"In an article published in the December 29, 2005, issue of the journal
Cell, the researchers report that knocking out a single gene encoding
the enzyme GnT-4a glycosyltransferase (GnT-4a ) disrupts insulin
production. Importantly, the scientists showed that a high-fat diet
suppresses the activity of GnT-4a and leads to type 2 diabetes due to
failure of the pancreatic beta cells.
"We have discovered a mechanistic explanation for beta cell failure
in response to a high-fat diet and obesity, a molecular trigger which
begins the chain of events leading from hyperglycemia to insulin
resistance and type 2 diabetes," said Jamey Marth, a Howard Hughes
Medical Institute investigator at the University of California, San
Diego (UCSD). Marth and first author Kazuaki Ohtsubo at UCSD
collaborated on the studies with researchers from the Kirin Brewery Co.
Ltd., and the University of Fukui, both in Japan."
San Diego, CA (PRWEB) May 25, 2009 -- Coming on the heels of the publishing in the Annals of Epidemiology of a new study led by Dr. Cedric Garland, on the preventive measures of vitamin D, GrassrootsHealth D*action Project is calling on physicians, health clinics and groups throughout the country to recognize the need for determining vitamin D levels and to ensure the public have their blood levels of vitamin D tested.
According to research from the newly published study by Cedric F. Garland, Dr. P.H., FACE, Department of Family and Preventive Medicine and Moores Cancer Center of the University of California, San Diego (UCSD), "It is projected that raising the minimum year-around serum 25(OH)D level to 40-60 ng/ml (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three quarters of deaths from these diseases, in the US and Canada."
"Results of the first placebo-controlled, multicenter clinical trial of the compound coenzyme Q10 suggest that it can slow disease progression in patients with early-stage Parkinson's disease (PD). While the results must be confirmed in a larger study, they provide hope that this compound may ultimately provide a new way of treating PD.
The phase II study, led by Clifford Shults, M.D., of the University of California, San Diego (UCSD) School of Medicine, looked at a total of 80 PD patients at 10 centers across the country to determine if coenzyme Q10 is safe and if it can slow the rate of functional decline. The study was funded by the National Institute of Neurological Disorders and Stroke (NINDS) and appears in the October 15, 2002, issue of the Archives of Neurology"
Diagnosis & Treatment of Vitamin D Deficiency
Wednesday, April 9, 2008 * 12:30pm - 6:00pm
Garren Auditorium, University of California, San Diego
Seminar Presentations
Reducing the Burden of Disease Through Adequate Intake of Vitamin D3.
A presentation at University of California, San Diego,
April 9, 2008
by William B. Grant, Ph.D