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The Klarman Family Foundation is interested in providing strategic investment in translational research that will accelerate progress in developing effective treatments for anorexia nervosa, bulimia nervosa and binge eating disorder. The Program's short-term goal is to support the most outstanding science and expand the pool of scientists whose research explores the basic biology of feeding, anorexia nervosa, bulimia nervosa, and/or binge eating disorder. The long-term goal is to improve the lives of patients suffering from these conditions. Examples of funding areas include but are not limited to molecular genetic analysis of relevant neural circuit assembly and function; genetic and epigenetic research; animal models created by genetically altering neural circuits; and testing of new chemical entities that might be used in animal models as exploratory treatments.  Please note that imaging studies involving humans are not eligible. Investigators conducting research in the neuro-circuitry of fear conditioning or reward behavior may also apply but must justify the relevance of their research projects to the basic biology of eating disorders. Clinical psychotherapeutic studies, medication trials and research in the medical complications of these disorders are outside the scope of this Program.

NASA's Human Research Program (HRP) has released solicited research response area NRA 80JSC017N0001-BPBA "Topics in Biological, Physiological, and Behavioral Adaptations to Spaceflight: Integrated One Year Mission Project and Other Opportunities" that solicits applied research in support of HRP goals and objectives. The first topic in the solicitation is for proposals in the area of Analyses of the Temporal Nature of Human Adaptation to Long-Duration Low-Earth Orbit Missions. HRP has a requirement for sufficient crewmember experience at one year in spaceflight to demonstrate the presence or absence of unacceptable deleterious physiological, psychological and medical effects of spaceflight on human health and performance beyond the experience base of six-month expeditions and to permit extrapolation to early interplanetary expeditions with durations of up to two to three years. Therefore, HRP is proposing an integrated One-Year Mission Project on the International Space Station (ISS) consisting of five one-year missions five standard-duration six-month missions paralleling the year-long expeditions, and five short-duration crew vehicle exchange expeditions lasting up to two months to occur at the mid-point of each 1YM. Proposals are solicited by NASA in the additional areas of Biological, Physiological, and Behavioral Functions of Mice during Partial (0 - 1) G-Exposures Provided by Centrifugation on the International Space Station; Novel Spaceflight-Associated Neuro-Ocular Syndrome Hypotheses and Countermeasures; Medical Countermeasures Targeting Multiple Tissues at Risk from Exposure to Space Radiation; Individual and Team Problem-Solving Skills Training for Exploration Missions; Sensory Stimulation for Cognitive and Behavioral Health; and Human Capabilities Assessments for Autonomous Missions (HCAAM) Virtual NASA Specialized Center of Research.

Research in HRP is organized around 32 risks and two concerns as outlined in the Human Research Roadmap (https://humanresearchroadmap.nasa.gov/Risks/). In this appendix of the 2017 HERO NRA, HRP is soliciting research for the following topics: · Topic 1: Analyses of the Temporal Nature of Human Adaptation to Long-Duration Low-Earth Orbit Missions Virtual NASA Specialized Center of Research (VNSCOR) · Topic 2: Biological, Physiological, and Behavioral Functions of Mice during Partial (0 - 1) G-Exposures Provided by Centrifugation on the International Space Station · Topic 3: Novel Spaceflight-Associated Neuro-Ocular Syndrome Hypotheses and Countermeasures · Topic 4: Medical Countermeasures Targeting Multiple Tissues at Risk from Exposure to Space Radiation · Topic 5: Individual and Team Problem-Solving Skills Training for Exploration Missions · Topic 6: Sensory Stimulation for Cognitive and Behavioral Health · Topic 7: Human Capabilities Assessments for Autonomous Missions (HCAAM) Virtual NASA Specialized Center of Research (VNSCOR)

The purpose of this cooperative agreement opportunity is to support the creation and/or maintenance of a transdisciplinary, multisite Research Network that will accelerate the translation of developmental science into MCH practice, promote scientific collaboration, and develop additional research capacity in the fields of adolescent and young adult (ages 10-25) health. A Research Network is a collaboration designed to conduct research across multiple sites, resulting in a greater collective impact. One institution serves as the primary awardee, and oversees and facilitates all Network activities. The Network must include researchers who study adolescence and young adulthood from a range of disciplines, including developmental neuroscience, behavioral and social sciences, and the medical and/or allied health fields, reflecting attention to the health and development of the whole person as well as to health care services for members of these two age groups.

PCORI seeks to fund pragmatic clinical trials, large simple trials, or large-scale observational studies that compare two or more alternatives for addressing prevention, diagnosis, treatment, or management of a disease or symptom; improving healthcare system-level approaches to managing care; communicating or disseminating research results to patients, caregivers, or clinicians; or eliminating health or healthcare disparities. Proposed studies must address critical clinical choices faced by patients, their caregivers, clinicians, or delivery systems. They must involve broadly representative patient populations and be large enough to provide precise estimates of hypothesized effectiveness differences and to support evaluation of potential differences in treatment effectiveness in patient subgroups.

This Funding Opportunity Announcement (FOA) invites applications to provide infrastructure support to provide infrastructure support for advancing development of specific high priority areas of behavioral and social research of relevance to Alzheimers disease and Alzheimers disease related dementias (AD/ADRD). The infrastructure support will facilitate research networks through meetings, conferences, small scale pilots, short term educational opportunities (such as intensive workshops, summer institutes, or visiting scholar programs), and dissemination to encourage growth and development of specified priority areas and build resources for advancing aging-relevant research in the field at large. Network applications are limited to the following areas: (1) AD/ADRD care and services research and (2) the coordination of international studies conducting the Harmonized Cognitive Assessment Protocol.

The NIH Directors Pioneer Award supports individual scientists of exceptional creativity who propose highly innovative and potentially transformative research towards the ultimate goal of enhancing human health. Individuals from diverse backgrounds are encouraged to apply. Applications in all topics, including, but not limited to, the behavioral, social, biomedical, applied, and formal sciences, relevant to the broad mission of NIH are welcome and may involve basic, translational, or clinical research. To be considered pioneering, the proposed research must reflect substantially different scientific directions from those already being pursued in the investigators research program or elsewhere. The NIH Directors Pioneer Award is a component of the High-Risk, High-Reward Research program of the NIH Common Fund.

NIDA and the following NIH Institutes and Centers (ICs), NIAAA, NICHD, NIMH, NIMHD, NINDS, OBSSR, and NCI intend to publish a limited competition Collaborative Research on Addiction at NIH (CRAN) funding opportunity announcement to solicit applications for a Coordinating Center in service of a nationwide, multisite, multi-modal, longitudinal cohort study to prospectively examine brain and behavioral development from late childhood (approximately age 9-10) through adolescence into early adulthood. Current primary awardees will be eligible to apply and this new award period will be extended to 7 years in duration.

The Adolescent Brain Cognitive Development (ABCD) Study is collecting data on health and mental health, cognitive function, substance use, cultural and environmental factors, and brain structure and function from youth starting when they are 9-10 years-old repeatedly for 10 years and makes that data available to the scientific community through the NIMH Data Archive. The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications proposing the analysis of this public use dataset to increase knowledge of adolescent health and development. More information about the ABCD Study may be found on the ABCD Study web page (www.abcdstudy.org).

The purpose of the NIDCD Research Career Enhancement Award for Established Investigators (K18) program is to enable established, proven investigators to augment or redirect their research programs through the acquisition of new research skills to answer questions relevant to the hearing, balance, smell, taste, voice, speech and language sciences.

This FOA encourages applications for multi-site exploratory and confirmatory clinical trials focused on promising interventions, as well as biomarker-or outcome measure validation studies that are immediately preparatory to trials in stroke prevention, treatment, and recovery.  Successful applicants will collaborate and conduct the trial within the NIH StrokeNet.  Following peer review, NINDS will prioritize trials among the highest scoring to be conducted in the NIH StrokeNet infrastructure. The NIH StrokeNet National Coordinating Center (NCC) will work with the successful applicant to implement the proposed study efficiently and the National Data Management Center (NDMC) will provide statistical and data management support.  The NIH StrokeNet Regional Coordinating Centers (RCCs) and their affiliated clinical sites will provide recruitment/retention support as well as on-site implementation of the clinical protocol.

The purpose of the NIDCD Research Career Enhancement Award for Established Investigators (K18) program is to enable established, proven investigators to augment or redirect their research programs through the acquisition of new research skills to answer questions relevant to the hearing, balance, smell, taste, voice, speech and language sciences.

This Funding Opportunity Announcement (FOA) encourages the translation of technologies for brain or behavioral research from academic and other non-small business research sectors to the marketplace. Encouraged from Small Business Concerns (SBCs) are Small Business Innovation Research (SBIR) grant applications that propose to further develop, make more robust, and make more user-friendly such technologies in preparation for commercial dissemination. It is expected that this activity will require partnerships and close collaboration between the original developers of these technologies and SBCs, which may be accomplished in any of a number of ways, including the use of multiple program directors/principal investigators.

CIFAR invites exceptional early career researchers to join CIFAR's global network of 370 researchers from 18 countries who together are pursuing answers to some of the most complex challenges facing the world today. The CIFAR Azrieli Global Scholars program provides funding, skills training, mentorship, and opportunities to collaborate with outstanding colleagues from diverse disciplines to position scholars as leaders and agents of change within academia and beyond. CIFAR Azrieli Global Scholars receive: * $100,000 CDN in unrestricted research support * A two-year membership to a CIFAR research program, with outstanding research leaders from across disciplines. Learn what it's like to be a CIFAR Fellow * Specialized leadership and communication skills training Applicants can be from anywhere in the world, must hold a PhD (or equivalent) and be within the first five years of a full-time academic appointment. Please note that postdoctoral fellows are not eligible to apply to the program. Scholars' research interests must be aligned with the themes of an eligible CIFAR research program.  In 2018, the eligible programs are: * Azrieli Program in Brain, Mind & Consciousness * Bio-Inspired Solar Energy * Gravity & the Extreme Universe * Humans & the Microbiome * Molecular Architecture of Life

This Funding Opportunity Announcement (FOA) solicits Edward R. Roybal Centers for translational intervention development research for Alzheimers Disease and Alzheimers Disease related dementias care provider support. The purpose of the Roybal Centers is to develop behavioral interventions that improve the health, well-being and/or capacity of individuals and/or systems that provide care to persons with AD-ADRD. Roybal Centers will conduct Stage 0 through IV pilot studies in accordance with the multidirectional, translational NIH Stage Model, to produce potent and implementable principle-driven behavioral interventions.

FY18 PRARP QUAL Overarching Challenges: This FY18 PRARP QUAL funding opportunity requires applications to address one or more of the following FY18 PRARP QUAL Overarching Challenges: Paucity of Clinical Studies: The paucity of clinical studies to examine the interrelationship between TBI and subsequent AD/ADRD for the military, Veteran, and civilian communities. This includes research into risk factors that may predispose individuals to AD/ADRD subsequent to TBI. Quality of Life: The need for technologies, assessments, interventions, or devices to benefit individuals living with the common symptoms or deficits of TBI and AD/ADRD. Caregiver Support: The need for technologies, assessments, interventions, or devices with the goal of enhancing the lives of caregivers for individuals living with the common symptoms or deficits of TBI and AD/ADRD. Epidemiology: The paucity of epidemiological research to examine the interrelationship between TBI and subsequent AD/ADRD for the military, Veteran, and civilian communities. This includes research into risk factors that may predispose individuals to AD/ADRD subsequent to TBI. FY18 PRARP QUAL Focus Areas: In addition to addressing one or more of the specified FY18 PRARP QUAL Overarching Challenges, applications should address at least one of the following FY18 PRARP QUAL Focus Areas in support of the FY18 PRARP QUAL Overarching Challenges. An application that proposes research outside of the FY18 PRARP QUAL Focus Areas is acceptable, as long as the applicant provides a strong rationale.

This Funding Opportunity Announcement (FOA) encourages the translation of technologies for brain or behavioral research from academic and other non-small business research sectors to the marketplace. Encouraged from Small Business Concerns (SBCs) are Small Business Innovation Research (SBIR) grant applications that propose to further develop, make more robust, and make more user-friendly such technologies in preparation for commercial dissemination. It is expected that this activity will require partnerships and close collaboration between the original developers of these technologies and SBCs, which may be accomplished in any of a number of ways, including the use of multiple program directors/principal investigators.

The goal of this FOA is to support short courses geared to behavioral and social scientists who have existing expertise in aging research and can make research contributions in Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) with additional knowledge about the disease and related research resources. Fields of behavioral and social science research relevant for this FOA are health economics, labor economics, health services research, healthcare policy, public policy, demography, sociology, social epidemiology, psychology, and social neuroscience. Priority areas of focus include, but are not limited to, the following: dementia care; dementia caregiver research; cognitive and dementia epidemiology; behavioral and social pathways of AD/ADRD; role of social, contextual, environmental, and institutional factors in AD/ADRD; early psychological changes preceding AD/ADRD onset; prevention of AD/ADRD; disparities in AD/ADRD or dementia-related outcomes; and research resources and methods for studying the determinants and impact of AD/ADRD.

Explainable Artificial Intelligence (XAI) aims to provide strong predictive value along with mechanistic understanding of AI by combining machine learning techniques with effective explanatory techniques. This Funding Opportunity Announcement (FOA) solicits applications in the area of XAI applied to neuroscientific questions of encoding, decoding, and modulation of neural circuits linked to behavior. This FOA encourages collaborations between computationally and experimentally-focused investigators. This FOA seeks the development of machine learning algorithms that are able to mechanistically explain how experimental manipulations affect cognitive, affective, or social processing in humans or animals. Proof-of-concept applications aimed at improving the current state of the technology that uses XAI to provide unbiased, hierarchical explanations of causal relationships between complex neural and behavioral data are also appropriate .

EXplainable Artificial Intelligence (XAI) aims to provide strong predictive value along with mechanistic understanding by combining machine learning techniques with effective explanatory techniques. This Funding Opportunity Announcement (FOA) solicits applications in the area of XAI applied to neuroscientific questions of encoding, decoding, and modulation of neural circuits linked to behavior. This FOA encourages collaborations between computationally and experimentally-focused investigators. This FOA seeks machine learning algorithms able to mechanistically explain how experimental manipulations can improve cognitive, affective, or social processing in humans or animals. Proof-of-concept applications aimed at improving the current state of the technology that use XAI to provide unbiased, hierarchical explanations of causal relationships between complex neural and behavioral data are also responsive.