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Matti Narkia

A Prospective Nested Case-Control Study of Vitamin D Status and Pancreatic Cancer Risk ... - 0 views

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    A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers.
    Stolzenberg-Solomon RZ, Vieth R, Azad A, Pietinen P, Taylor PR, Virtamo J, Albanes D.
    Cancer Res. 2006 Oct 15;66(20):10213-9.
    PMID: 17047087

    Higher vitamin D concentrations were associated with a 3-fold increased risk for pancreatic cancer (highest versus lowest quintile, >65.5 versus <32.0 nmol/L: OR, 2.92; 95% CI, 1.56-5.48, Ptrend = 0.001) that remained after excluding cases diagnosed early during follow-up. Contrary to expectations, subjects with higher prediagnostic vitamin D status had an increased pancreatic cancer risk compared with those with lower status. Our findings need to be replicated in other populations and caution is warranted in their interpretation and implication. Our results are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer.

    In conclusion, contrary to expectation, subjects with higher 25(OH)D concentrations were at greater risk for pancreatic cancer compared with those with lower concentrations in our prospective study with long-term follow-up. Caution is warranted in the interpretation and implication of our findings, however, as vitamin D inadequacy is an important public health problem and adequate status is desirable to prevent bone and other diseases (5). Our results, however, are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer.
Matti Narkia

Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a lo... - 0 views

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    Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study.
    Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, Arden NK, Godfrey KM, Cooper C; Princess Anne Hospital Study Group.
    Lancet. 2006 Jan 7;367(9504):36-43. Erratum in: Lancet. 2006 May 6;367(9521):1486.
    PMID: 16399151
    doi:10.1016/S0140-6736(06)67922-1

    Interpretation
    Maternal vitamin D insufficiency is common during pregnancy and is associated with reduced bone-mineral accrual in the offspring during childhood; this association is mediated partly through the concentration of umbilical venous calcium. Vitamin D supplementation of pregnant women, especially during winter months, could lead to longlasting reductions in the risk of osteoporotic fracture in their offspring.
Matti Narkia

Prospective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality ... - 0 views

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    Prospective study of predictors of vitamin D status and cancer incidence and mortality in men.
    Giovannucci E, Liu Y, Rimm EB, Hollis BW, Fuchs CS, Stampfer MJ, Willett WC.
    J Natl Cancer Inst. 2006 Apr 5;98(7):451-9.
    PMID: 16595781
    doi:10.1093/jnci/djj101

    Conclusions: Low levels of vitamin D may be associated with increased cancer incidence and mortality in men, particularly for digestive-system cancers. The vitamin D supplementation necessary to achieve a 25(OH)D increment of 25 nmol/L may be at least 1500 IU/day.
Matti Narkia

Association between serum 25(OH)D concentrations and bone stress fractures in Finnish y... - 0 views

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    Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men.
    Ruohola JP, Laaksi I, Ylikomi T, Haataja R, Mattila VM, Sahi T, Tuohimaa P, Pihlajamäki H.
    J Bone Miner Res. 2006 Sep;21(9):1483-8.
    doi: 10.1359/jbmr.060607

    Conclusions: A lower level of serum 25(OH)D concentration may be a generally predisposing element for bone stress fractures. Considering the obvious need of additional vitamin D in prevention of stress fractures, the effects of vitamin D fortification of foods and supplementation will be subjects of interest for future research
    PMID: 16939407
Matti Narkia

Vitamin D fortification as public health policy: significant improvement in vitamin D s... - 0 views

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    Vitamin D fortification as public health policy: significant improvement in vitamin D status in young Finnish men.
    Laaksi IT, Ruohola JP, Ylikomi TJ, Auvinen A, Haataja RI, Pihlajamäki HK, Tuohimaa PJ.
    Eur J Clin Nutr. 2006 Aug;60(8):1035-8. Epub 2006 Feb 15.
    PMID: 16482069
Matti Narkia

A Prospective Nested Case-Control Study of Vitamin D Status and Pancreatic Cancer Risk ... - 0 views

  •  
    A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers.
    Stolzenberg-Solomon RZ, Vieth R, Azad A, Pietinen P, Taylor PR, Virtamo J, Albanes D.
    Cancer Res. 2006 Oct 15;66(20):10213-9.
    PMID: 17047087
    doi: 10.1158/0008-5472.CAN-06-1876

    Contrary to expectations, subjects with higher prediagnostic vitamin D status had an increased pancreatic cancer risk compared with those with lower status. Our findings need to be replicated in other populations and caution is warranted in their interpretation and implication. Our results are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer.
Matti Narkia

Vitamin D Status and Glucose Homeostasis in the 1958 British Birth Cohort - Diabetes Care - 0 views

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    Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity.
    Hyppönen E, Power C.
    Diabetes Care. 2006 Oct;29(10):2244-6.
    PMID: 17003300
    doi: 10.2337/dc06-0946

    CONCLUSIONS-Body size was a strong determinant for 25(OH)D, with concentrations being suboptimal in most obese participants. Randomized controlled trials [using dosages sufficient to improve 25(OH)D also for the obese] are required to determine whether clinically relevant improvements in glucose metabolism can be obtained by vitamin D supplementation.
Matti Narkia

Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness amo... - 0 views

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    Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients.
    Targher G, Bertolini L, Padovani R, Zenari L, Scala L, Cigolini M, Arcaro G.
    Clin Endocrinol (Oxf). 2006 Nov;65(5):593-7.
    PMID: 17054459
    DOI: 10.1111/j.1365-2265.2006.02633.x

    CONCLUSIONS: Hypovitaminosis D is highly prevalent in type 2 diabetic adults and is strongly and independently associated with increased carotid IMT. Further investigation into whether vitamin D may play a role in the prevention of atherosclerosis appears to be warranted.

    In conclusion, our results show that type 2 diabetic adults have significant reductions in serum 25(OH)D concentrations (vs matched controls) that predict preclinical atherosclerosis, independent of classical risk factors, renal function tests, inflammatory markers, use of medications and presence of the metabolic syndrome. These findings suggest the need for ongoing evaluation of the possible protective role of vitamin D3 supplementation in the development of atherosclerosis.
Matti Narkia

Vitamin D and Pancreatic Cancer Risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prev... - 0 views

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    Vitamin D and pancreatic cancer risk in the alpha-tocopherol, beta-carotene cancer prevention cohort.
    Michaud DS.
    Cancer Res. 2006 Oct 15;66(20):9802-3.
Matti Narkia

JAMA -- Serum 25-Hydroxyvitamin D Levels and Risk of Multiple Sclerosis, December 20, 2... - 0 views

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    Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis.
    Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A.
    JAMA. 2006 Dec 20;296(23):2832-8.
    PMID: 17179460
Matti Narkia

Prospective study of predictors of vitamin D status and cancer incidence and mortality ... - 0 views

  •  
    Giovannucci E, Liu Y, Rimm EB, Hollis BW, Fuchs CS, Stampfer MJ, Willett WC.
    Prospective study of predictors of vitamin D status and cancer incidence and mortality in men.
    J Natl Cancer Inst. 2006 Apr 5;98(7):451-9.
    PMID: 16595781 [PubMed - indexed fo
Matti Narkia

Prospective study of predictors of vitamin D status and cancer incidence and mortality ... - 0 views

  •  
    Giovannucci E, Liu Y, Rimm EB, Hollis BW, Fuchs CS, Stampfer MJ, Willett WC.
Matti Narkia

Prospective study of predictors of vitamin D status and cancer incidence and mortality ... - 0 views

  •  
    Giovannucci E, Liu Y, Rimm EB, Hollis BW, Fuchs CS, Stampfer MJ, Willett WC.
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