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MiamiOH OARS

Changes in Cellular Architecture During Aging - 0 views

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    This FOA seeks applications that propose innovative research strategies aimed at increasing the understanding of the changes in cellular architecture that occur during the aging process. Studies on cytoskeleton structure and function, the impact of the cytoskeleton on intracellular organelle interactions, and signaling or regulatory molecules controlling cellular architecture will be considered. There is interest in studying the role of the cytoskeleton in nuclear-cytoplasmic communications, and in spatio-temporal relationships during the aging process and in age-related diseases.
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    This FOA seeks applications that propose innovative research strategies aimed at increasing the understanding of the changes in cellular architecture that occur during the aging process. Studies on cytoskeleton structure and function, the impact of the cytoskeleton on intracellular organelle interactions, and signaling or regulatory molecules controlling cellular architecture will be considered. There is interest in studying the role of the cytoskeleton in nuclear-cytoplasmic communications, and in spatio-temporal relationships during the aging process and in age-related diseases.
MiamiOH OARS

Validation of survey questions to distinguish type 1 and type 2 diabetes among adults w... - 0 views

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    Most survey-based prevalence estimates of type 1 diabetes among adults have been based on self-reported information about a young age at diagnosis (e.g.,30 years and 40 years) and insulin use within a year of diagnosis. However, this estimation approach misses type 1 diabetes in adults with older age of onset and may misclassify some cases of type 2 diabetes as type 1 if insulin use begins soon after diagnosis. The major goal of this project is to evaluate the validity of survey questions (or algorithms based on them) to distinguish between adults (aged 18 years of age) with type 1 and type 2 diabetes in a representative sample of adult diabetic patients in a diabetes patient registry or database. Using a gold standard, validity will be assessed by examining the sensitivity, specificity, and positive predictive value of algorithms to identify type of diabetes across demographic strata such as age, sex, and race. A secondary goal is to validate definitions of type of diabetes using electronic health records.
MiamiOH OARS

Role of Age-Associated Metabolic Changes in Alzheimer's Disease (AD) (R01) - 0 views

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    This FOA encourages innovative experimental approaches to explore the molecular and cellular bases for age-related change in metabolism that impact the development of Alzheimer's disease (AD).
MiamiOH OARS

RFA-FD-16-011: Generic Drug Substitution in Special Populations (U01) - 0 views

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    Bioequivalence studies that compare a reference formulation to an investigational formulation are typically conducted in healthy adult volunteers and occasionally are conducted in patients. Some populations have unique physical, biological, and physiological considerations that are not reflected by healthy volunteers or by the typical patient for whom a drug is indicated. Physicians have expressed concerns about generic drug substitution (especially for narrow therapeutic index drugs) in special patient populations whose experience with a drug may not be represented by those in whom bioequivalence studies are conducted. For instance, for products that do not have age-appropriate formulations (e.g., formulations do not differ by age of patient), the use of generic products under "off-label" practice patterns in special populations such as crushing or dissolving tablets in liquid for pediatric patients may influence their equivalence to brand name products. Special populations include, but are not limited to, pediatric patients, elderly patients who take multiple medications, women (particularly those who are pregnant), racial/ethnic minorities, and/or individuals with impaired kidney or liver function.
MiamiOH OARS

Limited Competition: Data Coordinating Center for the Accelerating Medicines Partnershi... - 0 views

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    The goal of this funding opportunity announcement is to solicit applications focused on 1) providing data enablement for the open-science, systems-biology enterprise of the AMP-AD Target Discovery and Preclinical Validation Consortium supported through the companion FOA (RFA-AG-18-013) and 2) sustaining and expanding the big-data infrastructure of the AMP-AD Knowledge Portal as a collaborative research platform through which members of the Consortium, researchers at large, and citizen scientists can engage in rapid translational learning and contribute to the development of predictive models of AD and AD-related dementias.
MiamiOH OARS

Integrative Research to Understand the Impact of Sex Differences on the Molecular Deter... - 0 views

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    This FOA invites applications that apply a cross-disciplinary, team science approach to gain comprehensive, mechanistic understanding of the impact of sex differences on the trajectories of brain aging and phenotypes of AD risk and on the responsiveness to pharmacologic and non-pharmacologic interventions.  
MiamiOH OARS

Biomechanics and Mechanobiology | NSF - National Science Foundation - 0 views

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    The BMMB Program supports fundamental research in biomechanics and mechanobiology. An emphasis is placed on multiscale mechanics approaches in the study of organisms that integrate across molecular, cell, tissue, and organ domains. The influence of in vivo mechanical forces on cell and matrix biology in the histomorphogenesis, maintenance, regeneration, and aging of tissues is an important concern. In addition, the relationships between mechanical behavior and extracellular matrix composition and organization are of interest. Funded projects may include theoretical, computational, and experimental approaches. The program encourages the consideration of diverse living tissues as smart materials that are self-designing.
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    The BMMB Program supports fundamental research in biomechanics and mechanobiology. An emphasis is placed on multiscale mechanics approaches in the study of organisms that integrate across molecular, cell, tissue, and organ domains. The influence of in vivo mechanical forces on cell and matrix biology in the histomorphogenesis, maintenance, regeneration, and aging of tissues is an important concern. In addition, the relationships between mechanical behavior and extracellular matrix composition and organization are of interest. Funded projects may include theoretical, computational, and experimental approaches. The program encourages the consideration of diverse living tissues as smart materials that are self-designing.
MiamiOH OARS

Clarifying the Relationship between Delirium and Alzheimers Disease and Related Dementi... - 0 views

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    This Funding Opportunity Announcement (FOA) invites applications that focus on clarifying the relationship between delirium and Alzheimer's disease and related dementias (ADRD). Specifically sought is research focusing on understanding why persons with ADRD are at increased risk to develop delirium, often with a worse prognosis compared to those without antecedent ADRD, and why patients who experience delirium are at higher risk to develop subsequent short- and/or long-term mild cognitive impairment or ADRD, often with an accelerated rate of cognitive decline compared to those without preceding delirium. Relevant research projects may focus on, but are not limited to, those that A) provide insight into possible common, sequential, causative, contributory and/or synergistic pathways underlying both ADRD and delirium, B) elucidate mechanisms that lead to the development of delirium against the background of aging and/or neurodegeneration, with particular emphasis on use of appropriate animal models, C) identify risk factors for the onset and/or progression of delirium in those with ADRD and vice versa, D) diagnose and assess one condition in the setting of the other, E) identify putative phenotypes of patients with co-existing ADRD and delirium, or F) test pharmacologic and/or non-pharmacologic strategies to prevent, treat, or reduce the impact of delirium in patients with ADRD and vice versa. Research supported by this FOA is intended to provide mechanistic insight to improve risk assessment, diagnosis, phenotyping, prevention, and management approaches for both delirium and ADRD.
MiamiOH OARS

Drug Discovery Program | Alzheimer's Drug Discovery Foundation - 0 views

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    The Alzheimer's Drug Discovery Foundation has issued a Request for Proposals for its Preclinical Drug Discovery program. Through the program, grants of up to $600,000 over two years will be awarded to promising preclinical drug discovery programs relevant to Alzheimer's disease, related dementias, and cognitive aging. Preclinical research funding priorities include high throughput screening, medicinal chemistry hit-to-lead development and optimization, in vitro and in vivo efficacy studies, ADME, toxicology, pharma-cokinetics and pharma-co-dynamics, and in vivo proof-of-concept with lead compounds and biologics. Program areas of particular interest include new chemical compounds for Alzheimer's disease, preclinical proof-of-concept, and re-purposing. With regards to potential drug targets, ADDF is interested in novel targets that include but are not limited to neuro-inflammation, protein degradation/autophagy, growth factor signaling, synaptic function/morphology, calcium regulation, energy utilization/mitochondria function, insulin sensitivity, epigenetics, ApoE function and cholesterol metabolism, vascular injury and the blood-brain barrier interface, cognitive enhancers, myelin changes, ischemia and oxidative stress, and tau-related toxicities. To be eligible, applicants must be academic investigators seeking to create and support innovative translational programs in academic medical centers and universities; biotechnology companies with programs dedicated to Alzheimer's disease translational development; and new biotechnology company spinouts or existing biotechnology companies that demonstrate a clear need for nonprofit funding. Funding is provided through program-related investments (PRIs) that require a return on investment based on scientific and/or business milestones.
MiamiOH OARS

Call for Nominations: Thieme/International Union of Pure and Applied Chemistry Prize - 0 views

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    The prize will be awarded on the basis of scientific merit for independent research dealing with synthesis in the broadest context of organic chemistry, including organometallic chemistry, medicinal and biological chemistry, designed molecules, and materials. Candidates must be under 40 years of age as of January 1 of the year in which the prize is awarded.
MiamiOH OARS

Thieme Chemistry -  Call for Nominations - 0 views

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    The prize is awarded to a scientist under 40 years of age whose research has had a major impact in synthetic organic chemistry.
MiamiOH OARS

Exosomes: From Biogenesis and Secretion to the Early Pathogenesis of Alzheimer's Diseas... - 0 views

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    This Funding Opportunity Announcement (FOA) invites innovative research focused on understanding the role of exosome biogenesis and secretion in modulating and propagation of early pathogenesis in sporadic and late-onset Alzheimer's disease (AD). Specifically, this FOA encourages collaborative approaches designed to identify and characterize the regulation of molecular machines that are responsible for exosome biogenesis and the secretion of exosomal cargo molecules in AD.
MiamiOH OARS

Interdisciplinary Research to Understand the Complex Biology of Resilience to Alzheimer... - 0 views

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    This funding opportunity announcement invites comprehensive, cross-disciplinary studies aimed at building predictive molecular models of cognitive resilience based on high-dimensional molecular data collected in individuals who remain free of dementia despite being at high risk for Alzheimer's disease. 
MiamiOH OARS

Engaging Youth and Young Adults from Health Disparity Populations in the HIV Treatment ... - 0 views

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    This initiative will support research projects that implement and test comprehensive service approaches to engage and retain youth and young adults (age 12 - 25 years) from health disparity populations in the HIV Treatment Cascade, which includes diagnosis, linkage to care, engagement in care, retention in care, initiation of antiretroviral therapy (ART), and achievement of viral suppression.   
MiamiOH OARS

View Opportunity | GRANTS.GOV - 0 views

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    The National Science Foundation (NSF) invites investigators at U.S. organizations to submit proposals to conduct research about the Arctic. Arctic research includes field and modeling studies, data analysis, and synthesis about the arctic region.The goal of the NSF Section for Arctic Sciences, Division of Polar Programs (PLR),??is to gain a better understanding of the Arctic's physical, biological, geological, chemical, social and cultural processes; the interactions of oceanic, terrestrial, atmospheric, biological, social, cultural, and economic systems; and the connections that define the Arctic. The Arctic Sciences and other NSF programs support projects that contribute to the development of the next generation of researchers and scientific literacy for all ages through education, outreach, and broadening participation in science, technology, engineering, and mathematics. Program representatives from polar and other non-polar NSF programs that support arctic research coordinate across NSF, including joint review and funding of arctic proposals and mutual support of special projects with high logistical costs.
MiamiOH OARS

Arctic Research Opportunities (nsf13592) - 0 views

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    The goal of the NSF Section for Arctic Sciences, Division of Polar Programs (PLR), is to gain a better understanding of the Arctic's physical, biological, geological, chemical, social and cultural processes; the interactions of oceanic, terrestrial, atmospheric, biological, social, cultural, and economic systems; and the connections that define the Arctic. The Arctic Sciences and other NSF programs support projects that contribute to the development of the next generation of researchers and scientific literacy for all ages through education, outreach, and broadening participation in science, technology, engineering, and mathematics. Program representatives from polar and other non-polar NSF programs that support arctic research coordinate across NSF, including joint review and funding of arctic proposals and mutual support of special projects with high logistical costs.
MiamiOH OARS

Call for Nominations: Robert M. Scarborough Award for Excellence in Medicinal Chemistry - 0 views

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    The Robert M. Scarborough Award for Excellence in Medicinal Chemistry is intended recognize individuals who have had primary, leading roles in the discovery of novel therapeutic agents or who have otherwise made significant scientific discoveries that enhance the field of medicinal chemistry. Candidate selection criteria include scientists under the age of 50 at the time of nomination. Nominees can be employed in industry, academia, government or a private research foundation.
MiamiOH OARS

nsf.gov - Funding - Arctic Research Opportunities - US National Science Foundation (NSF) - 0 views

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    The goal of the NSF Section for Arctic Sciences, Division of Polar Programs (PLR), is to gain a better understanding of the Arctic's physical, biological, geological, chemical, social and cultural processes; the interactions of oceanic, terrestrial, atmospheric, biological, social, cultural, and economic systems; and the connections that define the Arctic. The Arctic Sciences and other NSF programs support projects that contribute to the development of the next generation of researchers and scientific literacy for all ages through education, outreach, and broadening participation in science, technology, engineering, and mathematics. Program representatives from polar and other non-polar NSF programs that support arctic research coordinate across NSF, including joint review and funding of arctic proposals and mutual support of special projects with high logistical costs.
MiamiOH OARS

PA-16-100: Multidisciplinary Research in Vulvodynia (R21) - 0 views

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    The intention of this Funding Opportunity Announcement is to improve the prevention, diagnosis, and treatment of vulvodynia.  By definition, vulvar discomfort or pain without a clear etiology is termed vulvodynia. Some organizations use the term vulvodynia to indicate vulvar pain of unknown etiology for more than 3 months.  For the purposes of this announcement, vulvodynia and vulvar pain will be used interchangeably.  The overall incidence of vulvodynia has been reported as 4.2 cases per 100 person-years in one population based study, with others estimating that persistent vulvar pain affects 9 to 18 percent of women at some point during their lifetime. Current evidence suggests that incidence rates vary by age, ethnicity and marital status.
MiamiOH OARS

Developmental Pharmacodynamics and Models of Drug Effects in Pediatrics (R01 Clinical T... - 0 views

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    This Funding Opportunity Announcement (FOA) encourages grant applications from institutions or organizations that propose multidisciplinary, investigator-initiated basic translational and clinical research in developmental pharmacodynamics This FOA seek grant applications that propose studies to increase and establish data on developmental pharmacodynamics in the pediatric age groups and allows the determination of pharmacokinetic-pharmacodynamic relationship of drugs used in this population.
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