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Matti Narkia

Pharmacokinetics of a single, large dose of cholecalciferol -- Ilahi et al. 87 (3): 688... - 0 views

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    Pharmacokinetics of a single, large dose of cholecalciferol.
    Ilahi M, Armas LA, Heaney RP.
    Am J Clin Nutr. 2008 Mar;87(3):688-91.
    PMID: 1832660

    Conclusions: Cholecalciferol (100 000 IU) is a safe, effective, and simple way to increase calcidiol concentrations. The dosing interval should be ≤2 mo to ensure continuous serum calcidiol concentrations above baseline.

    Our study highlights that 100 000 IU cholecalciferol is a safe, efficient, and cost-effective means to increase calcidiol concentrations in the elderly. From this study we can safely recommend 100 000 IU cholecalciferol dosed every 2 mo in persons with moderate baseline calcidiol concentrations. However, in those persons with baseline calcidiol concentrations < 20 ng/mL, even this large dose will not adequately raise their calcidiol concentrations.
Matti Narkia

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and h... - 0 views

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    Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.\nChen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M.\nProc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54. Epub 2007 May 14.\nPMID: 17502596 \n doi: 10.1073/pnas.0702854104\n
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