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Matti Narkia

The Diet-Heart Hypothesis: Subdividing Lipoproteins - Whole Health Source - 0 views

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    The Diet-Heart Hypothesis: Subdividing Lipoproteins Two posts ago, we made the rounds of the commonly measured blood lipids (total cholesterol, LDL, HDL, triglycerides) and how they associate with cardiac risk. It's important to keep in mind that many things associate with cardiac risk, not just blood lipids. For example, men with low serum vitamin D are at a 2.4-fold greater risk of heart attack than men with higher D levels. That alone is roughly equivalent to the predictive power of the blood lipids you get measured at the doctor's office. Coronary calcium scans (a measure of blood vessel calcification) also associate with cardiac risk better than the most commonly measured blood lipids. Lipoproteins Can be Subdivided into Several Subcategories In the continual search for better measures of cardiac risk, researchers in the 1980s decided to break down lipoprotein particles into sub-categories. One of these researchers is Dr. Ronald M. Krauss. Krauss published extensively on the association between lipoprotein size and cardiac risk, eventually concluding (source): The plasma lipoprotein profile accompanying a preponderance of small, dense LDL particles (specifically LDL-III) is associated with up to a threefold increase in the susceptibility of developing [coronary artery disease]. This has been demonstrated in case-control studies of myocardial infarction and angiographically documented coronary disease. Krauss found that small, dense LDL (sdLDL) doesn't travel alone: it typically comes along with low HDL and high triglycerides*. He called this combination of factors "lipoprotein pattern B"; its opposite is "lipoprotein pattern A": large, buoyant LDL, high HDL and low triglycerides. Incidentally, low HDL and high triglycerides are hallmarks of the metabolic syndrome, the quintessential modern metabolic disorder. Krauss and his colleagues went on to hypothesize that sdLDL promotes atherosclerosis because of its ability to penetrate the artery wall more easily
Matti Narkia

Low-carbohydrate diets increase LDL: debunking the myth | The Blog of Michael R. Eades... - 0 views

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    This week sees the publication of yet another study showing the superiority of the low-carbohydrate diet as compared to the low-fat diet. This study, published in the prestigious American Journal of Clinical Nutrition, demonstrates that subjects following the low-carb diet experience a decrease in triglyceride levels and an increase in HDL-cholesterol (HDL) levels; and that these changes are accompanied by a minor increase in LDL-cholesterol (LDL), which prompts the authors to issue a caveat. Yes, although just about all the parameters that lipophobes worry about improved with the low-carb diet, the small increase in LDL has caused great concern and has prompted the authors to gravely announce that this small increase is troublesome and should be monitored closely in anyone who may be at risk for heart disease. Since most people who go on low-carb diets do so to deal with obesity issues, and since obesity is a risk factor for heart disease, it would appear that this small increase in LDL often seen in those following a low-carb diet could put these dieters at risk. Does it? We'll see.
Matti Narkia

JUPITER: Low LDL and low CRP best for reducing events in primary prevention - theheart.org - 0 views

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    "March 29, 2009 | Michael O'Riordan Orlando, FL - Reducing LDL cholesterol and high-sensitivity C-reactive protein (hs-CRP) in primary-prevention patients treated with rosuvastatin (Crestor, AstraZeneca) results in better event-free survival than when neither of these targets are achieved or when LDL cholesterol alone is reduced, a new analysis shows [1]. Presenting the results of the Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) study during an afternoon press conference at the American College of Cardiology 2009 Scientific Sessions, investigators say that initial interventions for low-risk primary-prevention patients remains lifestyle and dietary modifications, but for those choosing drug therapy, "reductions in both LDL cholesterol and hs-CRP are indicators of the success of treatment with statin therapy.""
Matti Narkia

Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipid... - 1 views

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    Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia -- Krauss et al. 83 (5): 1025 -- American Journal of Clinical Nutrition Changes in peak LDL diameter (Table 2) and mass concentrations of LDL subfractions (Table 3) induced by each of the diets were reflected by changes in the proportions of subjects exhibiting LDL subclass pattern B (Figure 2). There were linear reductions in the prevalence of pattern B as a function of reduced carbohydrate intake after both the stable-weight and weight-loss periods. However, the slopes of these relations differed (P = 0.04) such that the magnitude of the reduction in expression of pattern B induced by weight loss increased in association with the percentage of carbohydrate intake. Conclusions: Moderate carbohydrate restriction and weight loss provide equivalent but nonadditive approaches to improving atherogenic dyslipidemia. Moreover, beneficial lipid changes resulting from a reduced carbohydrate intake were not significant after weight loss. Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia. Krauss RM, Blanche PJ, Rawlings RS, Fernstrom HS, Williams PT. Am J Clin Nutr. 2006 May;83(5):1025-31; quiz 1205. Erratum in: Am J Clin Nutr. 2006 Sep;84(3):668. PMID: 16685042
Matti Narkia

Fish Consumption Shifts Lipoprotein Subfractions to a Less Atherogenic Pattern in Human... - 0 views

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    Fish consumption shifts lipoprotein subfractions to a less atherogenic pattern in humans. Li Z, Lamon-Fava S, Otvos J, Lichtenstein AH, Velez-Carrasco W, McNamara JR, Ordovas JM, Schaefer EJ. J Nutr. 2004 Jul;134(7):1724-8. PMID: 15226460 The effect of fish consumption on plasma lipoprotein subfraction concentrations was studied in 22 men and women (age > 40 y). Subjects were provided an average American diet (AAD, 35% of energy as fat, 14% as saturated fat, and 35 mg cholesterol/MJ) for 6 wk before being assigned to a National Cholesterol Education Program (NCEP) Step 2 high-fish diet (n = 11, 26% of energy as fat, 4.5% as saturated fat, and 15 mg cholesterol/MJ) or a NCEP Step 2 low-fish diet (n = 11, 26% of energy as fat, 4.0% as saturated fat, and 11 mg cholesterol/MJ) for 24 wk. All food and drink were provided to study participants. Consumption of the high-fish NCEP Step 2 diet was associated with a significant reduction in medium and small VLDL, compared with the AAD diet, whereas the low-fish diet did not affect VLDL subfractions. Both diets significantly reduced LDL cholesterol concentrations, without modifying LDL subfractions. Both diets also lowered HDL cholesterol concentrations. However, the high-fish diet significantly lowered only the HDL fraction containing both apolipoprotein (apo) AI and AII (LpAI:AII) and did not change HDL subfractions assessed by NMR, whereas the low-fish diet significantly lowered the HDL fraction containing only apo AI (LpAI) and the large NMR HDL fractions, resulting in a significant reduction in HDL particle size. Neither diet affected VLDL and LDL particle size. Our data indicate that within the context of a diet restricted in fat and cholesterol, a higher fish content favorably affects VLDL and HDL subspecies
Matti Narkia

Eggs distinctly modulate plasma carotenoid and lipoprotein subclasses in adult men foll... - 0 views

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    Eggs distinctly modulate plasma carotenoid and lipoprotein subclasses in adult men following a carbohydrate-restricted diet. Mutungi G, Waters D, Ratliff J, Puglisi M, Clark RM, Volek JS, Fernandez ML. J Nutr Biochem. 2009 Apr 13. [Epub ahead of print] PMID: 19369056 We previously reported that carbohydrate restriction (CR) (10-15% en) during a weight loss intervention lowered plasma triglycerides (TG) by 45% in male subjects (P<.05). However, only those subjects from the EGG group presented higher concentrations of these two carotenoids in plasma, which were correlated with the higher concentra
Matti Narkia

MedWire News - Lipidology - High serum selenium associated with elevated LDL and total ... - 4 views

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    "High serum selenium associated with elevated LDL and total cholesterol By Helen Albert 21 January 2010 Atherosclerosis 2009; Advance online publication MedWire News: High levels of serum selenium are associated with elevated total and low-density lipoprotein (LDL) cholesterol, report US researchers. The results add weight to those of a previous UK study, reported by MedWire News, that reported an association between high plasma selenium and an adverse lipid profile. Eliseo Guallar (Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland) and colleagues carried out a cross-sectional analysis of 1159 individuals aged 56.8 years on average who participated in the National Health and Nutrition Examination Survey (NHANES) 2003-2004."
Matti Narkia

Clinical Implications of JUPITER (Justification for the Use of statins in Prevention: a... - 0 views

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    Clinical Implications of JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) in a U.S. Population Insights From the ARIC (Atherosclerosis Risk in Communities) Study Yang EY et al. J Am Coll Cardiol, 2009; 54:2388-2395, doi:10.1016/j.jacc.2009.10.006 Conclusions: ARIC participants with elevated hs-CRP and low LDL-C had a CVD event rate of 1.57% per year over 6.9 years, similar to the CVD event rate noted in the JUPITER study placebo group (1.36% per year over 1.9 years). The association of hs-CRP ≥2.0 mg/l with increased CVD risk and mortality regardless of LDL-C provides us a simple method of using age and hs-CRP level for identifying higher risk individuals. (Atherosclerosis Risk in Communities study; NCT00005131)
Matti Narkia

The Effect of a Plant-Based Low-Carbohydrate ("Eco-Atkins") Diet on Body Weight and Blo... - 0 views

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    Conclusion A low-carbohydrate plant-based diet has lipid-lowering advantages over a high-carbohydrate, low-fat weight-loss diet in improving heart disease risk factors not seen with conventional low-fat diets with animal products. The Effect of a Plant-Based Low-Carbohydrate ("Eco-Atkins") Diet on Body Weight and Blood Lipid Concentrations in Hyperlipidemic Subjects David J. A. Jenkins; Julia M. W. Wong; Cyril W. C. Kendall; Amin Esfahani; Vivian W. Y. Ng; Tracy C. K. Leong; Dorothea A. Faulkner; Ed Vidgen; Kathryn A. Greaves; Gregory Paul; William Singer Arch Intern Med. 2009;169(11):1046-1054. DOI: 10.1001/archinternmed.2009.115
Matti Narkia

JUPITER: Primary-prevention statin therapy in women cuts cardiovascular risk in half - ... - 1 views

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    "November 25, 2009 | Michael O'Riordan Orlando, FL - Treating healthy women with low LDL cholesterol but elevated high-sensitivity C-reactive protein (hsCRP) levels with rosuvastatin (Crestor, AstraZeneca) cuts their risk of cardiovascular events in half, according to a new analysis of Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER). The reduction in risk is consistent with the reduction observed in the overall trial, and with the 42% benefit observed in men.
Matti Narkia

Long-term effects of a very-low-carbohydrate weight loss diet compared with an isocalor... - 0 views

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    Long-term effects of a very-low-carbohydrate weight loss diet compared with an isocaloric low-fat diet after 12 mo. Brinkworth GD, Noakes M, Buckley JD, Keogh JB, Clifton PM. Am J Clin Nutr. 2009 May 13. [Epub ahead of print] PMID: 19439458 doi:10.3945/ajcn.2008.27326
Matti Narkia

Consumption of 2 and 4 egg yolks/d for 5 wk increases macular pigment concentrations in... - 0 views

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    Consumption of 2 and 4 egg yolks/d for 5 wk increases macular pigment concentrations in older adults with low macular pigment taking cholesterol-lowering statins. Vishwanathan R, Goodrow-Kotyla EF, Wooten BR, Wilson TA, Nicolosi RJ. Am J Clin Nutr. 2009 Nov;90(5):1272-9. Epub 2009 Sep 16. PMID: 19759170 Conclusions: Consumption of 4 egg yolks/d, and possibly of 2 egg yolks/d, for 5 wk benefited macular health in older adults with low MPOD. Serum HDL cholesterol increased without an increase in LDL cholesterol in this study population, most of whom were taking cholesterol-lowering statins.
Matti Narkia

An Isoenergetic Very Low Carbohydrate Diet Improves Serum HDL Cholesterol and Triacylgl... - 0 views

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    An isoenergetic very low carbohydrate diet improves serum HDL cholesterol and triacylglycerol concentrations, the total cholesterol to HDL cholesterol ratio and postprandial pipemic responses compared with a low fat diet in normal weight, normolipidemic women. Volek JS, Sharman MJ, Gómez AL, Scheett TP, Kraemer WJ. J Nutr. 2003 Sep;133(9):2756-61. PMID: 12949361
Matti Narkia

Inhibitions of vascular endothelial growth factor expression and foam cell formation by... - 0 views

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    Inhibitions of vascular endothelial growth factor expression and foam cell formation by EGb 761, a special extract of Ginkgo biloba, in oxidatively modified low-density lipoprotein-induced human THP-1 monocytes cells. Liu HJ, Wang XL, Zhang L, Qiu Y, Li TJ, Li R, Wu MC, Wei LX, Rui YC. Phytomedicine. 2009 Jan 7. [Epub ahead of print] PMID: 19135347
Matti Narkia

Traditional Chinese Medicine in Treatment of Metabolic Syndrome - 0 views

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    Traditional chinese medicine in treatment of metabolic syndrome. Yin J, Zhang H, Ye J. Endocr Metab Immune Disord Drug Targets. 2008 Jun;8(2):99-111. Review. PMID: 18537696 Berberine from rhizoma coptidis is an oral hypoglycemic agent. It also has anti-obesity and anti-dyslipidemia activities. The action mechanism is related to inhibition of mitochondrial function, stimulation of glycolysis, activation of AMPK pathway, suppression of adipogenesis and induction of low-density lipoprotein (LDL) receptor expression.
Matti Narkia

Hyperlipid: Kwasniewski paper - 0 views

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    "A friend has emailed me the full text of Pawel Grieb's paper documenting a number of physiological parameters of medium to long term Optimal Diet (OD) eaters in Poland, as pointed out by Flo and Stan. There are a few points worth making. The biggest mistake, BTW, is that the authors claim (correctly) that the OD diet aims for >70% fat with (incorrectly) "no restriction on the type of fat (saturated or unsaturated) or cholesterol level". I think they meant that the OD does not ban saturated fats. This is of course true but the impression given is that the OD allows "healthy" fats, which are, of course, inedible. So the heavy emphasis on saturated fats is missed by the paper. A pity, anyone might be left thinking corn oil is a human food... The first positive aspect is that this is a multi author study, eleven authors from several medical centres/unversities. So it's not a one man band case report. I like that. The second is that it is remarkably positive about the findings throughout. Even the elevated LDL cholesterol levels are not taken as extreme and are not trumpeted from the rooftops as the portent of imminent cardiovascular doom. So refreshing!"
Matti Narkia

Coconut kernel protein modifies the effect of coconut oil on serum lipids. - Plant Food... - 0 views

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    Coconut kernel protein modifies the effect of coconut oil on serum lipids. Padmakumaran Nair KG, Rajamohan T, Kurup PA. Plant Foods Hum Nutr. 1999;53(2):133-44. PMID: 10472790 DOI: 10.1023/A:1008078103299 Feeding coconut kernel along with coconut oil in human volunteers has been found to reduce serum total and LDL cholesterol when compared to feeding coconut oil alone. This effect of the kernel was also observed in rats. Since many plant proteins have been reported to exert a cholesterol lowering effect, a study was carried out on the effect of isolated kernel protein in rats. Feeding kernel protein resulted in lower levels of cholesterol, phospholipids and triglycerides in the serum and most tissues when compared to casein fed animals. Rats fed kernel protein had (1) increased hepatic degradation of cholesterol to bile acids, (2) increased hepatic cholesterol biosynthesis, and (3) decreased esterification of free cholesterol. In the intestine, however, cholesterogenesis was decreased. The kernel protein also caused decreased lipogenesis in the liver and intestine. This beneficial effect of the kernel protein is attributed to its very low lysine/arginine ratio 2.13% lysine and 24.5% arginine....
Matti Narkia

A Diet Rich in Coconut Oil Reduces Diurnal Postprandial Variations in Circula... - 0 views

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    A diet rich in coconut oil reduces diurnal postprandial variations in circulating tissue plasminogen activator antigen and fasting lipoprotein (a) compared with a diet rich in unsaturated fat in women. Müller H, Lindman AS, Blomfeldt A, Seljeflot I, Pedersen JI. J Nutr. 2003 Nov;133(11):3422-7. PMID: 14608053 In conclusion, our results indicate that a coconut oil-based diet (HSAFA-diet) lowers postprandial t-PA antigen concentration, and this may favorably affect the fibrinolytic system and the Lp(a) concentration compared with the HUFA-diet. The proportions of dietary saturated fatty acids more than the percentage of saturated fat energy seem to have a beneficial influence on Lp(a) levels. The connection between Lp(a) and atherosclerosis is not entirely understood. Different studies have provided strong evidence that Lp(a) level is an independent risk factor for developing coronary artery disease in men (47,48), but the question of causality continues to be debated. Recent data suggest that Lp(a) might be atherogenic (49), in particular when combined with other risk factors. High levels of Lp(a) combined with other risk factors such as the ratio of plasma total/HDL cholesterol have been shown to increase the risk for coronary heart diseases (50). It has also been reported that when substantial LDL cholesterol reductions were obtained in men with coronary heart disease, persistent elevations of Lp(a) were no longer atherogenic or clinically threatening (51). In conclusion, the present results show that the HSAFA-diet lowered postprandial t-PA antigen and thus potentially improved fibrinolysis compared with the HUFA-diet. Diets with either high or low levels of saturated fatty acids from coconut oil beneficially decrease Lp(a) compared with a HUFA-diet. The proportions of dietary saturated fatty acids more than the percentage of saturated fat energy may be of importance if the goal is to decrease Lp(a).
Mango Dash india

Mango Dash: Nutritional And Health Benefits of Mango Juice - 0 views

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    Mango is a summer delicacy which is consumed worldwide. They are juicy, sweet and act as a natural coolant which is very effective in beating the summer heat. Many varieties of mango are available in the market which have different taste and flavors. They are usually consumed raw and are savored in fresh salads and juices. Mango shakes, pickles, sauces, ice-creams and smoothies are prepared from mangoes which provide different blend of flavor to them. Let us find out the nutritional and health benefits of mango. Nutritional Benefits of Mango Juice provides around 60 calories for 100 grams of its serving. It contains a lot of phytochemicals and nutrients and is a rich source of carbohydrates and fibre. Antioxidants and Vitamins like Vitamin-A, B, C, E and K are present in it. Mango is also a good source of various minerals like Calcium, Zinc, Potassium, Iron, Magnesium and Potassium. Some Main Benefits of Mango Juice - Beneficial for Prevents Cancer: Mangoes are rich in antioxidants which restrict the oxidation of cells in the body. These antioxidants are quercetin, isoquercitrin, astragalin, fisetin, gallic acid and methylgallat. Even Vitamin-A and flavonoids like beta-carotene, alpha-carotene, and beta-cryptoxanthin present in mango prevents lung and oral cancer. Improves Brain and Health Memory: Mango Juice in Vitamin-B6 is found in abundance in mango which helps in improving brain function. It helps in maintaining an efficient nervous system. It is a mood vitamin and enhances mood and controls stress. Beneficial for Aids Digestion: Mangoes are a rich source of dietary fibre which helps in proper digestion. Fibres help with proper bowel movement and keep the digestive tract clean. Mangoes are alkaline in nature thus reduce acidity in the stomach. Various bio-active compounds like Esters, Terpenes and Aldehydes make mangoes even more potent against indigestion. Lowering Cholesterol: Mango Juice are rich in fibre which reduce bad choleste
neotonics

Cardio Defend™ (Official) | Pay Just $49/Bottle + Free Bonus - 0 views

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    Cardio Defend™ Only $49/bottle - Limited Time Offer Flat Sale ONLY For Today - Special Offer Save Upto $120 + Special 71% Discount + 180 Day Money Back Guarantee CardioDefend Cardio Defend Rated FDA Approved CardioDefend Rated 5 Star Order TODAY And Save Up To $120! Save Over 71%! Cardio Defend is a dietary supplement that supports a healthy heart naturally. The lifestyle of individuals has evolved drastically, and with this evolution, mankind has seen a rise in individuals suffering from heart-related diseases. It supports healthy blood circulation and reduces blood pressure & the risk of heart disease naturally. Try CardioDefend For Over 71% OFF Today! Regular Price: $147.99/per bottle Only for: $49/per bottle Buy Cardio Defend Proven By Thousands Shannon Curry Mark Angelman Robert S Why Choose Cardio Defend? Made In The USA Made In The USA CardioDefend is manufactured on US soil. Cardio Defend 100% All Natural 100% All Natural All ingredients are pure, natural, and carefully sourced. FDA Approved Facility FDA Approved Facility CardioDefend is manufactured according to the latest standards. CardioDefend Supplement Cardio Defend Facts What is Cardio Defend? Heart disease is one of the top causes of death in the United States, but consumers continue to forgo the nourishment that they need. Even with all of the opportunities to eat better and exercise more, some people still struggle to improve their blood circulation and improve their heart health. Luckily, formulas like Cardio Defend can help a lot. CardioDefend is a dietary supplement that supports a healthy heart naturally. The lifestyle of individuals has evolved drastically, and with this evolution, mankind has seen a rise in individuals suffering from heart-related diseases. Even though exercise and healthy diets may help to reduce the risk of these conditions, they may not be 100% effective. The heart is an extremely important organ and must be taken good care of. CardioDefend naturally supports healt
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