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Matti Narkia

Vitamin D and prostate cancer - ScienceDirect - The Journal of Steroid Biochemistry and... - 0 views

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    Vitamin D and prostate cancer.
    Tuohimaa P, Lyakhovich A, Aksenov N, Pennanen P, Syvälä H, Lou YR, Ahonen M, Hasan T, Pasanen P, Bläuer M, Manninen T, Miettinen S, Vilja P, Ylikomi T.
    J Steroid Biochem Mol Biol. 2001 Jan-Mar;76(1-5):125-34.
    PMID: 11384870
    doi:10.1016/S0960-0760(00)00141-2
Matti Narkia

Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25... - 0 views

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    Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer risk.
    Mikhak B, Hunter DJ, Spiegelman D, Platz EA, Hollis BW, Giovannucci E.
    Prostate. 2007 Jun 15;67(9):911-23.
    PMID: 17440943
    DOI: 10.1002/pros.20570

    RESULTS
    No association was found between these SNPs or their associated haplotypes and all PC subtypes except that haplotype 2 (A-f-b) with Cdx2 A, Fok1 f, and Bsm1 b alleles and haplotype 3 (A-F-B) with Cdx2 A, Fok1 F and Bsm1 B alleles compared to the most common haplotype (A-F-b), were associated with reduced risk of aggressive PC (high stage or Gleason sum 7; P = 0.02), both with two alleles suspected of being low risk. Carriers of the variant Cdx2 A allele who were deficient in plasma 25-hydroxyvitamin D (15 ng/ml) compared to non-carriers with normal 25-hydroxyvitamin D, had a lower risk of total and poorly differentiated PCs (Gleason sum 7) (P for interaction = 0.02 and 0.04, respectively). Plasma 1,25-dihydroxyvitamin D deficiency (26 pg/ml) was associated with a threefold risk of poorly differentiated PC (P for interaction = 0.01) when comparing carriers of the Cdx2 A allele to non-carriers with normal 1,25-dihydroxyvitamin D.

    CONCLUSION
    In this population of men, none of the VDR polymorphisms studied was associated with susceptibility to PC.

    Carriers of the variant Cdx2 A allele with low plasma 25-hydroxyvitamin D may experience a reduction in risk of total and poorly differentiated prostate cancers compared to non-carriers with adequate 25-hydroxyvitamin D.
Matti Narkia

Serum Vitamin D Concentration and Prostate Cancer Risk: A Nested Case-Control Study -- ... - 0 views

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    Serum vitamin D concentration and prostate cancer risk: a nested case-control study.
    Ahn J, Peters U, Albanes D, Purdue MP, Abnet CC, Chatterjee N, Horst RL, Hollis BW, Huang WY, Shikany JM, Hayes RB; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Project Team.
    J Natl Cancer Inst. 2008 Jun 4;100(11):796-804. Epub 2008 May 27.
    PMID: 18505967
    doi:10.1093/jnci/djn152

    CONCLUSION: The findings of this large prospective study do not support the hypothesis that vitamin D is associated with decreased risk of prostate cancer; indeed, higher circulating 25(OH)D concentrations may be associated with increased risk of aggressive disease.

    In summary, results from this large prospective study of men who underwent standardized prostate cancer screening in the context of a screening trial do not support the hypothesis that higher serum vitamin D status is associated with decreased risk of prostate cancer. The study showed no association of vitamin D level with nonaggressive disease; however, it raises the possibility that higher vitamin D level may be associated with increased risks for aggressive disease, although a clear monotonic dose-response relationship was lacking. Along with recent reports of adverse associations for higher vitamin D status and risk of pancreatic (32) and esophageal (33,34) cancer, caution should be taken in recommending high doses of vitamin D or sunlight exposure to the general public for prostate cancer prevention. Future analyses are warranted to confirm these results and to further clarify the effects of vitamin D on aggressive prostate cancer.
Matti Narkia

Serum Vitamin D and Risk of Prostate Cancer in a Case-Control Analysis Nested Within th... - 0 views

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    Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).
    Travis RC, Crowe FL, Allen NE, Appleby PN, Roddam AW, Tjønneland A, Olsen A, Linseisen J, Kaaks R, Boeing H, Kröger J, Trichopoulou A, Dilis V, Trichopoulos D, Vineis P, Palli D, Tumino R, Sieri S, Bueno-de-Mesquita HB, van Duijnhoven FJ, Chirlaque MD, Barricarte A, Larrañaga N, González CA, Argüelles MV, Sánchez MJ, Stattin P, Hallmans G, Khaw KT, Bingham S, Rinaldi S, Slimani N, Jenab M, Riboli E, Key TJ.
    Am J Epidemiol. 2009 May 15;169(10):1223-32. Epub 2009 Apr 9.
    PMID: 19359375

    In summary, the results of this large nested case-control study provide no evidence in support of a protective effect of circulating concentrations of vitamin D on the risk of prostate cancer.
Matti Narkia

Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). - Ca... - 0 views

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    Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland).
    Ahonen MH, Tenkanen L, Teppo L, Hakama M, Tuohimaa P.
    Cancer Causes Control. 2000 Oct;11(9):847-52.
    PMID: 11075874
    DOI: 10.1023/A:1008923802001

    CONCLUSIONS: We conclude that low levels of 25-VD associated with an increased risk for subsequent earlier exposure and more aggressive development of prostate cancer, especially before the andropause.
Matti Narkia

Vitamin D may help treat prostate cancer - 0 views

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    The Toronto group gave a fixed low dose (2,000 units) of the prehormone, cholecalciferol, a very safe compound that never causes high calcium in the doses used. In fact, the lowest dose of cholecalciferol known to cause high blood calcium is more than 20,000 units. Therefore, the Toronto group got better results with one-tenth the comparable dose of deltanoids! Vieth wanted to use more cholecalciferol but widespread ignorance about the physiology and pharmacology of vitamin D remains and he could not get adequate dosing past the various review committees.
Matti Narkia

Rise in prostate-specific antigen in men with untreated low-grade prostate cancer is sl... - 0 views

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    Rise in prostate-specific antigen in men with untreated low-grade prostate cancer is slower during spring-summer.
    Vieth R, Choo R, Deboer L, Danjoux C, Morton GC, Klotz L.
    Am J Ther. 2006 Sep-Oct;13(5):394-9.
    PMID: 16988533
    doi: 10.1097/01.mjt.0000174346.36307.02
Matti Narkia

Pilot study: potential role of vitamin D (Cholecalciferol) in patients with PSA relapse... - 0 views

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    Pilot study: potential role of vitamin D (Cholecalciferol) in patients with PSA relapse after definitive therapy.
    Woo TC, Choo R, Jamieson M, Chander S, Vieth R.
    Nutr Cancer. 2005;51(1):32-6.
    PMID: 15749627
Matti Narkia

Serum Vitamin D and Risk of Prostate Cancer in a Case-Control Analysis Nested Within th... - 0 views

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    Serum Vitamin D and Risk of Prostate Cancer in a Case-Control Analysis Nested Within the European Prospective Investigation into Cancer and Nutrition (EPIC).
    Travis RC, Crowe FL, Allen NE, Appleby PN, Roddam AW, Tjønneland A, Olsen A, Linseisen J, Kaaks R, Boeing H, Kröger J, Trichopoulou A, Dilis V, Trichopoulos D, Vineis P, Palli D, Tumino R, Sieri S, Bueno-de-Mesquita HB, van Duijnhoven FJ, Chirlaque MD, Barricarte A, Larrañaga N, González CA, Argüelles MV, Sánchez MJ, Stattin P, Hallmans G, Khaw KT, Bingham S, Rinaldi S, Slimani N, Jenab M, Riboli E, Key TJ.
    Am J Epidemiol. 2009 Apr 9. [Epub ahead of print]
    PMID: 19359375
    doi:10.1093/aje/kwp022
Matti Narkia

Sham vs. Wham: The Health Insider: Omega 3 In the News Again - Lower Advanced Prostate ... - 0 views

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    A new (March 24th) report in Clinical Cancer Research, a journal of the American Association for Cancer Research, shows that Omega-3 fatty acids appear protective against advanced prostate cancer.

    Dr. John S. Witte, Ph.D., professor of epidemiology and biostatistics at the University of California San Francisco, says that previous research has shown protection against prostate cancer, but that this is one of the first studies to show protection against advanced prostate cancer.
Matti Narkia

Dietary Omega-3 Fatty Acids, Cyclooxygenase-2 Genetic Variation, and Aggressive Prostat... - 0 views

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    Dietary Omega-3 Fatty Acids, Cyclooxygenase-2 Genetic Variation, and Aggressive Prostate Cancer Risk.
    Fradet V, Cheng I, Casey G, Witte JS.
    Clin Cancer Res. 2009 Mar 24. [Epub ahead of print]
    PMID: 19318492
    DOI: 10.1158/1078-0432.CCR-08-2503
Matti Narkia

Pilot study of dietary fat restriction and flaxseed supplementation in men with prostat... - 0 views

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    Demark-Wahnefried W, Price DT, Polascik TJ, Robertson CN, Anderson EE, Paulson DF, Walther PJ, Gannon M, Vollmer RT.
    Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects o
Matti Narkia

Suter DA, Thomson WK, Wahlqvist ML. Effects of a diet rich in phytoestrogens on prosta... - 0 views

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    Dalais FS, Meliala A, Wattanapenpaiboon N, Frydenberg M, Suter DA, Thomson WK, Wahlqvist ML.
    Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer.
    Urology. 2004 Sep;64(3):510-5.
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