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Matti Narkia

Blueberry Supplementation Improves Memory in Older Adults† - Journal of Agric... - 4 views

    Blueberry Supplementation Improves Memory in Older Adults (dagger).
    Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA.
    J Agric Food Chem. 2010 Jan 4. [Epub ahead of print]
    PMID: 20047325
    DOI: 10.1021/jf9029332

    The findings of this preliminary study suggest that moderate-term blueberry supplementation can confer neurocognitive benefit and establish a basis for more comprehensive human trials to study preventive potential and neuronal mechanisms.
Matti Narkia

Blueberry juice enhances memory in older adults - Life Extension Update - 1 views

    In an article published online on January 4, 2010 in the Journal of Agricultural and Food Chemistry, Robert Krikorian of the University of Cincinnati, along with his colleagues from the US and Canadian Departments of Agriculture, report that consuming blueberry juice was associated with improvements in learning and memory in individuals with age-related memory decline.

    The trial enrolled five men and four women over the age of 70 who reported forgetfulness and memory lapses characteristic of early memory decline. Participants were given the equivalent of 2 to 2 ½ cups of a commercially available blueberry juice daily for 12 weeks. Cognitive assessments were conducted at the beginning of the study and during the final week of the trial.

    At the study's conclusion, learning and recall were improved, and depressive symptoms and glucose levels tended to be reduced. When subjects who received blueberry juice were compared with a demographically matched sample who received a placebo beverage in a companion trial, test scores for learning ability were significantly better.
Matti Narkia

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adipo... - 0 views

    Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.
    Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ.
    J Clin Invest. 2009 May;119(5):1322-34. Epub 2009 Apr 20.
    PMID: 19381015
    doi: 10.1172/JCI37385.

    Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle-triglyceride and -cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.
Matti Narkia

Vitamin B Niacin Offers No Additional Benefit To Statin Therapy In Seniors Already Diag... - 0 views

    "The routine prescription of extended-release niacin, a B vitamin (1,500 milligrams daily), in combination with traditional cholesterol-lowering therapy offers no extra benefit in correcting arterial narrowing and diminishing plaque buildup in seniors who already have coronary artery disease, a new vascular imaging study from Johns Hopkins experts shows.

    In tests on 145 Baltimore-area men and women with existing atherosclerosis, all over age 65, researchers found that after 18 months of drug therapy, reductions in arterial wall thickness were measurably no different between the half who took dual niacin-statin therapy and the rest who remained on statin therapy alone. "
Matti Narkia

Fish Intake and Risk of Incident Atrial Fibrillation -- Mozaffarian et al. 110 (4): 368... - 0 views

    Fish intake and risk of incident atrial fibrillation.
    Mozaffarian D, Psaty BM, Rimm EB, Lemaitre RN, Burke GL, Lyles MF, Lefkowitz D, Siscovick DS.
    Circulation. 2004 Jul 27;110(4):368-73. Epub 2004 Jul 19.
    PMID: 15262826
    doi: 10.1161/01.CIR.0000138154.00779.A5

    Conclusions- Among elderly adults, consumption of tuna or other broiled or baked fish, but not fried fish or fish sandwiches, is associated with lower incidence of AF. Fish intake may influence risk of this common cardiac arrhythmia.
Matti Narkia

Fish consumption and risk of subclinical brain abnormalities on MRI in older adults - 0 views

    Fish consumption and risk of subclinical brain abnormalities on MRI in older adults.
    Virtanen JK, Siscovick DS, Longstreth WT Jr, Kuller LH, Mozaffarian D.
    Neurology. 2008 Aug 5;71(6):439-46.
    PMID: 18678827
    doi: 10.1212/01.wnl.0000324414.12665.b0

    Among older adults, modest consumption of tuna/other fish, but not fried fish, was associated with lower prevalence of subclinical infarcts and white matter abnormalities on MRI examinations. Our results add to prior evidence that suggest that dietary intake of fish with higher eicosapentaenoic acid and docosahexaenoic acid content, and not fried fish intake, may have clinically important health benefits
Matti Narkia

A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone... - 0 views

    A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women.
    Gleason CE, Carlsson CM, Barnet JH, Meade SA, Setchell KD, Atwood CS, Johnson SC, Ries ML, Asthana S.
    Age Ageing. 2009 Jan;38(1):86-93. Epub 2008 Dec 2.
    PMID: 19054783

    Conclusions: these data suggest that administration of 100 mg/day of isoflavones was well tolerated. Plasma genistein and daidzein levels, but not equol, increased with isoflavone administration. Finally, data support the potential cognitive effects of soy isoflavones in older adults.
Matti Narkia

High Tofu Intake Is Associated with Worse Memory in Elderly Indonesian Men and Women - 0 views

    High tofu intake is associated with worse memory in elderly Indonesian men and women.
    Hogervorst E, Sadjimim T, Yesufu A, Kreager P, Rahardjo TB.
    Dement Geriatr Cogn Disord. 2008;26(1):50-7. Epub 2008 Jun 27.
    PMID: 18583909
    DOI: 10.1159/000141484

    CONCLUSION: The results for tofu consumption as a risk factor for low memory function may tie in with the Honolulu Asia Aging Study data. It is unclear whether these negative associations could be attributed to potential toxins or to its phytoestrogen levels. Estrogen (through which receptors phytoestrogens can exert effects) was found to increase dementia risk in women over 65 years of age. Tempe contains high levels of phytoestrogens, but (due to fermentation) also exhibits high folate levels which may exert protective effects. Future studies should validate these findings and investigate potential mechanisms.
Matti Narkia

Vitamin D, Nutritional Deficiency, and the Medical Paradigm -- Heaney 88 (11): 5107 -- ... - 0 views

    Vitamin D, nutritional deficiency, and the medical paradigm.
    Heaney RP.
    J Clin Endocrinol Metab. 2003 Nov;88(11):5107-8. Review. No abstract available.
    PMID: 14602734
Matti Narkia

Low Vitamin D Status, High Bone Turnover, and Bone Fractures in Centenarians -- Passeri... - 0 views

    Low vitamin D status, high bone turnover, and bone fractures in centenarians.
    Passeri G, Pini G, Troiano L, Vescovini R, Sansoni P, Passeri M, Gueresi P, Delsignore R, Pedrazzoni M, Franceschi C.
    J Clin Endocrinol Metab. 2003 Nov;88(11):5109-15.
    PMID: 14602735

    We conclude that the extreme decades of life are characterized by a pathophysiological sequence of events linking vitamin D deficiency, low serum calcium, and secondary hyperparathyroidism with an increase in bone resorption and severe osteopenia. These data offer a rationale for the possible prevention of elevated bone turnover, bone loss, and consequently the reduction of osteoporotic fractures and fracture-induced disability in the oldest olds through the supplementation with calcium and vitamin D.
Matti Narkia

Vitamin D and mortality in older men and women. - Clin Endocrinol (Oxf). 2009 Nov;71(5)... - 0 views

    Vitamin D and mortality in older men and women.
    Pilz S, Dobnig H, Nijpels G, Heine RJ, Stehouwer CD, Snijder MB, van Dam RM, Dekker JM.
    Clin Endocrinol (Oxf). 2009 Nov;71(5):666-72. Epub 2009 Feb 18.
    PMID: 19226272
    DOI: 10.1111/j.1365-2265.2009.03548.x

    Conclusions Low 25(OH)D levels are associated with all-cause mortality and even more pronounced with cardiovascular mortality, but it remains unclear whether vitamin D deficiency is a cause or a consequence of a poor health status. Therefore, intervention studies are warranted to evaluate whether vitamin D supplementation reduces mortality and cardiovascular diseases.
Matti Narkia

Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mort... - 0 views

    Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women.
    Semba RD, Houston DK, Ferrucci L, Cappola AR, Sun K, Guralnik JM, Fried LP.
    Nutr Res. 2009 Aug;29(8):525-30.
    PMID: 19761886

    Older community-dwelling women with low 25(OH)D levels are at an increased risk of death.
Matti Narkia

Consumption of 2 and 4 egg yolks/d for 5 wk increases macular pigment concentrations in... - 0 views

    Consumption of 2 and 4 egg yolks/d for 5 wk increases macular pigment concentrations in older adults with low macular pigment taking cholesterol-lowering statins.
    Vishwanathan R, Goodrow-Kotyla EF, Wooten BR, Wilson TA, Nicolosi RJ.
    Am J Clin Nutr. 2009 Nov;90(5):1272-9. Epub 2009 Sep 16.
    PMID: 19759170

    Conclusions: Consumption of 4 egg yolks/d, and possibly of 2 egg yolks/d, for 5 wk benefited macular health in older adults with low MPOD. Serum HDL cholesterol increased without an increase in LDL cholesterol in this study population, most of whom were taking cholesterol-lowering statins.
Matti Narkia

Association of vitamin D deficiency with cognitive impairment in older women. Cross-sec... - 0 views

    Association of vitamin D deficiency with cognitive impairment in older women. Cross-sectional study.
    Annweiler C, Schott AM, Allali G, Bridenbaugh SA, Kressig RW, Allain P, Herrmann FR, Beauchet O.
    Neurology. 2009 Sep 30. [Epub ahead of print]
    PMID: 19794127

    Conclusions: 25-Hydroxyvitamin D deficiency was associated with cognitive impairment in this cohort of community-dwelling older women.
Matti Narkia

Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged... - 0 views

    Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men.
    Lee DM, Tajar A, Ulubaev A, Pendleton N, O'Neill TW, O'Connor DB, Bartfai G, Boonen S, Bouillon R, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Punab M, Silman AJ, Vanderschueren D, Wu FC; EMAS study group.
    J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):722-9. Epub 2009 May 21.
    PMID: 19460797

    Conclusion: In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.
Matti Narkia

Vitamin D deficiency is associated with worse cognitive performance and lower bone dens... - 0 views

    Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans.
    Wilkins CH, Birge SJ, Sheline YI, Morris JC.
    J Natl Med Assoc. 2009 Apr;101(4):349-54.
    PMID: 19397226

    CONCLUSIONS: Vitamin D deficiency in older African Americans was associated with worse cognitive performance and lower BMD of the hip
Matti Narkia

Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elde... - 0 views

    Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elderly Chinese.
    Pan A, Lu L, Franco OH, Yu Z, Li H, Lin X.
    J Affect Disord. 2009 Nov;118(1-3):240-3. Epub 2009 Feb 27.
    PMID: 19249103

    Depressive symptoms are not associated with 25(OH)D concentrations in middle-aged and elderly Chinese. Further prospective studies are required to determine whether they are correlated.
Matti Narkia

Arch Gen Psychiatry -- Depression Is Associated With Decreased 25-Hydroxyvitamin D and ... - 0 views

    Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults.
    Hoogendijk WJ, Lips P, Dik MG, Deeg DJ, Beekman AT, Penninx BW.
    Arch Gen Psychiatry. 2008 May;65(5):508-12.
    PMID: 18458202

    Conclusion The results of this large population-based study show an association of depression status and severity with decreased serum 25(OH)D levels and increased serum PTH levels in older individuals.
Matti Narkia

Urgent action needed to improve vitamin D status among older people in England! - [Age ... - 0 views

    Urgent action needed to improve vitamin D status among older people in England!
    Hirani V, Tull K, Ali A, Mindell J.
    Age Ageing. 2009 Nov 23. [Epub ahead of print]
    PMID: 19934073

    CONCLUSIONS: poor vitamin D status of older people continues to be a public health problem in England. Hypovitaminosis D is associated with many risk factors and poor health outcomes. There is now an urgent need for a uniform policy on assessment and dietary supplementation of vitamin D in older people to prevent poor vitamin D status and its negative consequences
Matti Narkia

Vitamin D Newsletter Mar 2006 | Dr. Wactawski-Wende, New England Journal of Medicine, a... - 0 views

    "Good research is good for medicine. The only thing more important than good research is ethical research. The February 16th issue of the New England Journal of Medicine (NEJM) had a research paper on vitamin D and colon cancer. Was it good research? Was it ethical research? At stake are the lives of 36,000 older American women who agreed to participate in the Women's Health Initiative. "
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