OARS funding Biomed

Environmental exposure induced perturbations of epigenomic marks are correlated with disease pathogenesis.  Identifying changes in epigenomic marks, (e.g., DNA methylation, histone modifications, chromatin accessibility) in affected tissues/cells is not always feasible in humans. This Funding Opportunity Announcement (FOA) seeks applications for a Data Coordination Center (DCC) as part of an ongoing NIEHS program in environmental epigenomics. The purpose of this FOA is to establish a data coordinating center that serves as a component of the TaRGET II Consortium. This Consortium will explore the conservation of perturbations of epigenomic marks across target tissues/cells and surrogate tissues/cells using mouse models of environmentally relevant diseases. The DCC will make available the resulting data for utilization by the broader scientific community. Ultimately, the TaRGET II program will provide insights into the design and interpretation of human studies where target tissues are inaccessible.

A variety of grants from the ATS Foundation

The purpose of this Funding Opportunity Announcement (FOA) is to enhance the diversity of the mental health research workforce by providing dissertation awards in all research areas within the strategic priorities of the NIMH to individuals from diverse backgrounds underrepresented in biomedical, behavioral, clinical and social sciences research. This two-year award supports the completion of the doctoral research project.

Environmental exposure induced perturbations of epigenomic marks are correlated with disease pathogenesis.  Identifying changes in epigenomic marks (e.g., DNA methylation, histone modifications, chromatin accessibility) in affected tissues/cells is not always feasible in humans. The purpose of this Funding Opportunity Announcement (FOA) is to establish a consortium that will explore the conservation of perturbations of epigenomic marks across target tissues/cells and surrogate tissues/cells using mouse models of environmentally relevant diseases. Ultimately, these analyses will provide insights into the design and interpretation of human studies where target tissues are inaccessible.

The purpose of this FOA is to support the expansion of the National Institute of Neurological Disorders and Stroke (NINDS) Human Cell and Data Repository. The repository will maintain the current collection of fibroblast and induced pluripotent stem cell (iPSC) lines as well as develop, characterize, expand and where appropriate genetically modify new high-quality iPSC, fibroblast cell lines and peripheral blood monocyte cells in accordance with the NINDS mission.  The NINDS Human Cell and Data Repository will distribute human cell resources broadly to qualified academic and industry researchers.   

The purpose of the Funding Opportunity Announcement (FOA) is to support research on the host immunological response to Hepatitis C Virus (HCV) infection with the goal of defining the immune requirements critical to a) protection against HCV infection, and b) successful clearance of HCV infection, conducted through Hepatitis C Cooperative Research Centers (HepC Center(s)).

Diseases Network (UDN) building upon the NIH Intramural Research Programs Undiagnosed Diseases Program (NIH-UDP). Responsive applications will propose to investigate the underlying genetics, biochemistry and/or pathophysiology of newly diagnosed diseases in association with the respective gene variant(s) identified through the UDN. In recent years, gene function studies combined with genetic and genomic analyses and metabolic studies have greatly improved diagnoses of these very rare diseases and advanced scientific knowledge of the underlying pathogenesis. This initiative is funded through the NIH Common Fund, which supports cross-cutting programs that are expected to have exceptionally high impact.

JDRF is launching an initiative to overcome challenges for increased longevity for delivery of insulin via sub-cutaneous infusion. Components include infusion sets and cannula used in patch pumps. Based on these EOIs, potential applications will be subsequently invited to be developed and submitted as full proposal. In this call, JDRF intends to fund innovative approaches to identifying the fundamental mechanism of failure and/or provide mitigations to known failure modes when delivering insulin via sub-cutaneous cannula. The immediate aim is to increase the reliability of insulin infusion, with an ultimate aim to extend the wear duration of infusion sets and patch pumps to match the wear duration of CGMs, for the majority of people with T1D. The objective of this initiative is to identify common mechanisms of failure, or demonstrate effective mitigation of known failure mechanisms, in continuous sub-cutaneous insulin infusion. Examples of mechanisms of failure discovery may include, but are not limited to: * ECM or other protein deposition * Inflammation and wound healing process * Fibrosis * Tissue Granulation Examples of mitigations for known failure modes may include: * Drug eluting materials * Cannula Coatings or Surface treatments * Insulin Excipients Discovery proposals must have a clear pathway to commercial viability, and particular emphasis will be given to novel mechanisms of mitigation. Evaluations of proposed mitigations will require preliminary evidence of an underlying mechanism to be addressed. MECHANISM Successful EOIs from for profit entities would be invited under our Industry Development and Discovery Program mechanism1. Applications from nonprofit organizations, public and private universities, colleges, hospitals, laboratories, units of state and local governments would be invited under our Strategic Research Agreement mechanism2. Projects should request costs commen

This Funding Opportunity Announcement (FOA) solicits research projects that study the mechanisms of oral immune system plasticity relevant to chronic HIV infection and oral coinfections. In this context, we encourage studies on reversal of immune activation, residual inflammation, immune reconstitution inflammatory syndrome (IRIS), and microbial and by-product translocation. These conditions occur in persons chronically infected with HIV who are treated with combination antiretroviral therapy (cART) and who also experience oral opportunistic infections. The ultimate goals of this FOA are: 1) to gain knowledge regarding the pathogenesis and persistence of these oral conditions; and 2) to guide the development of novel oral immune modulatory therapies that will aid in re-building the oral immune system to reverse these diseases, mitigate their progression, prevent their occurrence, and eliminate persistence of residual HIV and other oral pathogens in reservoirs.

This Funding Opportunity Announcement (FOA) solicits research projects that study the mechanisms of oral immune system plasticity relevant to chronic HIV infection and oral coinfections.  In this context, we encourage studies on reversal of immune activation, residual inflammation, immune reconstitution inflammatory syndrome (IRIS), and microbial and by-product translocation.  These conditions occur in persons chronically infected with HIV who are treated with combination antiretroviral therapy (cART) and who also experience oral opportunistic infections.  The ultimate goals of this FOA are: 1) to gain knowledge regarding the pathogenesis and persistence of these oral conditions; and 2) to guide the development of novel oral immune modulatory therapies that will aid in re-building the oral immune system to reverse these diseases, mitigate their progression, prevent their occurrence, and eliminate persistence of residual HIV and other oral pathogens in reservoirs.

The purpose of this FOA is to expand the number of CDC Prevention Epicenters to translate basic, epidemiologic and technologic discoveries into new strategies for preventing healthcare-associated transmission of Ebola and/or infectious pathogens (viral or bacterial) that can be spread by mechanisms similar to Ebola. This might include, but is not limited to, project proposals that focus on the effectiveness of personal protective equipment against such pathogens, healthcare worker self-contamination with pathogens, or the role of the healthcare environment in pathogen transmission.

This Funding Opportunity Announcement (FOA) encourages R21 applications that propose to conduct secondary analyses of existing data sets relevant to diabetes and selected endocrine and metabolic diseases including thyroid, parathyroid and Cushing's diseases and acromegaly; and genetic metabolic disease including cystic fibrosis, lysosomal storage diseases, and disorders of the urea cycle, amino acid metabolism and metal transport where the focus is on peripheral metabolism or organ function; obesity, liver diseases, alimentary GI tract diseases and nutrition; kidney, urologic, and hematologic diseases. The goal of this program is to facilitate research that explores innovative hypotheses through the use of existing data sets. 

The purpose of this Funding Opportunity Announcement (FOA) is to support multi-component, multi-disciplinary projects that address important scientific questions relevant to AIDS prophylactic vaccine discovery research. Extensive modeling of vaccine concepts in non-human primates may be included.

Alcohol abuse has long been associated with increased susceptibility to opportunistic infections. This association has led to extensive research demonstrating that alcohol abuse has a profound and negative impact on immune cell number and function and development of immune defense against pathogens. This pattern of drinking differentially affects the outcome of alcohol abuse: binge alcohol consumption suppresses host innate immune defense; chronic alcohol consumption suppresses most immune functions including phagocytic activity of macrophages and development of adaptive immune defense, yet paradoxically activates chronic inflammation.  Cumulative evidence now also supports a role for alcohol-induced immune alterations, in particular inflammation, in a wide range of alcohol related illnesses involving organ or tissue injury. In some cases, interventions against such alcohol-induced immune dysfunctions, such as anti-oxidant supplements and probiotics, are found to be effective in improving the clinical outcome. A comprehensive understanding of alcohol-induced immune dysfunctions and the underlying mechanisms is critical for developing effective diagnostic, preventive, and treatment approaches.  

The purpose of this funding opportunity announcement (FOA) is to support research that will contribute to the overall understanding of vaccine safety. This research opportunity invites studies that address scientific areas potentially relevant to vaccine safety such as 1) physiological and immunological responses to vaccines and vaccine components, 2) how genetic variations affect immune/physiological responses that may impact vaccine safety, 3) identification of risk factors and biological markers that may be used to assess whether there is a relationship between certain diseases or disorders and licensed vaccines, 4) creation/evaluation of statistical methodologies for analyzing data on vaccine safety, including data available from existing data sources such as passive reporting systems, or 5) the application of genomic/molecular technologies to improve knowledge of vaccine safety.

The purpose of this Funding Opportunity Announcement (FOA) is to provide continuing support for the Informatics, Coordination and Service Center (ICSC) unit of the Mutant Mouse Resource and Research Centers (MMRRC) program. The ICSC is expected to provide informatics and coordinating services to the centers of the MMRRC and biomedical researchers. These services include maintenance and further development of a public website portal and Customer Service Center; operation of the order processing system; review and processing of applications from donating investigators; facilitation of interactions with biomedical investigators, informatics services, database activities, and the archive of MMRRC documents and files; coordination of requests to donate mouse strains to the MMRRC and to order mouse strains from the MMRRC; oversight of marketing efforts; and completion of monthly and yearly metrics reports. Moreover, the ICSC will host and actively participate in the monthly teleconference, annual consortium meeting, and compose reports and summaries from these forums.

To further scientific and technological cooperation between the scientific communities of Germany and the United States, a Letter of Intent was signed on May 27, 2014 to enable U.S.-based scientists and engineers with NSF-funded CAREER awards to pursue research collaboration with colleagues supported through German Research Foundation (DFG) grants. Connecting researchers with complementary strengths and shared interests promotes scientific progress in solving some of the world's most vexing problems. This international research opportunity is mutually beneficial to the U.S. participants and their hosts through cooperative activities during research visits and also by establishing international research partnerships to enrich future research activities in Germany and the U.S. Under the Letter of Intent, the DFG identifies DFG-funded research groups who wish to host CAREER awardees for research visits of up to one year in connection with their DFG funding. This Dear Colleague Letter (DCL) invites current CAREER awardees to apply for supplemental funding to support travel for research visits to any identified, appropriate DFG-funded research group. Further, the DCL gives instructions on how to apply and other relevant policies and requirements.

The purpose of this Funding Opportunity Announcement (FOA) and the companion FOA is to solicit applications for computational and functional analysis of gene networks and complex pathways that confer susceptibility to severe mental illnesses. These studies should leverage existing diverse multi-scale datasets and apply a combination of cutting-edge bioinformatics, computational predictive modeling, and systems biology approaches to identify and begin to evaluate novel genetic factors and molecular networks underlying functional pathways relevant to psychiatric disorders to verify their relationship or causality with disease/disease risk.  The computational model predictions should be further replicated through independent datasets and confirmed using biological measures from existing and/or new experimental data.

This Funding Opportunity Announcement (FOA) invites applications that propose to understand social determinants of health as they relate to HIV infection and disease outcomes.  

The Geobiology and Low-Temperature Geochemistry Program focuses on geochemical processes in terrestrial Earth's surface environmental systems, as well as the interaction of geochemical and biological processes. The program supports field, laboratory, theoretical, and modeling studies of these processes and related mechanisms at all spatial and temporal scales. Studies may address: 1) inorganic and/or organic geochemical processes occurring at or near the Earth's surface now and in the past, and across the broad spectrum of interfaces ranging in scale from planetary and regional to mineral-surface and supramolecular; 2) the role of life in the transformation and evolution of Earth's geochemical cycles; 3) surficial chemical and biogeochemical systems and cycles, including their modification through environmental change and human activities; 4) low-temperature aqueous geochemical processes; 5) mineralogy and chemistry of earth materials; 6) geomicrobiology and biomineralization processes; and 7) medical mineralogy and geochemistry. The Program encourages research that focuses on geochemical processes as they are coupled with physical and biological processes in the critical zone. The Program also supports work on the development of tools, methods, and models for the advancement of low-temperature geochemistry and geobiology. The Geobiology and Low-Temperature Geochemistry Program is interested in supporting transformational and cutting-edge research. The Program is highly interdisciplinary and interfaces with other programs within the Earth Surface Section and with programs in biology, chemistry and engineering.