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Matti Narkia

The Bioavailability of Vitamin D from Fortified Cheeses and Supplements Is Equivalent i... - 0 views

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    The bioavailability of vitamin D from fortified cheeses and supplements is equivalent in adults.
    Wagner D, Sidhom G, Whiting SJ, Rousseau D, Vieth R.
    J Nutr. 2008 Jul;138(7):1365-71.
    PMID: 18567762

    Compared with baseline, serum parathyroid hormone decreased with both fortification (P = 0.003) and supplementation (P = 0.012). These data demonstrate that vitamin D is equally bioavailable from fortified hard cheeses and supplements, making cheese suitable for vitamin D fortification.
Matti Narkia

Decreased bioavailability of vitamin D in obesity -- Wortsman et al. 72 (3): 690 -- Ame... - 0 views

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    Decreased bioavailability of vitamin D in obesity.
    Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF.
    Am J Clin Nutr. 2000 Sep;72(3):690-3. Erratum in: Am J Clin Nutr. 2003 May;77(5):1342.
    PMID: 10966885

    Conclusions: Obesity-associated vitamin D insufficiency is likely due to the decreased bioavailability of vitamin D3 from cutaneous and dietary sources because of its deposition in body fat compartments.
Matti Narkia

How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptati... - 0 views

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    How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
    Vieth R.
    Anticancer Res. 2009 Sep;29(9):3675-84. Review.
    PMID: 19667164
Matti Narkia

The Effect of Vitamin D2 and Vitamin D3 on Intestinal Calcium Absorption in Nigerian Ch... - 0 views

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    The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets.
    Thacher TD, Obadofin MO, O'Brien KO, Abrams SA.
    J Clin Endocrinol Metab. 2009 Sep;94(9):3314-21. Epub 2009 Jun 30.
    PMID: 19567516

    Conclusions: Despite similar increases in 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with vitamin D2 or vitamin D3, fractional calcium absorption did not increase, indicating that rickets in Nigerian children is not primarily due to vitamin D-deficient calcium malabsorption
Matti Narkia

Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sun... - 0 views

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    Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?
    Pignotti GA, Genaro PS, Pinheiro MM, Szejnfeld VL, Martini LA.
    Eur J Nutr. 2009 Nov 28. [Epub ahead of print]
    PMID: 19946776

    CONCLUSION: The dose given (400 IU/day) was not enough to achieve 25(OH)D concentration, considered optimal for bone health.
Matti Narkia

Twice single doses of 100,000 IU of vitamin D in winter is adequate and safe ... - 1 views

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    Twice single doses of 100,000 IU of vitamin D in winter is adequate and safe for prevention of vitamin D deficiency in healthy children from Ushuaia, Tierra Del Fuego, Argentina.
    Tau C, Ciriani V, Scaiola E, Acuña M.
    J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):651-4. Epub 2007 Jan 25.
    PMID: 17257830
    doi:10.1016/j.jsbmb.2006.12.027

    These results disclosed that to prevent vitamin D deficiency for children at zones of risk at the south of our country, double supplementation of 100,000 IU of vitamin D during autumn and winter, would be adequate and safe.
Matti Narkia

Safety of vitamin D3 in adults with multiple sclerosis -- Kimball et al. 86 (3): 645 --... - 0 views

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    Safety of vitamin D3 in adults with multiple sclerosis.
    Kimball SM, Ursell MR, O'Connor P, Vieth R.
    Am J Clin Nutr. 2007 Sep;86(3):645-51.
    PMID: 17823429

    Conclusions: Patients' serum 25(OH)D concentrations reached twice the top of the physiologic range without eliciting hypercalcemia or hypercalciuria. The data support the feasibility of pharmacologic doses of vitamin D3 for clinical research, and they provide objective evidence that vitamin D intake beyond the current upper limit is safe by a large margin.
Matti Narkia

How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptati... - 0 views

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    How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
    Vieth R.
    Anticancer Res. 2009 Sep;29(9):3675-84. Review.
    PMID: 19667164
Matti Narkia

Plasma Vitamin D and 25OHD Responses of Young and Old Men to Supplementation with Vitam... - 0 views

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    Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3.
    Harris SS, Dawson-Hughes B.
    J Am Coll Nutr. 2002 Aug;21(4):357-62.
    PMID: 12166534

    Conclusions: There appears to be no age-related impairment among men in the absorption or metabolism of 20 µg/day of vitamin D3 taken orally for at least eight weeks.
Matti Narkia

Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after ... - 0 views

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    Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol.
    Glendenning P, Chew GT, Seymour HM, Gillett MJ, Goldswain PR, Inderjeeth CA, Vasikaran SD, Taranto M, Musk AA, Fraser WD.
    Bone. 2009 Nov;45(5):870-5. Epub 2009 Jul 23.
    PMID: 19631774
    doi:10.1016/j.bone.2009.07.015

    Cholecalciferol supplementation resulted in a 31% greater increase in total HPLC-measured 25OHD (p=0.010) and 52% greater rise in RIA-measured 25OHD (p<0.001) of supplementation dose with than ergocalciferol equivalent an>0.05). In vitamin D-insufficient hip fracture patients, supplementation with cholecalciferol 1000 IU/day for three months was more effective in increasing serum 25OHD than an equivalent dose of ergocalciferol. However, the lack of difference in PTH lowering between calciferol treatments raises questions about the biological importance of this observation.
Matti Narkia

Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of ran... - 0 views

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    Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials.
    Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J.
    BMJ. 2009 Oct 1;339:b3692. doi: 10.1136/bmj.b3692.
    PMID: 19797342
    doi: 10.1136/bmj.b3692

    Conclusions Supplemental vitamin D in a dose of 700-1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D. Doses of supplemental vitamin D of less than 700 IU or serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l may not reduce the risk of falling among older individuals.
Matti Narkia

Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy m... - 0 views

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    Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men.
    Barger-Lux MJ, Heaney RP, Dowell S, Chen TC, Holick MF.
    Osteoporos Int. 1998;8(3):222-30.
    PMID: 9797906
Matti Narkia

Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (... - 0 views

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    Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients.
    Vieth R, Kimball S, Hu A, Walfish PG.
    Nutr J. 2004 Jul 19;3:8.
    PMID: 15260882
    doi:10.1186/1475-2891-3-8

    CONCLUSION: The highest AI for vitamin D brought summertime 25(OH)D to >40 nmol/L, lowered PTH, and its use was associated with improved wellbeing. The 100 mcg/day dose produced greater responses. Since it was ethically necessary to provide a meaningful dose of vitamin D to these insufficient patients, we cannot rule out a placebo wellbeing response, particularly for those on the lower dose. This work confirms the safety and efficacy of both 15 and 100 mcg/day vitamin D3 in patients who needed additional vitamin D.
Matti Narkia

Epidemiology of Vitamin D Insufficiency and Cancer Mortality - Anticancer Research - 0 views

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    Epidemiology of vitamin D insufficiency and cancer mortality.
    Pilz S, Tomaschitz A, Obermayer-Pietsch B, Dobnig H, Pieber TR.
    Anticancer Res. 2009 Sep;29(9):3699-704. Review.
    PMID: 19667167

    In conclusion, we still need further studies to evaluate the association of vitamin D insufficiency and cancer incidence and mortality, but the multiple health benefits of vitamin D and the easy, safe and inexpensive way by which vitamin D can be supplemented should already guide current public health strategies to achieve 25(OH)D levels of at least 75 nmol/l (30 ng/ml) in the general population.
Matti Narkia

A positive dose-response effect of vitamin D supplementation on site-specific bone mine... - 0 views

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    A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention.
    Viljakainen HT, Natri AM, Kärkkäinen M, Huttunen MM, Palssa A, Jakobsen J, Cashman KD, Mølgaard C, Lamberg-Allardt C.
    J Bone Miner Res. 2006 Jun;21(6):836-44.
    PMID: 16753014
    doi: 10.1359/jbmr.060302

    We conclude that the current vitamin D recommendation for adolescent girls, at least in the northern latitudes, is too low to ensure sufficient vitamin D status during winter. Intake of vitamin D at rates of 10-15 μg/day aids to maintain stable S-25(OH)D concentrations during winter. Vitamin D induced BMC augmentation by decreasing bone resorption, but not affecting bone formation, which was reflected by the biochemical markers of bone turnover. Optimizing bone mineral gain in adolescence is crucial to the prevention of osteoporosis later in life. Increasing vitamin D intake to 10-15 μg/day aids in attaining this goal.
Matti Narkia

Vitamin D2 Is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 2... - 0 views

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    Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D.
    Holick MF, Biancuzzo RM, Chen TC, Klein EK, Young A, Bibuld D, Reitz R, Salameh W, Ameri A, Tannenbaum AD.
    J Clin Endocrinol Metab. 2008 Mar;93(3):677-81. Epub 2007 Dec 18.
    PMID: 18089691

    Conclusion: A 1000 IU dose of vitamin D2 daily was as effective as 1000 IU vitamin D3 in maintaining serum 25-hydroxyvitamin D levels and did not negatively influence serum 25-hydroxyvitamin D3 levels. Therefore, vitamin D2 is equally as effective as vitamin D3 in maintaining 25-hydroxyvitamin D status.
Matti Narkia

Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does... - 0 views

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    Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2.
    Trang HM, Cole DE, Rubin LA, Pierratos A, Siu S, Vieth R.
    Am J Clin Nutr. 1998 Oct;68(4):854-8.
    PMID: 9771862

    Although the 1.7-times
    greater efficacy for vitamin D3 shown here may seem small, it is
    more than what others have shown for 25(OH)D increases when
    comparing 2-fold differences in vitamin D3 dose. The
    assumption that vitamins D2 and D3 have equal nutritional value
    is probably wrong and should be reconsidered.
Matti Narkia

Vitamin D2 Is Much Less Effective than Vitamin D3 in Humans -- Armas et al. 89 (11): 53... - 0 views

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    Vitamin D2 is much less effective than vitamin D3 in humans.
    Armas LA, Hollis BW, Heaney RP.
    J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91.
    PMID: 15531486

    Vitamin D2 potency is less than one third that of vitamin D3. Physicians resorting to use of vitamin D2 should be aware of its markedly lower potency and shorter duration of action relative to vitamin D3.
Matti Narkia

Supplementation with cholecalciferol does not improve glycaemic control in diabetic sub... - 0 views

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    Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels.
    Jorde R, Figenschau Y.
    Eur J Nutr. 2009 Apr 16. [Epub ahead of print]
    PMID: 19370371
    10.1007/s00394-009-0020-3

    Conclusions We were not able to demonstrate that vitamin D supplementation had a significant effect on glucose metabolism in subjects with type 2 diabetes but without vitamin D deficiency. Further studies are needed in larger groups of subjects with type 2 diabetes or impaired glucose tolerance, who also exhibit low serum 25-hydroxyvitamin D levels.
Matti Narkia

Pharmacokinetics of a single, large dose of cholecalciferol -- Ilahi et al. 87 (3): 688... - 0 views

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    Pharmacokinetics of a single, large dose of cholecalciferol.
    Ilahi M, Armas LA, Heaney RP.
    Am J Clin Nutr. 2008 Mar;87(3):688-91.
    PMID: 1832660

    Conclusions: Cholecalciferol (100 000 IU) is a safe, effective, and simple way to increase calcidiol concentrations. The dosing interval should be ≤2 mo to ensure continuous serum calcidiol concentrations above baseline.

    Our study highlights that 100 000 IU cholecalciferol is a safe, efficient, and cost-effective means to increase calcidiol concentrations in the elderly. From this study we can safely recommend 100 000 IU cholecalciferol dosed every 2 mo in persons with moderate baseline calcidiol concentrations. However, in those persons with baseline calcidiol concentrations < 20 ng/mL, even this large dose will not adequately raise their calcidiol concentrations.
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