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Matti Narkia

Decreased bioavailability of vitamin D in obesity -- Wortsman et al. 72 (3): 690 -- Ame... - 0 views

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    Decreased bioavailability of vitamin D in obesity.
    Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF.
    Am J Clin Nutr. 2000 Sep;72(3):690-3. Erratum in: Am J Clin Nutr. 2003 May;77(5):1342.
    PMID: 10966885

    Conclusions: Obesity-associated vitamin D insufficiency is likely due to the decreased bioavailability of vitamin D3 from cutaneous and dietary sources because of its deposition in body fat compartments.
Matti Narkia

Holick explains how Vit D made the Dinosaurs extinct - Prof. Marshall's Perspective - P... - 0 views

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    On 29th September, Dr Michael Holick appeared on the "Coast to Coast" radio show, hosted by George Noory:

    http://www.coasttocoastam.com/guest/holick-dr-michael/41323

    As many of you can't afford a subscription to listen to the whole show, I have edited the broadcast into an MP3 file of short snippets, so that we can (intelligently) discuss what was said. There is a "beep tone" to separate each snippet of info.

    You can download it from:
    http://MarshallProtocol.com/video/Holick.mp3

    First is the introduction, setting out Dr Holick's overview of Vit D.
Matti Narkia

GrassrootsHealth | Vitamin D Action - Vitamin D Scientists' Call to Action Statement - 0 views

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    "We are aware of substantial scientific evidence supporting the role of vitamin D in prevention of cancer. It has been reasonably established that adequate serum vitamin D metabolite levels are associated with substantially lower incidence rates of several types of cancer, including those of the breast, colon, and ovary, and other sites.

    We have concluded that the vitamin D status of most individuals in North America will need to be greatly improved for substantial reduction in incidence of cancer. Epidemiological studies have shown that higher vitamin D levels are also associated with lower risk of Type I diabetes in children and of multiple sclerosis. Several studies have found that markers of higher vitamin D levels are associated with lower incidence and severity of influenza and several other infectious diseases."
Matti Narkia

Vitamin D and prevention of breast cancer: pooled analysis. - ScienceDirect - The Journ... - 0 views

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    Vitamin D and prevention of breast cancer: pooled analysis.
    Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC.
    J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11.
    PMID: 17368188

    CONCLUSIONS: Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies.
Matti Narkia

Vitamin D content in Alaskan Arctic zooplankton, fishes, and marine mammals - Wiley Int... - 0 views

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    Vitamin D content in Alaskan Arctic zooplankton, fishes, and marine mammals.
    David E. Kenny 1, Todd M. O'Hara, Tai C. Chen, Zhiren Lu, Xiao Tian, Michael F. Holick.
    Zoo Biology
    Volume 23 Issue 1, Pages 33 - 43
    Published Online: 13 Feb 2004
    Doi: 10.1002/zoo.10104
Matti Narkia

The Role of Vitamin D in Cancer Prevention -- Garland et al. 96 (2): 252 -- American Jo... - 0 views

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    The role of vitamin D in cancer prevention.
    Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
    Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
    PMID: 16380576
    DOI: 10.2105/AJPH.2004.045260

    Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.

    The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.
Matti Narkia

The Role of Vitamin D in Cancer Prevention -- Garland et al. 96 (2): 252 -- American Jo... - 0 views

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    The role of vitamin D in cancer prevention.
    Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
    Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
    PMID: 16380576
    DOI: 10.2105/AJPH.2004.045260

    Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.

    The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects
Matti Narkia

An international comparison of serum 25-hydroxyvitamin D measurements. - Osteoporos Int... - 0 views

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    An international comparison of serum 25-hydroxyvitamin D measurements.
    Lips P, Chapuy MC, Dawson-Hughes B, Pols HA, Holick MF.
    Osteoporos Int. 1999;9(5):394-7.
    PMID: 10550457
    DOI: 10.1007/s001980050162

    The results show that 25(OH)D values from different laboratories can not be assumed to be comparable unless a careful cross-calibration has been performed.
Matti Narkia

Estimates of optimal vitamin D status. - Osteoporos Int. 2005 Jul;16(7):713-6. - Spring... - 0 views

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    Estimates of optimal vitamin D status.
    Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R.
    Osteoporos Int. 2005 Jul;16(7):713-6. Epub 2005 Mar 18.
    PMID: 15776217
Matti Narkia

Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy m... - 0 views

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    Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men.
    Barger-Lux MJ, Heaney RP, Dowell S, Chen TC, Holick MF.
    Osteoporos Int. 1998;8(3):222-30.
    PMID: 9797906
Matti Narkia

Epidemic influenza and vitamin D. - Epidemiol Infect. 2006 Dec;134(6):1129-40. (full t... - 0 views

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    Epidemic influenza and vitamin D.
    Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E.
    Epidemiol Infect. 2006 Dec;134(6):1129-40. Epub 2006 Sep 7. Review.
    PMID: 16959053
Matti Narkia

NEJM -- Vitamin D Intoxication Associated with an Over-the-Counter Supplement - 0 views

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    Vitamin D intoxication associated with an over-the-counter supplement.
    Koutkia P, Chen TC, Holick MF.
    N Engl J Med. 2001 Jul 5;345(1):66-7.
    PMID: 11439958
Matti Narkia

Prevalence of Vitamin D Inadequacy among Postmenopausal North American Women Receiving ... - 0 views

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    Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy.
    Holick MF, Siris ES, Binkley N, Beard MK, Khan A, Katzer JT, Petruschke RA, Chen E, de Papp AE.
    J Clin Endocrinol Metab. 2005 Jun;90(6):3215-24. Epub 2005 Mar 29.
    PMID: 15797954
    doi:10.1210/jc.2004-2364

    Conclusions: More than half of North American women receiving therapy to treat or prevent osteoporosis have vitamin D inadequacy, underscoring the need for improved physician and public education regarding optimization of vitamin D status in this population.
Matti Narkia

Chronic Sunscreen Use Decreases Circulating Concentrations of 25-Hydroxyvitamin D: A Pr... - 0 views

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    Matsuoka, L. Y., Wortsman, J., Hanifan, N. & Holick, M. F. (1988)
    Chronic sunscreen use decreases circulating concentrations of 25-hydroxyvitamin D: a preliminary study.
    Arch. Dermatol. 124:1802-1804
Matti Narkia

Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an ess... - 0 views

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    Holick, M. F., MacLaughlin, J. A. & Doppelt, S. H. (1981)
    Factors that influence the cutaneous photosynthesis of previtamin D3. Science 211:590-593

    When human skin was exposed to simulated solar ultraviolet radiation, epidermal 7-dehydrocholesterol was converted to previtamin D3. During prolonged exposure to simulated solar ultraviolet radiation, the synthesis of previtamin D3 reached a plateau at about 10 to 15 percent of the original 7-dehydrocholesterol content, and previtamin D3 was photoisomerized to two biologically inert isomers, lumisterol3 and tachysterol3. Increases either in skin melanin concentration or in latitude necessitated increases in the exposure time to simulated solar ultraviolet radiation required to maximize the formation, but not the total content, of previtamin D3. In order of importance, the significant determinants limiting the cutaneous production of previtamin D3 are (i) photochemical regulation, (ii) pigmentation, and (iii) latitude.
Matti Narkia

Vitamin D Deficiency - Treatment and Diagnosis - UCSD-TV - University of California Tel... - 0 views

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    Vitamin D Deficiency - Treatment and Diagnosis
Matti Narkia

An evaluation of the relative contributions of exposure to sunlight and of diet to the ... - 0 views

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    An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston.
    Webb AR, Pilbeam C, Hanafin N, Holick MF.
    Am J Clin Nutr. 1990 Jun;51(6):1075-81.
    PMID: 2349922
Matti Narkia

Aging decreases the capacity of human skin to produce vitamin D3. - Journal of Clinical... - 0 views

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    Aging decreases the capacity of human skin to produce vitamin D3.
    MacLaughlin J, Holick MF.
    J Clin Invest. 1985 Oct;76(4):1536-8.
    PMID: 2997282
    doi:10.1172/JCI112134

    An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.
Matti Narkia

Vitamin D deficiency: a worldwide problem with health consequences -- Holick and Chen 8... - 0 views

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    Vitamin D deficiency: a worldwide problem with health consequences.
    Holick MF, Chen TC.
    Am J Clin Nutr. 2008 Apr;87(4):1080S-6S. Review.
    PMID: 18400738

    A reevaluation needs to take place of what the adequate intakes of vitamin D should be for children and adults. The literature over the past decade suggests that the Institute of Medicine recommendations in 1997 (83) are inadequate, and some experts including us suggest that both children and adults should take ≥800-1000 IU vitamin D/d from dietary and supplemental sources (4, 9, 77) when sunlight is unable to provide it. This recommendation, however, has not yet been embraced either by official government or pediatric organizations in the United States, Canada, or Europe for either children or adults.
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