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Matti Narkia

Vitamin D and the vitamin D receptor are critical for control of the innate immune resp... - 0 views

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    Conclusion

    The data point to a critical role for the VDR and 1,25(OH)2D3 in control of innate immunity and the response of the colon to chemical injury.

    Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury.
    Froicu M, Cantorna MT.
    BMC Immunol. 2007 Mar 30;8:5.
    PMID: 17397543
    doi:10.1186/1471-2172-8-5
Matti Narkia

Exapation of an ancient Alu short interspersed element provides a highly conserved vita... - 0 views

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    Conclusion

    We demonstrated that the VDRE in the CAMP gene originated from the exaptation of an AluSx SINE in the lineage leading to humans, apes, OWMs and NWMs and remained under purifying selection for the last 55-60 million years. We present convincing evidence of an evolutionarily fixed, Alu-mediated divergence in steroid hormone nuclear receptor gene regulation between humans/primates and other mammals. Evolutionary selection to place the primate CAMP gene under regulation of the vitamin D pathway potentiates the innate immune response and may counter the anti-inflammatory properties of vitamin D.

    Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.
    Gombart AF, Saito T, Koeffler HP.
    BMC Genomics. 2009 Jul 16;10:321.
    PMID: 19607716
    doi:10.1186/1471-2164-10-321
Matti Narkia

Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 2... - 0 views

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    Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women.
    Peterson CA, Heffernan ME.
    J Inflamm (Lond). 2008 Jul 24;5:10.
    PMID: 18652680
    doi:10.1186/1476-9255-5-10

    Conclusion
    Serum 25(OH)D status is inversely related to TNF-α concentrations in healthy women, which may in part explain this vitamin's role in the prevention and treatment of inflammatory diseases. Results gleaned from this investigation also support the need to re-examine the biological basis for determining optimal vitamin D status.
Matti Narkia

Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin ... - 0 views

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    Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.\nGombart AF, Borregaard N, Koeffler HP.\nFASEB J. 2005 Jul;19(9):1067-77.\nPMID: 15985530
Matti Narkia

Vitamin D Induces Innate Antibacterial Responses in Human Trophoblasts via an Intracrin... - 0 views

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    'Vitamin D Induces Innate Antibacterial Responses in Human Trophoblasts via an Intracrine Pathway.\nLiu N, Kaplan AT, Low J, Nguyen L, Liu GY, Equils O, Hewison M.\nBiol Reprod. 2009 Mar;80(3):398-406. Epub 2008 Nov 12.\nPMID: 19005165DOI: 10.1095/biolreprod.108.073577
Matti Narkia

Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tub... - 0 views

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    Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin.\nLiu PT, Stenger S, Tang DH, Modlin RL.\nJ Immunol. 2007 Aug 15;179(4):2060-3.\nPMID: 1767546
Matti Narkia

Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-co... - 0 views

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    Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438).\nAvenell A, Cook JA, Maclennan GS, Macpherson GC.\nAge Ageing. 2007 Sep;36(5):574-7. Epub 2007 Aug 15. No abstract available.\nPMID: 17702768 \ndoi:10.1093/ageing/afm091
Matti Narkia

Plasma 25-hydroxyvitamin D levels in young children undergoing placement of tympanostom... - 0 views

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    Plasma 25-hydroxyvitamin D levels in young children undergoing placement of tympanostomy tubes.\nLinday LA, Shindledecker RD, Dolitsky JN, Chen TC, Holick MF.\nAnn Otol Rhinol Laryngol. 2008 Oct;117(10):740-4.\nPMID: 18998501
Matti Narkia

Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infecti... - 0 views

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    Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection. \nAdit A. Ginde, MD, MPH; Jonathan M. Mansbach, MD; Carlos A. Camargo Jr, MD, DrPH . \nArch Intern Med. 2009;169(4):384-390\n
Matti Narkia

A Single Dose of Vitamin D Enhances Immunity to Mycobacteria -- Martineau et al. 176 (2... - 0 views

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    Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, Packe GE, Davidson RN, Eldridge SM, Maunsell ZJ, Rainbow SJ, Berry JL, Griffiths CJ.
    A single dose of vitamin D enhances immunity to mycobacteria.
    Am J Respir Crit Care Med. 2007
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