, behavioral, and economic dimensions of disease transmission. Research may be on zoonotic, environmentally-borne, vector-borne, or enteric diseases of either terrestrial or freshwater systems and organisms, including diseases of animals and plants, at any scale from specific pathogens to inclusive environmental systems. Proposals for research on disease systems of public health concern to developing countries are strongly encouraged, as are disease systems of concern in agricultural systems. Investigators are encouraged to develop the appropriate multidisciplinary team, including for example, modelers, bioinformaticians, genomics researchers, social scientists, economists, epidemiologists, entomologists, parasitologists, microbiologists, bacteriologists, virologists, pathologists or veterinarians, with the goal of integrating knowledge across disciplines to enhance our ability to predict and control infectious diseases.

The goal of the Environmental Sustainability program is to promote sustainable engineered systems that support human well-being and that are also compatible with sustaining natural (environmental) systems.  These systems provide ecological services vital for human survival.  Research efforts supported by the program typically consider long time horizons and may incorporate contributions from the social sciences and ethics. The program supports engineering research that seeks to balance society's need to provide ecological protection and maintain stable economic conditions.

The goal of the Environmental Sustainability program is to promote sustainable engineered systems that support human well-being and that are also compatible with sustaining natural (environmental) systems.  These systems provide ecological services vital for human survival.  Research efforts supported by the program typically consider long time horizons and may incorporate contributions from the social sciences and ethics. The program supports engineering research that seeks to balance society's need to provide ecological protection and maintain stable economic conditions. 

Coastal SEES is focused on the sustainability of coastal systems. For this solicitation we define coastal systems as the swath of land closely connected to the sea, including barrier islands, wetlands, mudflats, beaches, estuaries, cities, towns, recreational areas, and maritime facilities; the continental seas and shelves; and the overlying atmosphere. Scientific understanding is foundational and must include an understanding of reciprocal feedbacks between humans and the natural environment; how people and organizations interpret, assess, and act upon scientific and other evidence; and how they weigh these interpretations against other interests to influence governance and decision-making. Thus, coastal sustainability relies on broad and intimately interconnected areas of scholarship about natural and human processes. Coastal SEES projects will be expected to lead to generalizable theoretical advances in natural sciences and engineering while, at the same time, integrating key aspects of human processes required to address issues of coastal sustainability.

The CNH2 Program supports research projects that advance basic scientific understanding of integrated socio-environmental systems and the complex interactions (dynamics, processes, and feedbacks) within and among the environmental (biological, physical and chemical) and human ("socio") (economic, social, political, or behavioral) components of such a system. The program seeks proposals that emphasize the truly integrated nature of a socio-environmental system versus two discrete systems (a natural one and a human one) that are coupled.CNH2 projects must explore a connected and integrated socio-environmental system that includes explicit analysis of the processes and dynamics between the environmental and human components of the system. PIs are encouraged to develop proposals that push conceptual boundaries and build new theoretical framings of the understanding of socio-environmental systems.Additionally, we encourage the exploration of multi-scalar dynamics, processes and feedbacks between and within the socio-environmental system.

The Environmental Engineering program is part of the Environmental Engineering and Sustainability cluster together with 1) the Biological and Environmental Interactions of Nanoscale Materials program and 2) the Environmental Sustainability program. Environmental engineering is an interdisciplinary field that applies chemical, biological, and physical scientific principles to protect human and ecological health. The goal of the Environmental Engineering program is tosupport potentially transformative fundamental research that applies scientific and engineering principles to 1) prevent or minimize solid, liquid, and gaseous discharges of pollution to soil, water, and air; 2) mitigate the ecological and human-health impacts of such releases by smart/adaptive/reactive amendments or manipulation of the environment, and 3) remediate polluted environments through engineered chemical, biological, and/or geo-physical processes. Integral to achieving these goals is a fundamental understanding of the transport and biogeochemical reactivity of pollutants in the environment. Therefore, research on environmental micro/biology, environmental chemistry, and environmental geophysics may be relevant providing there is a clear connection to the application of environmental engineering to protect human and ecological health.

The fishery research program consists of a portfolio of funded basic (discovery, descriptive, or hypothesis generation) and applied (descriptive or hypothesis-driven) research organized by theme areas given below. Research theme areas are: Human Dimensions of Great Lakes Fishery Management -- Human dimensions-related issues play a central role in Great Lakes fisheries in terms of values and beliefs, management challenges and desired outcomes, economics, and governance. Fishery objectives often focus on a limited number of ecological and social management goals; this theme aims to expand our understanding of the human dimension of fishery management and help in having that dimension reflected in fishery management practices. Physical Processes and Fish Recruitment in Large Lakes -- TBD. Energy Dynamics of Great Lakes Food Webs -- To understand energy dynamics in Great Lakes food webs and the role of food web members in structuring resilient communities and ecosystems. The Great Lakes Fishery Commission (Commission) grants funds to academic institutions, government agencies, and private corporations through research contracts. A Principal Investigator (PI) for each research project must be designated; the PI must be a permanent employee of the institution receiving the funds who can be held accountable for ensuring the work is completed as outlined in the contract.

The foundation is focused on making grants to support environmental, human services and other causes although our interests are fairly diverse and may lead us into other areas on an occasional basis. We make both program and operating grants and do not have any geographic restrictions on our grants. Nonprofit organizations that qualify for public charity status under section 501(c)(3) of the Internal Revenue Code or public schools and libraries are eligible for contributions or grants. Grants Made by the Foundation The foundation makes grants to US based qualified charitable organizations. To date we have funded organizations that address the following areas of interest: Environment (US headquartered organizations operating programs in the US or elsewhere in the world), Human Services Disaster relief (US headquartered organizations responding to disasters in the US or elsewhere in the world on an occasional basis), Other (US headquartered organizations operating programs in the US or elsewhere in the world).