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Matti Narkia

PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells. - .[Biochem Pharmacol. 2009] - PubMed Result - 0 views

www.ncbi.nlm.nih.gov/...19426685

2009 May study research in_vitro PPARalpha clioquinol DHA omega-3 cancer nutrition medline synergy synergistic

shared by Matti Narkia on 06 Aug 09 - No Cached
  • Matti Narkia on 06 Aug 09
     
    The combination effects index (CI) analysis confirmed the synergy of clioquinol and clofibrate on inhibiting cancer cell viability. Using inhibitors to block PPARalpha signaling diminished the synergistic cytotoxicity of clioquinol and DHA. These results provide pharmacological evidence that the synergistic anticancer action of clioquinol and DHA is mediated by PPARalpha signaling in human cancer cells. PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells. Tuller ER, Brock AL, Yu H, Lou JR, Benbrook DM, Ding WQ. Biochem Pharmacol. 2009 May 1;77(9):1480-6. Epub 2009 Feb 13. PMID: 19426685
Matti Narkia

Fish oil feeding alters liver gene expressions to defend against PPARalpha activation and ROS production -- Takahashi et al. 282 (2): 338 -- AJP - Gastrointestinal and Liver Physiology - 0 views

ajpgi.physiology.org/...G338

2002 February study research in_vivo animal_study mice fish_oil omega-3 fibrate sulfotransferase glutathione_transferase dehydroepiandrosterone PPARalpha PPAR ROS lipogenesis inhibition oxidation antixidant lipid_peroxidation nutrition medline

shared by Matti Narkia on 06 Aug 09 - Cached
  • Matti Narkia on 06 Aug 09
     
    These data indicate that fish oil feeding downregulated the endogenous PPAR-activation system and increased antioxidant gene expressions to protect against ROS excess Fish oil feeding alters liver gene expressions to defend against PPARalpha activation and ROS production. Takahashi M, Tsuboyama-Kasaoka N, Nakatani T, Ishii M, Tsutsumi S, Aburatani H, Ezaki O. Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G338-48. PMID: 11804856
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