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Matti Narkia

Fish Oil-Derived Fatty Acids, Docosahexaenoic Acid and Docosapentaenoic Acid, and the R... - 0 views

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    Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study.
    Rissanen T, Voutilainen S, Nyyssönen K, Lakka TA, Salonen JT.
    Circulation. 2000 Nov 28;102(22):2677-9.
    PMID: 11094031

    Methods and Results-We studied this association in the Kuopio Ischaemic Heart Disease Risk Factor Study, a prospective population study in Eastern Finland. Subjects were randomly selected and included 1871 men aged 42 to 60 years who had no clinical coronary heart disease at baseline examination. A total of 194 men had a fatal or nonfatal acute coronary event during follow-up. In a Cox proportional hazards' model adjusting for other risk factors, men in the highest fifth of the proportion of serum DHA+DPA in all fatty acids had a 44% reduced risk (P=0.014) of acute coronary events compared with men in the lowest fifth. Men in the highest fifth of DHA+DPA who had a low hair content of mercury (<=2.0 µg />2.0 µg/g). There was no association between proportion of eicosapentaenoic acid and the risk of acute coronary events.

    Conclusions-Our data provide further confirmation for the concept that fish oil-derived fatty acids reduce the risk of acute coronary events. However, a high mercury content in fish could attenuate this protective effect.
Matti Narkia

Mercury, Fish Oils, and Risk of Acute Coronary Events and Cardiovascular Disease, Coron... - 0 views

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    Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland.
    Virtanen JK, Voutilainen S, Rissanen TH, Mursu J, Tuomainen TP, Korhonen MJ, Valkonen VP, Seppänen K, Laukkanen JA, Salonen JT.
    Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):228-33. Epub 2004 Nov 11.
    PMID: 15539625
    doi: 10.1161/01.ATV.0000150040.20950.61

    Conclusions- High content of mercury in hair may be a risk factor for acute coronary events and CVD, CHD, and all-cause mortality in middle-aged eastern Finnish men. Mercury may also attenuate the protective effects of fish on cardiovascular health.

    Mercury may increase the risk of cardiovascular diseases. In this study, high mercury content in hair increased the risk of cardiovascular morbidity and mortality in middle-aged Finnish men and attenuated the beneficial effects of fish oils on cardiovascular health. Regular consumption of fish with high mercury content should be avoided.
Matti Narkia

High dietary methionine intake increases the risk of acute coronary events in middle-ag... - 0 views

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    High dietary methionine intake increases the risk of acute coronary events in middle-aged men.
    Virtanen JK, Voutilainen S, Rissanen TH, Happonen P, Mursu J, Laukkanen JA, Poulsen H, Lakka TA, Salonen JT.
    Nutr Metab Cardiovasc Dis. 2006 Mar;16(2):113-20. Epub 2005 Nov 2.
    PMID: 16487911
    doi:10.1016/j.numecd.2005.05.005

    Conclusions
    The main finding of this study is that long-term, moderately high dietary methionine intake may increase the risk of acute coronary events in middle-aged Finnish men free of prior CHD. More prospective research is needed to confirm the role of dietary methionine in the development of CVD, and whether its effects are independent of homocysteine.
Matti Narkia

Glycemic index, glycemic load, and the risk of acute myocardial infarction in Finnish m... - 0 views

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    Glycemic index, glycemic load, and the risk of acute myocardial infarction in Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study.
    Mursu J, Virtanen JK, Rissanen TH, Tuomainen TP, Nykänen I, Laukkanen JA, Kortelainen R, Voutilainen S.
    Nutr Metab Cardiovasc Dis. 2009 Oct 14. [Epub ahead of print]
    PMID: 19836217
    doi:10.1016/j.numecd.2009.08.001

    Conclusions
    Our results suggest that both high dietary GI and GL are associated with increased risk of AMI among overweight and GL possibly among less physically active men.
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