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Matti Narkia

Fat Hormone May Protect Against Alzheimer's - 0 views

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    "High blood levels of leptin, a hormone that regulates appetite, may guard against Alzheimer's disease, new research suggests.

    "Hopefully, in 10 or 15 years this may be one of many agents that we use to reduce the risk of Alzheimer's disease," said senior study author Dr. Sudha Seshadri, an associate professor of neurology at Boston University School of Medicine. "Or it may be one of many markers that we measure in combination to predict risk."

    But many more studies of different population groups are needed to determine whether leptin can play such a pivotal role in predicting the risk of Alzheimer's, Seshadri said.

    The research, which was reported in the Dec. 16 issue of the Journal of the American Medical Association, was done because "there has been some data relating body weight to the risk of Alzheimer's disease," Seshadri said. "When we looked at animal studies, we found some data to indicate that leptin not only produces a feeling of satiety but also has a beneficial effect on the hippocampus. It was important to see if that was true in humans."

    The hippocampus is a portion of the brain that plays a role in important aspects of memory."
Matti Narkia

Polyphenols and polyunsaturated fatty acids boost the birth of new neurons, study finds - 0 views

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    "ScienceDaily (Nov. 30, 2009) - Universitat Autònoma de Barcelona (UAB) researchers have confirmed that a diet rich in polyphenols and polyunsaturated fatty acids, patented as an LMN diet, helps boost the production of the brain's stem cells -neurogenesis- and strengthens their differentiation in different types of neuron cells.

    The research revealed that mice fed an LMN diet, when compared to those fed a control diet, have more cell proliferation in the two areas of the brain where neurogenesis is produced, the olfactory bulb and the hippocampus, both of which are greatly damaged in patients with Alzheimer's disease. These results give support to the hypothesis that a diet made up of foods rich in these antioxidant substances could delay the onset of this disease or even slow down its evolution.

    The study will be published in the December issue of the Journal of Alzheimer's Disease and was directed by Mercedes Unzeta, professor of the UAB Department of Biochemistry and Molecular Biology"
Matti Narkia

Diet high in methionine could increase risk of Alzheimer's - 0 views

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    "ScienceDaily (Dec. 17, 2009) - A diet rich in methionine, an amino acid typically found in red meats, fish, beans, eggs, garlic, lentils, onions, yogurt and seeds, can possibly increase the risk of developing Alzheimer's disease, according to a study by Temple researchers.

    "When methionine reaches too high a level, our body tries to protect itself by transforming it into a particular amino acid called homocysteine," said lead researcher Domenico Praticò, an associate professor of pharmacology in the School of Medicine. "The data from previous studies show -- even in humans -- when the level of homocysteine in the blood is high, there is a higher risk of developing dementia. We hypothesized that high levels of homocysteine in an animal model of Alzheimer's would accelerate the disease."

    Using a seven-month old mouse model of the disease, they fed one group an eight-month diet of regular food and another group a diet high in methionine. The mice were then tested at 15 months of age -- the equivalent of a 70-year-old human.
Matti Narkia

Berberine: a plant alkaloid with therapeutic potential for central nervous system disor... - 0 views

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    Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders.
    Kulkami SK et al.
    Phytotherapy Research, Published Online: 8 Dec 2009

    This review attempts to discuss the pharmacological basis of the use of berberine in various central nervous system
    and related disorders. Its protective effect in Alzheimer's, cerebral ischemia, mental depression, schizophrenia
    and anxiety are highlighted. However, more detailed clinical trials along with a safety assessment of berberine
    are warranted for positioning the alkaloid in the treatment of neurological disorders.
Matti Narkia

Dietary composition modulates brain mass and amyloid beta levels in a mouse model of ag... - 0 views

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    Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology.
    Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho L, Fraser P, Westaway D, Hyslop PS, Martins RN, Buxbaum JD, Pasinetti GM, Dickstein DL, Hof PR, Ehrlich ME, Gandy S.
    Mol Neurodegener. 2009 Oct 21;4:40.
    PMID: 19845940
    doi:10.1186/1750-1326-4-40

    INTERPRETATION: Dissociation of Abeta changes from brain mass changes raises the possibility that diet plays a role not only in modulating amyloidosis but also in modulating neuronal vulnerability. However, in the absence of a study of the effects of a high protein/low carbohydrate diet on nontransgenic mice, one cannot be certain how much, if any, of the loss of brain mass exhibited by high protein/low carbohydrate diet-fed TgCRND8 mice was due to an interaction between cerebral amyloidosis and diet. Given the recent evidence that certain factors favor the maintenance of cognitive function in the face of substantial structural neuropathology, we propose that there might also exist factors that sensitize brain neurons to some forms of neurotoxicity, including, perhaps, amyloid neurotoxicity. Identification of these factors could help reconcile the poor clinicopathological correlation between cognitive status and structural neuropathology, including amyloid pathology.
Matti Narkia

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease... - 0 views

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    A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease.
    Van der Auwera I, Wera S, Van Leuven F, Henderson ST.
    Nutr Metab (Lond). 2005 Oct 17;2:28.
    PMID: 16229744
    doi:10.1186/1743-7075-2-28

    CONCLUSION: Previous studies have suggested that diets rich in cholesterol and saturated fats increased the deposition of Abeta and the risk of developing AD. Here we demonstrate that a diet rich in saturated fats and low in carbohydrates can actually reduce levels of Abeta. Therefore, dietary strategies aimed at reducing Abeta levels should take into account interactions of dietary components and the metabolic outcomes, in particular, levels of carbohydrates, total calories, and presence of ketone bodies should be considered.
Matti Narkia

Weekly curry 'may fight dementia' - BBC NEWS | Health - 0 views

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    Eating a curry once or twice a week could help prevent the onset of Alzheimer's disease and dementia, a US researcher suggests.
    The key ingredient is curcumin, a component of the spice turmeric.
Matti Narkia

WHFoods: Mushrooms, crimini - 0 views

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    White button mushrooms (Agaricus bisporus), although often considered a poor relation of exotic, expensive varieties like maitake and matsutake mushrooms, provide as much or even more anti-oxidant activity as their costly cousins.

    Researchers at the Institut National de la Recherche Agrinomique in France found that the free radical scavenging ability of the humble button mushroom was equivalent to, if not higher than, that of maitake and the matsutake mushrooms - both of which are highly prized in Japanese cuisine for their reputed ability to lower blood pressure and fight cancer.
Matti Narkia

Is vitamin D deficiency linked to Alzheimer's disease and vascular dementia? - 0 views

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    Amsterdam, The Netherlands, May 26, 2009 - There are several risk factors for the development of Alzheimer's disease and vascular dementia. Based on an increasing number of studies linking these risk factors with Vitamin D deficiency, an article in the current issue of the Journal of Alzheimer's Disease (May 2009) by William B. Grant, PhD of the Sunlight, Nutrition, and Health Research Center (SUNARC) suggests that further investigation of possible direct or indirect linkages between Vitamin D and these dementias is needed.

    Low serum levels of 25-hydroxyvitamin D [25(OH)D] have been associated with increased risk for cardiovascular diseases, diabetes mellitus, depression, dental caries, osteoporosis, and periodontal disease, all of which are either considered risk factors for dementia or have preceded incidence of dementia. In 2008, a number of studies reported that those with higher serum 25(OH)D levels had greatly reduced risk of incidence or death from cardiovascular diseases
Matti Narkia

Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. - Curr Opin Clin N... - 0 views

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    Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection.
    Bazan NG.
    Curr Opin Clin Nutr Metab Care. 2007 Mar;10(2):136-41. Review.
    PMID: 17285000
Matti Narkia

Phospholipase A(2) activation as a therapeutic approach for cognitive enhancement in ea... - 0 views

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    Phospholipase A(2) activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease.
    Schaeffer EL, Forlenza OV, Gattaz WF.
    Psychopharmacology (Berl). 2009 Jan;202(1-3):37-51. Epub 2008 Oct 14.
    PMID: 18853146
    DOI: 10.1007/s00213-008-1351-0
Matti Narkia

Phospholipase A(2) activation as a therapeutic approach for cognitive enhancement in ea... - 0 views

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    Phospholipase A(2) activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease.
    Schaeffer EL, Forlenza OV, Gattaz WF.
    Psychopharmacology (Berl). 2009 Jan;202(1-3):37-51. Epub 2008 Oct 14.
    PMID: 18853146
    DOI: 10.1007/s00213-008-1351-0
Matti Narkia

Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal ... - 0 views

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    Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations and Alzheimer's disease.
    Bazan NG.
    Lipid Res. 2008 Nov 18. [Epub ahead of print]
    PMID: 19018037
Matti Narkia

Phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugl... - 0 views

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    Phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugly.
    Farooqui AA, Horrocks LA.
    Neuroscientist. 2006 Jun;12(3):245-60. Review.
    PMID: 16684969
    DOI: 10.1177/1073858405285923
Matti Narkia

Sham vs. Wham: The Health Insider: Fermented Asian Food Shown to Have Possible Protecti... - 0 views

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    People in Asia have been eating fermented foods for more than 1,000 years. One vegan fermented food, renowned in Asia for its ability to protect against heart attacks, was recently shown to have a powerful ability in lab experiments to prevent formation of the clumps of tangled protein involved in Alzheimer's disease. if this works as well in the human brain as scientists expect, it will be a great addition to the tables of anyone who is concerned about this terrible disease
Matti Narkia

Amyloid-degrading ability of nattokinase from Bacillus subtilis natto. - J Agric Food C... - 0 views

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    Amyloid-degrading ability of nattokinase from Bacillus subtilis natto.
    Hsu RL, Lee KT, Wang JH, Lee LY, Chen RP.
    J Agric Food Chem. 2009 Jan 28;57(2):503-8.
    PMID: 19117402
    DOI: 10.1021/jf803072r\n
Matti Narkia

LE Magazine, September 2002 - Report: Phosphatidylserine (PS) The Essential Brain Nutrient - 0 views

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    Phosphatidylserine (PS) is a phospholipid that is found in all cells, but is most highly concentrated in the walls (membranes) of brain cells, making up about 70% of its nerve tissue mass. There it aids in the storage, release and activity of many vital neurotransmitters and their receptors. Phosphatidylserine also aids in cell-to-cell communication.
Matti Narkia

Soybean Product Fights Abnormal Protein Involved In Alzheimer's Disease - 0 views

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    ScienceDaily (Feb. 20, 2009) - A vegan food renowned in Asia for its ability to protect against heart attacks also shows a powerful ability in lab experiments to prevent formation of the clumps of tangled protein involved in Alzheimer's disease, scientists in Taiwan are reporting. \n\nRita P. Y. Chen and colleagues point out that people in Asia have been eating natto - a fermented food made from boiled soybeans -for more than 1,000 years. Natto contains an enzyme, nattokinase, that has effects similar to clot-busting drugs used in heart disease.Nattokinase is sold a dietary supplement to impro 
Matti Narkia

Phosphatidylserine. Monograph. - Altern Med Rev. 2008 Sep;13(3):245-7. - 0 views

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    Phosphatidylserine. Monograph.\nAltern Med Rev. 2008 Sep;13(3):245-7. \nPMID: 18950250 [PubMed - indexed for MEDLINE]
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