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Matti Narkia

The Bioavailability of Vitamin D from Fortified Cheeses and Supplements Is Equivalent i... - 0 views

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    The bioavailability of vitamin D from fortified cheeses and supplements is equivalent in adults.
    Wagner D, Sidhom G, Whiting SJ, Rousseau D, Vieth R.
    J Nutr. 2008 Jul;138(7):1365-71.
    PMID: 18567762

    Compared with baseline, serum parathyroid hormone decreased with both fortification (P = 0.003) and supplementation (P = 0.012). These data demonstrate that vitamin D is equally bioavailable from fortified hard cheeses and supplements, making cheese suitable for vitamin D fortification.
Matti Narkia

Arch Ophthalmol -- Cigarette Smoking, Fish Consumption, Omega-3 Fatty Acid Intake, and ... - 0 views

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    Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration.
    Seddon JM, George S, Rosner B.
    Arch Ophthalmol. 2006 Jul;124(7):995-1001.
    PMID: 16832023

    Conclusions This study of twins provides further evidence that cigarette smoking increases risk while fish consumption and omega-3 fatty acid intake reduce risk of AMD
Matti Narkia

Fish Consumption Shifts Lipoprotein Subfractions to a Less Atherogenic Pattern in Human... - 0 views

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    Fish consumption shifts lipoprotein subfractions to a less atherogenic pattern in humans.
    Li Z, Lamon-Fava S, Otvos J, Lichtenstein AH, Velez-Carrasco W, McNamara JR, Ordovas JM, Schaefer EJ.
    J Nutr. 2004 Jul;134(7):1724-8.
    PMID: 15226460

    The effect of fish consumption on plasma lipoprotein subfraction concentrations was studied in 22 men and women (age > 40 y). Subjects were provided an average American diet (AAD, 35% of energy as fat, 14% as saturated fat, and 35 mg cholesterol/MJ) for 6 wk before being assigned to a National Cholesterol Education Program (NCEP) Step 2 high-fish diet (n = 11, 26% of energy as fat, 4.5% as saturated fat, and 15 mg cholesterol/MJ) or a NCEP Step 2 low-fish diet (n = 11, 26% of energy as fat, 4.0% as saturated fat, and 11 mg cholesterol/MJ) for 24 wk. All food and drink were provided to study participants. Consumption of the high-fish NCEP Step 2 diet was associated with a significant reduction in medium and small VLDL, compared with the AAD diet, whereas the low-fish diet did not affect VLDL subfractions. Both diets significantly reduced LDL cholesterol concentrations, without modifying LDL subfractions. Both diets also lowered HDL cholesterol concentrations. However, the high-fish diet significantly lowered only the HDL fraction containing both apolipoprotein (apo) AI and AII (LpAI:AII) and did not change HDL subfractions assessed by NMR, whereas the low-fish diet significantly lowered the HDL fraction containing only apo AI (LpAI) and the large NMR HDL fractions, resulting in a significant reduction in HDL particle size. Neither diet affected VLDL and LDL particle size. Our data indicate that within the context of a diet restricted in fat and cholesterol, a higher fish content favorably affects VLDL and HDL subspecies
Matti Narkia

Fish Intake and Risk of Incident Atrial Fibrillation -- Mozaffarian et al. 110 (4): 368... - 0 views

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    Fish intake and risk of incident atrial fibrillation.
    Mozaffarian D, Psaty BM, Rimm EB, Lemaitre RN, Burke GL, Lyles MF, Lefkowitz D, Siscovick DS.
    Circulation. 2004 Jul 27;110(4):368-73. Epub 2004 Jul 19.
    PMID: 15262826
    doi: 10.1161/01.CIR.0000138154.00779.A5

    Conclusions- Among elderly adults, consumption of tuna or other broiled or baked fish, but not fried fish or fish sandwiches, is associated with lower incidence of AF. Fish intake may influence risk of this common cardiac arrhythmia.
Matti Narkia

Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and g... - 0 views

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    Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and gastric cancers.
    Chen W, Dawsey SM, Qiao YL, Mark SD, Dong ZW, Taylor PR, Zhao P, Abnet CC.
    Br J Cancer. 2007 Jul 2;97(1):123-8. Epub 2007 Jun 5.
    PMID: 17551495

    We prospectively examined the relation between pretrial serum vitamin D status and risk of oesophageal and gastric cancers among subjects who developed cancer over 5.25 years of follow-up, including 545 oesophageal squamous cell carcinomas (ESCC), 353 gastric cardia adenocarcinomas, 81 gastric noncardia adenocarcinomas, and an age- and sex-stratified random sample of 1105 subjects.

    We found no associations for gastric cardia or noncardia adenocarcinoma. Among subjects with low vitamin D status, higher serum 25(OH)D concentrations were associated with significantly increased risk of ESCC in men, but not in women. Further refinements of the analysis did not suggest any factors, which could explain this unexpected result.

    In conclusion, we found a direct association between higher serum 25(OH)D concentration and increased risk of ESCC in men but not women in a large population-based prospective cohort study from rural China. We found no association with risk of gastric cardia or noncardia adenocarcinoma in either sex. Greater than 50% of our cohort had an inadequate serum 25(OH)D concentration, yet higher concentrations were associated with increased risk of ESCC compared to lower concentrations.
Matti Narkia

Efficacy and safety of berberine for congestive heart failure secondary to ischemic or ... - 1 views

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    Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
    Zeng XH, Zeng XJ, Li YY.
    Am J Cardiol. 2003 Jul 15;92(2):173-6.
    PMID: 12860219
    doi:10.1016/S0002-9149(03)00533-2

    Thus, berberine improved quality of life and decreased VPCs and mortality in patients with CHF.
Matti Narkia

Evidence for alteration of the vitamin D-endocrine system in obese subjects. - Journal ... - 0 views

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    Evidence for alteration of the vitamin D-endocrine system in obese subjects.
    Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S.
    J Clin Invest. 1985 Jul;76(1):370-3.
    PMID: 2991340

    The results provide evidence that alteration of the vitamin D-endocrine system in obese subjects is characterized by secondary hyperparathyroidism which is associated with enhanced renal tubular reabsorption of calcium and increased circulating 1,25(OH)2D. The reduction of serum 25-OHD in them is attributed to feedback inhibition of hepatic synthesis of the precursor by the increased serum 1,25(OH)2D.
Matti Narkia

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine... - 0 views

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    Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.
    Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning G.
    J Clin Endocrinol Metab. 2008 Jul;93(7):2559-65. Epub 2008 Apr 8.
    PMID: 18397984
    doi:10.1210/jc.2007-2404

    Conclusions: Berberine is effective and safe in the treatment of type 2 diabetes and dyslipidemia.
Matti Narkia

Berberine suppresses in vitro migration and invasion of human SCC-4 tongue sq... - 0 views

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    Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9.
    Ho YT, Yang JS, Li TC, Lin JJ, Lin JG, Lai KC, Ma CY, Wood WG, Chung JG.
    Cancer Lett. 2009 Jul 8;279(2):155-62. Epub 2009 Feb 28.
    PMID: 19251361
    doi:10.1016/j.canlet.2009.01.033

    There is increasing evidence that urokinase-type plasminogen activator (u-PA) and matrix metalloproteinases (MMPs) play an important role in cancer metastasis and angiogenesis. Inhibition of u-PA and MMPs could suppress migration and invasion of cancer cells. Berberine, one of the main constituents of the plant Rhizoma coptidis, is a type of isoquinoline alkaloid, reported to have anti-cancer effects in different human cancer cell lines. There is however, no available information on effects of berberine on migration and invasion of human tongue cancer cells. Here, we report that berberine inhibited migration and invasion of human SCC-4 tongue squamous carcinoma cells. This action was mediated by the p-JNK, p-ERK, p-p38, IκK and NF-κB signaling pathways resulting in inhibition of MMP-2 and -9 in human SCC-4 tongue squamous carcinoma cells. Our Western blowing analysis also showed that berberine inhibited the levels of urokinase-plasminogen activator (u-PA). These results suggest that berberine down-regulates u-PA, MMP-2 and -9 expressions in SCC-4 cells through the FAK, IKK and NF-κB mediated pathways and a novel function of berberine is to inhibit the invasive capacity of malignant cells.
Matti Narkia

Egg consumption, serum cholesterol, and cause-specific and all-cause mortality: the Nat... - 0 views

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    Egg consumption, serum cholesterol, and cause-specific and all-cause mortality: the National Integrated Project for Prospective Observation of Non-communicable Disease and Its Trends in the Aged, 1980 (NIPPON DATA80).
    Nakamura Y, Okamura T, Tamaki S, Kadowaki T, Hayakawa T, Kita Y, Okayama A, Ueshima H; NIPPON DATA80 Research Group.
    Am J Clin Nutr. 2004 Jul;80(1):58-63.
    PMID: 15213028

    Results: The subjects were categorized into 5 egg consumption groups on the basis of their responses to a questionnaire (≥2/d, 1/d, 1/2 d, 1-2/wk, and seldom). There were 69, 1396, 1667, 1742, and 315 women in each of the 5 groups, respectively. Age-adjusted total cholesterol (5.21, 5.04, 4.95, 4.91, and 4.92 mmol/L in the 5 egg consumption categories, respectively) was related to egg consumption (P < 0.0001, analysis of covariance). In women, unadjusted IHD mortality and all-cause mortality differed significantly between the groups [IHD mortality: 1.1, 0.5, 0.4, 0.5, and 2.0 per 1000 person-years, respectively (P = 0.008, chi-square test); all-cause mortality: 14.8, 8.0, 7.5, 7.5, and 14.5 per 1000 person-years, respectively (P < 0.0001, chi-square test)]. In men, egg consumption was not related to age-adjusted total cholesterol. Cox analysis found that, in women, all-cause mortality in the 1-2-eggs/wk group was significantly lower than that in the 1-egg/d group, whereas no such relations were noted in men.

    Conclusion: Limiting egg consumption may have some health benefits, at least in women in geographic areas where egg consumption makes a relatively large contribution to total dietary cholesterol intake.
Matti Narkia

Prevention of skeletal muscle insulin resistance by dietary cod protein in high fat-fed... - 0 views

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    Prevention of skeletal muscle insulin resistance by dietary cod protein in high fat-fed rats.
    Lavigne C, Tremblay F, Asselin G, Jacques H, Marette A.
    Am J Physiol Endocrinol Metab. 2001 Jul;281(1):E62-71.
    PMID: 11404223

    These data demonstrate that feeding cod protein prevents obesity-induced muscle insulin resistance in high fat-fed obese rats at least in part through a direct action of amino acids on insulin-stimulated glucose uptake in skeletal muscle cells.
Matti Narkia

Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged... - 0 views

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    Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men.
    Lee DM, Tajar A, Ulubaev A, Pendleton N, O'Neill TW, O'Connor DB, Bartfai G, Boonen S, Bouillon R, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Punab M, Silman AJ, Vanderschueren D, Wu FC; EMAS study group.
    J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):722-9. Epub 2009 May 21.
    PMID: 19460797
    doi:10.1136/jnnp.2008.165720

    Conclusion: In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.
Matti Narkia

{alpha}-Linolenic Acid and Risk of Nonfatal Acute Myocardial Infarction -- Campos et al... - 0 views

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    Alpha-linolenic acid and risk of nonfatal acute myocardial infarction.
    Campos H, Baylin A, Willett WC.
    Circulation. 2008 Jul 22;118(4):339-45. Epub 2008 Jul 7. Erratum in: Circulation. 2008 Sep 16;118(12):e492.
    PMID: 18606916
    doi: 10.1161/CIRCULATIONAHA.107.762419

    Conclusions - Consumption of vegetable oils rich in {alpha}-linolenic acid could confer important cardiovascular protection. The apparent protective effect of {alpha}-linolenic acid is most evident among subjects with low intakes.
Matti Narkia

High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their inf... - 0 views

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    High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study.
    Wagner CL, Hulsey TC, Fanning D, Ebeling M, Hollis BW.
    Breastfeed Med. 2006 Summer;1(2):59-70.
    PMID: 17661565
    doi:10.1089/bfm.2006.1.59.

    Objective: To examine the effect of high-dose maternal vitamin D3 (vitD) supplementation on the nutritional vitD status of breastfeeding (BF) women and their infants compared with maternal and infant controls receiving 400 and 300 IU vitD/day, respectively.

    Design: Fully lactating women (n = 19) were enrolled at 1-month postpartum into a randomized- control pilot trial. Each mother received one of two treatments for a 6-month study period: 0 or 6000 IU vitD3 plus a prenatal vitamin containing 400 IU vitD3. The infants of mothers assigned to the control group received 300 IU vitD3/day; those infants of mothers in the high-dose group received 0 IU (placebo). Maternal serum and milk vitD and 25(OH)D were measured at baseline then monthly; infant serum vitD and 25(OH)D were measured at baseline, and months 4 and 7. Urinary calcium/creatinine ratios were measured monthly in both mothers and infants. Dietary and BF history and outdoor activity questionnaires were completed at each visit. Changes in skin pigmentation were measured by spectrophotometry. Data were analyzed using chi-square, t-test, and analysis of variance (ANOVA) on an intent-to-treat basis.

    Conclusion: With limited sun exposure, an intake of 400 IU/day vitamin D3 did not sustain circulating maternal 25(OH)D levels, and thus, supplied only extremely limited amounts of vitamin D to the nursing infant via breast milk. Infant levels achieved exclusively through maternal supplementation were equivalent to levels in infants who received oral vitamin D supplementation. Thus, a maternal intake of 6400 IU/day vitamin D elevated circulating 25(OH)D in both mother and nursing infant.
Matti Narkia

Can lifestyle changes reverse coronary heart disease? : The Lancet - 0 views

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    Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial.
    Ornish D, Brown SE, Scherwitz LW, Billings JH, Armstrong WT, Ports TA, McLanahan SM, Kirkeeide RL, Brand RJ, Gould KL.
    Lancet. 1990 Jul 21;336(8708):129-33.
    PMID: 1973470
Matti Narkia

Incremental effects of eicosapentaenoic acid on cardiovascular events in statin-treated... - 0 views

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    Incremental effects of eicosapentaenoic acid on cardiovascular events in statin-treated patients with coronary artery disease.
    Matsuzaki M, Yokoyama M, Saito Y, Origasa H, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, Shirato K, Matsuzawa Y; JELIS Investigators.
    Circ J. 2009 Jul;73(7):1283-90. Epub 2009 May 8.
    PMID: 19423946

    Conclusions: EPA is effective for secondary prevention of CAD, especially in individuals with prior MI, and
    should be added to conventional treatment.
Matti Narkia

Serum omega-3 fatty acids are associated with variation in mood, personality and behavi... - 0 views

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    Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers.
    Conklin SM, Harris JI, Manuck SB, Yao JK, Hibbeln JR, Muldoon MF.
    Psychiatry Res. 2007 Jul 30;152(1):1-10. Epub 2007 Mar 23.PMID: 17383013
Matti Narkia

Effects of chili consumption on postprandial glucose, insulin, and energy metabolism --... - 0 views

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    Effects of chili consumption on postprandial glucose, insulin, and energy metabolism.
    Ahuja KD, Robertson IK, Geraghty DP, Ball MJ.
    Am J Clin Nutr. 2006 Jul;84(1):63-9.
    PMID: 16825682
Matti Narkia

Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids - Journal... - 0 views

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    Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids.
    Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Smith A, Edwards IJ, D'Agostino R, Zhang H, Wu H, Kang JX, Chen YQ.
    J Clin Invest. 2007 Jul;117(7):1866-75.
    PMID: 17607361

    Our data suggest that modulation of prostate cancer development by polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis. This study highlights the importance of gene-diet interactions in prostate cancer.
Matti Narkia

The Association of Solar Ultraviolet B (UVB) with Reducing Risk of Cancer: Multifactori... - 0 views

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    The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates.
    Grant WB, Garland CF.
    Anticancer Res. 2006 Jul-Aug;26(4A):2687-99.
    PMID: 16886679

    CONCLUSION: These results provide additional support for the hypothesis that solar UVB, through photosynthesis of vitamin D, is inversely-associated with cancer mortality rates, and that various other cancer risk-modifying factors do not detract from this link. It is thought that sun avoidance practices after 1980, along with improved cancer treatment, led to reduced associations in the latter period. The results regarding solar UVB should be studied further with additional observational and intervention studies of vitamin D indices and cancer incidence, mortality and survival rates.
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