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Matti Narkia

Vitamin D and prostate cancer - ScienceDirect - The Journal of Steroid Biochemistry and... - 0 views

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    Vitamin D and prostate cancer.
    Tuohimaa P, Lyakhovich A, Aksenov N, Pennanen P, Syvälä H, Lou YR, Ahonen M, Hasan T, Pasanen P, Bläuer M, Manninen T, Miettinen S, Vilja P, Ylikomi T.
    J Steroid Biochem Mol Biol. 2001 Jan-Mar;76(1-5):125-34.
    PMID: 11384870
    doi:10.1016/S0960-0760(00)00141-2
Matti Narkia

Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-α) in pr... - 0 views

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    Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-alpha) in prostate cancer cells.
    Golovko O, Nazarova N, Tuohimaa P.
    Life Sci. 2005 Jun 17;77(5):562-77. Epub 2005 Feb 25.
    PMID: 15904673
    doi:10.1016/j.lfs.2004.10.072

    Combined addition of human recombinant TNF-alpha with calcitriol or CB1093 cause enhanced effect in induction of apoptosis. We conclude that under physiological conditions vitamin D activates only the transcription of TNF-alpha gene, for TNF-alpha protein synthesis additional cofactors are required. Therefore a cooperation of vitamin D and TNF-alpha may play an important role in the control of cell growth in prostate cancer.
Matti Narkia

The role of Vitamin D3 metabolism in prostate cancer - ScienceDirect - The Journal of S... - 0 views

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    The role of Vitamin D3 metabolism in prostate cancer.
    Lou YR, Qiao S, Talonpoika R, Syvälä H, Tuohimaa P.
    J Steroid Biochem Mol Biol. 2004 Nov;92(4):317-25. Epub 2004 Dec 19. Review.
    PMID: 15663995
    doi:10.1016/j.jsbmb.2004.10.007

    In summary, the local metabolism of hormonal Vitamin D seems to play an important role in the development and progression of prostate cancer.
Matti Narkia

Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). - Ca... - 0 views

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    Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland).
    Ahonen MH, Tenkanen L, Teppo L, Hakama M, Tuohimaa P.
    Cancer Causes Control. 2000 Oct;11(9):847-52.
    PMID: 11075874
    DOI: 10.1023/A:1008923802001

    CONCLUSIONS: We conclude that low levels of 25-VD associated with an increased risk for subsequent earlier exposure and more aggressive development of prostate cancer, especially before the andropause.
Matti Narkia

Calcidiol and prostate cancer - ScienceDirect - The Journal of Steroid Biochemistry and... - 0 views

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    Calcidiol and prostate cancer.
    Tuohimaa P, Golovko O, Kalueff A, Nazarova N, Qiao S, Syvälä H, Talonpoika R, Lou YR.
    J Steroid Biochem Mol Biol. 2005 Feb;93(2-5):183-90. Epub 2005 Jan 22. Review.
    PMID: 15860261
Matti Narkia

Geographic variation of prostate cancer mortality rates in the United States: Implicati... - 0 views

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    Geographic variation of prostate cancer mortality rates in the United States: Implications for prostate cancer risk related to vitamin D.
    Grant WB.
    Int J Cancer. 2004 Sep 1;111(3):470-1; author reply 472. No abstract available.
    PMID: 15221981
    10.1002/ijc.20220

    The implications of our results and those of Tuohimaa et al.[1] include the following. Vitamin D supplementation should be undertaken in wintertime, a period when it is impossible to produce vitamin D by solar UVB exposure in northeastern states.[13] Given these new results, the optimal vitamin D intake and production and serum 25(OH)-vitamin D3 levels for prostate cancer appear to be lower than for other cancers. However, when developing guidelines for vitamin D fortification, many factors should be included in the analysis, including all of the potential health benefits and possible risks of vitamin D, as well as age, sex, residence, child-bearing status, etc.[14] Also, the suggestion that daily vitamin D3 supplement doses of 100 g (4,000 IU)/day are safe[15] should be reexamined. Finally, in terms of preventing prostate cancer, more attention should be given to diet, which has the greatest environmental impact on risk of prostate cancer, with animal products being important risk factors and vegetable products, especially onions and other allium family members, being important risk-reduction factors.[16]
Matti Narkia

Both high and low levels of blood vitamin D are associated with a higher prostate cance... - 0 views

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    Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries.
    Tuohimaa P, Tenkanen L, Ahonen M, Lumme S, Jellum E, Hallmans G, Stattin P, Harvei S, Hakulinen T, Luostarinen T, Dillner J, Lehtinen M, Hakama M.
    Int J Cancer. 2004 Jan 1;108(1):104-8.
    PMID: 14618623
    DOI: 10.1002/ijc.11375
Matti Narkia

Enzyme kinetics hypothesis to explain the U-shaped risk curve for prostate cancer vs. 2... - 0 views

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    Enzyme kinetics hypothesis to explain the U-shaped risk curve for prostate cancer vs. 25-hydroxyvitamin D in nordic countries.
    Vieth R.
    Int J Cancer. 2004 Sep 1;111(3):468; author reply 469.
    PMID: 15221979
    DOI: 10.1002/ijc.20218
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