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The National Science Foundation (NSF) seeks to develop and nurture a national innovation ecosystem that builds upon research to guide the output of scientific discoveries closer to the development of technologies, products and processes that benefit society.

The purpose of this program is to develop next generation health care solutions and encourage existing and new research communities to focus on breakthrough ideas in a variety of areas of value to health, such as sensor technology, networking, information and machine learning technology, decision support systems, modeling of behavioral and cognitive processes, as well as system and process modeling. Effective solutions must satisfy a multitude of constraints arising from clinical/medical needs, social interactions, cognitive limitations, barriers to behavioral change, heterogeneity of data, semantic mismatch and limitations of current cyberphysical systems. Such solutions demand multidisciplinary teams ready to address technical, behavioral and clinical issues ranging from fundamental science to clinical practice.

The purpose of this program is to develop next generation health care solutions and encourage existing and new research communities to focus on breakthrough ideas in a variety of areas of value to health, such as sensor technology, networking, information and machine learning technology, decision support systems, modeling of behavioral and cognitive processes, as well as system and process modeling. Effective solutions must satisfy a multitude of constraints arising from clinical/medical needs, social interactions, cognitive limitations, barriers to behavioral change, heterogeneity of data, semantic mismatch and limitations of current cyberphysical systems. Such solutions demand multidisciplinary teams ready to address technical, behavioral and clinical issues ranging from fundamental science to clinical practice.

These awards encourage and support scientists working on the development of novel and creative approaches to understanding brain function. The fund supports efforts to examine how a new technology may be used to monitor, manipulate, analyze, or model brain function at any level, from the molecular to the entire organism. Technology may take any form, from biochemical tools to instruments to software and mathematical approaches. Because the program seeks to advance and enlarge the range of technologies available to the neurosciences, research based primarily on existing techniques will not be considered.

These awards encourage and support scientists working on the development of novel and creative approaches to understanding brain function. The fund supports efforts to examine how a new technology may be used to monitor, manipulate, analyze, or model brain function at any level, from the molecular to the entire organism. Technology may take any form, from biochemical tools to instruments to software and mathematical approaches. Because the program seeks to advance and enlarge the range of technologies available to the neurosciences, research based primarily on existing techniques will not be considered.

The Emerging Frontiers in Research and Innovation (EFRI) program of the NSF Directorate for Engineering (ENG) serves a critical role in helping ENG focus on important emerging areas in a timely manner. This solicitation is a funding opportunity for interdisciplinary teams of researchers to embark on rapidly advancing frontiers of fundamental engineering research. For this solicitation, we will consider proposals that aim to investigate emerging frontiers in the following two research areas: Chromatin and Epigenetic Engineering (CEE) Continuum, Compliant, and Configurable Soft Robotics Engineering (C3 SoRo)

The Cellular and Biochemical Engineering (CBE)program is part of the Engineering Biology and Health cluster, which also includes 1) Biophotonics; 2) Biosensing; 3) Disability and Rehabilitation Engineering; and 4) Engineering of Biomedical Systems. TheCellular and Biochemical Engineering program supports fundamental engineering research that advances understanding of cellular andbiomolecular processes in engineering biology. CBE-funded research eventually leads to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cell, biochemical, biopharmaceutical, and biotechnology industries. Fundamental to many research projects in this area is the understanding of how biomolecules, subcellular systems, cells, and cell populations interact in the biomanufacturing environment, and how those interactions lead to changes in structure, function, and behavior. A quantitative treatment of problems related to biological processes is considered vital to successful research projects in the CBE program. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches. The CBE program also encourages proposals that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.

The mission of BTO is to foster, demonstrate, and transition breakthrough fundamental research, discoveries, and applications that integrate biology, engineering, computer science, mathematics, and the physical sciences. BTO's investment portfolio goes far beyond life sciences applications in medicine to include areas of research such as human-machine interfaces, microbes as production platforms, and deep exploration of the impact of evolving ecologies and environments on U.S. readiness and capabilities. BTO's programs operate across a wide range of scales, from individual cells to the warfighter to global ecosystems. BTO responds to the urgent and long-term needs of the Department of Defense (DoD) and addresses national security priorities.

This Funding Opportunity Announcement (FOA) seeks grant applications to catalyze major advances in genomics through technology development (beyond developing nucleic acid sequencing technologies). The goal is to provide a mechanism for support of very novel and high impact work from across this gamut of genomics technology development. This initiative seeks to support technologies that will have a major impact in the next five to seven years.

This Funding Opportunity Announcement (FOA) is to invite applications for new applications for the Data Management and Coordinating Center (DMCC) for the Rare Diseases Clinical Research Network (RDCRN). Each consortium within the RDCRN is intended to advance the diagnosis, management, and treatment of rare diseases. The DMCC will facilitate and support the activities of each Rare Diseases Clinical Research Consortium (RDCRC) along with trans-network activities that broadly facilitate the advancement of rare disease research via four Cores; 1) Administrative; 2) Data Management; 3) Clinical Research and; 4) Engagement and Dissemination.

* The frontiers of science-exploring nature's mysteries from the study of fundamental subatomic particles, atoms, and molecules that are the building blocks of the materials of our universe and everything in it to the DNA, proteins, and cells that are the building blocks of life. Each of the programs in SC supports research probing the most fundamental disciplinary questions. * The 21st Century tools of science-providing the nation's researchers with 27 state-of-the-art national scientific user facilities - the most advanced tools of modern science - propelling the U.S. to the forefront of science, technology development and deployment through innovation. * Science for energy and the environment―paving the knowledge foundation to spur discoveries and innovations for advancing the Department's mission in energy and environment. SC supports a wide range of funding modalities from single principal investigators to large team-based activities to engage in fundamental research on energy production, conversion, storage, transmission, and use, and on our understanding of the earth systems.

The National Science Foundation (NSF), through its Divisions of Electrical, Communications and Cyber Systems (ECCS), Computing and Communication Foundations (CCF), Molecular and Cellular Biosciences (MCB), and Materials Research (DMR) announces a follow-up solicitation on the Semiconductor Synthetic Biology for Information Storage and Retrieval Program (SemiSynBio-II).  Future ultra-low energy storage-based computing systems can be built on principles derived from organic systems that are at the intersection of physics, chemistry, biology, computer science and engineering.  Next-generation information storage technologies can be envisioned that are driven by biological principles and use biomaterials in the fabrication of devices and systems that can store data for more than 100 years with storage capacity 1,000 times more than current storage technologies.  Such a research effort can have a significant impact on the future of information storage and retrieval technologies. This focused solicitation seeks high-risk/high-return interdisciplinary research on novel concepts and enabling technologies that will address the fundamental scientific issues and technological challenges associated with the underpinnings of synthetic biology integrated with semiconductor technology. This research will foster interactions among various disciplines including biology, physics, chemistry, materials science, computer science and engineering that will enable in heretofore unanticipated breakthroughs.

The purpose of this Funding Opportunity Announcement (FOA) is to stimulate translation of scientific discoveries and engineering developments in imaging, data science and/or spectroscopic technologies into methods or tools that address contemporary problems in understanding the fundamental biology, potential risk of development, diagnosis, treatment, and/or disease status for cancer or other disease.

The National Science Foundation (NSF) Directorates for Engineering (ENG) and Geosciences (GEO), the Divisions of Integrative Organismal Systems (IOS) and Environmental Biology (DEB), in the Directorate for Biological Sciences (BIO), the Division of Computer and Network Systems in the Directorate Computer and Information Science and Engineering (CISE/CNS), and the Division of Chemistry (CHE) in the Directorate for Mathematical and Physical Sciences, in collaboration with the US Department of Agriculture National Institute of Food and Agriculture (USDA NIFA) encourage convergent research that transforms existing capabilities in understanding dynamic soil processes, including soil formation, through advances in sensor systems and modeling. The Signals in the Soil (SitS) program fosters collaboration among the two partner agencies and the researchers they support by combining resources and funding for the most innovative and high-impact projects that address their respective missions. To make transformative advances in our understanding of soils, multiple disciplines must converge to produce environmentally-benign novel sensing systems with multiple modalities that can adapt to different environments and collect and transmit data for a wide range of biological, chemical, and physical parameters. Effective integration of sensor data will be key for achieving a better understanding of signaling interactions among plants, animals, microbes, the soil matrix, and aqueous and gaseous components. New sensor networks have the potential to inform models in novel ways, to radically change how data is obtained from various natural and managed (both urban and rural) ecosystems, and to better inform the communities that directly rely on soils for sustenance and livelihood.

The National Science Foundation (NSF), through its Divisions of Electrical, Communications and Cyber Systems (ECCS), Computing and Communication Foundations (CCF), Molecular and Cellular Biosciences (MCB), and Materials Research (DMR) announces a follow-up solicitation on the Semiconductor Synthetic Biology for Information Storage and Retrieval Program (SemiSynBio-II). Future ultra-low energy storage-based computing systems can be built on principles derived from organic systems that are at the intersection of physics, chemistry, biology, computer science and engineering. Next-generation information storage technologies can be envisioned that are driven by biological principles and use biomaterials in the fabrication of devices and systems that can store data for more than 100 years with storage capacity 1,000 times more than current storage technologies. Such a research effort can have a significant impact on the future of information storage and retrieval technologies. This focused solicitation seeks high-risk/high-return interdisciplinary research on novel concepts and enabling technologies that will address the fundamental scientific issues and technological challenges associated with the underpinnings of synthetic biology integrated with semiconductor technology. This research will foster interactions among various disciplines including biology, physics, chemistry, materials science, computer science and engineering that will enable in heretofore unanticipated breakthroughs.

The purpose of this Funding Opportunity Announcement (FOA) is to continue development and expansion of the NIDDK Information Network (dkNET) under the direction of the dkNET Coordinating Unit (dkNET-CU). dkNET supports NIDDK research by providing a user-friendly web portal that seamlessly connects the NIDDK research community to an expanding universe of biomedical resources and data. The dkNET-CU will be responsible for providing the scientific direction, vision, and administrative management needed to advance dkNET goals.

This funding opportunity announcement (FOA) encourages grant applications for national Biomedical Technology Research Resources (BTRR). These Resources conduct research and development of new or improved technologies driven by the needs of basic, translational, and clinical researchers. The Resources are charged to make their technologies available to the research community in a sustainable manner, to provide user training, and to disseminate the Resources technologies and experimental results. Resources should be at the leading edge of their field with respect to both technology development and engagement of the relevant research community. New applicants are strongly encouraged to submit a pre-application in response to PAR-17-315 The pre-application process provides feedback on whether the proposed technology development is appropriate for the NIGMS BTRR program, and the potential competitiveness of a full application.

This announcement encourages pre-applications for the creation of national Biomedical Technology Research Resources (BTRRs). These Resources develop new or improved technology driven by the needs of basic, translational, and clinical researchers. The BTRRs are charged to make their technologies available to the biomedical research community, to train members of this community in the use of the technologies, and to disseminate both the technologies and the Resources experimental results broadly.

The specific areas of interest are: 1. HED Hydrodynamics 2. Radiation-Dominated Dynamics and Material Properties 3. Magnetized HED Plasma Physics 4. Nonlinear Optics of Plasmas and Laser-Plasma Interactions 5. Relativistic HED Plasmas and Intense Beam Physics 6. Warm Dense Matter 7. High-Z, Multiply Ionized HED Atomic Physics 8. Diagnostics for HED Laboratory Plasmas Proposed research efforts can include experimental, theoretical, and/or computational science. Applications integrating experiments, theory, and simulation are encouraged. Grant applications are sought in the following subfields and crosscutting areas of HED laboratory plasmas, as described in the Report of the 2009 Workshop on Basic Research Needs for High-Energy-Density Laboratory Physics.

This Funding Opportunity Announcement (FOA) encourages grant applications for Biomedical Technology Resource Centers (BTRCs). BTRCs are national resource centers for conducting research and development on new technologies that are driven by the needs of basic, translational, and/or clinical researchers. BTRCs also make their technologies available to other investigators, train members of the research community in the use of the technologies, and disseminate the technologies broadly.

This Funding Opportunity Announcement (FOA) seeks to develop and test the next generation of interventions delivered through mobile health (mHealth) technology to improve diagnosis, linkage to care, retention in care, and viral suppression among youth living with human immunodeficiency virus (YLWH). This FOA supports planning for a clinical trial and can include a small pilot clinical trial that a) incorporates emerging and cutting edge technologies to enhance outcomes along the HIV care continuum, b) supports real-time clinical decision making, and c) facilitates effective long-term management of HIV. Critical to this FOA, proposed research should identify specific patient outcomes along the HIV care continuum that are expected to improve from technological approaches.

The purpose of this funding opportunity announcement (FOA) is twofold: 1. to accelerate translational and clinical Phase I and II a/b safety and efficacy studies for substantiating measurable functional benefits of probiotic/prebiotic components and/or their combinations; and; 2. to understand the underlying mechanisms of their action(s), and variability in responses to these interventions. This FOA calls for interdisciplinary collaborations across scientific disciplines engaged in microbiome and pro/prebiotic research including, but not limited to: nutritional science, microbiology, virology, microecology and microbiome, genomics, immunology, computational biology, chemistry, bioengineering, as well as integration of omics and computational approaches in DNA technologies.