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Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients. Zhou W, Suk R, Liu G, Park S, Neuberg DS, Wain JC, Lynch TJ, Giovannucci E, Christiani DC. Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2303-9. PMID: 16214909 In conclusion, the joint effects of surgery season and recent vitamin D intake seem to be associated with the survival of early-stage non-small cell lung cancer patients. In summary, for early-stage NSCLC patients, patients who had surgery in summer with "high" recent vitamin D intake have a statistically significantly improved RFS and OS than patients who had surgery in winter with "low" vitamin D intake. These results should be confirmed in a prospective study to assess the serum vitamin D levels at time of surgery. If the results are confirmed, our results, combined with findings in other studies, suggest that dietary vitamin D supplementation may be advisable for early stages of lung cancer patients, particularly during the winter season and in groups that tend to be deficient in vitamin D.

Heliotherapy improves vitamin D balance and atopic dermatitis. Vähävihu K, Ylianttila L, Salmelin R, Lamberg-Allardt C, Viljakainen H, Tuohimaa P, Reunala T, Snellman E. Br J Dermatol. 2008 Jun;158(6):1323-8. Epub 2008 Mar 20. PMID: 18363748 DOI: 10.1111/j.1365-2133.2008.08518.x CONCLUSIONS: A 2-week course of HT significantly improved vitamin D balance by increasing serum calcidiol concentration, and caused a marked healing of AD. These parallel positive responses should be taken into account when the benefits of HT are considered..

Vitamin D supplementation improves neuromuscular function in older people who fall. Dhesi JK, Jackson SH, Bearne LM, Moniz C, Hurley MV, Swift CG, Allain TJ. Age Ageing. 2004 Nov;33(6):589-95. PMID: 15501836 doi:10.1093/ageing/afh20 9 CONCLUSIONS: vitamin D supplementation, in fallers with vitamin D insufficiency, has a significant beneficial effect on functional performance, reaction time and balance, but not muscle strength. This suggests that vitamin D supplementation improves neuromuscular or neuroprotective function, which may in part explain the mechanism whereby vitamin D reduces falls and fractures.

Improved cholecalciferol nutrition in rats is noncalcemic, suppresses parathyroid hormone and increases responsiveness to 1, 25-dihydroxycholecalciferol. Vieth R, Milojevic S, Peltekova V. J Nutr. 2000 Mar;130(3):578-84. PMID: 10702588 We conclude suppression of 1,25(OH)(2)D and PTH, and higher renal VDR mRNA and 24-hydroxylase did not involve higher free 1,25(OH)(2)D concentration or a first pass effect at the gut. Thus, 25(OH)D or a metabolite other than 1,25(OH)(2)D is a physiological, transcriptionally and biochemically active, noncalcemic vitamin D metabolite. When viewed from a perspective that starts with higher vitamin D nutrition, the results indicate that low vitamin D nutrition may bring about a form of resistance to 1,25(OH)2D. This situation would explain why, in humans, nutritional rickets and osteomalacia are commonly associated with normal or increased levels of 1,25(OH)2D (Chesney et al. 1981Citation , Eastwood et al. 1979Citation , Garabedian et al. 1983Citation ,Rasmussen et al. 1980Citation )-these are not like the low hormone levels associated with any other endocrine-deficiency disorder. A connection between lower vitamin D nutrition and vitamin D resistance helps to explain why the supposedly inactive compound 25(OH)D is more relevant in diagnosing nutritional rickets than is the active hormone 1,25(OH)2D. If the features of improved vitamin D nutrition shown here were demonstrated for any newly synthesized compound, the compound would be classified as a noncalcemic 1,25(OH)2D analogue (Brown et al. 1989Citation , Finch et al. 1999Citation , Goff et al. 1993Citation , Koshizuka et al. 1999Citation ). Thus, we contend that 25(OH)D or a metabolite of it other than 1,25(OH)2D exists as a physiological and biologically-active noncalcemic vitamin D metabolite whose effects require further examination, particularly in relationship to studies involving the synthetic analogs of 1,25(OH)2D.

Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. von Hurst PR, Stonehouse W, Coad J. Br J Nutr. 2009 Sep 28:1-7. [Epub ahead of print] PMID: 19781131 In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion. Optimal vitamin D concentrations for reducing IR were shown to be 80-119 nmol/l, providing further evidence for an increase in the recommended adequate levels. Registered Trial No. ACTRN12607000642482.

Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy. Sorrentino SA, Besler C, Rohrer L, Meyer M, Heinrich K, Bahlmann FH, Mueller M, Horváth T, Doerries C, Heinemann M, Flemmer S, Markowski A, Manes C, Bahr MJ, Haller H, von Eckardstein A, Drexler H, Landmesser U. Circulation. 2009 Dec 21. [Epub ahead of print] PMID: 20026785 doi: 10.1161/CIRCULATIONAHA.108.836346 Conclusions-HDL from patients with type 2 diabetes mellitus and metabolic syndrome has substantially impaired endothelial-protective effects compared with HDL from healthy subjects. ER niacin therapy not only increases HDL plasma levels but markedly improves endothelial-protective functions of HDL in these patients, which is potentially more important.

A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Lindeberg S, Jönsson T, Granfeldt Y, Borgstrand E, Soffman J, Sjöström K, Ahrén B. Diabetologia. 2007 Sep;50(9):1795-807. Epub 2007 Jun 22. PMID: 17583796 DOI: 10.1007/s00125-007-0716-y Conclusions/interpretation A Palaeolithic diet may improve glucose tolerance independently of decreased waist circumference.

Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Eyjolfson V, Spriet LL, Dyck DJ. Med Sci Sports Exerc. 2004 May;36(5):814-20. PMID: 15126715 CONCLUSIONS: Our results indicate that a common dosage of a commercially available CLA supplement can improve ISI in young, sedentary individuals. However, there is considerable individual variability in the response. Additional studies are required to identify underlying metabolic changes in human skeletal muscle.

Dietary cod protein improves insulin sensitivity in insulin-resistant men and women: a randomized controlled trial. Ouellet V, Marois J, Weisnagel SJ, Jacques H. Diabetes Care. 2007 Nov;30(11):2816-21. Epub 2007 Aug 6. PMID: 17682120 CONCLUSIONS - Dietary cod protein improves insulin sensitivity in insulin-resistant individuals and thus could contribute to prevention of type 2 diabetes by reducing the metabolic complications related to insulin resistance.

Mango is a summer delicacy which is consumed worldwide. They are juicy, sweet and act as a natural coolant which is very effective in beating the summer heat. Many varieties of mango are available in the market which have different taste and flavors. They are usually consumed raw and are savored in fresh salads and juices. Mango shakes, pickles, sauces, ice-creams and smoothies are prepared from mangoes which provide different blend of flavor to them. Let us find out the nutritional and health benefits of mango. Nutritional Benefits of Mango Juice provides around 60 calories for 100 grams of its serving. It contains a lot of phytochemicals and nutrients and is a rich source of carbohydrates and fibre. Antioxidants and Vitamins like Vitamin-A, B, C, E and K are present in it. Mango is also a good source of various minerals like Calcium, Zinc, Potassium, Iron, Magnesium and Potassium. Some Main Benefits of Mango Juice - Beneficial for Prevents Cancer: Mangoes are rich in antioxidants which restrict the oxidation of cells in the body. These antioxidants are quercetin, isoquercitrin, astragalin, fisetin, gallic acid and methylgallat. Even Vitamin-A and flavonoids like beta-carotene, alpha-carotene, and beta-cryptoxanthin present in mango prevents lung and oral cancer. Improves Brain and Health Memory: Mango Juice in Vitamin-B6 is found in abundance in mango which helps in improving brain function. It helps in maintaining an efficient nervous system. It is a mood vitamin and enhances mood and controls stress. Beneficial for Aids Digestion: Mangoes are a rich source of dietary fibre which helps in proper digestion. Fibres help with proper bowel movement and keep the digestive tract clean. Mangoes are alkaline in nature thus reduce acidity in the stomach. Various bio-active compounds like Esters, Terpenes and Aldehydes make mangoes even more potent against indigestion. Lowering Cholesterol: Mango Juice are rich in fibre which reduce bad choleste

Mango Juice Perhaps you are surprised to know that mangoes are closely related to skin health. Other than bringing a healthy glow to your face, mango Juice also help to lighten skin color. You can easily enhance your beauty by including this tasty fruit in your diet on a regular basis.



Mangoes effectively treat acne by opening the clogged pores of the skin. Once these pores are opened, acne formation will eventually stop. Unclogging the pores of the skin is the most effective way to eliminate acne. To enjoy this benefit, there is no need to eat mangoes every day you need to remove the mango pulp and apply it on the skin for around 10 minutes, then rinse it off.



Consuming this Mango Juice regularly will help keep your body healthy and slow down premature skin aging caused by environmentally stresses such as pollution and sun damage.



THE ROLE OF JUICE IN SKIN HEALTH

Mango Juices are anti-inflammatory, antioxidant, astringent, loaded with phytonutrients and they help build and repair skin collagen and connective tissue, thus reducing acne scars and acne scarring.

Some juices may also help to balance hormones, whereas others may have antibacterial and antibiotic properties.

Furthermore, these juices can help reduce stress, improve circulation, and speed healing.



Five Best Skin Health Benefits of Mango Juice:

Besides being extremely pleasing to your taste buds, mango is amazing for your skin as it is a great source of antioxidants, particularly vitamin C, which keep your skin healthy and glowing. It is often used in various face masks and scrubs. Its various skin benefits are as follows:



1. Mango juice for Glowing Skin:



Mango Juice are great for your skin as they have the ability to reduce dark spots, blemishes and acne, thus imparting a natural glow to

Mango Juice have Promotes Brain Health abundant quantities of vitamin B-6, which is vital for maintaining and improving the brain's function. These vitamins aid in the amalgamation of the major neurotransmitters that contributes in determining mood and the modification of sleeping patterns. Mangoes naturally provide significant quantities of this vitamin. With mangoes as a part of your diet, you can be assured of a healthy brain and effective nerve functioning. You will also be avoiding medicinal supplements, which have a long list of possible side effects. The Glutamine acid content in mangoes also improves concentration and the power of your memory. Vitamin A is also required for maintaining healthy mucus membranes and skin.

Mental Weakness over come with mango juice
Mango juice contains a lot of glutamine acid an important protein for concentration and memory. Taking _ cup sweet Mango juice with 25 grams curd and tsp. Ginger juice 2 or 3 times a day controls loose motions. Boil 20 grams powder of Mango bark in a liter of water and reduce it to 250 gram. Taking this decoction with 1 gram of black salt cures diarrhea.

Mango Juice mentioned Body Immunity
As mentioned earlier, similar to carrots, mangoes are rich in beta-carotene, a powerful carotenoid. This element of mango helps in to enhance the immune system of the body and make it impervious to bacteria and toxins. Excess beta-carotene is also transformed into vitamin A inside the body. Vitamin A is another antioxidant vitamin and gives you additional protection against the free radicals that can harm your internal systems. Thus, mangoes are great choice for food items to add into your regular diet. They not only increase your chances of living a disease-free life, but is also a pleasure to eat due to its magnificent taste.

Blueberry Supplementation Improves Memory in Older Adults (dagger). Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA. J Agric Food Chem. 2010 Jan 4. [Epub ahead of print] PMID: 20047325 DOI: 10.1021/jf9029332 The findings of this preliminary study suggest that moderate-term blueberry supplementation can confer neurocognitive benefit and establish a basis for more comprehensive human trials to study preventive potential and neuronal mechanisms.

Continuous changes in the healthcare reimbursement criteria require executives across the industry to focus on enterprise-wide changes that have a positive effect on supply chain savings. It's a complex problem and it's easy to get distracted on one issue when having the ability to see a clear BIG picture of your entire supply chain is what can lead to the most dramatic results and return on investments. Register for MHS' webinar on November 01 (2:00pm EST) to learn about how their customers experience an average 4:1 ROI with continual savings into the millions and a positive financial impact to their bottom line through inventory reduction, avoidance of obsolete and expired inventory, improved charge capture for each patient, and physician preference card optimization. Click on http://bit.ly/UvD3nq Presenters *Michael Ferris: Co-Founder, MHS with over 30 years of supply chain management experience *Steve Basiliere: Former Director of Supply Chain Services at Saints Medical Center, Lowell, MA *Art Kozyrovicius: Finance and Procurement Systems Support at New York-Presbyterian Hospital, New York, NY WHY ATTEND? Join a unique discussion with healthcare supply chain thought leaders and understand how to drive significant and sustainable supply chain operational improvements. Get a jump on making an immediate and positive impact on your bottom line as you head into 2013. Register by clicking on http://bit.ly/UvD3nq Note: Event will be online, through WebEx Please Register at http://bit.ly/UvD3nq

Improvement of chronic back pain or failed back surgery with vitamin D repletion: a case series.\nSchwalfenberg G.\nJ Am Board Fam Med. 2009 Jan-Feb;22(1):69-74.\nPMID: 19124636

Improved Memory and Brain Function is now suggested by a new report on blueberries by Russell Martin. This research has linked blueberries with improved memory retention and motor coordination that normally accompany aging.

Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity. Hyppönen E, Power C. Diabetes Care. 2006 Oct;29(10):2244-6. PMID: 17003300 doi: 10.2337/dc06-0946 CONCLUSIONS-Body size was a strong determinant for 25(OH)D, with concentrations being suboptimal in most obese participants. Randomized controlled trials [using dosages sufficient to improve 25(OH)D also for the obese] are required to determine whether clinically relevant improvements in glucose metabolism can be obtained by vitamin D supplementation.

Vitamin D in preventive medicine: are we ignoring the evidence? Zittermann A. Br J Nutr. 2003 May;89(5):552-72. Review. PMID: 12720576 Vitamin D is metabolised by a hepatic 25-hydroxylase into 25-hydroxyvitamin D (25(OH)D) and by a renal 1alpha-hydroxylase into the vitamin D hormone calcitriol. Calcitriol receptors are present in more than thirty different tissues. Apart from the kidney, several tissues also possess the enzyme 1alpha-hydroxylase, which is able to use circulating 25(OH)D as a substrate. Serum levels of 25(OH)D are the best indicator to assess vitamin D deficiency, insufficiency, hypovitaminosis, adequacy, and toxicity. European children and young adults often have circulating 25(OH)D levels in the insufficiency range during wintertime. Elderly subjects have mean 25(OH)D levels in the insufficiency range throughout the year. In institutionalized subjects 25(OH)D levels are often in the deficiency range. There is now general agreement that a low vitamin D status is involved in the pathogenesis of osteoporosis. Moreover, vitamin D insufficiency can lead to a disturbed muscle function. Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer. Some intervention trials have demonstrated that supplementation with vitamin D or its metabolites is able: (i) to reduce blood pressure in hypertensive patients; (ii) to improve blood glucose levels in diabetics; (iii) to improve symptoms of rheumatoid arthritis and multiple sclerosis. The oral dose necessary to achieve adequate serum 25(OH)D levels is probably much higher than the current recommendations of 5-15 microg/d.

Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. Hyppönen E, Power C. Am J Clin Nutr. 2007 Mar;85(3):860-8. PMID: 17344510 Conclusion: Prevalence of hypovitaminosis D in the general population was alarmingly high during the winter and spring, which warrants action at a population level rather than at a risk group level. Data from the 1958 birth cohort suggest that, at different cutoffs for hypovitaminosis D, a substantial public health problem exists in British whites. Obese participants and those living in Scotland were at the highest risk of hypovitaminosis D. However, the prevalence in the general population was very high during the winter and spring, which suggests that, to improve the situation, action is required at a population level rather than at a risk-group level. In the United States, calls have gone out for an increase in vitamin D fortification of foods (11), and the data from the current study suggest that such action is also warranted in the United Kingdom. Vitamin D is currently available without prescription as a dietary supplement only as part of cod liver oil or multivitamin products; hence, a need clearly exists to consider increased availability of over-the-counter supplements. Hypovitaminosis D has been implicated in the development of serious conditions, including diabetes, various types of cancer, and cardiovascular diseases, in addition to its essential role in maintaining bone health (1, 2). The high rates of hypovitaminosis D reported in this study suggest that immediate action is needed to improve the vitamin D status of the British population.

Vitamin D fortification as public health policy: significant improvement in vitamin D status in young Finnish men. Laaksi IT, Ruohola JP, Ylikomi TJ, Auvinen A, Haataja RI, Pihlajamäki HK, Tuohimaa PJ. Eur J Clin Nutr. 2006 Aug;60(8):1035-8. Epub 2006 Feb 15. PMID: 16482069