Skip to main content

Home/ Nutrition/ Group items tagged research calcitriol

Rss Feed Group items tagged

Matti Narkia

Evidence for alteration of the vitamin D-endocrine system in obese subjects. - Journal ... - 0 views

  •  
    Evidence for alteration of the vitamin D-endocrine system in obese subjects.
    Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S.
    J Clin Invest. 1985 Jul;76(1):370-3.
    PMID: 2991340

    The results provide evidence that alteration of the vitamin D-endocrine system in obese subjects is characterized by secondary hyperparathyroidism which is associated with enhanced renal tubular reabsorption of calcium and increased circulating 1,25(OH)2D. The reduction of serum 25-OHD in them is attributed to feedback inhibition of hepatic synthesis of the precursor by the increased serum 1,25(OH)2D.
Matti Narkia

Vitamin D supplementation during the first year of life and risk of schizophrenia: a Fi... - 0 views

  •  
    Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study.
    McGrath J, Saari K, Hakko H, Jokelainen J, Jones P, Järvelin MR, Chant D, Isohanni M.
    Schizophr Res. 2004 Apr 1;67(2-3):237-45.
    PMID: 14984883

    Conclusion: Vitamin D supplementation during the first year of life is associated with a reduced risk of schizophrenia in males. Preventing hypovitaminosis D during early life may reduce the incidence of schizophrenia.
Matti Narkia

Induction of Ovarian Cancer Cell Apoptosis by 1,25-Dihydroxyvitamin D3 through the Down... - 0 views

  •  
    Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase.
    Jiang F, Bao J, Li P, Nicosia SV, Bai W.
    J Biol Chem. 2004 Dec 17;279(51):53213-21. Epub 2004 Oct 12.
    PMID: 15485861
    doi: 10.1074/jbc.M410395200

    Overall, the study suggests that the down-regulation of telomerase activity by 1,25(OH)2VD3 and the resulting cell death are important components of the response of OCa cells to 1,25(OH)2VD3-induced growth suppression.

    Progressive shortening of telomere associated with cell divisions limits the life span of normal cells and eventually leads to senescence. To become immortal, human cancers including OCa are invariably associated with activation of mechanism that maintains telomere length. Approximately 85-90% of cancers show reactivation of telomerase. The present study shows that telomerase in OCa cells is down-regulated by 1,25(OH)2VD3. Down-regulation of telomerase is due to decreased stability of hTERT mRNA rather than VDRE-mediated transcriptional repression through the putative VDRE present in the regulatory region of the hTERT gene.

    It is known that the inhibition of telomerase may lead to a phenotypic lag during which cells would continue to divide until the point at which the telomeres became critically short. This phenomenon may explain why the apoptotic induction by 1,25(OH)2VD3 needs the treatment for more than 6 days. As mentioned in the results, no detectable shortening of telomeric repeats was observed in parental OVCAR3 cells after 9 days of treatment with 1,25(OH)2VD3 (Fig. 4D). This is likely due to the fact that the short telomere (about 3 kb) in OVCAR3 cells is very close to the minimal length required for survival and that cells with detectably shorter telomere may have been selected against apoptosis. It has been shown that transformed human cells enter crisis once the terminal restriction fragment of the telomere reaches a length of about 4 kb. This is insufficient to protect chro
Matti Narkia

1,25(OH)2 Vitamin D Inhibits Foam Cell Formation and Suppresses Macrophage Cholesterol ... - 0 views

  •  
    1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus.
    Oh J, Weng S, Felton SK, Bhandare S, Riek A, Butler B, Proctor BM, Petty M, Chen Z, Schechtman KB, Bernal-Mizrachi L, Bernal-Mizrachi C.
    Circulation. 2009 Aug 25;120(8):687-98. Epub 2009 Aug 10.
    PMID: 19667238
    doi: 10.1161/CIRCULATIONAHA.109.856070

    Conclusion- These results identify reduced vitamin D receptor signaling as a potential mechanism underlying increased foam cell formation and accelerated cardiovascular disease in diabetic subjects.
Matti Narkia

Serum Levels of Vitamin D Metabolites and Breast Cancer Risk in the Prostate, Lung, Col... - 0 views

  •  
    Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial.

    Freedman DM, Chang SC, Falk RT, Purdue MP, Huang WY, McCarty CA, Hollis BW, Graubard BI, Berg CD, Ziegler RG.
    Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):889-94. Epub 2008 Apr 1.
    PMID: 18381472
    doi: 10.1158/1055-9965.EPI-07-2594

    In this prospective study of postmenopausal women, we did not observe an inverse association between circulating 25(OH)D or 1,25(OH)2D and breast cancer risk, although we cannot exclude an association in younger women or with long-term or earlier exposure
Matti Narkia

Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D and Risk of Incident Ovarian Can... - 0 views

  •  
    Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of incident ovarian cancer.
    Tworoger SS, Lee IM, Buring JE, Rosner B, Hollis BW, Hankinson SE.
    Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):783-8.
    PMID: 17416771
    doi: 10.1158/1055-9965.EPI-06-0981

    Overall, our results do not suggest that plasma vitamin D levels are associated with risk of ovarian cancer. However, we observed significant associations in some subgroups, which should be evaluated further in other studies because increasing vitamin D intake is an easy preventive measure to adopt.
Matti Narkia

Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset... - 0 views

  •  
    Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density.
    Abreu MT, Kantorovich V, Vasiliauskas EA, Gruntmanis U, Matuk R, Daigle K, Chen S, Zehnder D, Lin YC, Yang H, Hewison M, Adams JS.
    Gut. 2004 Aug;53(8):1129-36.
    PMID: 15247180
    doi: 10.1136/gut.2003.036657.

    Conclusions: These data demonstrate that elevated 1,25(OH)2D is more common in CD than previously appreciated and is independently associated with low bone mineral density. The source of the active vitamin D may be the inflamed intestine. Treatment of the underlying inflammation may improve metabolic bone disease in this subgroup of patients.
Matti Narkia

Vitamin D metabolites as clinical markers in autoimmune and chronic disease. - Ann N Y ... - 0 views

  •  
    Vitamin D metabolites as clinical markers in autoimmune and chronic disease.
    Blaney GP, Albert PJ, Proal AD.
    Ann N Y Acad Sci. 2009 Sep;1173:384-90.
    PMID: 19758177
    DOI: 10.1111/j.1749-6632.2009.04875.x
Matti Narkia

Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolite... - 0 views

  •  
    Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis.
    Smolders J, Damoiseaux J, Menheere P, Tervaert JW, Hupperts R.
    Ann N Y Acad Sci. 2009 Sep;1173:515-20.
    PMID: 19758194
    DOI: 10.1111/j.1749-6632.2009.04656.x

    Discussion: We found no association of the Apal and Taql VDR gene SNPs with MS or with vitamin D metabolism in our population. Further research should assess the complex interaction between vitamin D, the VDR, and susceptibility to MS.
Matti Narkia

Improved Cholecalciferol Nutrition in Rats Is Noncalcemic, Suppresses Parathyroid Hormo... - 0 views

  •  
    Improved cholecalciferol nutrition in rats is noncalcemic, suppresses parathyroid hormone and increases responsiveness to 1, 25-dihydroxycholecalciferol.
    Vieth R, Milojevic S, Peltekova V.
    J Nutr. 2000 Mar;130(3):578-84.
    PMID: 10702588

    We conclude suppression of 1,25(OH)(2)D and PTH, and higher renal VDR mRNA and 24-hydroxylase did not involve higher free 1,25(OH)(2)D concentration or a first pass effect at the gut. Thus, 25(OH)D or a metabolite other than 1,25(OH)(2)D is a physiological, transcriptionally and biochemically active, noncalcemic vitamin D metabolite.

    When viewed from a perspective that starts with higher vitamin D nutrition, the results indicate that low vitamin D nutrition may bring about a form of resistance to 1,25(OH)2D. This situation would explain why, in humans, nutritional rickets and osteomalacia are commonly associated with normal or increased levels of 1,25(OH)2D (Chesney et al. 1981Citation , Eastwood et al. 1979Citation , Garabedian et al. 1983Citation ,Rasmussen et al. 1980Citation )-these are not like the low hormone levels associated with any other endocrine-deficiency disorder. A connection between lower vitamin D nutrition and vitamin D resistance helps to explain why the supposedly inactive compound 25(OH)D is more relevant in diagnosing nutritional rickets than is the active hormone 1,25(OH)2D.

    If the features of improved vitamin D nutrition shown here were demonstrated for any newly synthesized compound, the compound would be classified as a noncalcemic 1,25(OH)2D analogue (Brown et al. 1989Citation , Finch et al. 1999Citation , Goff et al. 1993Citation , Koshizuka et al. 1999Citation ). Thus, we contend that 25(OH)D or a metabolite of it other than 1,25(OH)2D exists as a physiological and biologically-active noncalcemic vitamin D metabolite whose effects require further examination, particularly in relationship to studies involving the synthetic analogs of 1,25(OH)2D.
Matti Narkia

Serum Levels of Free 1,25-Dihydroxyvitamin D in Vitamin D Toxicity -- Pettifor et al. 1... - 0 views

  •  
    Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity.
    Pettifor JM, Bikle DD, Cavaleros M, Zachen D, Kamdar MC, Ross FP.
    Ann Intern Med. 1995 Apr 1;122(7):511-3.
    PMID: 7872586

    CONCLUSIONS: Although the patients had normal or near-normal total 1,25-(OH)2D values, most patients had elevated free 1,25-(OH)2D levels. These findings suggest that elevated free 1,25-(OH)2D levels might play a role in the pathogenesis of hypercalcemia in vitamin D toxicity.
Matti Narkia

An evaluation of the relative contributions of exposure to sunlight and of diet to the ... - 0 views

  •  
    An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston.
    Webb AR, Pilbeam C, Hanafin N, Holick MF.
    Am J Clin Nutr. 1990 Jun;51(6):1075-81.
    PMID: 2349922
Matti Narkia

Low Vitamin D Levels Predict Stroke in Patients Referred to Coronary Angiography -- Pil... - 0 views

  •  
    Low vitamin d levels predict stroke in patients referred to coronary angiography.
    Pilz S, Dobnig H, Fischer JE, Wellnitz B, Seelhorst U, Boehm BO, März W.
    Stroke. 2008 Sep;39(9):2611-3. Epub 2008 Jul 17.
    PMID: 18635847
    doi: 10.1161/STROKEAHA.107.513655

    Conclusions- Low levels of 25(OH)D and 1,25(OH)2D are independently predictive for fatal strokes, suggesting that vitamin D supplementation is a promising approach in the prevention of strokes.
Matti Narkia

Independent Association of Low Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Le... - 0 views

  •  
    Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality.
    Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, Kinkeldei J, Boehm BO, Weihrauch G, Maerz W.
    Arch Intern Med. 2008 Jun 23;168(12):1340-9.
    PMID: 18574092

    Conclusions Low 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels are independently associated with all-cause and cardiovascular mortality. A causal relationship has yet to be proved by intervention trials using vitamin D.
Matti Narkia

Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascu... - 0 views

  •  
    Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers.
    Zittermann A, Frisch S, Berthold HK, Götting C, Kuhn J, Kleesiek K, Stehle P, Koertke H, Koerfer R.
    Am J Clin Nutr. 2009 May;89(5):1321-7. Epub 2009 Mar 25.
    PMID: 19321573
Matti Narkia

Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple ... - 0 views

  •  
    Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women.
    Kragt J, van Amerongen B, Killestein J, Dijkstra C, Uitdehaag B, Polman Ch, Lips P.
    Mult Scler. 2009 Jan;15(1):9-15. Epub 2008 Aug 13.
    PMID: 18701572
    DOI: 10.1177/1352458508095920

    CONCLUSIONS: Our data suggest that higher circulating levels of 25(OH)D are associated with a lower incidence of MS and MS-related disability in women. This may imply clues to the pathogenesis of the sex difference in risk and to the nature of the environmental factors involved in MS.
Matti Narkia

Vitamin D and the vitamin D receptor are critical for control of the innate immune resp... - 0 views

  •  
    Conclusion

    The data point to a critical role for the VDR and 1,25(OH)2D3 in control of innate immunity and the response of the colon to chemical injury.

    Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury.
    Froicu M, Cantorna MT.
    BMC Immunol. 2007 Mar 30;8:5.
    PMID: 17397543
    doi:10.1186/1471-2172-8-5
Matti Narkia

Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin ... - 0 views

  •  
    Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.\nGombart AF, Borregaard N, Koeffler HP.\nFASEB J. 2005 Jul;19(9):1067-77.\nPMID: 15985530
Matti Narkia

Vitamin D Induces Innate Antibacterial Responses in Human Trophoblasts via an Intracrin... - 0 views

  •  
    'Vitamin D Induces Innate Antibacterial Responses in Human Trophoblasts via an Intracrine Pathway.\nLiu N, Kaplan AT, Low J, Nguyen L, Liu GY, Equils O, Hewison M.\nBiol Reprod. 2009 Mar;80(3):398-406. Epub 2008 Nov 12.\nPMID: 19005165DOI: 10.1095/biolreprod.108.073577
Matti Narkia

Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tub... - 0 views

  •  
    Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin.\nLiu PT, Stenger S, Tang DH, Modlin RL.\nJ Immunol. 2007 Aug 15;179(4):2060-3.\nPMID: 1767546
1 - 20 of 24 Next ›
Showing 20 items per page