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Upper levels of vitamin D intake were set at 50 microg/d (2000 IU/d) for all ages. Some individuals would require higher levels than these to achieve serum 25-hydroxyvitamin D concentrations for optimal calcium absorption. So much new information on vitamin D and health has been collected since the requirements were set in 1997 that this nutrient is likely the most in need of revised requirements. Vitamin D requirements: current and future. Weaver CM, Fleet JC. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1735S-9S. Review. Erratum in: Am J Clin Nutr. 2005 Mar;81(3):729. PMID: 15585797

Research has uncovered the fact that vitamin K also plays a crucial role in maintaining bone health. It was found that the amount of vitamin K required to halt bone absorption leading to osteoporosis requires much greater intakes than that required for blood clot regulation. Further, it appears that bone and vascular tissue (like coronary arteries) maintain a preference for a different form of vitamin K than that required for blood clotting regulation. Rather than vitamin K1 needed for clotting, vitamin K2 is the form preferred by bones and arteries (Schurgers LJ et al 2001). It appears that much of the information generated over the years for vitamin K focused on the K1 form, ignoring the K2 form necessary for bone and vascular health. Normal deposition of calcium occurs only in bone and in teeth. Abnormal deposition of calcium in the body occurs in three places: the inner lining of the arteries of the body (the intima) that causes atherosclerotic plaque; the muscle layer of arteries ("medial calcification"); and heart valves. K2 appears to be the form of vitamin K responsible for controlling these phenomena.

Estimation of the dietary requirement for vitamin D in free-living adults >=64 y of age. Cashman KD, Wallace JM, Horigan G, Hill TR, Barnes MS, Lucey AJ, Bonham MP, Taylor N, Duffy EM, Seamans K, Muldowney S, Fitzgerald AP, Flynn A, Strain JJ, Kiely M. Am J Clin Nutr. 2009 May;89(5):1366-74. Epub 2009 Mar 18. PMID: 19297462 doi:10.3945/ajcn.2008.27334 Conclusion: To ensure that the vitamin D requirement is met by the vast majority (>97.5%) of adults aged ≥64 y during winter, between 7.9 and 42.8 µg vitamin D/d is required, depending on summer sun exposure and the threshold of adequacy of 25(OH)D. .

During an ISO audit, the auditor will be asking for records or evidence the quality System being audited has effectively maintained the records required. For example, when an auditor is reviewing the corrective and preventive action system, he or she will be looking for a CAPA Report to provide evidence that the CAPA system has met the requirements for section 8.52 Corrective Action and 8.5.3 Preventive Action.

Vitamin D and type 2 diabetes: are we ready for a prevention trial? Scragg R. Diabetes. 2008 Oct;57(10):2565-6. PMID: 18820212 doi: 10.2337/db08-0879 Despite evidence from the current article (3) and the Finnish study (17), doubts still remain about whether low vitamin status is a cause of type 2 diabetes. Further cohort studies are required, assessing baseline vitamin D status using blood 25(OH)D to be sure that the Ely and Finnish studies are not false-positive results. Glucose clamp studies are also required because we are still not sure of the mechanism influenced by vitamin D-whether it is insulin resistance, secretion, or both. But most importantly, given that nearly three decades have passed since the first studies linking vitamin D with insulin metabolism (6,7), well-designed clinical trials of the effect of vitamin D supplementation on glycemia status and diabetes risk are urgently required to settle this question. And they need to prevent past mistakes. In particular, the vitamin D dose given in such trials needs to be high enough-above 2,000 IU per day (19)-to raise blood 25(OH)D levels above 80 nmol/l because diabetes risk is lowest at this level (9,20). If well-designed trials are carried out and confirm a protective effect from vitamin D, it could be used by the general population as a simple and cheap solution to help prevent the diabetes epidemic.

Dietary recommendations for vitamin D: a critical need for functional end points to establish an estimated average requirement. Whiting SJ, Calvo MS. J Nutr. 2005 Feb;135(2):304-9. Review. PMID: 15671232 In summary, vitamin D has emerged as a critical nutrient for which there is a compelling health need to establish adequate dietary guidelines in North America and worldwide given the increasing evidence of vitamin D deficiency and insufficient links to risk of chronic disease. We strongly argue that now there are enough data to consider setting an estimated average requirement for vitamin D and to recognize the crucial need for more research to determine the role of vitamin D in noncalciotropic functions and prevention of chronic diseases

ISO is Short form of International Organization for Standard. ISO 9001:2008 require an organization to develop a quality management system that fits the product & Process requirement as well as regulatory requirement AS an ISO 9001:2008 certified company,

ISO is Short form of International Organization for Standard. ISO 9001:2008 require an organization to develop a quality management system that fits the product & Process requirement as well as regulatory requirement AS an ISO 9001:2008 certified company, iso 9000

Mangoes are the richest source of most important vitamins (A, C, B, E, K), minerals, dietary fibbers, electrolytes and iron which are mostly required by the for better growth and development as well as being healthy and live life without any diseases and infections. It is liked by all people due to its nice color, taste, flavor and quality health aspects. I have mentioned below the few beneficial aspects of the mangoes which you must know to enhance your interest while eating mangoes: Benefits of Mango juice for Cancer Prevention Mango fruit has antioxidant compounds (such as quercetin, fisetin, astragalin, gallic acid, isoquercitrin, methyl gallate and etc) and lots of enzymes which help in protecting against various body organs cancers like colon, leukemia, breast, stomach, prostate, lungs, cervical, oral cavity cancers and etc. These compounds include, as well as the abundant. Polyphenols found in it acts as an anti inflammatory agent and restricts the growth of cancerous cells. The soluble dietary fibers, pectin found in it has property of decreasing the action of protein (galectin) found in the cancerous cells. Benefits of Mango juice for Heart health It contains highest level of soluble dietary fibers (pectin) and vitamin C which involves in lowering the bad serum cholesterol levels means Low-Density Lipoproteins as well as enhancing the good serum cholesterol levels means High-Density Lipoproteins thus keeps the heart healthy by keeping all the heart problems away. It is the rich source of potassium which involves in controlling the blood pressure thus heart rate. Benefits of Mango juice for Skin It is beneficial for the skin in both ways whether it is eaten or applied externally on the skin. It India juice has antioxidants which make the skin healthy, smooth, glowing and wrinkles free. It clear out the blocked pores and provides solution to get free from the pimples if applied on the face. It makes the skin glowing by reducing the dark spot

Weight gain: Mango Juice is highly beneficial in gaining weight because of the presence of adequate amount of protein both in milk and mango. The underweight people can drink mango juice regularly during summer. 150 grams of mango has about 86 calories, and starch easily converts into sugar thereby helps in weight gain. This is the most important health benefits of mango juice. However, obese person should avoid drinking of mango Juice. Good for anemia patient: The mango Juice is the most delicious juice and filled with important nutrients like iron, protein and beta-carotene. It is good for anemia patient and those have protein deficiency. One of the important benefits of mango juice is to increase red blood cells count in the body. Mango juice also has significant amount of iron. Regular drinking of one glass of mango juice is enough to provide necessary amount of iron to the body. Mango juice is also beneficial for pregnant mother as far as iron content is concern. A number of studies have shown that iron content is beneficial in reduction of muscle cramp, anxiety, stress and heart related problems. Good for eyes: Mango contains vitamin A, which is beneficial for eyes and skin. The sufficient amount of vitamin A helps the eyes against dryness, night blindness along with facilitating good eye sight. Strengthen bones: Milk, which is the integral part of mango juice, is having vitamin D and calcium, helps in strengthening of bones. Maintains blood pressure: Mango juice is rich in potassium and magnesium, which helps to keep blood pressure under control. Potassium assists the heart and regulates blood pressure as well as balance fluids in your body. Mango juice also lowers blood pressure due to tinnginya fiber, pectin and vitamin C. Pectin and vitamin C reduces the serum cholesterol levels, especially the low-density lipoprotein For heart health: Mango in Mango Drinks has high amount of pectin, a dietary fiber and helpful in lowering cholesterol

Mango juice Summary of the Health benefits Mango Fruit Juice are rich in iron, thus patients with anemia and pregnant women are advised to consume it regularly. Phenols are presents in Mango Juice and Mango drinks this compound phenol has strong antioxidant and anticancer capacities. mangoes and it's Juice helps in relieving congested pores of the skin. Patients suffering from acidity and weak digestion can benefit from the consumption of mango juice. It is a fruit which is low in carbohydrates and is an rich antioxidant. The rich source of vitamin A (beta-carotene), E and Selenium present in Mangoes helps in protection from heart diseases and other problems. Mango Juice is rich in pre-biotic dietary fiber, vitamins, minerals, and poly-phenolic flavonoid antioxidant compounds. According to new research study, mango fruit juice has been found to protect against colon, breast, leukemia and prostate cancers. Several trial studies suggest that polyphenolic anti-oxidant compounds in mango are known to offer protection against breast and colon cancers. Mango Juice is an excellent source of Vitamin-A and flavonoids like beta-carotene, alpha-carotene,and beta-cryptoxanthin. 100 g of fresh Mango juice provides 765 mg or 25% of recommended daily levels of vitamin A. Together these compounds are known to have antioxidant properties and are essential for vision. Vitamin A is also required for maintaining healthy mucus membranes and skin. Consumption of natural fruits rich in carotenes is known to protect body from lung and oral cavity cancers. Fresh mango Juice is a very rich source of potassium. Potassium is an important component of cell and body fluids that helps controlling heart rate and blood pressure. mango juice is also a very good source of vitamin-B6 (pyridoxine), vitamin-C and vitamin-E. Consumption of foods rich in vitamin C helps body develop resistance against infectious agents and scavenge harmful oxygen free radicals. Vitamin B-6 o

Five servings of fruits or vegetables have been able to meet the daily requirement of vitamin C to 200 mg per day. With no excessive supplementation.

Daily requirement of vitamin C - Consumption of vitamin C more than 1000 mg per day may causes nausea, abdominal cramps, and formation of kidney stones

Estimation of the dietary requirement for vitamin D in healthy adults.\nCashman KD, Hill TR, Lucey AJ, Taylor N, Seamans KM, Muldowney S, Fitzgerald AP, Flynn A, Barnes MS, Horigan G, Bonham MP, Duffy EM, Strain JJ, Wallace JM, Kiely M.\nAm J Clin Nutr. 2008 Dec;88(6):1535-42.\nPMID: 19064513 [

Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev. 2005 Jun;10(2):94-111. Review. PMID: 15989379 [PubMed - indexed for MEDLINE]

Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. Vieth R, Ladak Y, Walfish PG. J Clin Endocrinol Metab. 2003 Jan;88(1):185-91. PMID: 12519850 This study shows that all age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism. Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function

Assessment of dietary vitamin D requirements during pregnancy and lactation. Hollis BW, Wagner CL. Am J Clin Nutr. 2004 May;79(5):717-26. Review. PMID: 15113709 We found that high-dose maternal vitamin D supplementation not only improves the nutritional vitamin D status of breastfeeding infants but also elevates the maternal concentrations into the mid-normal range. Thus, a dual benefit is achieved from high-dose maternal supplementation. It is noteworthy that in the Finnish study, the authors added a disclaimer, "A sufficient supply of vitamin D to the breastfed infant is achieved only by increasing the maternal supplementation up to 2000 IU/d. Such a dose is far higher than the RDA [DRI] for lactating mothers [and therefore] its safety over prolonged periods is not known and should be examined by further study." This point of concern was valid when this study was conducted in 1986 (92); however, on the basis of the current findings of Vieth et al (2) and of Heaney et al (3)-which showed that vitamin D intakes <= 10 000 IU/d (250 µg) are safe for prolonged periods (up to 5 mo)-we believe that it is time to reexamine the understated DRI of vitamin D for lactating mothers. This work is now being conducted in our clinics and laboratory.

Despite inadequacies in information concerning the minimum prophylactic requirement of vitamin D for all age groups beyond infancy, there is no doubt that a total intake of 400 I.U. per day is adequate to prevent vitamin D deficiency in substantially all normal children from birth through adolescence. Evidence derived from the study of idiopathic hypercalcemia suggests that certain infants excessively sensitive to the toxic action of vitamin D may, on rare occasions, be adversely affected by daily intakes of 3,000 to 4,000 I.U. and sometimes considerably less. Because of the prevalent practice of food fortification in the United States and Canada, there is now a definite possibility that the individual, even the young infant, may ingest considerably more than the recommended vitamin D allowance, and intakes of 2,000 to 3,500 I.U. per day are possible, particularly beyond infancy. Although there has been no specific evidence that intakes of this order produce deleterious effects beyond infancy, it is pointed out that the long-term consequences of this new nutritional situation on older children or adults are entirely unknown.

Written by, Samuel K. Burlum, Investigative Reporter and author of The Green Lane, a syndicated column Published on 6/01/16, a SamBurlum.com Exclusive Water; without it our society comes to a screeching holt. Water is the source of life, and the vast majority of our way of being depends on it. From manufacturing, to food production, water is required to help us feed our planet and build the modern conveniences of today. Water is our most precious resource on planet earth, yet we put our future at risk every time we either waste this valuable commodity, and/or abuse it with pollutants.

Written by, Samuel K. Burlum, Investigative Reporter and author of The Green Lane, a syndicated column Published on 6/01/16, a SamBurlum.com Exclusive Water; without it our society comes to a screeching holt. Water is the source of life, and the vast majority of our way of being depends on it. From manufacturing, to food production, water is required to help us feed our planet and build the modern conveniences of today. Water is our most precious resource on planet earth, yet we put our future at risk every time we either waste this valuable commodity, and/or abuse it with pollutants.

Written by, Samuel K. Burlum, Investigative Reporter and author of The Green Lane, a syndicated column Published on 6/01/16, a SamBurlum.com Exclusive Water; without it our society comes to a screeching holt. Water is the source of life, and the vast majority of our way of being depends on it. From manufacturing, to food production, water is required to help us feed our planet and build the modern conveniences of today. Water is our most precious resource on planet earth, yet we put our future at risk every time we either waste this valuable commodity, and/or abuse it with pollutants.

Vitamin K has been known as the coagulation vitamin, because of its role in the blood-clotting process. However, research over the last few decades has shown that the role of K Vitamins - and natural Vitamin K2, the menaquinones, in particular - has been greatly expanded. Of note, K Vitamins activity outside the liver is required for calcium utilization, the key factor in maintaining both bone and cardiovascular health.\n\nVitamin K2 helps to activate vitamin K-dependent proteins responsible for healthy tissues. In bone, it activates osteocalcin, a protein required to bind calcium to the mineral matrix, thus strengthening the skeleton. In circulation, Vitamin K2 participates in carboxylation of Matrix Gla Protein (MGP), the most potent inhibitor of arterial calcification known, lowering the risk of vascular damage.