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Matti Narkia

Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients... - 0 views

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    Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy.
    Sorrentino SA, Besler C, Rohrer L, Meyer M, Heinrich K, Bahlmann FH, Mueller M, Horváth T, Doerries C, Heinemann M, Flemmer S, Markowski A, Manes C, Bahr MJ, Haller H, von Eckardstein A, Drexler H, Landmesser U.
    Circulation. 2009 Dec 21. [Epub ahead of print]
    PMID: 20026785
    doi: 10.1161/CIRCULATIONAHA.108.836346

    Conclusions-HDL from patients with type 2 diabetes mellitus and metabolic syndrome has substantially impaired endothelial-protective effects compared with HDL from healthy subjects. ER niacin therapy not only increases HDL plasma levels but markedly improves endothelial-protective functions of HDL in these patients, which is potentially more important.
Matti Narkia

NEJM -- Extended-Release Niacin or Ezetimibe and Carotid Intima-Media Thickness - 0 views

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    Extended-release niacin or ezetimibe and carotid intima-media thickness.
    Taylor AJ, Villines TC, Stanek EJ, Devine PJ, Griffen L, Miller M, Weissman NJ, Turco M.
    N Engl J Med. 2009 Nov 26;361(22):2113-22. Epub 2009 Nov 15.
    PMID: 19915217

    Conclusions This comparative-effectiveness trial shows that the use of extended-release niacin causes a significant regression of carotid intima-media thickness when combined with a statin and that niacin is superior to ezetimibe. (ClinicalTrials.gov number, NCT00397657 [ClinicalTrials.gov] .
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