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Matti Narkia

Benefits of Vitamin D Supplementation - Journal of American Physicians and Surgeons Vol... - 0 views

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    Benefits of Vitamin D Supplementation
    Joel M. Kauffman, Ph.D.
    Journal of American Physicians and Surgeons
    Volume 14 Number 2 - Summer 2009

    Clinical trials show that vitamin D supplementation at higher
    levels than previously recommended is beneficial for many
    conditions. It decreases the frequency of falls and fractures, helps
    prevent cardiovascular disease, and reduces symptoms of colds or
    influenza. Benefits are also seen in diabetes mellitus, multiple
    sclerosis, Crohn disease, pain, depression, and possibly autism.
    Sunlight does not cause an overdose of vitamin D production,
    and toxicity from supplementation is rare. Dose recommendations
    are increasing, but appear to be lagging the favorable trial results. A
    number of common drugs deplete vitamin D levels, and others may
    limit its biosynthesis from sunlight.
    People with adequate levels from sun exposure will not benefit
    from supplementation. While dietary intake is helpful,
    supplementation is better able to raise serum 25-hydroxyvitamin D ,
    the major circulating metabolite, to the level now thought adequate,
    30-50 ng/mL.
    Where there is inadequate daily sun exposure, oral doses of
    1,000-2,000 IU/d are now considered routine, with much higher
    doses (up to 50,000 IU) for rapid repletion now considered safe.
Matti Narkia

Vitamin D for cancer prevention: global perspective. Garland CF et al. -Ann Epidemiol. ... - 0 views

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    Vitamin D for cancer prevention: global perspective.
    Garland CF, Gorham ED, Mohr SB, Garland FC.
    Ann Epidemiol. 2009 Jul;19(7):468-83. Review.
    PMID: 19523595
Matti Narkia

How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptati... - 0 views

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    How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
    Vieth R.
    Anticancer Res. 2009 Sep;29(9):3675-84. Review.
    PMID: 19667164
Matti Narkia

Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependen... - 0 views

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    Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells.
    Mantena SK, Sharma SD, Katiyar SK.
    Mol Cancer Ther. 2006 Feb;5(2):296-308.
    PMID: 16505103
    doi: 10.1158/1535-7163.MCT-05-0448

    The effectiveness of berberine in checking the growth of androgen-insensitive, as well as androgen-sensitive, prostate cancer cells without affecting the growth of normal prostate epithelial cells indicates that it may be a promising candidate for prostate cancer therapy.

    The evaluation of ancient herbal medicines may indicate novel strategies for the treatment of prostate cancer, which remains the leading cause of cancer-related deaths in American men (1). In our present investigation, we show that a naturally occurring isoquinoline alkaloid, berberine, significantly inhibits the proliferation and reduces the viability of DU145 and PC-3 as well as LNCaP cells (Fig. 1), which suggests that berberine may be an effective chemotherapeutic agent against both androgen-sensitive and androgen-insensitive prostate cancer cells. Importantly, we found that berberine did not exhibit toxicity to nonneoplastic human prostate epithelial cells under the conditions used, except for a moderate reduction in cell viability at higher concentrations when cells were treated in vitro for an extended period of time.

    In conclusion, the results of the present study indicate that berberine inhibits proliferation and induces G1-phase arrest and apoptosis in human prostate cancer cells but not in normal human prostate epithelial cells. In addition, we provide mechanistic evidence that berberine-induced apoptosis in prostate carcinoma cells, particularly hormone-refractory prostate carcinoma cells, is mediated through enhanced expression of Bax, disruption of the mitochondrial membrane potential, and activation of caspase-3.
Matti Narkia

The Polyp Prevention Trial-Continued Follow-up Study: No Effect of a Low-Fat, High-Fibe... - 0 views

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    The polyp prevention trial continued follow-up study: no effect of a low-fat, high-fiber, high-fruit, and -vegetable diet on adenoma recurrence eight years after randomization.
    Lanza E, Yu B, Murphy G, Albert PS, Caan B, Marshall JR, Lance P, Paskett ED, Weissfeld J, Slattery M, Burt R, Iber F, Shike M, Kikendall JW, Brewer BK, Schatzkin A; Polyp Prevention Trial Study Group.
    Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1745-52.
    PubMed PMID: 17855692
    doi: 10.1158/1055-9965.EPI-07-0127

    his study failed to show any effect of a low-fat, high-fiber, high-fruit and -vegetable eating pattern on adenoma recurrence even with 8 years of follow-up.
Matti Narkia

JAMA -- Influence of a Diet Very High in Vegetables, Fruit, and Fiber and Low in Fat on... - 0 views

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    Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized trial.
    Pierce JP, Natarajan L, Caan BJ, Parker BA, Greenberg ER, Flatt SW, Rock CL, Kealey S, Al-Delaimy WK, Bardwell WA, Carlson RW, Emond JA, Faerber S, Gold EB, Hajek RA, Hollenbach K, Jones LA, Karanja N, Madlensky L, Marshall J, Newman VA, Ritenbaugh C, Thomson CA, Wasserman L, Stefanick ML.
    JAMA. 2007 Jul 18;298(3):289-98.
    PMID: 17635889

    Conclusion Among survivors of early stage breast cancer, adoption of a diet that was very high in vegetables, fruit, and fiber and low in fat did not reduce additional breast cancer events or mortality during a 7.3-year follow-up period.
Matti Narkia

Meta-analysis of vitamin D, calcium and the prevention of breast cancer. - [Breast Canc... - 0 views

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    Meta-analysis of vitamin D, calcium and the prevention of breast cancer.
    Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H.
    Breast Cancer Res Treat. 2009 Oct 23. [Epub ahead of print]
    PMID: 19851861

    These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.
Matti Narkia

Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 ... - 0 views

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    Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 countries.
    Mohr SB, Garland CF, Gorham ED, Grant WB, Garland FC.
    Breast J. 2008 May-Jun;14(3):255-60. Epub 2008 Apr 17.
    PMID: 18422861
    DOI: 10.1111/j.1524-4741.2008.00571.x

    There was a protective effect of UVB irradiance on risk of breast cancer that was independent of fertility rate, proportion of the population overweight, alcohol intake, animal energy intake, and other covariates.
Matti Narkia

Vitamin D for Cancer Prevention: Global Perspective - 0 views

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    Vitamin D for cancer prevention: global perspective.
    Garland CF, Gorham ED, Mohr SB, Garland FC.
    Ann Epidemiol. 2009 Jul;19(7):468-83. Review.
    PMID: 19523595

    RESULTS/CONCLUSIONS: It is projected that raising the minimum year-around serum 25(OH)D level to 40 to 60 ng/mL (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three fourths of deaths from these diseases in the United States and Canada, based on observational studies combined with a randomized trial. Such intakes also are expected to reduce case-fatality rates of patients who have breast, colorectal, or prostate cancer by half. There are no unreasonable risks from intake of 2000 IU per day of vitamin D(3), or from a population serum 25(OH)D level of 40 to 60 ng/mL. The time has arrived for nationally coordinated action to substantially increase intake of vitamin D and calcium.
Matti Narkia

Vitamin D and prevention of breast cancer: pooled analysis. - ScienceDirect - The Journ... - 0 views

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    Vitamin D and prevention of breast cancer: pooled analysis.
    Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC.
    J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11.
    PMID: 17368188

    CONCLUSIONS: Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies.
Matti Narkia

How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptati... - 0 views

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    How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
    Vieth R.
    Anticancer Res. 2009 Sep;29(9):3675-84. Review.
    PMID: 19667164
Matti Narkia

Association between Plasma 25-Hydroxyvitamin D and Breast Cancer Risk -- Crew et al. 2 ... - 0 views

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    Association between plasma 25-hydroxyvitamin D and breast cancer risk.
    Crew KD, Gammon MD, Steck SE, Hershman DL, Cremers S, Dworakowski E, Shane E, Terry MB, Desai M, Teitelbaum SL, Neugut AI, Santella RM.
    Cancer Prev Res (Phila Pa). 2009 Jun;2(6):598-604. Epub 2009 May 26.
    PMID: 19470790

    In summary, these results add to a growing body of evidence that adequate vitamin D stores may prevent breast cancer development. Whereas circulating 25-OHD levels of >32 ng/mL are associated with normal bone mineral metabolism, our data suggest that the optimal level for breast cancer prevention is ≥40 ng/mL. Well-designed clinical trials are urgently needed to determine whether vitamin D supplementation is effective for breast cancer chemoprevention.
Matti Narkia

The Role of Vitamin D in Cancer Prevention -- Garland et al. 96 (2): 252 -- American Jo... - 0 views

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    The role of vitamin D in cancer prevention.
    Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
    Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
    PMID: 16380576
    DOI: 10.2105/AJPH.2004.045260

    Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.

    The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.
Matti Narkia

The Role of Vitamin D in Cancer Prevention -- Garland et al. 96 (2): 252 -- American Jo... - 0 views

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    The role of vitamin D in cancer prevention.
    Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
    Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
    PMID: 16380576
    DOI: 10.2105/AJPH.2004.045260

    Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.

    The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects
Matti Narkia

Sunlight, vitamin D and the prevention of cancer: a systematic review of epidemiologica... - 0 views

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    Sunlight, vitamin D and the prevention of cancer: a systematic review of epidemiological studies.
    Rhee HV, Coebergh JW, Vries ED.
    Eur J Cancer Prev. 2009 Aug 26. [Epub ahead of print]
    PMID: 19730382

    We, therefore, conclude that there is accumulating evidence for sunlight as a protective factor for several types of cancer. The same conclusion can be made concerning high vitamin D levels and the risk of colorectal cancer. This evidence, however, is not conclusive, because the number of (good quality) studies is still limited and publication biases cannot be excluded. The discrepancies between the epidemiological evidence for a possible preventive effect of sunlight and vitamin D and the question of how to apply the findings on the beneficial effects of sunlight to (public) health recommendations are discussed.
Matti Narkia

Vitamin D in preventive medicine: are we ignoring the evidence? - 0 views

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    Vitamin D in preventive medicine: are we ignoring the evidence?
    Zittermann A.
    Br J Nutr. 2003 May;89(5):552-72. Review.
    PMID: 12720576

    Vitamin D is metabolised by a hepatic 25-hydroxylase into 25-hydroxyvitamin D (25(OH)D) and by a renal 1alpha-hydroxylase into the vitamin D hormone calcitriol. Calcitriol receptors are present in more than thirty different tissues. Apart from the kidney, several tissues also possess the enzyme 1alpha-hydroxylase, which is able to use circulating 25(OH)D as a substrate. Serum levels of 25(OH)D are the best indicator to assess vitamin D deficiency, insufficiency, hypovitaminosis, adequacy, and toxicity. European children and young adults often have circulating 25(OH)D levels in the insufficiency range during wintertime. Elderly subjects have mean 25(OH)D levels in the insufficiency range throughout the year. In institutionalized subjects 25(OH)D levels are often in the deficiency range. There is now general agreement that a low vitamin D status is involved in the pathogenesis of osteoporosis. Moreover, vitamin D insufficiency can lead to a disturbed muscle function. Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer. Some intervention trials have demonstrated that supplementation with vitamin D or its metabolites is able: (i) to reduce blood pressure in hypertensive patients; (ii) to improve blood glucose levels in diabetics; (iii) to improve symptoms of rheumatoid arthritis and multiple sclerosis. The oral dose necessary to achieve adequate serum 25(OH)D levels is probably much higher than the current recommendations of 5-15 microg/d.
Matti Narkia

A critical review of Vitamin D and cancer: A report of the IARC Working Group on vitami... - 0 views

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    A critical review of Vitamin D and cancer: A report of the IARC Working Group on vitamin D
    William B. Grant
    Dermato-Endocrinology. Volume 1, Issue 1
    January/February 2009
    Pages: 25 - 33

    The International Agency for Research on Cancer (IARC) released a report, Vitamin D and Cancer, on November 25, 2008. The report focused on the current state of knowledge and level of evidence of a causal association between vitamin D status and cancer risk. Although presenting and evaluating evidence for the beneficial role of UVB and vitamin D in reducing the risk of cancer, it discounted or omitted important evidence in support of the efficacy of vitamin D. The report largely dismissed or ignored ecological studies on the grounds that confounding factors might have affected the findings. The report accepted a preventive role of vitamin D in colorectal cancer but not for breast cancer.
Matti Narkia

Current Impediments to Acceptance of the Ultraviolet-B-Vitamin D-Cancer Hypothesis - An... - 0 views

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    Current impediments to acceptance of the ultraviolet-B-vitamin D-cancer hypothesis.
    Grant WB, Boucher BJ.
    Anticancer Res. 2009 Sep;29(9):3597-604.
    PMID: 19667154

    The ultraviolet-B (UVB)-vitamin D-cancer hypothesis was proposed in 1980. There have been numerous ecological, observational and other studies of the hypothesis. There are about 14 types of cancer for which it seems to apply: bladder, breast, colon, endometrial, esophageal, gallbladder, gastric, ovarian, pancreatic, rectal, renal and vulvar cancer and both Hodgkin's and non-Hodgkin's lymphoma. Nonetheless, the hypothesis has not yet been accepted by public health agencies. Some of the reasons for this include a distrust of ecological studies, some mistrust of observational studies, and the existence of just one positive randomized controlled trial, an analysis of a vitamin D and calcium supplementation study involving post-menopausal women in Nebraska. Paradigm shifts such as this generally take time, in part due to opposition from those content with the status quo. In this paper, results of ecological studies in the United States using summertime solar UVB as the index of vitamin D production, which is highly asymmetrical with respect to latitude, and indices for other cancer risk-modifying factors (air pollution, alcohol consumption, dietary iron and zinc, ethnic background, socioeconomic status, smoking and urban/rural residence) are discussed in terms of supporting the hypothesis. These studies were not considered while other ecological studies were examined in recent critiques of the hypothesis. While additional randomized controlled trials would, of course, be helpful, the current evidence seems to satisfy the criteria for causality as outlined by A. Bradford Hill.
Matti Narkia

Ecological Studies Of Ultraviolet B, Vitamin D And Cancer Since 2000 - 0 views

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    Ecological studies of ultraviolet B, vitamin D and cancer since 2000.
    Grant WB, Mohr SB.
    Ann Epidemiol. 2009 Jul;19(7):446-54. Epub 2009 Mar 9.
    PMID: 19269856

    CONCLUSION: These findings provide strong evidence that vitamin D status plays an important role in controlling the outcome of cancer. Support for the UVB-vitamin D-cancer theory is now scientifically strong enough to warrant use of vitamin D in cancer prevention, and as a component of treatment. More research studies would help to explore whether there are benefits beyond the substantial effects that have been observed.
Matti Narkia

Vitamin D and calcium supplementation reduces cancer risk: results of a randomized tria... - 0 views

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    Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial.
    Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP.
    Am J Clin Nutr. 2007 Jun;85(6):1586-91. Erratum in: Am J Clin Nutr. 2008 Mar;87(3):794.
    PMID: 17556697

    Conclusions: Improving calcium and vitamin D nutritional status substantially reduces all-cancer risk in postmenopausal women.
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