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Matti Narkia

Low vitamin D serum level is related to severe fibrosis and low responsiveness to IFN-b... - 0 views

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    Low vitamin D serum level is related to severe fibrosis and low responsiveness to IFN-based therapy in genotype 1 chronic hepatitis C
    Salvatore Petta et al.
    Hepatology, Volume 9999 Issue 999A, Page NA. Published Online: 4 Dec 2009
    DOI: 10.1002/hep.23489

    Conclusions:
    G1 CHC patients had low 25(OH)D serum levels, possibly due to reduced CYP27A1 expression. Low vitamin D is linked to severe fibrosis and low SVR on IFN-based therapy. (HEPATOLOGY 2010.)
Matti Narkia

The High Prevalence of Vitamin D Insufficiency across Australian Populations Is Only Pa... - 1 views

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    The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude.
    van der Mei IA, Ponsonby AL, Engelsen O, Pasco JA, McGrath JJ, Eyles DW, Blizzard L, Dwyer T, Lucas R, Jones G.
    Environ Health Perspect. 2007 Aug;115(8):1132-9.
    PMID: 17687438
    doi: 10.1289/ehp.9937.

    Conclusion
    Vitamin D insufficiency is common over a wide latitude range in Australia. Season appears to be more important than latitude, but both accounted for less than one-fifth of the variation in serum 25(OH)D levels, highlighting the importance of behavioral factors. Current sun exposure guidelines do not seem to fully prevent vitamin D insufficiency, and consideration should be given to their modification or to pursuing other means to achieve vitamin D adequacy.
Matti Narkia

Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patient... - 0 views

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    Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patients.
    Romagnoli E, Caravella P, Scarnecchia L, Martinez P, Minisola S.
    Br J Nutr. 1999 Feb;81(2):133-7.
    PMID: 10450331

    The results of the present study emphasize the importance of 25-hydroxyvitamin D measurement, and the need to increase vitamin D intake in Italy; foodstuff fortification and supplement use must be considered in order to prevent negative effects of vitamin D deficiency on skeletal integrity.

    All hospitalized patients, both in summer and in winter,
    are characterized by the highest prevalence of hypovitaminosis
    D, especially the older patients. Medical
    inpatients may be at risk for vitamin D deficiency,
Matti Narkia

Low Vitamin D Status, High Bone Turnover, and Bone Fractures in Centenarians -- Passeri... - 0 views

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    Low vitamin D status, high bone turnover, and bone fractures in centenarians.
    Passeri G, Pini G, Troiano L, Vescovini R, Sansoni P, Passeri M, Gueresi P, Delsignore R, Pedrazzoni M, Franceschi C.
    J Clin Endocrinol Metab. 2003 Nov;88(11):5109-15.
    PMID: 14602735

    We conclude that the extreme decades of life are characterized by a pathophysiological sequence of events linking vitamin D deficiency, low serum calcium, and secondary hyperparathyroidism with an increase in bone resorption and severe osteopenia. These data offer a rationale for the possible prevention of elevated bone turnover, bone loss, and consequently the reduction of osteoporotic fractures and fracture-induced disability in the oldest olds through the supplementation with calcium and vitamin D.
Matti Narkia

Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need... - 0 views

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    Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need More Vitamin D?
    Mansbach JM, Ginde AA, Camargo CA Jr.
    Pediatrics. 2009 Nov;124(5):1404-1410.
    PMID: 19951983

    CONCLUSIONS: On the basis of a nationally representative sample of US children aged 1 to 11 years, millions of children may have suboptimal levels of 25(OH)D, especially non-Hispanic black and Hispanic children. More data in children are needed not only to understand better the health implications of specific serum levels of 25(OH)D but also to determine the appropriate vitamin D supplement requirements for children.
Matti Narkia

Vitamin D deficiency is associated with worse cognitive performance and lower bone dens... - 0 views

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    Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans.
    Wilkins CH, Birge SJ, Sheline YI, Morris JC.
    J Natl Med Assoc. 2009 Apr;101(4):349-54.
    PMID: 19397226

    CONCLUSIONS: Vitamin D deficiency in older African Americans was associated with worse cognitive performance and lower BMD of the hip
Matti Narkia

Prevalence of low serum vitamin D concentration in an urban population of elderly women... - 0 views

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    Prevalence of low serum vitamin D concentration in an urban population of elderly women in Poland.
    Napiórkowska L, Budlewski T, Jakubas-Kwiatkowska W, Hamzy V, Gozdowski D, Franek E.
    Pol Arch Med Wewn. 2009 Nov;119(11):699-703.
    PMID: 19920793

    CONCLUSIONS: The prevalence of low vitamin D concentrations in an urban population of elderly women in Poland is very high. Lower vitamin D levels are associated with a higher PTH concentration
Matti Narkia

Severe vitamin D deficiency in Swiss hip fracture patients. - [Bone. 2008] - PubMed Result - 0 views

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    Severe vitamin D deficiency in Swiss hip fracture patients.
    Bischoff-Ferrari HA, Can U, Staehelin HB, Platz A, Henschkowski J, Michel BA, Dawson-Hughes B, Theiler R.
    Bone. 2008 Mar;42(3):597-602. Epub 2007 Nov 28.
    PMID: 18180211

    BACKGROUND: Most clinical guidelines for the prevention of hip fractures recommend 800 IU vitamin D per day. This dose shifted serum 25-hydroxyvitamin D levels (25(OH)D) in previous studies to between 60 and 100 nmol/l. AIM: To measure 25(OH)D levels and prevalence of vitamin D supplementation in individuals age 65+ with acute hip fracture. METHODS: 222 consecutive hip fracture patients were investigated over a 12 month period. Mean age of patients was 86 years and 77% were women. RESULTS: Mean serum 25(OH)D levels were low among hip fracture patients admitted from home (34.6 nmol/l), from assisted living (27.7 nmol/l), and from nursing homes (24 nmol/l). Severe vitamin D deficiency below 30 nmol/l was present in 60%, 80% were below 50 nmol/l, and less than 4% reached desirable levels of at least 75 nmol/l. Consistently, only 10% of hip fracture patients had any vitamin D supplementation on admission to acute care with significantly higher 25(OH)D levels among individuals supplemented with 800-880 IU/day (63.5 nmol/l). Controlling for age and gender, vitamin D supplementation, type of dwelling, and season were independently and significantly associated with 25(OH)D levels. CONCLUSION: These data provide evidence that current guidelines for the prevention of hip fractures need further effort to be translated into clinical practice.
Matti Narkia

Arch Intern Med -- Vitamin D as an Analgesic for Patients With Type 2 Diabetes and Neur... - 0 views

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    Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain.
    Lee P, Chen R.
    Arch Intern Med. 2008 Apr 14;168(7):771-2.
    PMID: 18413561
Matti Narkia

Hypovitaminosis D is associated with insulin resistance and {beta} cell dysfunction -- ... - 0 views

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    Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction.
    Chiu KC, Chu A, Go VL, Saad MF.
    Am J Clin Nutr. 2004 May;79(5):820-5.
    PMID: 15113720

    Conclusions: The data show a positive correlation of 25(OH)D concentration with insulin sensitivity and a negative effect of hypovitaminosis D on ß cell function. Subjects with hypovitaminosis D are at higher risk of insulin resistance and the metabolic syndrome. Further studies are required to explore the underlying mechanisms.
Matti Narkia

Relation of body fat indexes to vitamin D status and deficiency among obese adolescents... - 0 views

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    Relation of body fat indexes to vitamin D status and deficiency among obese adolescents.
    Lenders CM, Feldman HA, Von Scheven E, Merewood A, Sweeney C, Wilson DM, Lee PD, Abrams SH, Gitelman SE, Wertz MS, Klish WJ, Taylor GA, Chen TC, Holick MF; Elizabeth Glaser Pediatric Research Network Obesity Study Group.
    Am J Clin Nutr. 2009 Sep;90(3):459-67. Epub 2009 Jul 29.
    PMID: 19640956

    RESULTS: The mean (+/-SD) age of the adolescents was 14.9 +/- 1.4 y; 38 (66%) were female, and 8 (14%) were black. The mean (+/-SD) body mass index (in kg/m(2)) was 36 +/- 5, FM was 40.0 +/- 5.5%, and VAT was 12.4 +/- 4.3%. Seventeen of the adolescents were vitamin D deficient, but none had elevated PTH concentrations. Bone mineral content and bone mineral density were within 2 SDs of national standards. In a multivariate analysis, 25(OH)D decreased by 0.46 +/- 0.22 ng/mL per 1% increment in FM (beta +/- SE, P = 0.05), whereas PTH decreased by 0.78 +/- 0.29 pg/mL per 1% increment in VAT (P = 0.01). CONCLUSIONS: To the best of our knowledge, our results show for the first time that obese adolescents with 25(OH)D deficiency, but without elevated PTH concentrations, have a bone mass within the range of national standards (+/-2 SD). The findings provide initial evidence that the distribution of fat may be associated with vitamin D status, but this relation may be dependent on metabolic factors
Matti Narkia

Vitamin D Deficiency and Seasonal Variation in an Adult South Florida Population -- Lev... - 0 views

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    Vitamin d deficiency and seasonal variation in an adult South Florida population.
    Levis S, Gomez A, Jimenez C, Veras L, Ma F, Lai S, Hollis B, Roos BA.
    J Clin Endocrinol Metab. 2005 Mar;90(3):1557-62. Epub 2005 Jan 5.
    PMID: 15634725

    The prevalence of hypovitaminosis D is considerable even in southern latitudes and should be taken into account in the evaluation of postmenopausal and male osteoporosis.
Matti Narkia

Demographic Differences and Trends of Vitamin D Insufficiency in the US Population, 198... - 0 views

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    Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004.
    Ginde AA, Liu MC, Camargo CA Jr.
    Arch Intern Med. 2009 Mar 23;169(6):626-32.
    PMID: 19307527

    Conclusions National data demonstrate a marked decrease in serum 25(OH)D levels from the 1988-1994 to the 2001-2004 NHANES data collections. Racial/ethnic differences have persisted and may have important implications for known health disparities. Current recommendations for vitamin D supplementation are inadequate to address the growing epidemic of vitamin D insufficiency.
Matti Narkia

Prevalence and Associations of 25-Hydroxyvitamin D Deficiency in US Children: NHANES 20... - 0 views

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    Prevalence and Associations of 25-Hydroxyvitamin D Deficiency in US Children: NHANES 2001-2004.
    Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML.
    Pediatrics. 2009 Aug 3. [Epub ahead of print]
    PMID: 19661054

    CONCLUSIONS: 25(OH)D deficiency is common in the general US pediatric population and is associated with adverse cardiovascular risks.
Matti Narkia

Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone... - 0 views

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    Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls.
    Cheng S, Tylavsky F, Kröger H, Kärkkäinen M, Lyytikäinen A, Koistinen A, Mahonen A, Alen M, Halleen J, Väänänen K, Lamberg-Allardt C.
    Am J Clin Nutr. 2003 Sep;78(3):485-92. Erratum in: Am J Clin Nutr. 2006 Jan;83(1):174.
    PMID: 12936933

    CONCLUSIONS: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.
Matti Narkia

Teenage girls and elderly women living in northern Europe have low winter vitamin D sta... - 0 views

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    Teenage girls and elderly women living in northern Europe have low winter vitamin D status.
    Andersen R, Mølgaard C, Skovgaard LT, Brot C, Cashman KD, Chabros E, Charzewska J, Flynn A, Jakobsen J, Kärkkäinen M, Kiely M, Lamberg-Allardt C, Moreiras O, Natri AM, O'brien M, Rogalska-Niedzwiedz M, Ovesen L.
    Eur J Clin Nutr. 2005 Apr;59(4):533-41.
    PMID: 15714215
    doi:10.1038/sj.ejcn.1602108

    CONCLUSION: Vitamin D status is low in northern Europe during winter. More than one-third of the adolescent girls have vitamin D status below 25 nmol/l and almost all are below 50 nmol/l. Two-thirds of the elderly community-dwelling women have vitamin D status below 50 nmol/l. Use of vitamin D supplements is a significant positive determinant for S-25OHD for both girls and women (P = 0.001). SPONSORSHIP: The European Fifth Framework Programme (Contract No. QLK1-CT-2000-00623)
Matti Narkia

Low serum 25-hydroxyvitamin D concentrations and secondary hyperparathyroidism in middl... - 0 views

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    Low serum 25-hydroxyvitamin D concentrations and secondary hyperparathyroidism in middle-aged white strict vegetarians.
    Lamberg-Allardt C, Kärkkäinen M, Seppänen R, Biström H.
    Am J Clin Nutr. 1993 Nov;58(5):684-9.
    PMID: 8237875

    In conclusion, white strict vegetarians are at risk of vitamin D deficiency, at least in the winter, primarily because of a low dietary vitamin D intake, despite a normal sunlight exposure in summer. Low serum 25(OH)D concentrations are accompanied by high S-iPTH concentrations, which also are affected by a low calcium intake. The effect of these changes on bone health remains to be evaluated.
Matti Narkia

Vitamin D status affects serum parathyroid hormone concentrations during winter in fema... - 0 views

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    Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density.
    Outila TA, Kärkkäinen MU, Lamberg-Allardt CJ.
    Am J Clin Nutr. 2001 Aug;74(2):206-10.
    PMID: 11470722

    Conclusion: A large percentage of adolescent females have low vitamin D status during the winter in Finland, which seems to have negative effects on bone health.
Matti Narkia

Healthy elderly French women living at home have secondary hyperparathyroidism and high... - 0 views

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    Healthy elderly French women living at home have secondary hyperparathyroidism and high bone turnover in winter. EPIDOS Study Group.
    Chapuy MC, Schott AM, Garnero P, Hans D, Delmas PD, Meunier PJ.
    J Clin Endocrinol Metab. 1996 Mar;81(3):1129-33.
    PMID: 8772587

    These results show that vitamin D status of a French aged population in good health and living at home depends mainly on lifestyle. Like institutionalized women, old women living at home exhibit clear evidence of senile hyperparathyroidism in the winter, secondary in part to a reduced 25OHD level and associated with biological signs of increased bone turnover. The maintenance of PTH within the normal range for healthy adults by vitamin D and calcium treatment might constitute an approach for the prevention of bone loss in the entire
Matti Narkia

A high prevalence of hypovitaminosis D in Finnish medical in- and outpatients. - J Inte... - 0 views

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    A high prevalence of hypovitaminosis D in Finnish medical in- and outpatients.
    Kauppinen-Mäkelin R, Tähtelä R, Löyttyniemi E, Kärkkäinen J, Välimäki MJ.
    J Intern Med. 2001 Jun;249(6):559-63.
    PMID: 11422663
    DOI: 10.1046/j.1365-2796.2001.00847.x

    CONCLUSION: Hypovitaminosis D is very common amongst Finnish in- and outpatients in both sexes, causing secondary hyperparathyroidism in females. More extensive studies are warranted to elucidate the vitamin D status of the Finnish population.
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