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Matti Narkia

Benefit-risk assessment of vitamin D supplementation. - Osteoporos Int. 2009 Dec 3. - S... - 0 views

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    Benefit-risk assessment of vitamin D supplementation.
    Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC.
    Osteoporos Int. 2009 Dec 3. [Epub ahead of print]
    PMID: 19957164

    Conclusion Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.
Matti Narkia

How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptati... - 0 views

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    How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
    Vieth R.
    Anticancer Res. 2009 Sep;29(9):3675-84. Review.
    PMID: 19667164
Matti Narkia

How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptati... - 0 views

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    How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
    Vieth R.
    Anticancer Res. 2009 Sep;29(9):3675-84. Review.
    PMID: 19667164
Matti Narkia

Optimal Serum 25-Hydroxyvitamin D Levels for Multiple Health Outcomes - SpringerLink - ... - 0 views

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    Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes.
    Bischoff-Ferrari HA.
    Adv Exp Med Biol. 2008;624:55-71. Review.
    PMID: 18348447
    DOI: 10.1007/978-0-387-77574-6_5

    Recent evidence suggests that higher vitamin D intakes beyond current recommendations may be associated with better health outcomes. In this chapter, evidence is summarized from different studies that evaluate threshold levels for serum 25(OH)D levels in relation to bone mineral density (BMD), lower extremity function, dental health, risk of falls, admission to nursing home, fractures, cancer prevention and incident hypertension. For all endpoints, the most advantageous serum levels for 25(OH)D appeared to be at least 75 nmol/l (30 ng/ml) and for cancer prevention, desirable 25(OH)D levels are between 90-120 nmol/l (36-48 ng/ml). An intake of no less than 1000IU (25 meg) of vitamin D3 (cholecalciferol) per day for all adults may bring at least 50% of the population up to 75 nmol/l. Thus, higher doses of vitamin D are needed to bring most individuals into the desired range. While estimates suggest that 2000 IU vitamin D3 per day may successfully and safely achieve this goal, the implications of 2000 IU or higher doses for the total adult population need to be addressed in future studies.
Matti Narkia

Estimates of optimal vitamin D status. - Osteoporos Int. 2005 Jul;16(7):713-6. - Spring... - 0 views

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    Estimates of optimal vitamin D status.
    Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R.
    Osteoporos Int. 2005 Jul;16(7):713-6. Epub 2005 Mar 18.
    PMID: 15776217
Matti Narkia

Epidemiology of Vitamin D Insufficiency and Cancer Mortality - Anticancer Research - 0 views

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    Epidemiology of vitamin D insufficiency and cancer mortality.
    Pilz S, Tomaschitz A, Obermayer-Pietsch B, Dobnig H, Pieber TR.
    Anticancer Res. 2009 Sep;29(9):3699-704. Review.
    PMID: 19667167

    In conclusion, we still need further studies to evaluate the association of vitamin D insufficiency and cancer incidence and mortality, but the multiple health benefits of vitamin D and the easy, safe and inexpensive way by which vitamin D can be supplemented should already guide current public health strategies to achieve 25(OH)D levels of at least 75 nmol/l (30 ng/ml) in the general population.
Matti Narkia

Optimal vitamin D status attenuates the age-associated increase in systolic blood press... - 0 views

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    Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey.
    Judd SE, Nanes MS, Ziegler TR, Wilson PW, Tangpricha V.
    Am J Clin Nutr. 2008 Jan;87(1):136-41.
    PMID: 18175747

    Conclusions: SBP is inversely associated with serum vitamin D concentrations in nonhypertensive white persons in the United States. This observation provides a rationale for studies on the potential effects of vitamin D supplementation as a method to reduce SBP in persons at risk of hypertension.
Matti Narkia

Circulating 25-Hydroxyvitamin D Levels Indicative of Vitamin D Sufficiency: Implication... - 0 views

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    Using these functional indicators, several studies have more accurately defined vitamin D deficiency as circulating levels of 25(OH)D ≤ 80 nmol or 32 µg/L. Recent studies reveal that current dietary recommendations for adults are not sufficient to maintain circulating 25(OH)D levels at or above this level, especially in pregnancy and lactation.

    Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D.
    Hollis BW.
    J Nutr. 2005 Feb;135(2):317-22. Review.
    PMID: 15671234 [
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