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The mission of the Biomedical Engineering (BME) program is to provide opportunities to develop novel ideas into discovery-level and transformative projects that integrate engineering and life science principles in solving biomedical problems that serve humanity in the long-term.  The Biomedical Engineering (BME) program supports fundamental research in the following BME themes: Neural engineering (brain science, computational neuroscience, brain-computer interface, neurotech, cognitive engineering) Cellular biomechanics (motion, deformation, and forces in biological systems; how mechanical forces alter cell growth, differentiation, movement, signal transduction, transport, cell adhesion, cell cytoskeleton dynamics, cell-cell and cell-ECM interactions; genetically engineered stem cell differentiation with long-term impact in tissue repair and regenerative medicine) The BME projects must be at the interface of engineering and life sciences, and advance both engineering and life sciences.  The projects should focus on high impact transforming methods and technologies. The project should include methods, models and tools of understanding and controlling of living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; new approaches to the design of structures and materials for eventual medical use in the long-term; and new novel methods of reducing health care costs through new technologies. The projects should emphasize the advancement of fundamental engineering knowledge, possibly leading to the development of new methods and technologies in the long-term; and highlight multi-disciplinary nature, integrating engineering and the sciences. The long-term impact of the projects can be related to disease diagnosis and/or treatment, improved health care delivery, or product development.

The Engineering of Biomedical Systems (EBMS)program is part of the Engineering Biology and Health cluster, which also includes 1) Biophotonics; 2) Biosensing; 3) Cellular and Biochemical Engineering; and 4) Disability and Rehabilitation Engineering. The goal of theEBMS program is to provide research opportunities for creating discovery-level and transformative projects that integrate engineering and life sciences to solve biomedical problems and serve humanity in the long term.EBMS projects must be at the interface of engineering and biomedical sciences. They are expected to use an engineering framework (for example, design or modeling) that supports increased understanding of physiological or pathophysiological processes. The project must include objectives that advance both engineering and biomedical sciences. EMBS projects should focus on high-impact, transformative methods and technologies -- especially those that potentially will have a broad impact on biomedical challenges. Projects may include: methods, models, and enabling tools applied to understand or control living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; or new approaches to the design of systems that include both living and non-living components for eventual medical use in the long term. TheEBMS programsupports fundamental and transformative research in the following areas of biomedical engineering:

The mission of the Biomedical Engineering (BME) program is to provide opportunities to develop novel ideas into discovery-level and transformative projects that integrate engineering and life science principles in solving biomedical problems that serve humanity in the long-term.  The Biomedical Engineering (BME) program supports fundamental research in the following BME themes: Neural engineering (brain science, computational neuroscience, brain-computer interface, neurotech, cognitive engineering) Cellular biomechanics (motion, deformation, and forces in biological systems; how mechanical forces alter cell growth, differentiation, movement, signal transduction, transport, cell adhesion, cell cytoskeleton dynamics, cell-cell and cell-ECM interactions; genetically engineered stem cell differentiation with long-term impact in tissue repair and regenerative medicine) The BME projects must be at the interface of engineering and life sciences, and advance both engineering and life sciences.  The projects should focus on high impact transforming methods and technologies. The project should include methods, models and tools of understanding and controlling of living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; new approaches to the design of structures and materials for eventual medical use in the long-term; and new novel methods of reducing health care costs through new technologies.

The Cellular and Biochemical Engineering (CBE)program is part of the Engineering Biology and Health cluster, which also includes 1) Biophotonics; 2) Biosensing; 3) Disability and Rehabilitation Engineering; and 4) Engineering of Biomedical Systems. TheCellular and Biochemical Engineering program supports fundamental engineering research that advances understanding of cellular andbiomolecular processes in engineering biology. CBE-funded research eventually leads to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cell, biochemical, biopharmaceutical, and biotechnology industries. Fundamental to many research projects in this area is the understanding of how biomolecules, subcellular systems, cells, and cell populations interact in the biomanufacturing environment, and how those interactions lead to changes in structure, function, and behavior. A quantitative treatment of problems related to biological processes is considered vital to successful research projects in the CBE program. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches. The CBE program also encourages proposals that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.

The goal of theBiomedical Engineering(BME)program is to provide research opportunities to develop novel ideas into discovery-level and transformative projects that integrate engineering and life sciences in solving biomedical problems that serve humanity in the long-term. BME projects must be at the interface of engineering and life sciences, and advance both engineering and life sciences. The projects should focus on high impact transformative methods and technologies. Projects should include methods, models and enabling tools of understanding and controlling living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; new approaches to the design of structures and materials for eventual medical use in the long-term; and novel methods for reducing health care costs through new technologies. The long-term impact of the projects can be related to fundamental understanding of cell and tissue function, effective disease diagnosis and/or treatment, improved health care delivery, or product development.

The goal of theBiomedical Engineering(BME)program is to provide research opportunities to develop novel ideas into discovery-level and transformative projects that integrate engineering and life sciences in solving biomedical problems that serve humanity in the long-term. BME projects must be at the interface of engineering and life sciences, and advance both engineering and life sciences. The projects should focus on high impact transformative methods and technologies. Projects should include methods, models and enabling tools of understanding and controlling living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; new approaches to the design of structures and materials for eventual medical use in the long-term; and novel methods for reducing health care costs through new technologies. The long-term impact of the projects can be related to fundamental understanding of cell and tissue function, effective disease diagnosis and/or treatment, improved health care delivery, or product development.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program. 

TheDisability and Rehabilitation Engineeringprogram is part of the Engineering Biology and Health cluster, which also includes: 1) the Biophotonics program; 2) the Biosensing program; 3) the Cellular and Biochemical Engineering program; and 4) the Engineering of Biomedical Systems program. TheDisability andRehabilitation Engineeringprogram supports fundamental engineering research that will improve the quality of life of persons with disabilities through: development of new technologies, devices, or software; advancement of knowledge regarding healthy or pathological human motion; or understanding of injury mechanisms. Research may be supported that is directed toward the characterization, restoration, rehabilitation, and/or substitution of human functional ability or cognition, or to the interaction between persons with disabilities and their environment. Areas of particular interest are neuroengineering and rehabilitation robotics. The program will also consider research in the areas of: new engineering approaches to understand healthy or pathological motion, both as a target for rehabilitation and as a means to characterize motion related to disability or injury; understanding injury at the tissue- or system-level such that interventions may be developed to reduce the impact of trauma and subsequent disability; or understanding the role of gut microbiota in modulating disability in the context of rehabilitation. Emphasis is placed on significant advancement of fundamental engineering knowledge that facilitates transformative outcomes.

Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE) hereby announces its interest in receiving applications for research of interest to the Genomic Science Program (http://genomicscience.energy.gov) in the following research areas: a) Integrating large-scale systems biology data to model, design, and engineer microbial systems for the production of biofuels and bioproducts: Interdisciplinary approaches to develop innovative, high-throughput modeling, genome-wide design and editing, and engineering technologies for a broad range of microbes relevant for the production of biofuels and bioproducts from biomass. b) Plant systems design for bioenergy: To develop novel technologies for genome-scale engineering to re-design bioenergy crops that can grow in marginal environments while producing high yield of biomass that can be easily converted to biofuels and bioproducts. Applications should include strategies to address biocontainment, minimizing risks of potential release of engineered organisms into the environment or other unintended outcomes.

Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE) hereby announces its interest in receiving applications for research of interest to the Genomic Science Program (http://genomicscience.energy.gov) in the following research areas: a) Integrating large-scale systems biology data to model, design, and engineer microbial systems for the production of biofuels and bioproducts: Interdisciplinary approaches to develop innovative, high-throughput modeling, genome-wide design and editing, and engineering technologies for a broad range of microbes relevant for the production of biofuels and bioproducts from biomass. b) Plant systems design for bioenergy: To develop novel technologies for genome-scale engineering to re-design bioenergy crops that can grow in marginal environments while producing high yield of biomass that can be easily converted to biofuels and bioproducts. Applications should include strategies to address biocontainment, minimizing risks of potential release of engineered organisms into the environment or other unintended outcomes.

TheBiophotonicsprogram is part of the Engineering Biology and Health cluster, which also includes: 1) the Biosensing program; 2) the Cellular and Biochemical Engineering program; 3) the Disability and Rehabilitation Engineering program; and 4) the Engineering of Biomedical Systems program. The goal of theBiophotonicsprogram is to explore the research frontiers in photonics principles, engineering and technology that are relevant for critical problems in fields of medicine, biology and biotechnology. Fundamental engineering research and innovation in photonics is required to lay the foundations for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies. Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key motivating application goals.

TheCellular and Biochemical Engineering(CBE)program is part of theEngineering Biology and Healthcluster, which also includes: 1) the Biophotonics program; 2) the Biosensing program; 3) the Disability and Rehabilitation Engineering program; and 4) the Engineering of Biomedical Systems program. TheCellular and Biochemical Engineering program supports fundamental engineering research that advances understanding of cellular andbiomolecular processes. CBE-funded research may lead to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cell, biochemical, biopharmaceutical, and biotechnology industries. Fundamental to many research projects in this area is the understanding of how biomolecules, subcellular systems, cells, and cell populations interact, and how those interactions lead to changes in structure, function, and behavior. A quantitative treatment of problems related to biological processes is considered vital to successful research projects in the CBE program. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches. The CBE program also encourages proposals that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular andbiomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment. A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program. Fundamental to many research projects in this area is the understanding of how biomolecules, cells and cell populations interact in their environment, and how those molecular level interactions lead to changes in structure, function, phenotype, and/or behavior. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and manufacturing approaches, and proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities. 

The Cellular and Biochemical Engineering (CBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cells, biochemical, biopharmaceutical and biotechnology industries.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the CBE program.  Fundamental to many research projects in this area is the understanding of how biomolecules, cells and cell populations interact in the biomanufacturing environment, and how those molecular-level interactions lead to changes in structure, function, and behavior.  The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches, and proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.

The Biotechnology, Biochemical, and Biomass Engineering (BBBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes (in vivo, in vitro, and/or ex vivo) and eventually leads to the development of enabling technology and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  Quantitative assessments of bioprocesses are considered vital to successful research projects in the BBBE program.  Fundamental to many research projects in this area is the understanding of how biomolecules and cells interact in their environment, and how those molecular level interactions lead to changes in structure, function, phenotype, and/or behavior.  The program encourages proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines, and effectively incorporate ongoing research into educational activities. Research projects of particular interest in BBBE include, but are not limited to: Metabolic engineering and synthetic biology Quantitative systems biotechnology Tissue engineering and stem cell culture technologies Protein engineering/protein design Development of novel "omics" tools for biotechnology applications

The Nano-Biosensing program is part of the Engineering Biology and Health cluster, which includes also 1) Cellular and Biochemical Engineering; 2) Engineering of Biomedical Systems; 3) Biophotonics; and 4) Disability and Rehabilitation Engineering. The Nano-Biosensing program supports fundamental engineering research on devices and methods for measurement and quantification of biological analytes. Proposals that incorporate emerging nanotechnology methods are especially encouraged. Areas of interest include: -Multi-purpose sensor platforms that exceed the performance of current state-of-the-art devices. -Novel transduction principles, mechanisms and sensor designs suitable for measurement in practical matrix and sample-preparation-free approaches. These include error-free detection of pathogens and toxins in food matrices, waterborne pathogens, parasites, toxins, biomarkers in body fluids, and others that improve human condition. -Nano-biosensors that enable measurement of biomolecular interactions in their native states, transmembrane transport, intracellular transport and reactions, and other biological phenomena. -Studies that examine intracellular measurements must include discussion on the significance of the measurement. 

The Biotechnology, Biochemical, and Biomass Engineering (BBBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes (in vivo, in vitro, and/or ex vivo) and eventually leads to the development of enabling technology and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  Quantitative assessments of bioprocesses are considered vital to successful research projects in the BBBE program.  Fundamental to many research projects in this area is the understanding of how biomolecules and cells interact in their environment, and how those molecular level interactions lead to changes in structure, function, phenotype, and/or behavior.  The program encourages proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines, and effectively incorporate ongoing research into educational activities. Research projects of particular interest in BBBE include, but are not limited to: Metabolic engineering and synthetic biology Quantitative systems biotechnology Tissue engineering and stem cell culture technologies Protein engineering/protein design Development of novel "omics" tools for biotechnology applications

The Biosensing program is part of the Engineering Biology and Health cluster, which also includes 1) the Biophotonics program; 2) the Cellular and Biochemical Engineering program; 3) the Disability and Rehabilitation Engineering program; and 4) the Engineering of Biomedical Systems program. The Biosensing program supports fundamental engineering research on devices and methods for measurement and quantification of biological analytes. Examples of biosensors include, but are not limited to, electrochemical/electrical biosensors, optical biosensors, plasmonic biosensors, and paper-based and nanopore-based biosensors. In addition to advancing biosensor technology development, proposals that address critical needs in biomedical research, public health, food safety, agriculture, forensic, environmental protection, and homeland security are highly encouraged. Proposals that incorporate emerging nanotechnology methods are especially encouraged.

The Nano-Biosensing program is part of the Engineering Biology and Health cluster, which includes also 1) Cellular and Biochemical Engineering; 2) Engineering of Biomedical Systems; 3) Biophotonics; and 4) Disability and Rehabilitation Engineering. The Nano-Biosensing program supports fundamental engineering research on devices and methods for measurement and quantification of biological analytes. Proposals that incorporate emerging nanotechnology methods are especially encouraged. Areas of interest include: Multi-purpose sensor platforms that exceed the performance of current state-of-the-art devices. Novel transduction principles, mechanisms and sensor designs suitable for measurement in practical matrix and sample-preparation-free approaches. These include error-free detection of pathogens and toxins in food matrices, waterborne pathogens, parasites, toxins, biomarkers in body fluids, and others that improve human condition. Nano-biosensors that enable measurement of biomolecular interactions in their native states, transmembrane transport, intracellular transport and reactions, and other biological phenomena. Studies that examine intracellular measurements must include discussion on the significance of the measurement.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program. 

In 2016, the National Science Foundation (NSF) unveiled a set of "Big Ideas," 10 bold, long-term research and process ideas that identify areas for future investment at the frontiers of science and engineering (see https://www.nsf.gov/news/special_reports/big_ideas/index.jsp). The Big Ideas represent unique opportunities to position our Nation at the cutting edge of global science and engineering leadership by bringing together diverse disciplinary perspectives to support convergence research. As such, when responding to this solicitation, even though proposals must be submitted to the Directorate for Computer & Information Science & Engineering/Office of Advanced Cyberinfrastructure(CISE/OAC), once received, the proposals will be managed by a cross-disciplinary team of NSF Program Directors. NSF's Harnessing the Data Revolution (HDR) Big Ideais a national-scale activity to enable new modes of data-driven discovery that will allow fundamental questions to be asked and answered at the frontiers of science and engineering.

The Nano-Biosensing Program supports innovative, transformative, and insightful fundamental investigations of original technologies with broad long-term impact.  The program also supports fundamental development of applications that require novel use of nano-scale bio-inspired engineering principles and approaches that will meet the engineering and technology needs of the nation.  The program is targeting research in the area of the monitoring, identification and/or quantification of biological signals and is particularly interested in projects at the intersection of engineering, life sciences, and information technology.  Projects submitted to the Program must advance both engineering and life sciences.