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Matti Narkia

Conjugated Linoleic Acid Promotes Human Adipocyte Insulin Resistance through ... - 0 views

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    Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production.
    Chung S, Brown JM, Provo JN, Hopkins R, McIntosh MK.
    J Biol Chem. 2005 Nov 18;280(46):38445-56. Epub 2005 Sep 9.
    PMID: 16155293
    doi: 10.1074/jbc.M508159200

    Collectively, these data demonstrate for the first time that trans-10, cis-12 CLA promotes NFkappaB activation and subsequent induction of IL-6, which are at least in part responsible for trans-10, cis-12 CLA-mediated suppression of peroxisome proliferator-activated receptor gamma target gene expression and insulin sensitivity in mature human adipocytes.

    In summary, our in vitro data demonstrate that a physiological level of trans-10, cis-12 CLA activates NFκB- and ERK1/2-dependent cytokine production, which together suppress PPARγ and Glut4 levels and lead to impaired glucose uptake. Studies are currently under way examining 1) how CLA regulates PPARγ and the expression of its target genes, 2) the specific signaling role of SV cells and adipocytes in mediating the TG-lowering actions of CLA, and 3) the CLA-induced, upstream signal that activates NFκB and ERK1/2.
Matti Narkia

Putting cardiovascular disease and vitamin D insufficiency into perspective - 0 views

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    Vitamin D and disease prevention with special reference to cardiovascular disease.
    Zittermann A.
    Prog Biophys Mol Biol. 2006 Sep;92(1):39-48. Epub 2006 Feb 28. Review.
    PMID: 1660034

Matti Narkia

Limited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers... - 0 views

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    Limited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers and functions in healthy young males.
    Miles EA, Banerjee T, Wells SJ, Calder PC.
    Nutrition. 2006 May;22(5):512-9.
    PMID: 16600816
    doi:10.1016/j.nut.2005.11.011
Matti Narkia

Fish oil and treatment of cancer cachexia - Genes Nutr. 2008 Apr. - 0 views

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    Fish oil and treatment of cancer cachexia.
    Giacosa A, Rondanelli M.
    Genes Nutr. 2008 Apr;3(1):25-8.
    PMID: 18850196
Matti Narkia

Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease - ... - 0 views

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    Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease.
    Sijben JW, Calder PC.
    Proc Nutr Soc. 2007 May;66(2):237-59. Review.
    PMID: 17466105
    doi:10.1017/S0029665107005472
Matti Narkia

Prostaglandin E2 production and T cell function after fish-oil supplementation: respons... - 0 views

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    Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation.
    Trebble TM, Wootton SA, Miles EA, Mullee M, Arden NK, Ballinger AB, Stroud MA, Burdge GC, Calder PC.
    Am J Clin Nutr. 2003 Sep;78(3):376-82.
    PMID: 12936918
Matti Narkia

Comparison of the effects of linseed oil and different doses of fish oil on mononuclear... - 0 views

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    Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects.
    Wallace FA, Miles EA, Calder PC.
    Br J Nutr. 2003 May;89(5):679-89.
    PMID: 12720588

Matti Narkia

Modulation of inflammation in brain: a matter of fat. - J Neurochem. 2007 May - 0 views

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    Modulation of inflammation in brain: a matter of fat.
    Farooqui AA, Horrocks LA, Farooqui T.
    J Neurochem. 2007 May;101(3):577-99. Epub 2007 Jan 25. Review.
    PMID: 17257165
    DOI: 10.1111/j.1471-4159.2006.04371.x
Matti Narkia

Modulation of inflammatory cytokines by omega-3 fatty acids. - .[Subcell Biochem. 2008]... - 0 views

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    Modulation of inflammatory cytokines by omega-3 fatty acids.
    Kang JX, Weylandt KH.
    Subcell Biochem. 2008;49:133-43. Review.
    PMID: 18751910
Matti Narkia

Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimula... - 0 views

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    Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid.
    Weldon SM, Mullen AC, Loscher CE, Hurley LA, Roche HM.
    J Nutr Biochem. 2007 Apr;18(4):250-8. Epub 2006 Jun 16.
    PMID: 16781858
    doi:10.1016/j.jnutbio.2006.04.003
Matti Narkia

The immunobiology of mushrooms. - Exp Biol Med (Maywood). 2008 Mar - 0 views

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    The immunobiology of mushrooms.
    Borchers AT, Krishnamurthy A, Keen CL, Meyers FJ, Gershwin ME.
    Exp Biol Med (Maywood). 2008 Mar;233(3):259-76. Review.
    PMID: 18296732
    doi: 10.3181/0708-MR-227
Matti Narkia

Vitamin D supplementation improves cytokine profiles in patients with congestive heart ... - 0 views

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    Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial.Am J Clin Nutr. 2006 Apr;
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