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MiamiOH OARS

View Opportunity | GRANTS.GOV - 0 views

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    The Understanding the Rules of Life: Microbiome Theory and Mechanisms (URoL:MTM) program is an integrative collaborationacross Directorates and Offices within the National Science Foundation. The objective of URoL:MTM is to understand and establish the theory and mechanisms that govern the structure and function of microbiomes, a collection of microbes in a specific habitat/environment. This may include but is not limited to host-associated microbiomes, such as those with humans and other organisms, where i) the microbiome impacts host physiology, behavior, development, and fitness; ii) the host influences the metabolic activity, dynamics and evolution of the microbiome, and iii) the environment (biological, chemical, physical, and social) influences and is influenced by both the host and the microbiome. Recent progress has transformed our ability to identify and catalogue the microbes present in a given environment and measure multiple aspects ofbiological, chemical, physical, and social environments that affect the interactions among the members of the microbiome, the host, and/or habitat. Much descriptive and correlative work has been performed on many microbiome systems, particularly those in the human, soil, aquatic, and built environments. This research has resulted in new hypotheses about the microbiome's contributions to potential system function or dysfunction. The current challenge is to integrate the wide range of accumulated data and information and build on them to develop new causal/mechanistic models or theories of interactions and interdependencies across scales and systems.
MiamiOH OARS

Biosystems Design to Enable Next-Generation Biofuels and Bioproducts - 0 views

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    Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE) hereby announces its interest in receiving applications for research of interest to the Genomic Science Program (http://genomicscience.energy.gov) in the following research areas: a) Integrating large-scale systems biology data to model, design, and engineer microbial systems for the production of biofuels and bioproducts: Interdisciplinary approaches to develop innovative, high-throughput modeling, genome-wide design and editing, and engineering technologies for a broad range of microbes relevant for the production of biofuels and bioproducts from biomass. b) Plant systems design for bioenergy: To develop novel technologies for genome-scale engineering to re-design bioenergy crops that can grow in marginal environments while producing high yield of biomass that can be easily converted to biofuels and bioproducts. Applications should include strategies to address biocontainment, minimizing risks of potential release of engineered organisms into the environment or other unintended outcomes.
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    Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE) hereby announces its interest in receiving applications for research of interest to the Genomic Science Program (http://genomicscience.energy.gov) in the following research areas: a) Integrating large-scale systems biology data to model, design, and engineer microbial systems for the production of biofuels and bioproducts: Interdisciplinary approaches to develop innovative, high-throughput modeling, genome-wide design and editing, and engineering technologies for a broad range of microbes relevant for the production of biofuels and bioproducts from biomass. b) Plant systems design for bioenergy: To develop novel technologies for genome-scale engineering to re-design bioenergy crops that can grow in marginal environments while producing high yield of biomass that can be easily converted to biofuels and bioproducts. Applications should include strategies to address biocontainment, minimizing risks of potential release of engineered organisms into the environment or other unintended outcomes.
MiamiOH OARS

Grants.gov - Find Grant Opportunities - Opportunity Synopsis - 0 views

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    Overview: The Department of the Navy, Bureau of Medicine and Surgery (BUMED) is interested in receiving applications for a new Naval Medical Research Center (NMRC) program dedicated to improving prevention, early recognition, diagnosis, and effective treatment of severe sepsis from all causes in austere environments. This program will be supported through the establishment of a consortium of investigators with skills and expertise in infectious disease, critical care, systems biology, global health, and other relevant fields who will work together on a coordinated program of research. This consortium, named the Austere Environments Consortium for Enhanced Sepsis Outcomes (ACESO), will focus on the generation of knowledge that can rapidly translate into preventing and improving the outcome of severe sepsis in austere or resource-limited settings. Particular attention will focus on etiologic causes that currently have no specific therapies and that pose unique risks to the military with respect to outbreaks, deployed forces, or deliberate-use scenarios (e.g., viral hemorrhagic fever [VHF]). ACESO will establish a platform for research to address gaps in the Department of Defense's (DoD) capabilities for improving knowledge on severe sepsis and biological threats that manifest as severe sepsis in austere settings. ACESO will leverage a network of investigators, trained study staff, and in-country infrastructure to execute research that will evaluate clinical management strategies and the pathogenesis of severe sepsis, characterize the clinical aspects of sepsis related to various potential biological threats, improve outcomes for severe sepsis in austere environments, investigate the immunopathogenesis and long-term sequelae of infectious etiologies (especially hemorrhagic fevers), and augment the capability to gather important clinical data in outbreak settings of severe emerging disease.
MiamiOH OARS

Grants.gov - Find Grant Opportunities - Opportunity Synopsis - 0 views

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    The Program is pleased to announce that it is seeking proposals for funding to support forensic and biometric research and its application. The requested proposals should focus on DFBA activities and needs of the Program's other customers (AFMES, DC3, JPAC-CIL). Forensic research proposals should focus on the creation of new and improved field or laboratory functional capabilities that result in faster, more robust, more informative, less costly, or less labor-intensive recognition, identification, collection, preservation, and/or analysis of forensic evidence. Biometric research proposals should contribute to biometric applications or operations, including military functions such as combat identification (friend, foe, or neutral), offensive operations (intelligence support to targeting), force protection (physical access control), detention operations, civil-military operations (track target members of a population), personnel recovery and identification, and recognition and recovery of human remains. Proposals that will assist the DoD in achieving these goals are solicited, particularly proposals involving the development of equipment that is portable, sustainable, and useful in an expeditionary or field environment. The expeditionary and field environments require systems that are lightweight, portable, inexpensive, fast, and capable of operating in extreme environments of temperature, dust, humidity, etc. The systems must also be capable of secure data communications.
MiamiOH OARS

Biotechnology Risk Assessment Grants Program - 0 views

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    The purpose of the BRAG program is to support the generation of new information that will assist Federal regulatory agencies in making science-based decisions about the effects of introducing into the environment genetically engineered organisms (GE), including plants, microorganisms (including fungi, bacteria, and viruses), arthropods, fish, birds, mammals and other animals excluding humans. Investigations of effects on both managed and natural environments are relevant. The BRAG program accomplishes its purpose by providing Federal regulatory agencies with scientific information relevant to regulatory issues. 
MiamiOH OARS

Biotechnology Risk Assessment Grants Program - 0 views

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    The purpose of the BRAG program is to support the generation of new information that will assist Federal regulatory agencies in making science-based decisions about the effects of introducing into the environment genetically engineered organisms (GE), including plants, microorganisms - such as fungi, bacteria, and viruses - arthropods, fish, birds, mammals and other animals excluding humans. Investigations of effects on both managed and natural environments are relevant. The BRAG program accomplishes its purpose by providing federal regulatory agencies with scientific information relevant to regulatory issues
MiamiOH OARS

PAR-19-293: Development of Novel and Robust Systems for Mechanistic Studies of Gene-Env... - 0 views

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    This Funding Opportunity Announcement (FOA) is intended to foster research towards a better understanding of the biological mechanisms of gene-environment interplay in human diseases and conditions. Through this FOA, the NIDCR, NIEHS , and NICHD solicit applications to develop novel and robust experimental systems that offer approaches complementary to human epidemiologic or in vivo studies to facilitate mechanistic investigation of gene-environment interplay in dental, oral, craniofacial, and other diseases and conditions.
MiamiOH OARS

FY 2018 Continuation of Solicitation for the Office of Science Financial Assistance Pro... - 0 views

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    * The frontiers of science-exploring nature's mysteries from the study of fundamental subatomic particles, atoms, and molecules that are the building blocks of the materials of our universe and everything in it to the DNA, proteins, and cells that are the building blocks of life. Each of the programs in SC supports research probing the most fundamental disciplinary questions. * The 21st Century tools of science-providing the nation's researchers with 27 state-of-the-art national scientific user facilities - the most advanced tools of modern science - propelling the U.S. to the forefront of science, technology development and deployment through innovation. * Science for energy and the environment―paving the knowledge foundation to spur discoveries and innovations for advancing the Department's mission in energy and environment. SC supports a wide range of funding modalities from single principal investigators to large team-based activities to engage in fundamental research on energy production, conversion, storage, transmission, and use, and on our understanding of the earth systems.
MiamiOH OARS

Biotechnology and Biochemical Engineering - 0 views

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    The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular andbiomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment. A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program. Fundamental to many research projects in this area is the understanding of how biomolecules, cells and cell populations interact in their environment, and how those molecular level interactions lead to changes in structure, function, phenotype, and/or behavior. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and manufacturing approaches, and proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities. 
MiamiOH OARS

DoD Joint Program Committee 1 (JPC-1) - Medical Simulation and Information Sciences (MS... - 0 views

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    The FY17 JPC-1/MSIS TRANSfeR Award Program Announcement/Funding Opportunity is seeking research to determine whether the medical skill learned on a simulation system has a downstream beneficial effect to patients and/or the MHS in the real clinical world. The Program Announcement/Funding Opportunity seeks applications for research to demonstrate that simulation-based medical training has a measurable outcome on patient care. Previous T1 studies have shown improvement in skills in the simulated environment when deliberate practice and mastery learning (a set of group-based, individualized, learning strategies based on the belief that students will achieve a high level of understanding in a given area when given enough time) occur as part of training. The next set of studies should measure whether these same techniques translate to patient care and affect systems of care such as return-to-duty rates and morbidity and mortality statistics. Such research will involve taking the lessons learned in the laboratory and measuring outcomes in the patients who are cared for either in an operational environment or medical treatment facility. Historical patient outcome data does exist for the way medical professionals are trained now, so the variable being introduced in new studies would be simulation-based training.
MiamiOH OARS

RESEARCH OPPORTUNITIES FOR FLIGHT EXPERIMENTS IN SPACE BIOLOGY - 0 views

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    This NASA Research Announcement (NRA) solicits hypothesis-driven space-flight research in Space Biology (SB) to be conducted on ISS. NASA SB experiments have one or more of the following primary goals: 1) to effectively use microgravity and the other characteristics of the space environment to enhance our understanding of basic biological processes; 2) to develop the scientific and technological foundations for a safe, productive human presence in space for extended periods and in preparation for exploration; and 3) to apply this knowledge and technology to improve our nation's competitiveness, education, and the quality of life on Earth. NASA SB experiments will be designed to discover how space flight affects a diverse group of microorganisms, plants, and animals; study the effects of gravity (g) across the g-spectrum, i.e., from micro- to hyper-gravity; and characterize the biological effects of radiation, magnetic fields, and the interaction among species i n the unusual environments of space and spacecraft. 
MiamiOH OARS

nsf.gov - Funding - Biotechnology, Biochemical, and Biomass Engineering - US National S... - 0 views

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    The Biotechnology, Biochemical, and Biomass Engineering (BBBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes (in vivo, in vitro, and/or ex vivo) and eventually leads to the development of enabling technology and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  Quantitative assessments of bioprocesses are considered vital to successful research projects in the BBBE program.  Fundamental to many research projects in this area is the understanding of how biomolecules and cells interact in their environment, and how those molecular level interactions lead to changes in structure, function, phenotype, and/or behavior.  The program encourages proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines, and effectively incorporate ongoing research into educational activities. Research projects of particular interest in BBBE include, but are not limited to: Metabolic engineering and synthetic biology Quantitative systems biotechnology Tissue engineering and stem cell culture technologies Protein engineering/protein design Development of novel "omics" tools for biotechnology applications
MiamiOH OARS

NAIS Business Opportunities - 0 views

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    This NASA Research Announcement (NRA) solicits hypothesis-driven space-flight research in Space Biology (SB) to be conducted on ISS. NASA SB experiments have one or more of the following primary goals: 1) to effectively use microgravity and the other characteristics of the space environment to enhance our understanding of basic biological processes; 2) to develop the scientific and technological foundations for a safe, productive human presence in space for extended periods and in preparation for exploration; and 3) to apply this knowledge and technology to improve our nation's competitiveness, education, and the quality of life on Earth. NASA SB experiments will be designed to discover how space flight affects a diverse group of microorganisms, plants, and animals; study the effects of gravity (g) across the g-spectrum, i.e., from micro- to hyper-gravity; and characterize the biological effects of radiation, magnetic fields, and the interaction among species in the unusual environments of space and spacecraft. 
MiamiOH OARS

Discovering Novel Targets: The Molecular Genetics of Drug Addiction and Related Co-Morb... - 0 views

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    This FOA encourages applications for research projects that identify and/or validate chromosomal loci and variations in genes that are associated with vulnerability to addiction and that inform the likelihood of responsiveness to treatment. Applications that propose to examine intermediate phenotypes or endophenotypes to assess the molecular genetics of drug addiction, addiction vulnerability and/or their associated co-morbidities and how they are related to drug addiction are especially encouraged. Also encouraged are genetic as well as computational and large-scale genomic approaches, which may include but are not limited to linkage, linkage disequilibrium, case-control or family-based studies, and integration of data from other databases that may supplement substance abuse genetics and genomics data. Data may be collected from the general population, special populations, recent admixed populations, and/or animal models. Secondary data analysis of data collected from the general population, special populations, recent admixed populations, and/or animal models is also appropriate for this announcement. Investigators are encouraged to include, as a component of their project and as appropriate, gene x gene interactions, gene x environment interactions, gene x environment x development interactions, pharmacogenetics, and non-human models.
MiamiOH OARS

Biotechnology, Biochemical, and Biomass Engineering - 0 views

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    The Biotechnology, Biochemical, and Biomass Engineering (BBBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes (in vivo, in vitro, and/or ex vivo) and eventually leads to the development of enabling technology and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  Quantitative assessments of bioprocesses are considered vital to successful research projects in the BBBE program.  Fundamental to many research projects in this area is the understanding of how biomolecules and cells interact in their environment, and how those molecular level interactions lead to changes in structure, function, phenotype, and/or behavior.  The program encourages proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines, and effectively incorporate ongoing research into educational activities. Research projects of particular interest in BBBE include, but are not limited to: Metabolic engineering and synthetic biology Quantitative systems biotechnology Tissue engineering and stem cell culture technologies Protein engineering/protein design Development of novel "omics" tools for biotechnology applications
MiamiOH OARS

Systems Biology Research to Advance Sustainable Bioenergy Crop Development - 0 views

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    The Office of Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE), hereby announces its interest in receiving applications for research that supports the Genomic Science research program (http://genomicscience.energy.gov). In this FOA, applications are requested for: i) Systems-level research to better understand the molecular and physiological mechanisms that control bioenergy crop vigor, resource use efficiency, and resilience/adaptability to abiotic stress, as well as interactions with the surrounding environment, in order to increase biomass productivity under changing and at times suboptimal conditions; ii) Systems biology-enabled investigations into the role(s) of microbial and microbial communities in the complex and multi-scaled interactions of the plant-soil-environment: contribution(s) to bioenergy feedstock plant performance, adaptation, and resilience in the face of a broad range of changing environmental conditions and abiotic stressors (e.g., climate), and the impacts of introducing bioenergy cropping systems on the local ecosystem.
MiamiOH OARS

NSF/CASIS Collaboration on Tissue Engineering and Mechanobiology on the International S... - 0 views

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    The unique high quality and long duration microgravity environment on the ISS National Lab provides an extraordinary research platform for experiments in the biological and medical sciences. Microgravity induces a vast array of changes in individual cells and model organisms ranging from viruses and microorganisms to humans, including global alterations in gene expression and 3-dimensional aggregation of cells into biofilms or tissue-like architectures that recapitulate the structure and function of organs. Moreover, studies of astronauts reveal a variety of space flight-induced health conditions, many of which may serve as accelerated models of ground-based ailments such as aging and trauma. Research into these and other effects of the space environment may advance our fundamental understanding of cell and tissue function, effective disease diagnosis and /or treatment, or improved health care delivery.
MiamiOH OARS

High-Resolution Exploration of the Human Islet Tissue Environment [HIRN Human Pancreas ... - 0 views

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    This Funding Opportunity Announcement (FOA) invites cooperative agreement applications that will contribute to a higher resolution understanding of the physical and functional organization of the human islet tissue environment by describing the composition (cellular and molecular) and function of important components of the pancreatic islet and peri-islet tissue architecture, the cell-cell relationships and means of communications used by cell types and cell subtypes within the pancreatic tissue ecosystem, and/or the contribution of adjacent (including acinar, ductal, lymphatic) and neighboring (intestinal, mesenteric and adipose) tissues to islet cell function and dysfunction. Successful projects will integrate the Human Pancreas Analysis Consortium (HPAC), that will consist of the research teams funded in response to this FOA with the Human Pancreas Analysis Program (HPAP), a resource-generation program that was funded in 2016 in response to RFA-DK-15-027. HPAC will become the fifth consortium of the Human Islet Research Network (HIRN, https://hirnetwork.org/ ). HIRN's overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This FOA will only support studies with a primary focus on increasing our understanding of human tissue structure and function, and human disease biology (as opposed to rodent or other animal models). This FOA will not accept applications proposing a clinical trial.
MiamiOH OARS

RFA-EB-18-004: Limited Competition: NeuroImaging Tools and Resources Collaboratory (R24... - 0 views

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    The functionality of the NeuroImaging Tools and Resources Collaboratory (NITRC) has enabled three distinct components to flourish: Resources Registry (NITRC-R): a collaboratory enabling the distribution, enhancement, and adoption of neuroimaging tools and resources. Image Repository (NITRC-IR): a curated repository of free neuroimaging datasets meeting global standards. Computational Environment (NITRC-CE): a freely downloadable or pay-as-you-go virtual computing cloud-based platform that is pre-configured with popular neuroimaging tools. NITRC-R has become the major web-based collaborative environment enabling the distribution, enhancement, and adoption of neuroinformatics resources. It currently hosts more than 1,000 tools and resources in areas such as magnetic resonance imaging (MRI), computed tomography (CT), optical imaging, positron emission tomography/single-photon emission computed tomography (PET/SPECT), electroencephalography/magnetoencephalography/electrocorticography (EEG/MEG/ECoG), computational neuroscience, and imaging genomics. Since NITRC's inception, there have been more than 10 million total downloads of tools from NITRC-R.
MiamiOH OARS

Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) (P50) - 0 views

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    Reissue of RFA-AR-18-001: The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRCs). These Centers promote collaborative basic, translational and clinical research and provide important resources that can be used by the national muscular dystrophy research community. A goal of this Centers program is to support important and innovative research in the muscular dystrophies that is best pursued through this interdisciplinary and collaborative center environment, and projects that may not be as effective if supported by "stand-alone" research project grants. The Centers also provide outstanding environments for the training of new scientists electing to pursue careers conducting research in high priority areas of muscular dystrophy. Finally, Center investigators are expected to engage the patient and advocacy communities in conversations to increase awareness of research, encourage patient participation in research and incorporate the perspectives of these communities in the conduct of patient-centered research.
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