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Matti Narkia

Blueberry Supplementation Improves Memory in Older Adults† - Journal of Agric... - 3 views

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    Blueberry Supplementation Improves Memory in Older Adults (dagger).
    Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA.
    J Agric Food Chem. 2010 Jan 4. [Epub ahead of print]
    PMID: 20047325
    DOI: 10.1021/jf9029332

    The findings of this preliminary study suggest that moderate-term blueberry supplementation can confer neurocognitive benefit and establish a basis for more comprehensive human trials to study preventive potential and neuronal mechanisms.
MrGhaz .

Learning Better Eating Habits - 1 views

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    Look at your patterns of eating diary. Are you eating all over your home or at work? Do you sometimes eat standing up? Or whilst doing other things? All of these situations may trigger of eating. Try to eat in just one place at home - and one at work. Sit down at a table and don't read or watch TV. You will gradually weaken your wide range of eating triggers and only want to eat in the 'proper place'.
MrGhaz .

A Balanced Diet - 2 views

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    The amount of energy to be provided by a balanced diet for any person will depend on several factors: age, sex, body size, lifestyle, occupation, and the climate of the area he is in. The proportion of the various food classes in a diet is also not the same for different persons, due to varying physical and physiological requirements..
MrGhaz .

The Importance of Taking Good Nutrition and Practicing Good Eating Habits - 4 views

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    If our bodies are unhealthy, the physiological process of our body will fail, leading to mental, physical and emotional problems. By eating nutritious food and practicing good eating habits, we can assure of a healthy, comfortable and peaceful life..
Matti Narkia

Meta-analysis of prospective cohort studies evaluating the association of saturated fat... - 2 views

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    Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease.
    Siri-Tarino PW, Sun Q, Hu FB, Krauss RM.
    Am J Clin Nutr. 2010 Jan 13. [Epub ahead of print]
    PMID: 20071648
    doi:10.3945/ajcn.2009.27725

    Conclusions: A meta-analysis of prospective epidemiologic studies showed that there is no significant evidence for concluding that dietary saturated fat is associated with an increased risk of CHD or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat.
Matti Narkia

25-Hydroxyvitamin D3 is an agonistic vitamin D receptor ligand - Lou et al. - J Steroi... - 1 views

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    25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand.
    Lou YR, Molnár F, Peräkylä M, Qiao S, Kalueff AV, St-Arnaud R, Carlberg C, Tuohimaa P.
    J Steroid Biochem Mol Biol. 2009 Nov 26. [Epub ahead of print]
    PMID: 19944755
    doi:10.1016/j.jsbmb.2009.11.011

    In conclusion, 25-hydroxyvitamin D3 is an agonistic vitamin D receptor ligand with gene regulatory and anti-proliferative properties.
Matti Narkia

Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk - Scien... - 0 views

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    Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk.
    Yin L, Raum E, Haug U, Arndt V, Brenner H.
    Cancer Epidemiol. 2009 Dec;33(6):435-45. Epub 2009 Nov 25.
    PMID: 19939760
    doi:10.1016/j.canep.2009.10.014

    CONCLUSIONS: According to available evidence from longitudinal studies, serum 25(OH)D is not associated with PC incidence.
Matti Narkia

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adipo... - 0 views

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    Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.
    Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ.
    J Clin Invest. 2009 May;119(5):1322-34. Epub 2009 Apr 20.
    PMID: 19381015
    doi: 10.1172/JCI37385.

    Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle-triglyceride and -cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.
Matti Narkia

Calcium:Magnesium Ratio in Local Groundwater and Incidence of Acute Myocardial Infarcti... - 0 views

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    Calcium:magnesium ratio in local groundwater and incidence of acute myocardial infarction among males in rural Finland.
    Kousa A, Havulinna AS, Moltchanova E, Taskinen O, Nikkarinen M, Eriksson J, Karvonen M.
    Environ Health Perspect. 2006 May;114(5):730-4.
    doi:10.1289/ehp.8438
    PMID: 16675428

    Results of this study with specific Bayesian statistical analysis support earlier findings of a protective role of Mg and low Ca:Mg ratio against coronary heart disease but do not support the earlier hypothesis of a protective role of Ca
Matti Narkia

Overview and perspective in human nutrition. Willett WC. - Asia Pac J Clin Nutr. 2008; - 0 views

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    Overview and perspective in human nutrition.
    Willett WC.
    Asia Pac J Clin Nutr. 2008;17 Suppl 1:1-4. Review.
    PMID: 18296289

    For the last decade, the focus of nutritional advice for prevention of chronic disease has been to limit or reduce
    total fat intake and to consume large amounts of carbohydrate. However, this advice is inconsistent with many
    lines of evidence indicating that unsaturated fats have beneficial metabolic effects and reduce risk of coronary
    heart disease. More recent evidence has also shown that the large majority of carbohydrates in Western diets,
    consisting of refined starches and sugars, have adverse metabolic effects and increase risks of coronary heart
    disease and type 2 diabetes. Unfortunately, a major opportunity for health improvement has been lost by failing
    to distinguish healthy from unhealthy forms of carbohydrates and fats. Recent analyses indicate that moderate
    changes in diet, together with regular physical activity and not smoking, can prevent the large majority of heart
    disease, type 2 diabetes, and some forms of cancer. These findings have substantial relevance for many populations
    in Asia, where incidence of type 2 diabetes is rising rapidly.
Matti Narkia

Retinol-induced Intestinal Tumorigenesis in Min/+ Mice and Importance of Vitamin D Stat... - 0 views

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    "Retinol-induced Intestinal Tumorigenesis in Min/+ Mice and Importance of Vitamin D Status.
    Hetland RB, Alexander J, Berg JP, Svendsen C, Paulsen JE.
    Anticancer Res. 2009 Nov;29(11):4353-60.
    PMID: 20032378

    The effects of life-long dietary exposure, starting in utero, to high retinol, low vitamin D, or high retinol in combination with low vitamin D on intestinal tumorigenesis in Min/+ mice were investigated. In males, high retinol alone significantly increased the number (2.6-fold) and size (1.3-fold) of small intestinal tumours; in females no significant increase in tumour number or size was seen. In both genders, low vitamin D intake alone did not affect intestinal tumorigenesis. In males, intake of the combined high retinol/low vitamin D diet did not further increase the effects caused by high retinol alone. In females, however, the high retinol/low vitamin D-induced increase in tumour number (3.1-fold) and tumour size (1.5-fold) exceeded that of high retinol alone. In conclusion, a high dietary intake of retinol stimulated intestinal tumorigenesis in Min/+ mice. Furthermore, the results indicate a combined effect of high retinol and low vitamin D on tumorigenesis in females"
Matti Narkia

Anticancer Properties of Ganoderma Lucidum Methanol Extracts In Vitro and In Vivo - Nut... - 0 views

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    Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo.
    Harhaji Trajković LM, Mijatović SA, Maksimović-Ivanić DD, Stojanović ID, Momcilović MB, Tufegdzić SJ, Maksimović VM, Marjanović ZS, Stosić-Grujicić SD.
    Nutr Cancer. 2009;61(5):696-707.
    PMID: 19838944
    DOI: 10.1080/01635580902898743

    Anticancer activities of various extracts of the medicinal mushroom, Ganoderma lucidum, have been widely demonstrated and are mainly associated with the presence of different bioactive polysaccharides and triterpenoids. We have evaluated and compared in vitro and in vivo the antitumor effects of two preparations from Ganoderma lucidum: a methanol extract containing total terpenoids (GLme) and a purified methanol extract containing mainly acidic terpenoids (GLpme). Both extracts inhibited tumor growth of B16 mouse melanoma cells inoculated subcutaneously into syngeneic C57BL/6 mice and reduced viability of B16 cells in vitro, whereby GLme exhibited stronger effect. Furthermore, anticancer activity of GLme was demonstrated for the first time against two other rodent tumor cell lines, L929-mouse fibrosarcoma and C6-rat astrocytoma. The mechanism of antitumor activity of GLme comprised inhibition of cell proliferation and induction of caspase-dependent apoptotic cell death mediated by upregulated p53 and inhibited Bcl-2 expression. Moreover, the antitumor effect of the GLme was associated with intensified production of reactive oxygen species, whereas their neutralization by the antioxidant, N-acetyl cysteine, resulted in partial recovery of cell viability. Thus, our results suggest that GLme might be a good candidate for treatment of diverse forms of cancers.
Matti Narkia

Glucose restriction can extend normal cell lifespan and impair precancerous cell growth... - 0 views

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    Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression.
    Li Y, Liu L, Tollefsbol TO.
    FASEB J. 2009 Dec 17. [Epub ahead of print]
    PMID: 20019239
    doi: 10.1096/fj.09-149328

    Cancer cells metabolize glucose at elevated rates and have a higher sensitivity to glucose reduction. However, the precise molecular mechanisms leading to different responses to glucose restriction between normal and cancer cells are not fully understood. We analyzed normal WI-38 and immortalized WI-38/S fetal lung fibroblasts and found that glucose restriction resulted in growth inhibition and apoptosis in WI-38/S cells, whereas it induced lifespan extension in WI-38 cells. Moreover, in WI-38/S cells glucose restriction decreased expression of hTERT (human telomerase reverse transcriptase) and increased expression of p16(INK4a). Opposite effects were found in the gene expression of hTERT and p16 in WI-38 cells in response to glucose restriction. The altered gene expression was partly due to glucose restriction-induced DNA methylation changes and chromatin remodeling of the hTERT and p16 promoters in normal and immortalized WI-38 cells. Furthermore, glucose restriction resulted in altered hTERT and p16 expression in response to epigenetic regulators in WI-38 rather than WI-38/S cells, suggesting that energy stress-induced differential epigenetic regulation may lead to different cellular fates in normal and precancerous cells. Collectively, these results provide new insights into the epigenetic mechanisms of a nutrient control strategy that may contribute to cancer therapy as well as antiaging approaches.
Matti Narkia

Coffee, Decaffeinated Coffee, and Tea Consumption in Relation to Incident Type 2 Diabet... - 0 views

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    Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: A systematic review with meta-analysis.
    Huxley R, Lee CM, Barzi F, Timmermeister L, Czernichow S, Perkovic V, Grobbee DE, Batty D, Woodward M.
    Arch Intern Med. 2009 Dec 14;169(22):2053-63.
    PMID: 20008687

    Conclusions Owing to the presence of small-study bias, our results may represent an overestimate of the true magnitude of the association. Similar significant and inverse associations were observed with decaffeinated coffee and tea and risk of incident diabetes. High intakes of coffee, decaffeinated coffee, and tea are associated with reduced risk of diabetes. The putative protective effects of these beverages warrant further investigation in randomized trials.
Matti Narkia

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortal... - 0 views

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    C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis.
    The Lancet, Early Online Publication, 22 December 2009
    doi:10.1016/S0140-6736(09)61717-7

    Interpretation
    CRP concentration has continuous associations with the risk of coronary heart disease, ischaemic stroke, vascular mortality, and death from several cancers and lung disease that are each of broadly similar size. The relevance of CRP to such a range of disorders is unclear. Associations with ischaemic vascular disease depend considerably on conventional risk factors and other markers of inflammation.
Matti Narkia

NEJM -- Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reacti... - 0 views

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    Conclusions In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events. \n\nRosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.\nRidker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group.\nN Engl J Med. 2008 Nov 20;359(21):2195-207. Epub 2008 Nov 9.\nPMID: 18997196
Matti Narkia

NEJM -- Expanding the Orbit of Primary Prevention -- Moving beyond JUPITER - 0 views

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    Expanding the orbit of primary prevention--moving beyond JUPITER.
    Hlatky MA.
    N Engl J Med. 2008 Nov 20;359(21):2280-2. Epub 2008 Nov 9.
    PMID: 18997195
Matti Narkia

Vitamin K2. Monograph. - Altern Med Rev. 2009 Sep;14(3):284-93 - 1 views

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    Vitamin K2. Monograph.
    [No authors listed]
    Altern Med Rev. 2009 Sep;14(3):284-93. Review.
    PMID: 19803553
Matti Narkia

The Bioavailability of Vitamin D from Fortified Cheeses and Supplements Is Equivalent i... - 0 views

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    The bioavailability of vitamin D from fortified cheeses and supplements is equivalent in adults.
    Wagner D, Sidhom G, Whiting SJ, Rousseau D, Vieth R.
    J Nutr. 2008 Jul;138(7):1365-71.
    PMID: 18567762

    Compared with baseline, serum parathyroid hormone decreased with both fortification (P = 0.003) and supplementation (P = 0.012). These data demonstrate that vitamin D is equally bioavailable from fortified hard cheeses and supplements, making cheese suitable for vitamin D fortification.
Matti Narkia

Bread Fortified with Cholecalciferol Increases the Serum 25-Hydroxyvitamin D Concentrat... - 0 views

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    Bread fortified with cholecalciferol increases the serum 25-hydroxyvitamin D concentration in women as effectively as a cholecalciferol supplement.
    Natri AM, Salo P, Vikstedt T, Palssa A, Huttunen M, Kärkkäinen MU, Salovaara H, Piironen V, Jakobsen J, Lamberg-Allardt CJ.
    J Nutr. 2006 Jan;136(1):123-7.
    PMID: 16365070

    Both fortified breads increased serum 25-hydroxyvitamin D concentration as effectively as the cholecalciferol supplement. Supplementation or fortification did not affect serum intact parathyroid hormone concentration or urinary calcium excretion. In conclusion, fortified bread is a safe and feasible way to improve vitamin D nutrition.
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