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Matti Narkia

Anticancer Properties of Ganoderma Lucidum Methanol Extracts In Vitro and In Vivo - Nut... - 0 views

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    Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo.
    Harhaji Trajković LM, Mijatović SA, Maksimović-Ivanić DD, Stojanović ID, Momcilović MB, Tufegdzić SJ, Maksimović VM, Marjanović ZS, Stosić-Grujicić SD.
    Nutr Cancer. 2009;61(5):696-707.
    PMID: 19838944
    DOI: 10.1080/01635580902898743

    Anticancer activities of various extracts of the medicinal mushroom, Ganoderma lucidum, have been widely demonstrated and are mainly associated with the presence of different bioactive polysaccharides and triterpenoids. We have evaluated and compared in vitro and in vivo the antitumor effects of two preparations from Ganoderma lucidum: a methanol extract containing total terpenoids (GLme) and a purified methanol extract containing mainly acidic terpenoids (GLpme). Both extracts inhibited tumor growth of B16 mouse melanoma cells inoculated subcutaneously into syngeneic C57BL/6 mice and reduced viability of B16 cells in vitro, whereby GLme exhibited stronger effect. Furthermore, anticancer activity of GLme was demonstrated for the first time against two other rodent tumor cell lines, L929-mouse fibrosarcoma and C6-rat astrocytoma. The mechanism of antitumor activity of GLme comprised inhibition of cell proliferation and induction of caspase-dependent apoptotic cell death mediated by upregulated p53 and inhibited Bcl-2 expression. Moreover, the antitumor effect of the GLme was associated with intensified production of reactive oxygen species, whereas their neutralization by the antioxidant, N-acetyl cysteine, resulted in partial recovery of cell viability. Thus, our results suggest that GLme might be a good candidate for treatment of diverse forms of cancers.
Matti Narkia

Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer c... - 0 views

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    It was concluded that omega-3 fatty acid could inhibit the proliferation of pancreatic cancer cell line SW1990 cells and promote their apoptosis. The down-regulation of the cyclin E expression by omega-3 fatty acid might be one of the mechanisms for its anti-tumor effect on pancreatic cancer.

    Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells.
    Zhang W, Long Y, Zhang J, Wang C.
    J Huazhong Univ Sci Technolog Med Sci. 2007 Oct;27(5):547-50.
    PMID: 18060632
Matti Narkia

Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis - 0 views

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    Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis.
    Cheung S, Tai J.
    Oncol Rep. 2007 Jun;17(6):1525-31.
    PMID: 17487414
Matti Narkia

Suppression of implanted MDA-MB 231 human breast cancer growth in nude mice by dietary ... - 0 views

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    Suppression of implanted MDA-MB 231 human breast cancer growth in nude mice by dietary walnut.
    Hardman WE, Ion G.
    Nutr Cancer. 2008;60(5):666-74.
    PMID: 18791931
Matti Narkia

Pilot study of dietary fat restriction and flaxseed supplementation in men with prostat... - 0 views

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    Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features.\nDemark-Wahnefried W, Price DT, Polascik TJ, Robertson CN, Anderson EE, Paulson DF, Walther PJ, Gannon M, Vollmer RT.\nUrology. 2001 Jul;58(1):47-52.\nPMID: 11445478 \ndoi:10.1016/S0090-4295(01)01014-7  
Matti Narkia

In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagi... - 0 views

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    In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice.
    Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D.
    J Nutr Biochem. 2005 Jun;16(6):360-7.
    PMID: 15936648
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