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Matti Narkia

Meta-analysis of prospective cohort studies evaluating the association of saturated fat... - 2 views

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    Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease.
    Siri-Tarino PW, Sun Q, Hu FB, Krauss RM.
    Am J Clin Nutr. 2010 Jan 13. [Epub ahead of print]
    PMID: 20071648
    doi:10.3945/ajcn.2009.27725

    Conclusions: A meta-analysis of prospective epidemiologic studies showed that there is no significant evidence for concluding that dietary saturated fat is associated with an increased risk of CHD or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat.
Matti Narkia

Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk - Scien... - 0 views

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    Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk.
    Yin L, Raum E, Haug U, Arndt V, Brenner H.
    Cancer Epidemiol. 2009 Dec;33(6):435-45. Epub 2009 Nov 25.
    PMID: 19939760
    doi:10.1016/j.canep.2009.10.014

    CONCLUSIONS: According to available evidence from longitudinal studies, serum 25(OH)D is not associated with PC incidence.
Matti Narkia

Coffee, Decaffeinated Coffee, and Tea Consumption in Relation to Incident Type 2 Diabet... - 0 views

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    Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: A systematic review with meta-analysis.
    Huxley R, Lee CM, Barzi F, Timmermeister L, Czernichow S, Perkovic V, Grobbee DE, Batty D, Woodward M.
    Arch Intern Med. 2009 Dec 14;169(22):2053-63.
    PMID: 20008687

    Conclusions Owing to the presence of small-study bias, our results may represent an overestimate of the true magnitude of the association. Similar significant and inverse associations were observed with decaffeinated coffee and tea and risk of incident diabetes. High intakes of coffee, decaffeinated coffee, and tea are associated with reduced risk of diabetes. The putative protective effects of these beverages warrant further investigation in randomized trials.
Matti Narkia

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortal... - 0 views

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    C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis.
    The Lancet, Early Online Publication, 22 December 2009
    doi:10.1016/S0140-6736(09)61717-7

    Interpretation
    CRP concentration has continuous associations with the risk of coronary heart disease, ischaemic stroke, vascular mortality, and death from several cancers and lung disease that are each of broadly similar size. The relevance of CRP to such a range of disorders is unclear. Associations with ischaemic vascular disease depend considerably on conventional risk factors and other markers of inflammation.
Matti Narkia

Effect of Fish Oil on Heart Rate in Humans: A Meta-Analysis of Randomized Controlled Tr... - 0 views

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    Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials.
    Mozaffarian D, Geelen A, Brouwer IA, Geleijnse JM, Zock PL, Katan MB.
    Circulation. 2005 Sep 27;112(13):1945-52. Epub 2005 Sep 19.
    PMID: 16172267
    doi: 10.1161/CIRCULATIONAHA.105.556886

    Conclusions- In randomized controlled trials in humans, fish oil reduces HR, particularly in those with higher baseline HR or longer treatment duration. These findings provide firm evidence that fish oil consumption directly or indirectly affects cardiac electrophysiology in humans. Potential mechanisms such as effects on the sinus node, ventricular efficiency, or autonomic function deserve further investigation.
Matti Narkia

Benefit-risk assessment of vitamin D supplementation. - Osteoporos Int. 2009 Dec 3. - S... - 0 views

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    Benefit-risk assessment of vitamin D supplementation.
    Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC.
    Osteoporos Int. 2009 Dec 3. [Epub ahead of print]
    PMID: 19957164

    Conclusion Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.
Matti Narkia

Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials -... - 0 views

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    Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials.
    Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, Watts GF.
    J Hum Hypertens. 2007 Apr;21(4):297-306. Epub 2007 Feb 8.
    PMID: 17287847

    We conclude that coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects.
Matti Narkia

Dietary protein and bone health: a systematic review and meta-analysis -- Darling et al... - 0 views

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    Dietary protein and bone health: a systematic review and meta-analysis.
    Darling AL, Millward DJ, Torgerson DJ, Hewitt CE, Lanham-New SA.
    Am J Clin Nutr. 2009 Nov 4. [Epub ahead of print]
    PMID: 19889822
Matti Narkia

Effects of n-3 long-chain polyunsaturated fatty acids on depressed mood: systematic rev... - 0 views

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    Effects of n-3 long-chain polyunsaturated fatty acids on depressed mood: systematic review of published trials.
    Appleton KM, Hayward RC, Gunnell D, Peters TJ, Rogers PJ, Kessler D, Ness AR.
    Am J Clin Nutr. 2006 Dec;84(6):1308-16. Review.
    PMID: 17158410

    Conclusions: Trial evidence that examines the effects of n-3 PUFAs on depressed mood is limited and is difficult to summarize and evaluate because of considerable heterogeneity. The evidence available provides little support for the use of n-3 PUFAs to improve depressed mood. Larger trials with adequate power to detect clinically important benefits are required.
Matti Narkia

Meta-analysis of vitamin D, calcium and the prevention of breast cancer. - [Breast Canc... - 0 views

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    Meta-analysis of vitamin D, calcium and the prevention of breast cancer.
    Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H.
    Breast Cancer Res Treat. 2009 Oct 23. [Epub ahead of print]
    PMID: 19851861

    These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.
Matti Narkia

Vitamin D and prevention of breast cancer: pooled analysis. - ScienceDirect - The Journ... - 0 views

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    Vitamin D and prevention of breast cancer: pooled analysis.
    Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC.
    J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11.
    PMID: 17368188

    CONCLUSIONS: Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies.
Matti Narkia

Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of ran... - 0 views

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    Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials.
    Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J.
    BMJ. 2009 Oct 1;339:b3692. doi: 10.1136/bmj.b3692.
    PMID: 19797342
    doi: 10.1136/bmj.b3692

    Conclusions Supplemental vitamin D in a dose of 700-1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D. Doses of supplemental vitamin D of less than 700 IU or serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l may not reduce the risk of falling among older individuals.
Matti Narkia

Vitamin K and the Prevention of Fractures: Systematic Review and Meta-analysis of Rando... - 0 views

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    Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ.
    Arch Intern Med. 2006 Jun 26;166(12):1256-61. Review.
    PMID: 16801507

    Conclusions This systematic review suggests that supplementation with phytonadione and menaquinone-4 reduces bone loss. In the case of the latter, there is a strong effect on incident fractures among Japanese patients.
Matti Narkia

Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. - Wi... - 0 views

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    Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk.
    Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H.
    Aliment Pharmacol Ther. 2009 Jul 1;30(2):113-25. Epub 2009 Apr 15.
    PMID: 19392870
    DOI: 10.1111/j.1365-2036.2009.04022.x

    Conclusions Our results support suggestions that serum 25(OH)D is inversely related to CRC risk.
Matti Narkia

Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk -- Raimond... - 0 views

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    Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk.
    Raimondi S, Johansson H, Maisonneuve P, Gandini S.
    Carcinogenesis. 2009 Jul;30(7):1170-80. Epub 2009 Apr 29. Review.
    PMID: 19403841
Matti Narkia

JAMA -- Fracture Prevention With Vitamin D Supplementation: A Meta-analysis of Randomiz... - 0 views

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    Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.
    Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B.
    JAMA. 2005 May 11;293(18):2257-64. Review.
    PMID: 15886381

    Conclusions Oral vitamin D supplementation between 700 to 800 IU/d appears to reduce the risk of hip and any nonvertebral fractures in ambulatory or institutionalized elderly persons. An oral vitamin D dose of 400 IU/d is not sufficient for fracture prevention.
Matti Narkia

Vitamin D Supplementation and Total Mortality: A Meta-analysis of Randomized Controlled... - 0 views

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    Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials.
    Autier P, Gandini S.
    Arch Intern Med. 2007 Sep 10;167(16):1730-7. Review.
    PMID: 17846391

    Conclusions Intake of ordinary doses of vitamin D supplements seems to be associated with decreases in total mortality rates. The relationship between baseline vitamin D status, dose of vitamin D supplements, and total mortality rates remains to be investigated. Population-based, placebo-controlled randomized trials with total mortality as the main end point should be organized for confirming these findings.
Matti Narkia

The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Anal... - 0 views

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    The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis.
    Pittas AG, Lau J, Hu FB, Dawson-Hughes B.
    J Clin Endocrinol Metab. 2007 Jun;92(6):2017-29. Epub 2007 Mar 27. Review.
    PMID: 17389701

    .CONCLUSIONS: Vitamin D and calcium insufficiency may negatively influence glycemia, whereas combined supplementation with both nutrients may be beneficial in optimizing glucose metabolism.
Matti Narkia

Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical ... - 0 views

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    Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials.
    Jee SH, He J, Appel LJ, Whelton PK, Suh I, Klag MJ.
    Am J Epidemiol. 2001 Feb 15;153(4):353-62.
    PMID: 11207153 [
Matti Narkia

Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 ... - 0 views

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    Conclusion: The associations suggest that replacing SFAs with PUFAs rather than MUFAs or carbohydrates prevents CHD over a wide range of intakes.

    Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies.
    Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Bälter K, Fraser GE, Goldbourt U, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A.
    Am J Clin Nutr. 2009 May;89(5):1425-32. Epub 2009 Feb 11.
    PMID: 19211817
    doi:10.3945/ajcn.2008.27124
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