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Matti Narkia

Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy m... - 0 views

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    Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men.
    Barger-Lux MJ, Heaney RP, Dowell S, Chen TC, Holick MF.
    Osteoporos Int. 1998;8(3):222-30.
    PMID: 9797906
Matti Narkia

Serum vitamin D level after an annual intramuscular injection of ergocalciferol. - [Cal... - 0 views

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    Serum vitamin D level after an annual intramuscular injection of ergocalciferol.
    Heikinheimo RJ, Haavisto MV, Harju EJ, Inkovaara JA, Kaarela RH, Kolho LA, Rajala SA.
    Calcif Tissue Int. 1991;49 Suppl:S87.
    PMID: 1933611

    An annual intramuscular injection of ergocalciferol (150,000 IU) normalized low serum (25(OH)D concentrations in elderly people for 1 year. The treatment had a slight effect on serum 24,25(OH)2D levels but no effect on 1,25(OH)2D levels.
Matti Narkia

Comparison of Daily, Weekly, and Monthly Vitamin D3 in Ethanol Dosing Protocols for Two... - 0 views

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    Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients.
    Ish-Shalom S, Segal E, Salganik T, Raz B, Bromberg IL, Vieth R.
    J Clin Endocrinol Metab. 2008 Sep;93(9):3430-5. Epub 2008 Jun 10.
    PMID: 18544622
    doi:10.1210/jc.2008-0241

    CONCLUSIONS: Supplementation with vitamin D can be achieved equally well with daily, weekly, or monthly dosing frequencies. Therefore, the choice of dose frequency can be based on whichever approach will optimize an individual's adherence with long-term vitamin D supplementation.
Matti Narkia

Estimation of the dietary requirement for vitamin D in free-living adults >=64 y of age... - 0 views

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    Estimation of the dietary requirement for vitamin D in free-living adults >=64 y of age.
    Cashman KD, Wallace JM, Horigan G, Hill TR, Barnes MS, Lucey AJ, Bonham MP, Taylor N, Duffy EM, Seamans K, Muldowney S, Fitzgerald AP, Flynn A, Strain JJ, Kiely M.
    Am J Clin Nutr. 2009 May;89(5):1366-74. Epub 2009 Mar 18.
    PMID: 19297462
    doi:10.3945/ajcn.2008.27334

    Conclusion: To ensure that the vitamin D requirement is met by the vast majority (>97.5%) of adults aged ≥64 y during winter, between 7.9 and 42.8 µg vitamin D/d is required, depending on summer sun exposure and the threshold of adequacy of 25(OH)D. .
Matti Narkia

Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration -- Aloia e... - 0 views

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    Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration.
    Aloia JF, Patel M, Dimaano R, Li-Ng M, Talwar SA, Mikhail M, Pollack S, Yeh JK.
    Am J Clin Nutr. 2008 Jun;87(6):1952-8.
    PMID: 18541590

    The mean daily dose was 86 microg (3440 IU). The use of computer simulations to obtain the most participants within the range of 75-220 nmol/L predicted an optimal daily dose of 115 microg/d (4600 IU). No hypercalcemia or hypercalciuria was observed. CONCLUSIONS: Determination of the intake required to attain serum 25(OH)D concentrations >75 nmol/L must consider the wide variability in the dose-response curve and basal 25(OH)D concentrations. Projection of the dose-response curves observed in this convenience sample onto the population of the third National Health and Nutrition Examination Survey suggests a dose of 95 microg/d (3800 IU) for those above a 25(OH)D threshold of 55 nmol/L and a dose of 125 microg/d (5000 IU) for those below that threshold.
Matti Narkia

Common genetic variants of the vitamin D binding protein (DBP) predict differences in r... - 0 views

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    BACKGROUND: To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year. METHODS: The DBP functional variant, T436K, was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: Mean 25(OH)D increases were 97% for TT (n=48), 151% for TK (n=31) and 307% (n=6) for KK genotypes (p=.004). CONCLUSIONS: As with baseline 25(OH)D, T436K genotype predicts 25(OH)D changes after long-term vitamin D supplementation.

    Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation.
    Fu L, Yun F, Oczak M, Wong BY, Vieth R, Cole DE.
    Clin Biochem. 2009 Jul;42(10-11):1174-7. Epub 2009 Mar 18.
    PMID: 19302999
Matti Narkia

Short- and Long-Term Safety of Weekly High-Dose Vitamin D3 Supplementation in School Ch... - 0 views

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    Conclusion: Vitamin D3 at doses equivalent to 2000 IU/d for 1 yr is safe in adolescents and results in desirable vitamin D levels.

    Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children.
    Maalouf J, Nabulsi M, Vieth R, Kimball S, El-Rassi R, Mahfoud Z, El-Hajj Fuleihan G.
    J Clin Endocrinol Metab. 2008 Jul;93(7):2693-701. Epub 2008 Apr 29.
    PMID: 18445674
    doi:10.1210/jc.2007-2530
Matti Narkia

The same annual dose of 292 000 IU of vitamin D(3) (cholecalciferol) on either daily or... - 0 views

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    The same annual dose of 292 000 IU of vitamin D(3) (cholecalciferol) on either daily or four monthly basis for elderly women: 1-year comparative study of the effects on serum 25(OH)D(3) concentrations and renal function.
    Pekkarinen T, Välimäki VV, Aarum S, Turpeinen U, Hämäläinen E, Löyttyniemi E, Välimäki MJ.
    Clin Endocrinol (Oxf). 2009 May 25. [Epub ahead of print]
    PMID: 19486025
    DOI: 10.1111/j.1365-2265.2009.03637.x
Matti Narkia

Vitamin D supplementation during Antarctic winter. - Am J Clin Nutr. 2009 Ap - 0 views

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    Vitamin D supplementation during Antarctic winter.
    Smith SM, Gardner KK, Locke J, Zwart SR.
    Am J Clin Nutr. 2009 Apr;89(4):1092-8. Epub 2009 Feb 18.
    PMID: 19225122
    doi:10.3945/ajcn.2008.27189
Matti Narkia

Estimation of the dietary requirement for vitamin D in healthy adults. - 0 views

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    Estimation of the dietary requirement for vitamin D in healthy adults.\nCashman KD, Hill TR, Lucey AJ, Taylor N, Seamans KM, Muldowney S, Fitzgerald AP, Flynn A, Barnes MS, Horigan G, Bonham MP, Duffy EM, Strain JJ, Wallace JM, Kiely M.\nAm J Clin Nutr. 2008 Dec;88(6):1535-42.\nPMID: 19064513 [
Matti Narkia

Dose response to vitamin D supplementation among postmenopausal African American women.... - 0 views

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    Dose response to vitamin D supplementation among postmenopausal African American women.\nTalwar SA, Aloia JF, Pollack S, Yeh JK.\nAm J Clin Nutr. 2007 Dec;86(6):1657-62.\nPMID: 18065583
Matti Narkia

Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalcif... - 0 views

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    Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol.
    Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ.
    Am J Clin Nutr. 2003 Jan;77(1):204-10. Erratum in: Am J Clin Nutr. 2003 Nov;78(5):1047.
    PMID: 12499343
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