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Matti Narkia

Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human... - 0 views

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    Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies.
    Kovacs CS.
    Am J Clin Nutr. 2008 Aug;88(2):520S-528S. Review.
    PMID: 18689394

    Dosing recommendations for women during pregnancy and lactation might be best directed toward ensuring that the neonate is vitamin D-sufficient and that this sufficiency is maintained during infancy and beyond. A dose of vitamin D that provides 25(OH)D sufficiency in the mother during pregnancy should provide normal cord blood concentrations of 25(OH)D. Research has shown that during lactation, supplements administered directly to the infant can easily achieve vitamin D sufficiency; the mother needs much higher doses (100 µg or 4000 IU per day) to achieve adult-normal 25(OH)D concentrations in her exclusively breastfed infant. In addition, the relation (if any) of vitamin D insufficiency in the fetus or neonate to long-term nonskeletal outcomes such as type 1 diabetes and other chronic diseases needs to be investigated.
Matti Narkia

Vitamin D requirements during lactation: high-dose maternal supplementation as therapy ... - 0 views

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    Vitamin D requirements during lactation: high-dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infant.
    Hollis BW, Wagner CL.
    Am J Clin Nutr. 2004 Dec;80(6 Suppl):1752S-8S.
    PMID: 15585800
Matti Narkia

Assessment of dietary vitamin D requirements during pregnancy and lactation -- Hollis a... - 0 views

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    Assessment of dietary vitamin D requirements during pregnancy and lactation.
    Hollis BW, Wagner CL.
    Am J Clin Nutr. 2004 May;79(5):717-26. Review.
    PMID: 15113709

    We found that high-dose maternal vitamin D supplementation not only improves the nutritional vitamin D status of breastfeeding infants but also elevates the maternal concentrations into the mid-normal range. Thus, a dual benefit is achieved from high-dose maternal supplementation. It is noteworthy that in the Finnish study, the authors added a disclaimer, "A sufficient supply of vitamin D to the breastfed infant is achieved only by increasing the maternal supplementation up to 2000 IU/d. Such a dose is far higher than the RDA [DRI] for lactating mothers [and therefore] its safety over prolonged periods is not known and should be examined by further study." This point of concern was valid when this study was conducted in 1986 (92); however, on the basis of the current findings of Vieth et al (2) and of Heaney et al (3)-which showed that vitamin D intakes <= 10 000 IU/d (250 µg) are safe for prolonged periods (up to 5 mo)-we believe that it is time to reexamine the understated DRI of vitamin D for lactating mothers. This work is now being conducted in our clinics and laboratory.
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