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Matti Narkia

n-3 Fatty acids and cardiovascular disease evidence explained and mechanisms explored. ... - 0 views

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    n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored.
    Calder PC.
    Clin Sci (Lond). 2004 Jul;107(1):1-11. Review.
    PMID: 15132735

    DIETARY RECOMMENDATIONS FOR INTAKE OF LONG-CHAIN n-3 PUFAS

    It is clear from the forgoing discussion that long-chain n-3 fatty acids have been proven to be effective in secondary prevention of MI, with a particularly marked effect on sudden death. Thus it would be prudent to advise post-MI patients to increase long-chain n-3 PUFA consumption. Epidemiological studies, studies investigating effects on classic and emerging risk factors and mechanistic studies indicate that long-chain n-3 fatty acids also play a key role in primary prevention. This is supported by studies in animal models, including monkeys. Thus long-chain n-3 fatty acid consumption should be promoted for all individuals especially those at risk of developing cardiovascular disease. This is the reason why a number of organizations have now made recommendations relating to the intake of fatty fish (for example [3]) and of long-chain n-3 PUFAs (Table 6). It is clear that there is a wide gap between current intakes of long-chain n-3 PUFAs and many of these recommendations (Table 6). To meet these recommendations strategies other than increased consumption of fatty fish may be required.
Matti Narkia

N-3 Fatty Acids and Cardiovascular Disease: Actions and Molecular Mechanisms - 0 views

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    n-3 Fatty acids and cardiovascular disease: actions and molecular mechanisms.
    Torrejon C, Jung UJ, Deckelbaum RJ.
    Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):319-26. Epub 2007 Dec 3. Review. Erratum in: Prostaglandins Leukot Essent Fatty Acids. 2008 Feb;78(2):157.
    PMID: 18060753

    In conclusion, a growing body of evidence, encompassing human to cellular and molecular studies are defining the roles for n-3 FA as bioactive agents for reducing the risks of and treating CVD.
Matti Narkia

Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaque... - 0 views

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    Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial.
    Thies F, Garry JM, Yaqoob P, Rerkasem K, Williams J, Shearman CP, Gallagher PJ, Calder PC, Grimble RF.
    Lancet. 2003 Feb 8;361(9356):477-85.
    PMID: 12583947
    doi:10.1016/S0140-6736(03)12468-3

    Interpretation
    Atherosclerotic plaques readily incorporate n-3 PUFAs from fish-oil supplementation, inducing changes that can enhance stability of atherosclerotic plaques. By contrast, increased consumption of n-6 PUFAs does not affect carotid plaque fatty-acid composition or stability over the time course studied here. Stability of plaques could explain reductions in non-fatal and fatal cardiovascular events associated with increased n-3 PUFA intake
Matti Narkia

Omega-3 fatty acids enter plaque, resulting in increased stability and less inflammatio... - 0 views

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    "June 21, 2006 | Michael O'Riordan

    Rome, Italy - One of the possible ways in which long-chain omega-3 fatty acids play a role in decreasing cardiovascular events is by entering advanced atherosclerotic plaques. According to the results of a new study, investigators were able to show that the incorporation of eicosapentaenoic acid (EPA) into advanced plaque was associated with a decreased expression of various matrix metalloproteinases (MMPs) involved in causing plaque instability, as well as with decreased plaque inflammation.

    These are results of the Omacor Carotid Endarterectomy Intervention (OCEAN) study, presented here this week at the International Symposium on Atherosclerosis by Dr Philip Calder (University of Southampton, UK).

    "By increasing the availability of omega-3 fatty acids, they appear in advanced atherosclerotic plaques, indicated in this study by the carotid artery, and this results in lower numbers of macrophages, foam cells, and T cells, as well as the lower expression of inflammatory markers," said Calder. "Histologically, this results in a plaque that appears to be less inflamed and more stable. This may contribute to reduced mortality in patients consuming omega-3 fatty acids, for example, in the GISSI Prevenzione trial.""
Matti Narkia

Resveratrol: Isomeric Molar Absorptivities and Stability - 0 views

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    Resveratrol: Isomeric Molar Absorptivities and Stability
    Brent C. Trela and Andrew L. Waterhouse
    J. Agric. Food Chem. 1996, 44, 1253-1257
    Department of Viticulture and Enology, University of California, Davis, California 95616
Matti Narkia

Resveratrol: Isomeric Molar Absorptivities and Stability - Abstract - 0 views

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    Resveratrol: Isomeric Molar Absorptivities and Stability Brent C. Trela and Andrew L. Waterhouse J. Agric. Food Chem. 1996, 44, 1253-1257 Department of Viticulture and Enology, University of California, Davis, California 95616
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